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  1. Article: Analyse des demandes d’appui en matière de prévention et contrôle de l’infection d’un CPias pendant la crise COVID-19

    Martin, M. / Chartier, M. / Germain, J. / Le Neindre, K. / Jan, V. / Ertzscheid, M. / Day, F. / Angibaud, M. / Bourgeois, J. / Piednoir, E.

    Médecine et Maladies Infectieuses

    Abstract: ... de soins Un outil informatique commun a été créé en 2019 pour tracer les demandes d’appui du CPias L ... La saisie de ces données se fait à partir d’un formulaire en ligne L’analyse des données est réalisée ... une interprétation pratique des doctrines nationales et/ou d’être confortés dans les conduites à tenir L’analyse ...

    Abstract Introduction Pendant la crise sanitaire liée au SARS-CoV-2, le Centre d’appui pour la Prévention des infections associées aux soins (CPias) a fortement été sollicité par les différents secteurs de l’offre de soins Un outil informatique commun a été créé en 2019 pour tracer les demandes d’appui du CPias L’objectif est d’analyser les thèmes abordés, les demandeurs et les réponses émises Matériels et méthodes La saisie de ces données se fait à partir d’un formulaire en ligne L’analyse des données est réalisée avec le logiciel statistique SAS® Après un contrôle de la qualité des données, une analyse descriptive des conseils donnés a été réalisée Ainsi, les variables recensées sont : la date, la fonction des appelants, le statut et le type de leurs établissements (sanitaire, ESMS, secteur libéral…) et les thèmes des demandes Une fois la base de données exportée et les demandes étiquetées « COVID-19 » filtrées, une seconde analyse qualitative des sous-thèmes a été faite Résultats Entre le 1er février et le 31 mai 2020, le CPias a répondu à 886 sollicitations sur le thème du COVID-19 contre 640 sur toute l’année 2019 (tous thèmes confondus), avec un pic visible autour de la semaine 12 Ainsi, 64 % (466) des demandes émanent d’établissements médicosociaux, 26 % (189) d’établissements sanitaires, 7 % (48) de tutelles et 3 % (22) de la médecine ambulatoire Quarante-trois pour cent (363) de ces demandes sont faites par des professionnels de santé (à parts égales entre professionnels médicaux et paramédicaux), 26 % (217) par des personnels non soignants (dont 80 % (174) de directeurs de structures médicosociales), 21 % (175) par des hygiénistes (praticiens et infirmiers) et 10 % (90) d’autres professionnels Les thèmes les plus souvent abordés concernent pour 30 % (264) les équipements de protection individuelle (conseils pour leur bonne utilisation, gestion de la pénurie), pour 23 % (206) l’environnement (entretien des locaux, gestion du risque environnemental) et pour 21 % (185) la conduite à tenir face à des patients/résidents suspects, positifs ou revenant d’hospitalisation Viennent ensuite des questions sur la conduite à tenir pour les professionnels soit 14 % (123) (suspects/contact, ceux travaillant en ville ou à domicile) et 14 % (120) sur la maladie elle-même (contagiosité, symptômes, prélèvement, unité dédiée aux patients COVID ou suspects) Parfois ces questions ont été relayées aux infectiologues selon le niveau d’expertise requis Enfin, 11 % (98) des demandes sont d’ordre organisationnel autour des flux internes et de l’organisation des consultations Conclusion Le CPias a été très investi dans ses missions régionales de prévention et contrôle de l’infection pendant cette crise sanitaire Nous en tirons que de nombreux acteurs en santé avaient besoin d’une adaptation ou d’une interprétation pratique des doctrines nationales et/ou d’être confortés dans les conduites à tenir L’analyse montre également la diversité des appelants sortants du cadre habituel de nos interlocuteurs témoignant de l’importance de l’épidémie
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #726702
    Database COVID19

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  2. Article ; Online: Analyse des demandes d’appui en matière de prévention et contrôle de l’infection d’un CPias pendant la crise COVID-19

    Martin, M. / Chartier, M. / Germain, J. / Le Neindre, K. / Jan, V. / Ertzscheid, M. / Day, F. / Angibaud, M. / Bourgeois, J. / Piednoir, E.

    Médecine et Maladies Infectieuses

    2020  Volume 50, Issue 6, Page(s) S65

    Keywords Infectious Diseases ; covid19
    Language French
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 423536-8
    ISSN 0399-077X ; 1166-8237
    ISSN 0399-077X ; 1166-8237
    DOI 10.1016/j.medmal.2020.06.125
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Differential Adsorption of l- and d-Lysine on Achiral MFI Zeolites as Determined by Synchrotron X-Ray Powder Diffraction and Thermogravimetric Analysis.

    Chen, Tianxiang / Huang, Bolong / Day, Sarah / Tang, Chiu Chung / Tsang, Shik Chi Edman / Wong, Kwok-Yin / Lo, Tsz Woon Benedict

    Angewandte Chemie (International ed. in English)

    2019  Volume 59, Issue 3, Page(s) 1093–1097

    Abstract: Reported here is the first crystallographic observation of stereospecific bindings of l- and d ... confinement effects for the enantiomeric difference in l- and d-Lys adsorption. Notable differences have been ... observed by circular dichroism (CD) spectroscopy and thermogravimetric analysis (TGA). Distinct l- and d ...

    Abstract Reported here is the first crystallographic observation of stereospecific bindings of l- and d-lysine (Lys) in achiral MFI zeolites. The MFI structure offers inherent geometric and internal confinement effects for the enantiomeric difference in l- and d-Lys adsorption. Notable differences have been observed by circular dichroism (CD) spectroscopy and thermogravimetric analysis (TGA). Distinct l- and d-Lys adsorption behaviours on the H-ZSM-5 framework have been revealed by the Rietveld refinement of high-resolution synchrotron X-ray powder diffraction (SXRD) data and the density-functional theory (DFT) calculations. Despite demonstrating the approach for l- and d-Lys over MFI zeolites at an atomistic resolution, the differential adsorption study sheds light on the rational engineering of molecular interaction(s) with achiral microporous materials for chiral separation purposes.
    Language English
    Publishing date 2019-11-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201909352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Synthesis of l-Vancosamine Derivatives from Methyl α-d-Mannopyranoside

    Hsu, Day-Shin / Matsumoto, Takashi / Suzuki, Keisuke

    Synlett

    2006  Volume 2006, Issue 03, Page(s) 469–471

    Abstract: Concise synthesis of L-vancosamine, the amino sugar constituent of vancomycin and other antibiotics ... to give L-vancos­amine derivative. C-Glycosidation of vancosaminyl acetate with ­iodoresorcinol proceeded ...

    Abstract Concise synthesis of L-vancosamine, the amino sugar constituent of vancomycin and other antibiotics, has been achieved. The key steps include (1) stereoselective addition of methylcerium reagent to oximino ether, and (2) stereoselective hydrogenation of 5,6-unsaturated glycoside with C(5) inversion to give L-vancos­amine derivative. C-Glycosidation of vancosaminyl acetate with ­iodoresorcinol proceeded in the presence of Sc(OTf) 3 in high yield.
    Keywords vancosamine ; oximino ether ; organocerium reagent ; stereoselectivity ; branched amino sugar ; aryl C-glycoside
    Language English
    Publishing date 2006-02-06
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/s-2006-926231
    Database Thieme publisher's database

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  5. Article: In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass.

    Day, Richard M / Maquet, Véronique / Boccaccini, Aldo R / Jérôme, Robert / Forbes, Alastair

    Journal of biomedical materials research. Part A

    2005  Volume 75, Issue 4, Page(s) 778–787

    Abstract: ... into poly(D,L-lactide-co-glycolide) secreted significantly increased quantities ... incorporated into three-dimensional macroporous poly(D,L-lactide-co-glycolide) foam scaffolds. The foam ...

    Abstract Recent studies have demonstrated the angiogenic potential of 45S5 Bioglass. However, it is not known whether the angiogenic properties of Bioglass remain when the bioactive glass particles are incorporated into polymer composites. The objectives of the current study were to investigate the angiogenic properties of 45S5 Bioglass particles incorporated into biodegradable polymer composites. In vitro studies demonstrated that fibroblasts cultured on discs consisting of specific quantities of Bioglass particles mixed into poly(D,L-lactide-co-glycolide) secreted significantly increased quantities of vascular endothelial growth factor. The optimal quantity of Bioglass particles determined from the in vitro experiments was incorporated into three-dimensional macroporous poly(D,L-lactide-co-glycolide) foam scaffolds. The foam scaffolds were fabricated using either compression molding or thermally induced phase separation processes. The foams were implanted subcutaneously into mice for periods of up to 6 weeks. Histological assessment was used to determine the area of granulation tissue around the foams, and the number of blood vessels within the granulation tissue was counted. The presence of Bioglass particles in the foams produced a sustained increase in the area of granulation tissue surrounding the foams. The number of blood vessels surrounding the neat foams was reduced after 2 weeks of implantation; however, compression-molded foams containing Bioglass after 4 and 6 weeks of implantation had significantly more blood vessels surrounding the foams compared with foams containing no Bioglass at the same time points. These results indicate that composite polymer foam scaffolds containing Bioglass particles retain granulation tissue and blood vessels surrounding the implanted foams. The use of this polymer composite for tissue engineering scaffolds might provide a novel approach for ensuring adequate vascular supply to the implanted device.
    MeSH term(s) Angiogenesis Inducing Agents/metabolism ; Animals ; Biocompatible Materials ; Ceramics ; Glass ; In Vitro Techniques ; Lactic Acid ; Male ; Mice ; Mice, Inbred C3H ; Microscopy, Electron, Scanning ; Neovascularization, Physiologic ; Polyglycolic Acid ; Polymers
    Chemical Substances Angiogenesis Inducing Agents ; Biocompatible Materials ; Polymers ; bioactive glass 45S5 ; polylactic acid-polyglycolic acid copolymer ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2005-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.30433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A massive machine regulates cell death.

    Mace, Peter D / Day, Catherine L

    Science (New York, N.Y.)

    2023  Volume 379, Issue 6637, Page(s) 1093–1094

    Abstract: Structural analysis reveals how the decision to induce apoptotic cell death is regulated. ...

    Abstract Structural analysis reveals how the decision to induce apoptotic cell death is regulated.
    MeSH term(s) Apoptosis ; Inhibitor of Apoptosis Proteins/chemistry ; Inhibitor of Apoptosis Proteins/metabolism ; Caspases/metabolism ; Enzyme Activation ; Humans
    Chemical Substances BIRC6 protein, human ; Inhibitor of Apoptosis Proteins ; Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg9605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Integrated Youth Service Preferences of Caregivers of Justice-Involved Youth: A Discrete Choice Conjoint Experiment.

    Klymkiw, Deanna F / Day, David M / Henderson, J L / Hawke, Lisa D

    International journal of integrated care

    2024  Volume 24, Issue 1, Page(s) 2

    Abstract: Introduction: Mental health and/or substance use (MHS) challenges affect approximately 95% of youth in the criminal justice system, with only three in ten justice-involved youth receiving treatment. Caregivers of justice-involved youth have identified ... ...

    Abstract Introduction: Mental health and/or substance use (MHS) challenges affect approximately 95% of youth in the criminal justice system, with only three in ten justice-involved youth receiving treatment. Caregivers of justice-involved youth have identified fragmented care as a barrier to youth accessing MHS services. One suggested solution to this problem is the implementation of integrated youth services (IYS). However, it is unknown which IYS components caregivers of justice-involved youth prioritize.
    Methods: Using a discrete choice conjoint experiment (DCE),
    Results: Both caregiver groups exhibited preferences for involvement and access to information regarding their youth's treatment, and fast access to broad range of core health and additional services, in a community setting, with the incorporation of e-health services. Caregivers of justice-involved youth showed a unique preference for involvement in family counseling with their youth. The incorporation of this service feature may help to engage caregivers of justice-involved youth in their youths' MHS treatment 3-fold.
    Conclusion: Data gleaned from this analysis provides an understanding of what components of IYS models may help to engage caregivers of justice-involved youth.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2119289-3
    ISSN 1568-4156
    ISSN 1568-4156
    DOI 10.5334/ijic.7044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: What do justice-involved youth want from integrated youth services? A conjoint analysis.

    Klymkiw, Deanna F / Day, David M / Henderson, J L / Hawke, Lisa D

    Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

    2024  Volume 33, Issue 1, Page(s) 18–32

    Abstract: Background: Many youth in the criminal justice system are affected by mental health and/or substance use (MHS) challenges, yet only a minority receive treatment. One way to increase access to MHS care is integrated youth services (IYS), a community- ... ...

    Abstract Background: Many youth in the criminal justice system are affected by mental health and/or substance use (MHS) challenges, yet only a minority receive treatment. One way to increase access to MHS care is integrated youth services (IYS), a community-based model of service delivery where youth can access evidence-based treatment for their MHS problems and other wellbeing needs, in one location. However, it is unknown what IYS services justice-involved youth prioritize.
    Objective: This study explored what components of IYS justice-involved youth deem to be the most important in meeting their MHS service needs, in comparison with non-justice-involved youth, by conducting a secondary analysis of data gathered from a larger Ontario-wide study.
    Method: Using a conjoint analysis,
    Results: Both justice-involved and non-justice-involved youth exhibited preferences for a broad range of core health services, including mental health services, substance misuse counseling, medication management, and physical or sexual health services. They also preferred a broad range of additional support services, in addition to fast access to care in a community setting that specializes in mental health services, with the incorporation of e-health services. Justice-involved youth prioritized working with a trained peer support worker to learn life skills and help them with the services they need. The importance of youth playing a leadership role in making decisions within IYS organizations was also a distinguishing preference among justice-involved youth.
    Conclusions: Tailoring IYS to meet the service preferences of justice-involved youth may enhance service utilization, potentially leading to better outcomes for justice-involved youth and their communities.
    Language English
    Publishing date 2024-03-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2381637-5
    ISSN 2293-6122 ; 1719-8429
    ISSN (online) 2293-6122
    ISSN 1719-8429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evaluation of Dual Domain Mass Transfer in Porous Media at the Pore Scale.

    Dorchester, Leland / Day-Lewis, Frederick D / Singha, Kamini

    Ground water

    2023  Volume 62, Issue 2, Page(s) 260–275

    Abstract: ... with the mass-transfer rate (L ...

    Abstract Dual-porosity models are often used to describe solute transport in heterogeneous media, but the parameters within these models (e.g., immobile porosity and mobile/immobile exchange rate coefficients) are difficult to identify experimentally or relate to measurable quantities. Here, we performed synthetic, pore-scale millifluidics simulations that coupled fluid flow, solute transport, and electrical resistivity (ER). A conductive-tracer test and the associated geoelectrical signatures were simulated for four flow rates in two distinct pore-scale model scenarios: one with intergranular porosity, and a second with an intragranular porosity also defined. With these models, we explore how the effective characteristic-length scale estimated from a best-fit dual-domain mass transfer (DDMT) model compares to geometric aspects of the flow field. In both model scenarios we find that: (1) mobile domains and immobile domains develop even in a system that is explicitly defined with one domain; (2) the ratio of immobile to mobile porosity is larger at faster flow rates as is the mass-transfer rate; and (3) a comparison of length scales associated with the mass-transfer rate (L
    MeSH term(s) Models, Theoretical ; Porosity ; Water Movements ; Groundwater ; Water Pollutants, Chemical ; Solutions
    Chemical Substances Water Pollutants, Chemical ; Solutions
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 246212-6
    ISSN 1745-6584 ; 0017-467X
    ISSN (online) 1745-6584
    ISSN 0017-467X
    DOI 10.1111/gwat.13328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trajectories of internalizing symptoms among autistic and nonautistic youth during the COVID-19 pandemic.

    Day, Talena C / Gerber, Alan / McNair, Morgan L / Reicher, Debra / Lerner, Matthew D

    Autism research : official journal of the International Society for Autism Research

    2023  Volume 16, Issue 7, Page(s) 1403–1412

    Abstract: The COVID-19 pandemic elicited increases in anxiety and depression in youth, and youth on the autism spectrum demonstrate elevations in such symptoms pre-pandemic. However, it is unclear whether autistic youth experienced similar increases in ... ...

    Abstract The COVID-19 pandemic elicited increases in anxiety and depression in youth, and youth on the autism spectrum demonstrate elevations in such symptoms pre-pandemic. However, it is unclear whether autistic youth experienced similar increases in internalizing symptoms after the COVID-19 pandemic onset or whether decreases in these symptoms were present, as speculated in qualitative work. In the current study, longitudinal changes in anxiety and depression during the COVID-19 pandemic in autistic youth were assessed in comparison to nonautistic youth. A well-characterized sample of 51 autistic and 25 nonautistic youth (age
    MeSH term(s) Child ; Humans ; Adolescent ; Autistic Disorder/epidemiology ; Pandemics ; Depression/epidemiology ; Autism Spectrum Disorder ; COVID-19 ; Anxiety/epidemiology
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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