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Article ; Online: Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics.

Benioudakis, Emmanouil / Karlafti, Eleni / Bekiaridou, Alexandra / Didangelos, Triantafyllos / Papavramidis, Theodossis S

Nutrients

2021 Volume 14, Issue 1

Abstract: Diabetes mellitus has been steadily increasing over the past decades and is one of the most significant global public health concerns. Diabetes mellitus patients have an increased risk of both surgical and post-surgical complications. The post-surgical ... ...

Abstract	Diabetes mellitus has been steadily increasing over the past decades and is one of the most significant global public health concerns. Diabetes mellitus patients have an increased risk of both surgical and post-surgical complications. The post-surgical risks are associated with the primary condition that led to surgery and the hyperglycaemia per se. Gut microbiota seems to contribute to glucose homeostasis and insulin resistance. It affects the metabolism through body weight and energy homeostasis, integrating the peripheral and central food intake regulatory signals. Homeostasis of gut microbiota seems to be enhanced by probiotics pre and postoperatively. The term probiotics is used to describe some species of live microorganisms that, when administered in adequate amounts, confer health benefits on the host. The role of probiotics in intestinal or microbial skin balance after abdominal or soft tissue elective surgeries on DM patients seems beneficial, as it promotes anti-inflammatory cytokine production while increasing the wound-healing process. This review article aims to present the interrelation of probiotic supplements with DM patients undergoing elective surgeries.
MeSH term(s)	Animals ; Bariatric Surgery/methods ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/surgery ; Comorbidity ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/microbiology ; Diabetes Mellitus/therapy ; Diabetes, Gestational/prevention & control ; Female ; Humans ; Obesity, Morbid/surgery ; Pregnancy ; Probiotics/adverse effects ; Probiotics/therapeutic use ; Rats ; Weight Loss
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14010192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Probiotics and Their Effect on Surgical Wound Healing: A Systematic Review and New Insights into the Role of Nanotechnology.

Bekiaridou, Alexandra / Karlafti, Eleni / Oikonomou, Ilias Marios / Ioannidis, Aristidis / Papavramidis, Theodossis S

Nutrients

2021 Volume 13, Issue 12

Abstract: Skin tissue repair is of fundamental importance for maintaining homeostasis regulation, protection barrier, absorption, and excretion of skin tissue. Wound healing is a complicated process that can be impaired by infections and therefore have a ... ...

Abstract	Skin tissue repair is of fundamental importance for maintaining homeostasis regulation, protection barrier, absorption, and excretion of skin tissue. Wound healing is a complicated process that can be impaired by infections and therefore have a significant economic and social impact. Simultaneously, the overuse of antibiotics has led to antimicrobial resistance and loss of their efficacy. Thus, the need for alternative antimicrobial agents is urgent. The newest approaches on wound dressings employ new therapeutic agents, such as probiotics. Probiotics alone or in tandem with nanotechnology-based techniques exhibit a broad range of benefits on surgical wounds. This systematic review aims to consider current knowledge of probiotic effects on animals and humans regarding surgical wound healing and provide new insights into the role of nanotechnology. The databases included were PubMed (MEDLINE), Scopus, and Cochrane Library (CENTRAL). Studies focused on burns, chronic wounds, and diabetic ulcers were excluded. The promising industry of probiotics demonstrates a significant upsurge as more and more healthy individuals rely their well-being on alternative medicine. Included probiotics illustrated positive results on wound re-epithelization, neovascularization, and wound healing. No adverse effects were noted.
MeSH term(s)	Animals ; Anti-Infective Agents/therapeutic use ; Humans ; Nanotechnology/methods ; Probiotics/administration & dosage ; Surgical Wound/microbiology ; Surgical Wound Infection/microbiology ; Surgical Wound Infection/prevention & control ; Wound Healing
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13124265
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Article: Gestational Diabetes, Colorectal Cancer, Bariatric Surgery, and Weight Loss among Diabetes Mellitus Patients: A Mini Review of the Interplay of Multispecies Probiotics

Benioudakis, Emmanouil / Karlafti, Eleni / Bekiaridou, Alexandra / Didangelos, Triantafyllos / Papavramidis, Theodossis S.

Nutrients. 2021 Dec. 31, v. 14, no. 1

2021

Abstract	Diabetes mellitus has been steadily increasing over the past decades and is one of the most significant global public health concerns. Diabetes mellitus patients have an increased risk of both surgical and post-surgical complications. The post-surgical risks are associated with the primary condition that led to surgery and the hyperglycaemia per se. Gut microbiota seems to contribute to glucose homeostasis and insulin resistance. It affects the metabolism through body weight and energy homeostasis, integrating the peripheral and central food intake regulatory signals. Homeostasis of gut microbiota seems to be enhanced by probiotics pre and postoperatively. The term probiotics is used to describe some species of live microorganisms that, when administered in adequate amounts, confer health benefits on the host. The role of probiotics in intestinal or microbial skin balance after abdominal or soft tissue elective surgeries on DM patients seems beneficial, as it promotes anti-inflammatory cytokine production while increasing the wound-healing process. This review article aims to present the interrelation of probiotic supplements with DM patients undergoing elective surgeries.
Keywords	bariatric surgery ; body weight ; colorectal neoplasms ; cytokines ; diabetes mellitus ; energy ; food intake ; gestational diabetes ; glucose ; homeostasis ; hyperglycemia ; insulin resistance ; intestinal microorganisms ; intestines ; metabolism ; probiotics ; public health ; risk ; tissues ; weight loss
Language	English
Dates of publication	2021-1231
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14010192
Database	NAL-Catalogue (AGRICOLA)

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Article: Probiotics and Their Effect on Surgical Wound Healing: A Systematic Review and New Insights into the Role of Nanotechnology

Bekiaridou, Alexandra / Karlafti, Eleni / Oikonomou, Ilias Marios / Ioannidis, Aristidis / Papavramidis, Theodossis S.

Nutrients. 2021 Nov. 26, v. 13, no. 12

2021

Abstract	Skin tissue repair is of fundamental importance for maintaining homeostasis regulation, protection barrier, absorption, and excretion of skin tissue. Wound healing is a complicated process that can be impaired by infections and therefore have a significant economic and social impact. Simultaneously, the overuse of antibiotics has led to antimicrobial resistance and loss of their efficacy. Thus, the need for alternative antimicrobial agents is urgent. The newest approaches on wound dressings employ new therapeutic agents, such as probiotics. Probiotics alone or in tandem with nanotechnology-based techniques exhibit a broad range of benefits on surgical wounds. This systematic review aims to consider current knowledge of probiotic effects on animals and humans regarding surgical wound healing and provide new insights into the role of nanotechnology. The databases included were PubMed (MEDLINE), Scopus, and Cochrane Library (CENTRAL). Studies focused on burns, chronic wounds, and diabetic ulcers were excluded. The promising industry of probiotics demonstrates a significant upsurge as more and more healthy individuals rely their well-being on alternative medicine. Included probiotics illustrated positive results on wound re-epithelization, neovascularization, and wound healing. No adverse effects were noted.
Keywords	absorption ; alternative medicine ; angiogenesis ; antibiotic resistance ; excretion ; homeostasis ; industry ; probiotics ; social impact ; systematic review ; tissue repair
Language	English
Dates of publication	2021-1126
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13124265
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Role of MicroRNA in the Diagnosis and Therapy of Hepatic Metastases from Colorectal Cancer.

Chorti, Angeliki / Bangeas, Petros / Papavramidis, Theodossis S / Tsoulfas, Georgios

MicroRNA (Shariqah, United Arab Emirates)

2018 Volume 7, Issue 3, Page(s) 167–177

Abstract: Introduction: Colorectal cancer is one of the most common malignancies in both genders and liver metastasis appear in more than 50% of patients with colorectal cancer, worsening its morbidity and mortality rates. The existing methods for the diagnosis ... ...

Abstract	Introduction: Colorectal cancer is one of the most common malignancies in both genders and liver metastasis appear in more than 50% of patients with colorectal cancer, worsening its morbidity and mortality rates. The existing methods for the diagnosis and prognosis of colorectal cancer seem to be insufficient to predict its aggressiveness, leading to poor outcomes for the patient. Objective: MicroRNAs are small non-coding RNAs, which interact with mRNAs in a posttranscriptional stage, and have been found to be involved in pathogenesis of cancer and its metastases. Their utility in diagnosis of colorectal liver metastasis gains ground through serum or tissue examination. Methods: Several miRNAs are related to colorectal cancer and its liver metastasis. Conclusion: Some of them have oncogenic and other tumor suppressive role in the development of colorectal liver metastasis, while many of them have been proved to be correlated with the overall survival and prognosis of patients with colorectal cancer. The aim of the present review is to give a detailed account of the different miRNAs that have been described as playing a role in hepatic metastases from colorectal cancer, emphasizing their diagnostic, prognostic and therapeutic implications.
MeSH term(s)	Biomarkers, Tumor/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; MicroRNAs/genetics ; Prognosis
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2018-05-24
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	2211-5374
ISSN (online)	2211-5374
DOI	10.2174/2211536607666180525073302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Calcifying Fibrous Tumor: Review of 157 Patients Reported in International Literature.

Chorti, Angeliki / Papavramidis, Theodossis S / Michalopoulos, Antonios

Medicine

2016 Volume 95, Issue 20, Page(s) e3690

Abstract: Calcifying fibrous tumor (CFT) is a benign lesion characterized by its specific histological findings and is found as solitary or multiple lesions in several locations of the human body. The aim of the present systematic review is to give a detailed ... ...

Abstract	Calcifying fibrous tumor (CFT) is a benign lesion characterized by its specific histological findings and is found as solitary or multiple lesions in several locations of the human body. The aim of the present systematic review is to give a detailed account of all reported cases of CFT in the literature and to analyze the available data, to completely characterize the entity from epidemiological, medical, and surgical aspects.A bibliographic research was performed from 1988 until 2015. A database with the patients' characteristics was made, including sex, age, location of the tumor, symptoms, symptoms duration, size of the tumor, diagnostic methods, treatment, metastasis, and follow-up.A total of 104 articles were identified, reporting 157 cases of CFT. Mean age of patients was 33.58 years and the ratio between men and women was 1:1.27. The most common locations of CFT were stomach (18%), small intestine (8.7%), pleura (9.9%), mesentery (5%), and peritoneum (6.8%). Mean diameter of the tumor was estimated 4.6 cm. The correlations proceeded showed that as age increases, size decreases (P = 0.001) and that the tumor is larger in females (P = 0.027). Kruskal-Wallis test showed that the larger tumors appear in the neck and adrenal gland (P = 0.001). The percentage of asymptomatic patients was 30.57%. Computed tomography and biopsy were the most common tests for the diagnosis of CFT. Open surgical procedure was performed in the majority of cases. The median hospitalization was 6.06 days and the mean follow-up period was 29.97 months. Recurrences were mentioned in 10 of 96 patients with available data. No deaths owing to CFT were mentioned in the literature.CFT should be included in the differential diagnosis of enlarging mass revealed by clinical or imaging examination either incidentally or after specific acute or chronic symptomatology.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Calcinosis/diagnosis ; Calcinosis/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Middle Aged ; Neoplasms, Fibrous Tissue/diagnosis ; Neoplasms, Fibrous Tissue/pathology ; Neoplasms, Fibrous Tissue/surgery ; Sex Factors ; Tumor Burden ; Young Adult
Language	English
Publishing date	2016-06-22
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000003690
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Article: Confronting gastrocutaneous fistulas.

Papavramidis, Theodossis S / Mantzoukis, Konstantinos / Michalopoulos, Nick

Annals of gastroenterology

2014 Volume 24, Issue 1, Page(s) 16–19

Abstract: A gastrocutaneous fistula (GCF) represents a fistula connecting the stomach with the skin. The aim of the present review is to clarify the entity of a GCF and to discuss the various treating strategies employed. In order to elucidate GCFs as an entity ... ...

Abstract	A gastrocutaneous fistula (GCF) represents a fistula connecting the stomach with the skin. The aim of the present review is to clarify the entity of a GCF and to discuss the various treating strategies employed. In order to elucidate GCFs as an entity etiology was pointed out and relative pathogenetic mechanisms were explored. Moreover, diagnostic modalities are discussed with a special focus on GCFs following bariatric operations. Finally, the treating strategies currently employed when confronting GCFs are presented, as well as their effectiveness.
Language	English
Publishing date	2014-04-08
Publishing country	Greece
Document type	Review
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
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Zs.A 2455: Show issues

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Article ; Online: Abdominal cocoon syndrome: Rare cause of intestinal obstruction-Case report and systematic review of literature.

Chorti, Angeliki / Panidis, Stavros / Konstantinidis, Dimitrios / Cheva, Angeliki / Papavramidis, Theodossis / Michalopoulos, Antonios / Paramythiotis, Daniel

Medicine

2022 Volume 101, Issue 27, Page(s) e29837

Abstract: Background: Abdominal cocoon or sclerosing encapsulating peritonitis is an uncommon condition in which the small bowel is completely or partially encased by a thick fibrotic membrane. Our study presents a case of sclerosing encapsulating peritonitis and ...

Abstract	Background: Abdominal cocoon or sclerosing encapsulating peritonitis is an uncommon condition in which the small bowel is completely or partially encased by a thick fibrotic membrane. Our study presents a case of sclerosing encapsulating peritonitis and conducts a literature review. Methods: A bibliographic research was conducted. Our research comprised 97 articles. Gender, age, symptoms, diagnostic procedures, and treatment were all included in the database of patient characteristics. Case presentation: A 51-year-old man complaining of a 2-day history of minor diffuse abdominal pain, loss of appetite, and constipation was presented in emergency department. Physical examination was indicative of intestinal obstruction. Laboratory tests were normal. Diffuse intraperitoneal fluid and dilated small intestinal loops were discovered on computed tomography (CT). An exploratory laparotomy was recommended, in which the sac membrane was removed and adhesiolysis was performed. He was discharged on the tenth postoperative day. Results: There were 240 cases of abdominal cocoon syndrome in total. In terms of gender, 151 of 240 (62.9%) were male and 89 of 240 (37%) were female. Ages between 20 and 40 are most affected. Symptoms include abdominal pain and obstruction signs. For the diagnosis of abdominal cocoon syndrome, CT may be the gold standard imaging method. The surgical operation was the treatment of choice in the vast majority of cases (96.7%). Only 69 of 239 patients (28.9%) were detected prior to surgery, and CT was applied in these cases. Conclusion: Abdominal cocoon is a rare condition marked by recurrent episodes of intestinal obstruction. Surgical therapy is the most effective treatment option.
MeSH term(s)	Abdominal Pain/etiology ; Adult ; Female ; Humans ; Intestinal Obstruction/diagnosis ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestine, Small/surgery ; Male ; Middle Aged ; Peritoneal Fibrosis/diagnosis ; Peritoneal Fibrosis/diagnostic imaging ; Peritonitis/complications ; Young Adult
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029837
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sporadic parathyroid adenoma: an updated review of molecular genetics.

Chorti, Angeliki / Cheva, Angeliki / Chatzikyriakidou, Anthoula / Achilla, Charoula / Boulogeorgou, Kassiani / Despoina, Krokou / Milias, Stefanos / Zarampoukas, Thomas / Papavramidis, Theodossis

Frontiers in endocrinology

2023 Volume 14, Page(s) 1180211

Abstract: Introduction: Primary HPT (PHPT) is a common disorder, affecting approximately 1% of the general population. Parathyroid adenomas emerge as non-familial sporadic in 90% of cases. The aim of this review is to give a detailed update of molecular genetics ... ...

Abstract	Introduction: Primary HPT (PHPT) is a common disorder, affecting approximately 1% of the general population. Parathyroid adenomas emerge as non-familial sporadic in 90% of cases. The aim of this review is to give a detailed update of molecular genetics of sporadic parathyroid adenoma reported in international literature. Methods: A bibliographic research was conducted in PubMed, Google Scholar, and Scopus. Results: Seventy-eight articles were included in our review. CaSR, MEN1, CCND1/PRAD, CDKI, angiogenic factors like VEGF, FGF, TGFβ, and IGF1, and apoptotic factors are important genes in parathyroid adenomas pathogenesis that have been established by several studies. A huge list of proteins is differently expressed in parathyroid adenomas measured by Western Blotting, MALDI/TOF, MS spectrometry, and immunohistochemistry. These proteins take part in several cell processes such as cell metabolism, cytoskeleton structural stability, cell oxidative stress regulation, cell death, transcription, translation, cell connection, and cell signaling transmission, while they can be found over- or underexpressed in abnormal tissues. Conclusion: This review gives a detailed analysis of all reported data on genomics and proteomics of parathyroid adenoma. Further studies should be applied on understanding parathyroid adenoma pathogenesis and introducing new biomarkers for early detection of primary hyperparathyroidism.
MeSH term(s)	Humans ; Parathyroid Neoplasms/genetics ; Cell Cycle ; Blotting, Western ; Cell Death ; Molecular Biology
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1180211
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Article: PARATHYROID FUNCTION AFTER TOTAL THYROIDECTOMY: A RANDOMIZED CLINICAL TRIAL CONCERNING THE INFLUENCE OF THE SURGICAL TECHNIQUE.

Papavramidis, Theodossis S / Anastasiou, Olympia / Pliakos, Ioannis / Kotsovolis, George / Panidis, Stavros / Michalopoulos, Antonios

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2017 Volume 24, Issue 2, Page(s) 150–155

Abstract: Objective: Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcemia. This study was prospective and evaluated the parathyroid hormone (PTH) function in nonclinically symptomatic patients ... ...

Abstract	Objective: Thyroidectomy impairs parathyroid function, even if it does not necessarily lead to postoperative clinical hypocalcemia. This study was prospective and evaluated the parathyroid hormone (PTH) function in nonclinically symptomatic patients after total thyroidectomy performed by two different techniques. Methods: Prospective randomized clinical trial including 269 patients undergoing classic or harmonic scalpel total thyroidectomy. Pre-operatively and at 48 hours, biochemical analysis was performed. Simultaneously, a sodium bicarbonate test (SBT) was performed. Results: Calcium and PTH were altered for both groups ( P<.001). During SBT at 3 minutes after infusion, PTH rose and reached its maximum for both groups ( P<.001) and then decreased at 5 minutes ( P<.001 and P = .004) and at 10 minutes ( P = .006 and P = .043) before returning to baseline levels. At 5 and 10 minutes of the SBT, some differences were observed between the groups. The difference in clinically obvious parathyroid dysfunction between groups was not significant, but there was a difference in the peak PTH levels after bicarbonate stimulation. Similarly, total secretion during the test, as well as total secretion for the first 10 minutes, was practically the same for the two groups. Additionally, partial subclinical postoperative hypoparathyroidism was clearly more common in the harmonic scalpel thyroidectomy group ( P<.001). Conclusion: SBT demonstrated more impairment in the harmonic scalpel group, as parathyroid function was altered after thyroidectomy. Abbreviations: HSTT = harmonic scalpel total thyroidectomy PTH = parathyroid hormone SBIT = sodium bicarbonate infusion test.
MeSH term(s)	Adult ; Aged ; Calcium/blood ; Diagnostic Techniques, Endocrine ; Female ; Humans ; Male ; Middle Aged ; Organs at Risk/physiology ; Parathyroid Glands/physiology ; Parathyroid Hormone/blood ; Postoperative Complications/blood ; Postoperative Complications/etiology ; Postoperative Period ; Sodium Bicarbonate/administration & dosage ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Thyroidectomy/rehabilitation ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; Sodium Bicarbonate (8MDF5V39QO) ; 25-hydroxyvitamin D (A288AR3C9H) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017-11-16
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.4158/EP-2017-0100
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