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Book: Harrison's principles of internal medicine / Volume 1 / Editors J. Larry Jameson (MD, PhD), Dennis L. Kasper (MD), Dan L. Longo (MD), Anthony S. Fauci (MD), Stephen L. Hauser (MD), Joseph Loscalzo (MD, PhD)

Harrison, Tinsley Randolph / Braunwald, Eugene / Kasper, Dennis L. / Fauci, Anthony S. / Longo, Dan L.

2018

Collection	Harrison's principles of internal medicine
Language	English
Size	xli, 1647, I-214 Seiten, Illustrationen, Diagramme
Edition	20th edition
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019827496
ISBN	978-1-259-64399-6 ; 9781259644009 ; 1-259-64399-9 ; 1259644006
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Cell-surface anchoring of Listeria adhesion protein on L. monocytogenes is fastened by internalin B for pathogenesis.

Liu, Dongqi / Bai, Xingjian / Helmick, Harrison D B / Samaddar, Manalee / Amalaradjou, Mary Anne Roshni / Li, Xilin / Tenguria, Shivendra / Gallina, Nicholas L F / Xu, Luping / Drolia, Rishi / Aryal, Uma K / Moreira, Gustavo Marçal Schmidt Garcia / Hust, Michael / Seleem, Mohamed N / Kokini, Jozef L / Ostafe, Raluca / Cox, Abigail / Bhunia, Arun K

Cell reports

2023 Volume 42, Issue 5, Page(s) 112515

Abstract: Listeria adhesion protein (LAP) is a secreted acetaldehyde alcohol dehydrogenase (AdhE) that anchors to an unknown molecule on the Listeria monocytogenes (Lm) surface, which is critical for its intestinal epithelium crossing. In the present work, ... ...

Abstract	Listeria adhesion protein (LAP) is a secreted acetaldehyde alcohol dehydrogenase (AdhE) that anchors to an unknown molecule on the Listeria monocytogenes (Lm) surface, which is critical for its intestinal epithelium crossing. In the present work, immunoprecipitation and mass spectrometry identify internalin B (InlB) as the primary ligand of LAP (K
MeSH term(s)	Animals ; Mice ; Bacterial Proteins/metabolism ; Membrane Proteins/metabolism ; Listeria/metabolism ; Listeria monocytogenes/metabolism ; Cell Membrane/metabolism ; Alcohol Dehydrogenase/metabolism
Chemical Substances	Bacterial Proteins ; Membrane Proteins ; Alcohol Dehydrogenase (EC 1.1.1.1)
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112515
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Liverpool Heart And bRain Project (L-HARP): Protocol for an Observational Cohort Study of Cardiovascular Risk and Outcomes Following Stroke.

Harrison, Stephanie L / Lane, Deirdre A / Buckley, Benjamin J R / Chatterjee, Kausik / Alobaida, Muath / Shipley, Emily / Lip, Gregory Y H

Vascular health and risk management

2022 Volume 18, Page(s) 313–318

Abstract: Further research is needed to refine risk prediction models for adverse cardiovascular outcomes following stroke in contemporary clinical practice, such as incident atrial fibrillation (AF), recurrent stroke, and cognitive impairment and dementia. The ... ...

Abstract	Further research is needed to refine risk prediction models for adverse cardiovascular outcomes following stroke in contemporary clinical practice, such as incident atrial fibrillation (AF), recurrent stroke, and cognitive impairment and dementia. The aims of this study are to prospectively investigate cardiovascular outcomes and risk factors for incident cardiovascular disease in a post-stroke cohort, and to externally validate, refine and expand current risk prediction models for cardiovascular and cardiovascular-related outcomes. The study sample size was based on the development of post-stroke risk prediction models for AF and was calculated as 1222 participants. The study design is a multicentre, prospective, observational cohort study. Participants will be adult patients admitted for ischaemic stroke confirmed by stroke physician or transient ischaemic attack (TIA) confirmed by MRI. Routinely collected data will be used in addition to the completion of simple validated questionnaires by the participants. Follow-up will be undertaken 12-months from the date of admission to hospital, in addition to linkage to routinely collected follow-up hospitalisation and mortality data. The primary outcomes are cardiovascular outcomes (including incident AF, stroke, TIA and myocardial infarction) at 12-month follow-up, all-cause mortality and mortality from cardiovascular causes, and incident cognitive impairment and dementia. Secondary outcomes include changes in function, depression, anxiety, fatigue and quality of life. The study has received approval from the Health Research Authority Research Ethics Committee (21/WA/0209), and is registered on https://www.clinicaltrials.gov/ (Identifier NCT05132465). Recruitment for the study began in October 2021 with completion of recruitment at all participating centres anticipated by October 2022.
MeSH term(s)	Adult ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Brain/diagnostic imaging ; Brain Ischemia/complications ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Carrier Proteins ; Cohort Studies ; Cytokines ; Dementia/complications ; Heart Disease Risk Factors ; Humans ; Ischemic Attack, Transient/complications ; Ischemic Attack, Transient/diagnosis ; Ischemic Attack, Transient/epidemiology ; Multicenter Studies as Topic ; Observational Studies as Topic ; Prospective Studies ; Quality of Life ; Risk Factors ; Stroke/complications ; Stroke/diagnosis ; Stroke/epidemiology
Chemical Substances	Carrier Proteins ; Cytokines ; pleiotrophin (134034-50-7)
Language	English
Publishing date	2022-04-26
Publishing country	New Zealand
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2186568-1
ISSN	1178-2048 ; 1176-6344
ISSN (online)	1178-2048
ISSN	1176-6344
DOI	10.2147/VHRM.S357829
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Harrison's principles of internal medicine / 2 / ed. Dan L. Longo ...

Harrison, Tinsley Randolph / Braunwald, Eugene / Kasper, Dennis L. / Fauci, Anthony S. / Longo, Dan L.

2012

Collection	Harrison's principles of internal medicine
Language	English
Size	XLIII S., S. 1797 - 3610, I-158 S. : zahlr. Ill., graph. Darst.
Edition	18. ed.
Publisher	McGraw-Hill
Publishing place	New York u.a.
Publishing country	Great Britain
Document type	Book
Accompanying material	1 DVD (12 cm)
HBZ-ID	HT016955509
ISBN	978-0-07-174887-2 ; 0-07-174887-3 ; 978-0-07-174888-9 ; 0-07-174888-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2008 A 7810	order for loan	Magazin
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2011 MO 607 <<[Begleitmaterial]>>	order to use in reading room	Magazin
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2011 MO 611 <<[Begleitmaterial]>>	order for loan	Magazin

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Book: Harrison's principles of internal medicine / 1 / ed. Dan L. Longo ...

Harrison, Tinsley Randolph / Braunwald, Eugene / Kasper, Dennis L. / Fauci, Anthony S. / Longo, Dan L.

2012

Collection	Harrison's principles of internal medicine
Language	English
Size	XLIII, 1796, I-158 S. : zahlr. Ill., graph. Darst.
Edition	18. ed.
Publisher	McGraw-Hill
Publishing place	New York u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT016955502
ISBN	978-0-07-163244-7 ; 0-07-163244-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2008 A 7809	order for loan	Magazin
2011 A 3676	order for loan	Magazin

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Article ; Online: Ecological Stoichiometry in Pinus massoniana L. Plantation

Ashfaq Ali / Majid Hussain / Saqib Ali / Kashif Akhtar / Mamoona Wali Muhammad / Ahmad Zamir / Arshad Ali / Syed Moazzam Nizami / Bilal Ahmad / Matthew Tom Harrison / Shah Fahad / Zhixiang Zhou / Shanjun Yi

Forests, Vol 13, Iss 469, p

Increasing Nutrient Limitation in a 48-Year Chronosequence

2022 Volume 469

Abstract: Stoichiometric ratios of carbon (C), nitrogen (N), and phosphorus (P) are considered indicators of nutrient status and ultimate ecosystem health. A detailed investigation of these elements in the leaves, branches, forest layer vegetation and soil, ... ...

Abstract	Stoichiometric ratios of carbon (C), nitrogen (N), and phosphorus (P) are considered indicators of nutrient status and ultimate ecosystem health. A detailed investigation of these elements in the leaves, branches, forest layer vegetation and soil, depending on stand age, was carried out. We investigated the effects of stand age (9-, 18-, 28-, and 48-year) on the aboveground plant parts (leaf, branch, herb, shrub, plant litter) and belowground pools (soil, roots) of P. massoniana plantations. The CNP stoichiometry of trees was affected by stand age. Mean N content in the aboveground parts in the nine-yr stand was greater than the other stands (18-, 28-, 48-yr), which decreased with increasing stand age. As stands aged, the nutrient demands of the plantations increased as well as their N:P ratios in soil. C content in the soil ranged from 30 to 105, the total N was 0.06 to 1.6, and the total P content ranged from 3.3–6.4 g kg −1 . Soil C, N and P contents were greatly influenced by both stand age and soil depth, because surface soil sequester C and N more actively compared to deeper horizons, and more nutrients are released to the topsoil by the plant litter layer. Similarly, the ratios of other layers had a similar pattern as CNP because more nutrients were taken up by the plantations, decreasing nutrient supply in the deeper soil horizons. The green leaves N:P ratios (16) indicate limited growth of P. massoniana , as the range for global nutrient limitation for woody plants oscillated between 14–16, indicating N and P limitation. Young stands were observed to have greater P content and P resorption efficiency (56.9%–67.3%), with lower C:P and N:P ratios (704.4; 14.8). We conclude that with stand development, the nutrient demands of the plantations also increase, and soil N:P stoichiometry shows that these improve soil quality.
Keywords	stand age ; stoichiometry ; P. massoniana ; nutrient resorption ; soil nutrients ; Plant ecology ; QK900-989
Subject code	580
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analyses of adult transcriptomes from four different populations of the spongy moth, Lymantria dispar L., from China and the USA.

Wang, Yi-Ming / Sparks, Michael E / Harrison, Robert L / Shi, Juan

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18232

Abstract: The spongy moth Lymantria dispar, formerly known as the gypsy moth, is a forest pest that occurs as two different biotypes: the European spongy moth (ESM), Lymantria dispar dispar, which is distributed in Europe and North America; and the Asian spongy ... ...

Abstract	The spongy moth Lymantria dispar, formerly known as the gypsy moth, is a forest pest that occurs as two different biotypes: the European spongy moth (ESM), Lymantria dispar dispar, which is distributed in Europe and North America; and the Asian spongy moth (ASM), which consists of subspecies Lymantria dispar asiatica and Lymantria dispar japonica and is distributed in China, Russia, Korea, and Japan. The Asian biotype is classified as a quarantine pest by the U.S. Department of Agriculture because of the superior flight ability of adult females compared to females of the European biotype. To identify genes that potentially account for differences in female flight capability between the two biotypes, we assembled and compared transcriptional profiles of two North American populations of ESM and two Chinese populations of ASM, including samples of unmated female adults and females after mating and oviposition. Of 129,286 unigenes identified, 306 were up-regulated in ASM samples relative to ESM, including genes involved in egg production. In contrast, 2309 unigenes were down-regulated in ASM samples, including genes involved in energy production. Although a previous study found that ASM female flight was reduced after oviposition, a comparison of gene expression before and after mating and oviposition did not reveal any genes which were consistently up- or down-regulated in the two ASM populations.
MeSH term(s)	Animals ; Female ; United States ; Moths/genetics ; Transcriptome ; China ; North America ; Japan
Language	English
Publishing date	2022-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-18377-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systemic Effects of Prenatal Carotenoid Supplementation in the Mother and her Child: The Lutein and Zeaxanthin in Pregnancy (L-ZIP) Randomized Trial -Report Number 1.

Addo, Emmanuel K / Allman, Susan J / Arunkumar, Ranganathan / Gorka, Joanna E / Harrison, Deborah Y / Varner, Michael W / Bernstein, Paul S

The Journal of nutrition

2023 Volume 153, Issue 8, Page(s) 2205–2215

Abstract: Background: Adding carotenoids, particularly lutein (L) and zeaxanthin (Z), to prenatal ... plus a 10 mg L and 2 mg Z softgel (the Carotenoid group) or standard-of-care prenatal vitamins ... in maternal serum L + Z concentrations, serum total carotenoid concentrations, and skin carotenoid status (P ...

Abstract	Background: Adding carotenoids, particularly lutein (L) and zeaxanthin (Z), to prenatal micronutrient formulations has been promoted to enhance infant visual and neural development and to maintain maternal health. Although these claims are biologically plausible, they are not yet supported by a compelling prospective trial. Objective: We investigated the effect of prenatal carotenoid supplementation on biomarkers of maternal and infant systemic carotenoid status. Methods: We randomly assigned 47 first trimester pregnant subjects by 1:1 allocation to receive standard-of-care prenatal vitamins plus a 10 mg L and 2 mg Z softgel (the Carotenoid group) or standard-of-care prenatal vitamins with a placebo softgel (the Control group) for 6-8 mo. Maternal carotenoid concentrations in the serum and skin at the end of each trimester and postpartum were measured with HPLC and resonance Raman spectroscopy, respectively. Infants' systemic carotenoid status was assessed using similar techniques but optimized for infants. Repeated measures and paired t-tests were determined, and a P value < 0.05 was considered statistically significant. Results: After supplementation, there was a statistically significant increase in maternal serum L + Z concentrations, serum total carotenoid concentrations, and skin carotenoid status (P < 0.001 for all) in the Carotenoid group relative to the Control group at all study time points. Similarly, infants whose mothers were in the Carotenoid group had a significant 5-fold increase in cord blood L + Z concentrations, over a 3-fold increase in cord blood total carotenoids, and a 38% increase in skin carotenoids compared with the Control group (P < 0.0001 for all). In addition, there was a strong positive, statistically significant correlation between postpartum maternal and infant systemic carotenoid status (P < 0.0001). Conclusion: Prenatal carotenoid supplementation significantly increased maternal and infant systemic (skin and serum) carotenoid status, which may benefit pregnant women and their infants' health. This trial was registered at clinicaltrials.gov as NCT03750968.
MeSH term(s)	Female ; Humans ; Infant ; Pregnancy ; Carotenoids ; Dietary Supplements ; Lutein ; Mothers ; Prospective Studies ; Vitamins ; Zeaxanthins
Chemical Substances	Carotenoids (36-88-4) ; Lutein (X72A60C9MT) ; Vitamins ; Zeaxanthins
Language	English
Publishing date	2023-05-27
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2023.05.024
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Article ; Online: Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.

Jenni, Simon / Bloyet, Louis-Marie / Diaz-Avalos, Ruben / Liang, Bo / Whelan, Sean P J / Grigorieff, Nikolaus / Harrison, Stephen C

Cell reports

2020 Volume 30, Issue 1, Page(s) 53–60.e5

Abstract: The large (L) proteins of non-segmented, negative-strand RNA viruses are multifunctional enzymes ... regulates the function and conformation of the L protein. We report the structure ... of vesicular stomatitis virus L in complex with its P cofactor determined by electron cryomicroscopy at 3.0 Å resolution ...

Abstract	The large (L) proteins of non-segmented, negative-strand RNA viruses are multifunctional enzymes that produce capped, methylated, and polyadenylated mRNA and replicate the viral genome. A phosphoprotein (P), required for efficient RNA-dependent RNA polymerization from the viral ribonucleoprotein (RNP) template, regulates the function and conformation of the L protein. We report the structure of vesicular stomatitis virus L in complex with its P cofactor determined by electron cryomicroscopy at 3.0 Å resolution, enabling us to visualize bound segments of P. The contacts of three P segments with multiple L domains show how P induces a closed, compact, initiation-competent conformation. Binding of P to L positions its N-terminal domain adjacent to a putative RNA exit channel for efficient encapsidation of newly synthesized genomes with the nucleoprotein and orients its C-terminal domain to interact with an RNP template. The model shows that a conserved tryptophan in the priming loop can support the initiating 5' nucleotide.
MeSH term(s)	Amino Acid Sequence ; Animals ; Cell Line ; Coenzymes/metabolism ; Humans ; Models, Molecular ; Phosphoproteins/chemistry ; Phosphoproteins/metabolism ; Phosphoproteins/ultrastructure ; Protein Binding ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; RNA-Dependent RNA Polymerase/ultrastructure ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; Viral Proteins/ultrastructure
Chemical Substances	Coenzymes ; Phosphoproteins ; Protein Subunits ; Viral Proteins ; L protein, vesicular stomatitis virus (EC 2.7.7.48) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2020-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.12.024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chlorine Disinfection of Legionella spp., L. pneumophila, and Acanthamoeba under Warm Water Premise Plumbing Conditions

Martin, Rebekah L. / Harrison, Kara / Proctor, Caitlin R. / Martin, Amanda / Williams, Krista / Pruden, Amy / Edwards, Marc A.

Microorganisms. 2020 Sept. 22, v. 8, no. 9

2020

Abstract: ... colonized by Legionella pneumophila and exposed to a sequence of 0, 0.1, 0.25, and 0.5 mg/L chlorine or ... in the presence of the magnesium anode by itself and or combination with other factors. In most cases, 0.5 mg/L ... Cl₂ caused a significant rapid reduction of L. pneumophila, Legionella spp., or total bacteria (16S ...

Abstract	Premise plumbing conditions can contribute to low chlorine or chloramine disinfectant residuals and reactions that encourage opportunistic pathogen growth and create risk of Legionnaires’ Disease outbreaks. This bench-scale study investigated the growth of Legionella spp. and Acanthamoeba in direct contact with premise plumbing materials—glass-only control, cross-linked polyethylene (PEX) pipe, magnesium anode rods, iron pipe, iron oxide, pH 10, or a combination of factors. Simulated glass water heaters (SGWHs) were colonized by Legionella pneumophila and exposed to a sequence of 0, 0.1, 0.25, and 0.5 mg/L chlorine or chloramine, at two levels of total organic carbon (TOC), over 8 weeks. Legionella pneumophila thrived in the presence of the magnesium anode by itself and or combination with other factors. In most cases, 0.5 mg/L Cl₂ caused a significant rapid reduction of L. pneumophila, Legionella spp., or total bacteria (16S rRNA) gene copy numbers, but at higher TOC (>1.0 mg C/L), a chlorine residual of 0.5 mg/L Cl₂ was not effective. Notably, Acanthamoeba was not significantly reduced by the 0.5 mg/L chlorine dose.
Keywords	Acanthamoeba ; Legionella pneumophila ; anodes ; chlorine ; crosslinking ; direct contact ; disinfectants ; disinfection ; genes ; glass ; iron oxides ; magnesium ; opportunistic pathogens ; pH ; polyethylene ; risk ; total organic carbon
Language	English
Dates of publication	2020-0922
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms8091452
Database	NAL-Catalogue (AGRICOLA)

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