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  1. Article ; Online: Mapping H

    David, Fred / Setzler, Caleb / Sorescu, Alexandra / Lieberman, Raquel L / Meilleur, Flora / Petty, Jeffrey T

    The journal of physical chemistry letters

    2022  Volume 13, Issue 48, Page(s) 11317–11322

    Abstract: When strands of DNA encapsulate silver clusters, supramolecular optical chromophores develop. However, how a particular structure endows a specific spectrum remains poorly understood. Here, we used neutron diffraction to map protonation in ( ... ...

    Abstract When strands of DNA encapsulate silver clusters, supramolecular optical chromophores develop. However, how a particular structure endows a specific spectrum remains poorly understood. Here, we used neutron diffraction to map protonation in (A
    MeSH term(s) Social Group ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c03161
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  2. Article ; Online: Genomic Comparison of Two O111:H- Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia.

    McAllister, Lauren J / Bent, Stephen J / Petty, Nicola K / Skippington, Elizabeth / Beatson, Scott A / Paton, James C / Paton, Adrienne W

    Infection and immunity

    2016  Volume 84, Issue 3, Page(s) 775–781

    Abstract: ... analyses conducted at the time suggested that the outbreak was caused by an O111:H(-) clone, with strains ...

    Abstract Enterohemorrhagic Escherichia coli (EHEC) is an important cause of diarrhea and hemolytic-uremic syndrome (HUS) worldwide. Australia's worst outbreak of HUS occurred in Adelaide in 1995 and was one of the first major HUS outbreaks attributed to a non-O157 Shiga-toxigenic E. coli (STEC) strain. Molecular analyses conducted at the time suggested that the outbreak was caused by an O111:H(-) clone, with strains from later in the outbreak harboring an extra copy of the genes encoding the potent Shiga toxin 2 (Stx2). Two decades later, we have used next-generation sequencing to compare two isolates from early and late in this important outbreak. We analyzed genetic content, single-nucleotide polymorphisms (SNPs), and prophage insertion sites; for the latter, we demonstrate how paired-end sequence data can be leveraged to identify such insertion sites. The two strains are genetically identical except for six SNP differences and the presence of not one but two additional Stx2-converting prophages in the later isolate. Isolates from later in the outbreak were associated with higher levels of morbidity, suggesting that the presence of the additional Stx2-converting prophages is significant in terms of the virulence of this clone.
    MeSH term(s) Australia/epidemiology ; Disease Outbreaks ; Enterohemorrhagic Escherichia coli/classification ; Enterohemorrhagic Escherichia coli/genetics ; Enterohemorrhagic Escherichia coli/isolation & purification ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Genome, Bacterial ; Genomics ; Hemolytic-Uremic Syndrome/microbiology ; Humans ; Phylogeny
    Chemical Substances Escherichia coli Proteins
    Language English
    Publishing date 2016-01-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.01229-15
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  3. Article: Pulsed DC electric fields couple to natural NAD(P)H oscillations in HT-1080 fibrosarcoma cells.

    Rosenspire, A J / Kindzelskii, A L / Petty, H R

    Journal of cell science

    2001  Volume 114, Issue Pt 8, Page(s) 1515–1520

    Abstract: Previously, we have demonstrated that NAD(P)H levels in neutrophils and macrophages are oscillatory ... increase the amplitude of, NAD(P)H oscillations in these cells. For these cells, increased NAD(P)H ... and macrophages, NAD(P)H levels oscillate. We find that weak (approximately 10(-5) V/m), but properly ...

    Abstract Previously, we have demonstrated that NAD(P)H levels in neutrophils and macrophages are oscillatory. We have also found that weak ultra low frequency AC or pulsed DC electric fields can resonate with, and increase the amplitude of, NAD(P)H oscillations in these cells. For these cells, increased NAD(P)H amplitudes directly signal changes in behavior in the absence of cytokines or chemotactic factors. Here, we have studied the effect of pulsed DC electric fields on HT-1080 fibrosarcoma cells. As in neutrophils and macrophages, NAD(P)H levels oscillate. We find that weak (approximately 10(-5) V/m), but properly phased DC (pulsed) electric fields, resonate with NAD(P)H oscillations in polarized and migratory, but not spherical, HT-1080 cells. In this instance, electric field resonance signals an increase in HT-1080 pericellular proteolytic activity. Electric field resonance also triggers an immediate increase in the production of reactive oxygen metabolites. Under resonance conditions, we find evidence of DNA damage in HT-1080 cells in as little as 5 minutes. Thus the ability of external electric fields to effect cell function and physiology by acting on NAD(P)H oscillations is not restricted to cells of the hematopoietic lineage, but may be a universal property of many, if not all polarized and migratory eukaryotic cells.
    MeSH term(s) Biological Clocks/physiology ; Biological Clocks/radiation effects ; DNA Damage/radiation effects ; Electromagnetic Fields ; Fibrosarcoma/physiopathology ; Humans ; Hydrolysis/radiation effects ; NAD/physiology ; NADP/physiology ; Proteins/metabolism ; Proteins/radiation effects ; Reactive Oxygen Species/metabolism ; Tumor Cells, Cultured
    Chemical Substances Proteins ; Reactive Oxygen Species ; NAD (0U46U6E8UK) ; NADP (53-59-8)
    Language English
    Publishing date 2001-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.114.8.1515
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  4. Article: Attentional modulation of secondary somatosensory and visual thalamus of mice.

    Petty, Gordon H / Bruno, Randy M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Each sensory modality has its own primary and secondary thalamic nuclei. While the primary thalamic nuclei are well understood to relay sensory information from the periphery to the cortex, the role of secondary sensory nuclei is elusive. One hypothesis ... ...

    Abstract Each sensory modality has its own primary and secondary thalamic nuclei. While the primary thalamic nuclei are well understood to relay sensory information from the periphery to the cortex, the role of secondary sensory nuclei is elusive. One hypothesis has been that secondary nuclei may support feature-based attention. If this is true, one would also expect the activity in different nuclei to reflect the degree to which modalities are or are not behaviorally relevant in a task. We trained head-fixed mice to attend to one sensory modality while ignoring a second modality, namely to attend to touch and ignore vision, or vice versa. Arrays were used to record simultaneously from secondary somatosensory thalamus (POm) and secondary visual thalamus (LP). In mice trained to respond to tactile stimuli and ignore visual stimuli, POm was robustly activated by touch and largely unresponsive to visual stimuli. A different pattern was observed when mice were trained to respond to visual stimuli and ignore touch, with POm now more robustly activated during visual trials. This POm activity was not explained by differences in movements (i.e., whisking, licking, pupil dilation) resulting from the two tasks. Post hoc histological reconstruction of array tracks through POm revealed that subregions varied in their degree of plasticity. LP exhibited similar phenomena. We conclude that behavioral training reshapes activity in secondary thalamic nuclei. Secondary nuclei may respond to behaviorally relevant, reward-predicting stimuli regardless of stimulus modality.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.22.586242
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  5. Article: Interferon-gamma and sinusoidal electric fields signal by modulating NAD(P)H oscillations in polarized neutrophils.

    Rosenspire, A J / Kindzelskii, A L / Petty, H R

    Biophysical journal

    2000  Volume 79, Issue 6, Page(s) 3001–3008

    Abstract: ... a 20-s period NAD(P)H oscillation in neutrophils and other polarized cells. Here we show ... with periods double that of the NAD(P)H oscillation, the amplitude of the NAD(P)H oscillations increases ... Furthermore, increases in NAD(P)H amplitude, whether mediated by interferon-gamma or by an oscillating ...

    Abstract Metabolic activity in eukaryotic cells is known to naturally oscillate. We have recently observed a 20-s period NAD(P)H oscillation in neutrophils and other polarized cells. Here we show that when polarized human neutrophils are exposed to interferon-gamma or to ultra-low-frequency electric fields with periods double that of the NAD(P)H oscillation, the amplitude of the NAD(P)H oscillations increases. Furthermore, increases in NAD(P)H amplitude, whether mediated by interferon-gamma or by an oscillating electric field, signals increased production of reactive oxygen metabolites. Hence, amplitude modulation of NAD(P)H oscillations suggests a novel signaling mechanism in polarized cells.
    MeSH term(s) Cell Size ; Electric Stimulation ; Humans ; In Vitro Techniques ; Interferon-gamma/pharmacology ; Kinetics ; NAD/blood ; NADP/blood ; Neutrophils/cytology ; Neutrophils/drug effects ; Neutrophils/physiology ; Oscillometry ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; NAD (0U46U6E8UK) ; NADP (53-59-8) ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2000-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/S0006-3495(00)76536-2
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  6. Article ; Online: H.Th.M. Lambooij, Sibrandus Leo en zijn abtenkronieken van de Friese premonstratenzerkloosters Lidlum en Mariëngaarde. Een nadere studie, editie en vertaling

    Petty Bange

    BMGN : Low Countries Historical Review, Vol 125, Iss

    2010  Volume 4

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2010-01-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: H.Th.M. Lambooij, Sibrandus Leo en zijn abtenkronieken van de Friese premonstratenzerkloosters Lidlum en Mariëngaarde. Een nadere studie, editie en vertaling

    Petty Bange

    BMGN : Low Countries Historical Review, Vol 125, Iss

    2010  Volume 4

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 2010-01-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Moving forwards not backwards: heterogeneity in autism spectrum disorders.

    Hobson, H / Petty, S

    Molecular psychiatry

    2021  Volume 26, Issue 12, Page(s) 7100–7101

    MeSH term(s) Autism Spectrum Disorder/genetics ; Humans
    Language English
    Publishing date 2021-07-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-021-01226-7
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  9. Article ; Online: Scoping review of return-to-work interventions for persons with traumatic brain injury.

    Petty, Joanne / McLennan, Vanette / Kendall, Elizabeth / Degeneffe, Charles Edmund

    Disability and rehabilitation

    2023  , Page(s) 1–13

    Abstract: ... gender, (f) RTW definition, (g) intervention approach, and (h) RTW outcome. The results were synthesized ...

    Abstract Purpose: The study approach sought to understand which vocational rehabilitation (VR) strategies are available for individuals seeking return to work (RTW) following traumatic brain injury (TBI). Secondly, the review aimed to identify how these RTW interventions and outcomes are evaluated.
    Materials and methods: Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) approach, the scoping review began by identifying relevant English language articles
    Results: A total of 23 studies met the search criteria. For each included study, the following data were extracted: (a) country of origin, (b) sample size, (c) civilian or military sample population, (d) age, (e) participant gender, (f) RTW definition, (g) intervention approach, and (h) RTW outcome. The results were synthesized by placement into one of four categories as a function of the study's underlying methodological approach.
    Conclusions: The development of effective RTW approaches has largely been neglected in the rehabilitation literature for persons with TBI in civilian and military populations. Effective strategies do exist to help guide efforts to return this population to productive activity, including work.Implications for RehabilitationLack of productive engagement in work and school among persons with traumatic brain injury (TBI) presents a chronic challenge in rehabilitation systems internationally.Rehabilitation professionals should utilize multidisciplinary and integrated return-to-work (RTW) interventions given the varied areas of function that can result from TBI.Rehabilitation professionals should apply RTW interventions that promote on-site training and workplace integration.Given the idiosyncratic nature of TBI, RTW interventions should be tailored to meet the specific needs of the person seeking support.
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2023.2243583
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  10. Article ; Online: Implementasi Strategi Pemasaran dalam Rangka Meningkatkan Jumlah Peserta Didik di Brilliant English Course

    Hadi Cipto Sanyoto / Petty Arisanti

    Jurnal Multidisiplin Madani, Vol 2, Iss 1, Pp 245-

    2022  Volume 250

    Abstract: This study aims to analyze marketing strategic at Brilliant English Course, then to know the analyze strategic which is on progress and strategy description so that it can be applied to increase product sales. This research uses qualitative method that ... ...

    Abstract This study aims to analyze marketing strategic at Brilliant English Course, then to know the analyze strategic which is on progress and strategy description so that it can be applied to increase product sales. This research uses qualitative method that is case study which produce descriptive data which poured in words. Data collection technique in this study author make direct visits to Brilliant English Course to conduct a personal interview with the Director of Brilliant English Course marketing and completed with the information data several years behind. The conclusion of the analysis conducted on marketing strategy correctly and precisely. Which companies can develop, maintain and improve product quality so that people continue to believe in Brilliant English Course. Then the company has fulfilled the character and paradigm of sharia marketing by winning mind share, market share and heart share
    Keywords marketing strategy ; increasing the numbers of new members ; Social Sciences ; H ; Science ; Q
    Subject code 420
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Formosa Publisher
    Document type Article ; Online
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