Article ; Online: Peripheral arterial disease and hypertension.
2022 Volume 37, Issue 5, Page(s) 403–412
Abstract: Purpose of review: Hypertension (HTN) is a well known risk factor for atherosclerosis and peripheral arterial disease (PAD). PAD affects more than 250 million people globally and is associated with worse clinical outcomes. Although multiple studies have ...
| Abstract | Purpose of review: Hypertension (HTN) is a well known risk factor for atherosclerosis and peripheral arterial disease (PAD). PAD affects more than 250 million people globally and is associated with worse clinical outcomes. Although multiple studies have been performed to evaluate treatment of HTN in patients with PAD, blood pressure management in this high-risk cohort remains poor. Recent findings: There has been conflicting evidence regarding blood pressure goals in PAD with some recent studies showing adverse outcomes with low blood pressure in this patient population. Current guidelines, however, continue to recommend treatment goals in PAD patients similar to patients without PAD. To date, no single antihypertensive drug class has shown a clear benefit in PAD population over other antihypertensive drug classes. Summary: Prospective randomized trials enrolling PAD patients are required that can shed light on optimum blood pressure target and also distinguish between different antihypertensive drugs in terms of reducing adverse outcomes. |
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| MeSH term(s) | Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Humans ; Hypertension ; Peripheral Arterial Disease/drug therapy ; Prospective Studies |
| Chemical Substances | Antihypertensive Agents |
| Language | English |
| Publishing date | 2022-07-19 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 645186-x |
| ISSN | 1531-7080 ; 0268-4705 |
| ISSN (online) | 1531-7080 |
| ISSN | 0268-4705 |
| DOI | 10.1097/HCO.0000000000000983 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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