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  1. Article ; Online: Real-Time Reporting of Complications in Hospitalized Surgical Patients by Surgical Team Members Using a Smartphone Application.

    Blackburn, Kyle W / Brubaker, Lisa S / Van Buren Ii, George / Feng, Emily / Mohamed, Sadde / Ramamurthy, Uma / Ramanathan, Vivek / Wood, Amy L / Navarro Cagigas, Martha E / Fisher, William E

    Joint Commission journal on quality and patient safety

    2024  

    Abstract: Background: The surgical morbidity and mortality (M&M) conference is a vital part of a resident's surgical education, but methods to collect and store M&M data are often rudimentary and unreliable. The authors propose a Health Insurance Portability and ... ...

    Abstract Background: The surgical morbidity and mortality (M&M) conference is a vital part of a resident's surgical education, but methods to collect and store M&M data are often rudimentary and unreliable. The authors propose a Health Insurance Portability and Accountability Act (HIPAA)-compliant, electronic health record (EHR)-connected application and database to report and store complication data.
    Methods: The app is linked to the patient's EHR, and as a result, basic data on each surgical case-including diagnosis, surgery type, and surgeon-are automatically uploaded to the app. In addition, all data are stored in a secure SQL database-with communications between the app and the database end-to-end encrypted for HIPAA compliance. The full surgical team has access to the app, democratizing complications reporting and allowing for reporting in both the inpatient and outpatient settings. This complication information can then be automatically pulled from the app with a premade presentation for the M&M conference. The data can also be accessed by a Power BI dashboard, allowing for easy quality improvement analyses.
    Results: When implemented, the app improved data collection for the M&M conference while providing a database for institutional quality improvement use. The authors also identified additional utility of the app, including ensuring appropriate revenue capture. The general appearance of the app and the dashboard can be found in the article.
    Conclusion: The app developed in this project significantly improves on more common methods for M&M conference complication reporting-transforming M&M data into a valuable resource for resident education and quality improvement.
    Language English
    Publishing date 2024-02-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1553-7250 ; 1070-3241 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1553-7250 ; 1070-3241 ; 1549-3741
    DOI 10.1016/j.jcjq.2024.02.004
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  2. Article: Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A review and novel case with dual germline SMARCA4 and BRCA2 mutations.

    Sanders, Brooke E / Wolsky, Rebecca / Doughty, Elizabeth S / Wells, Kristen L / Ghosh, Debashis / Ku, Lisa / Pressey, Joseph G / Bitler, Benjamin B / Brubaker, Lindsay W

    Gynecologic oncology reports

    2022  Volume 44, Page(s) 101077

    Abstract: Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare and aggressive disease. While classically linked to mutations ... ...

    Abstract Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare and aggressive disease. While classically linked to mutations in
    Language English
    Publishing date 2022-10-06
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2022.101077
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  3. Article ; Online: The brain, gut, and bladder health nexus: A conceptual model linking stress and mental health disorders to overactive bladder in women.

    Smith, Ariana L / Berry, Amanda / Brubaker, Linda / Cunningham, Shayna D / Gahagan, Sheila / Kane Low, Lisa / Mueller, Margaret / Sutcliffe, Siobhan / Williams, Beverly R / Brady, Sonya S

    Neurourology and urodynamics

    2023  Volume 43, Issue 2, Page(s) 424–436

    Abstract: Objective: A small, but growing literature links stressors and mental health disorders (MHDs) across the life course to overactive bladder (OAB) and urinary incontinence symptoms. Mechanisms by which stressors and MHDs may impact bladder health are not ... ...

    Abstract Objective: A small, but growing literature links stressors and mental health disorders (MHDs) across the life course to overactive bladder (OAB) and urinary incontinence symptoms. Mechanisms by which stressors and MHDs may impact bladder health are not fully understood, limiting novel prevention and treatment efforts. Moreover, potential biopsychosocial mechanisms involving the brain and gut have not been considered in an integrated, comprehensive fashion.
    Methods: Members of the prevention of lower urinary tract symptoms Research Consortium developed conceptual models to inform research on biopsychosocial mechanisms through which stress and MDHs may impact bladder health among girls and women, focusing on brain and gut physiology.
    Results: Two conceptual models were developed-one to explain central (brain-based) and peripheral (gut-based) mechanisms linking stressors and MHDs to OAB and bladder health, and one to highlight bidirectional communication between the brain, gut, and bladder. Traumatic events, chronic stressors, and MHDs may lead to a maladaptive stress response, including dysregulated communication and signaling between the brain, gut, and bladder. Gut bacteria produce molecules and metabolites that alter production of neurotransmitters, amino acids, short-chain fatty acids, and inflammatory immune response molecules that mediate communication between the gut and brain. Microbiota signal neurogenesis, microglia maturation, and synaptic pruning; they also calibrate brain-gut-bladder axis communication through neurotransmission and synaptogenesis, potentially influencing bladder symptom development. Life course trajectories of risk may be prevented or interrupted by central and peripheral resources for neuropsychological resilience.
    Conclusions: Depicted pathways, including brain-gut-bladder communication, have implications for research and development of novel prevention and treatment approaches.
    MeSH term(s) Humans ; Female ; Urinary Bladder, Overactive/therapy ; Urinary Bladder ; Mental Health ; Urinary Incontinence ; Brain
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25356
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  4. Article ; Online: A novel interaction between extracellular vimentin and fibrinogen in fibrin formation.

    Martinez-Vargas, Marina / Cebula, Adrian / Brubaker, Lisa S / Seshadri, Nitin / Lam, Fong W / Loor, Michele / Rosengart, Todd K / Yee, Andrew / Rumbaut, Rolando E / Cruz, Miguel A

    Thrombosis research

    2022  Volume 221, Page(s) 97–104

    Abstract: Introduction: Thrombosis is frequently manifested in critically ill patients with systemic inflammation, including sepsis and COVID-19. The coagulopathy in systemic inflammation is often associated with increased levels of fibrinogen and D-dimer. ... ...

    Abstract Introduction: Thrombosis is frequently manifested in critically ill patients with systemic inflammation, including sepsis and COVID-19. The coagulopathy in systemic inflammation is often associated with increased levels of fibrinogen and D-dimer. Because elevated levels of vimentin have been detected in sepsis, we sought to investigate the relationship between vimentin and the increased fibrin formation potential observed in these patients.
    Materials and methods: This hypothesis was examined by using recombinant human vimentin, anti-vimentin antibodies, plasma derived from healthy and critically ill patients, confocal microscopy, co-immunoprecipitation assays, and size exclusion chromatography.
    Results: The level of vimentin in plasma derived from critically ill subjects with systemic inflammation was on average two-fold higher than that of healthy volunteers. We determined that vimentin directly interacts with fibrinogen and enhances fibrin formation. Anti-vimentin antibody effectively blocked fibrin formation ex vivo and caused changes in the fibrin structure in plasma. Additionally, confocal imaging demonstrated plasma vimentin enmeshed in the fibrin fibrils. Size exclusion chromatography column and co-immunoprecipitation assays demonstrated a direct interaction between extracellular vimentin and fibrinogen in plasma from critically ill patients but not in healthy plasma.
    Conclusions: The results describe that extracellular vimentin engages fibrinogen in fibrin formation. In addition, the data suggest that elevated levels of an apparent aberrant extracellular vimentin potentiate fibrin clot formation in critically ill patients with systemic inflammation; consistent with the notion that plasma vimentin contributes to the pathogenesis of thrombosis.
    MeSH term(s) Humans ; COVID-19/complications ; Critical Illness ; Fibrin ; Fibrinogen/chemistry ; Hemostatics ; Inflammation/complications ; Thrombosis/etiology ; Vimentin/metabolism ; Extracellular Space/metabolism
    Chemical Substances Fibrin (9001-31-4) ; Fibrinogen (9001-32-5) ; Hemostatics ; Vimentin
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2022.11.028
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  5. Article ; Online: Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

    Brubaker, Lisa S / Saini, Arun / Nguyen, Trung C / Martinez-Vargas, Marina / Lam, Fong W / Yao, Qizhi / Loor, Michele M / Rosengart, Todd K / Cruz, Miguel A

    Critical care medicine

    2022  Volume 50, Issue 6, Page(s) e557–e568

    Abstract: Objectives: Disseminated fibrin-rich microthrombi have been reported in patients who died from COVID-19. Our objective is to determine whether the fibrin clot structure and function differ between critically ill patients with or without COVID-19 and to ... ...

    Abstract Objectives: Disseminated fibrin-rich microthrombi have been reported in patients who died from COVID-19. Our objective is to determine whether the fibrin clot structure and function differ between critically ill patients with or without COVID-19 and to correlate the structure with clinical coagulation biomarkers.
    Design: A cross-sectional observational study. Platelet poor plasma was used to analyze fibrin clot structure; the functional implications were determined by quantifying clot turbidity and porosity.
    Setting: ICU at an academic medical center and an academic laboratory.
    Patients: Patients admitted from July 1 to August 1, 2020, to the ICU with severe acute respiratory syndrome coronavirus 2 infection confirmed by reverse transcription-polymerase chain reaction or patients admitted to the ICU with sepsis.
    Interventions: None.
    Measurements and main results: Blood was collected from 36 patients including 26 ICU patients with COVID-19 and 10 ICU patients with sepsis but without COVID-19 at a median of 11 days after ICU admission (interquartile range, 3-16). The cohorts were similar in age, gender, body mass index, comorbidities, Sequential Organ Failure Assessment (SOFA) score, and mortality. More patients with COVID-19 (100% vs 70%; p = 0.003) required anticoagulation. Ex vivo fibrin clots formed from patients with COVID-19 appeared to be denser and to have smaller pores than those from patients with sepsis but without COVID-19 (percent area of fluorescent fibrin 48.1% [SD, 16%] vs 24.9% [SD, 18.8%]; p = 0.049). The turbidity and flow-through assays corroborated these data; fibrin clots had a higher maximum turbidity in patients with COVID-19 compared with patients without COVID-19 (0.168 vs 0.089 OD units; p = 0.003), and it took longer for buffer to flow through these clots (216 vs 103 min; p = 0.003). In patients with COVID-19, d-dimer levels were positively correlated with percent area of fluorescent fibrin (ρ = 0.714, p = 0.047). Denser clots (assessed by turbidity and thromboelastography) and higher SOFA scores were independently associated with delayed clot lysis.
    Conclusions: We found aberrant fibrin clot structure and function in critically ill patients with COVID-19. These findings may contribute to the poor outcomes observed in COVID-19 patients with widespread fibrin deposition.
    MeSH term(s) COVID-19 ; Critical Illness ; Cross-Sectional Studies ; Fibrin ; Fibrinolysis ; Humans ; Sepsis ; Thromboembolism ; Thrombosis
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005465
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  6. Article ; Online: Reply by Authors.

    Rickey, Leslie M / Constantine, Melissa L / Lukacz, Emily S / Lowder, Jerry L / Newman, Diane K / Brubaker, Linda / Rudser, Kyle / Lewis, Cora E / Low, Lisa K / Palmer, Mary H / Rockwood, Todd

    The Journal of urology

    2021  Volume 205, Issue 5, Page(s) 1414

    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001581.02
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  7. Article ; Online: Association Between Maternal Depression and Lower Urinary Tract Symptoms in Their Primary School-Age Daughters: A Birth Cohort Study.

    Cunningham, Shayna D / Lindberg, Sarah / Joinson, Carol / Shoham, David / Chu, Haitao / Newman, Diane / Epperson, Neill / Brubaker, Linda / Low, Lisa Kane / Camenga, Deepa R / LaCoursiere, D Yvette / Meister, Melanie / Kenton, Kimberly / Sutcliffe, Siobhan / Markland, Alayne D / Gahagan, Sheila / Coyne-Beasley, Tamera / Berry, Amanda

    Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society

    2024  Volume 51, Issue 1, Page(s) 53–60

    Abstract: Purpose: Although maternal depression is associated with adverse outcomes in women and children, its relationship with lower urinary tract symptoms (LUTS) in offspring is less well-characterized. We examined the association between prenatal and ... ...

    Abstract Purpose: Although maternal depression is associated with adverse outcomes in women and children, its relationship with lower urinary tract symptoms (LUTS) in offspring is less well-characterized. We examined the association between prenatal and postpartum maternal depression and LUTS in primary school-age daughters.
    Design: Observational cohort study.
    Subjects and setting: The sample comprised 7148 mother-daughter dyads from the Avon Longitudinal Study of Parents and Children.
    Method: Mothers completed questionnaires about depressive symptoms at 18 and 32 weeks' gestation and 21 months postpartum and their children's LUTS (urinary urgency, nocturia, and daytime and nighttime wetting) at 6, 7, and 9 years of age. Multivariable logistic regression models were used to estimate the association between maternal depression and LUTS in daughters.
    Results: Compared to daughters of mothers without depression, those born to mothers with prenatal and postpartum depression had higher odds of LUTS, including urinary urgency (adjusted odds ratio [aOR] range = 1.99-2.50) and nocturia (aOR range = 1.67-1.97) at 6, 7, and 9 years of age. Additionally, daughters born to mothers with prenatal and postpartum depression had higher odds of daytime wetting (aOR range = 1.81-1.99) and nighttime wetting (aOR range = 1.63-1.95) at 6 and 7 years of age. Less consistent associations were observed for depression limited to the prenatal or postpartum periods only.
    Conclusions: Exposure to maternal depression in the prenatal and postpartum periods was associated with an increased likelihood of LUTS in daughters. This association may be an important opportunity for childhood LUTS prevention. Prevention strategies should reflect an understanding of potential biological and environmental mechanisms through which maternal depression may influence childhood LUTS.
    MeSH term(s) Pregnancy ; Child ; Female ; Humans ; Cohort Studies ; Depression, Postpartum/complications ; Depression, Postpartum/epidemiology ; Longitudinal Studies ; Depression/complications ; Depression/epidemiology ; Nuclear Family ; Nocturia/complications ; Nocturia/epidemiology ; Lower Urinary Tract Symptoms/complications ; Lower Urinary Tract Symptoms/epidemiology ; Schools
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1188388-1
    ISSN 1528-3976 ; 1071-5754
    ISSN (online) 1528-3976
    ISSN 1071-5754
    DOI 10.1097/WON.0000000000001039
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  8. Article: Forming Consensus To Advance Urobiome Research.

    Brubaker, Linda / Gourdine, Jean-Philippe F / Siddiqui, Nazema Y / Holland, Amanda / Halverson, Thomas / Limeria, Roberto / Pride, David / Ackerman, Lenore / Forster, Catherine S / Jacobs, Kristin M / Thomas-White, Krystal J / Putonti, Catherine / Dong, Qunfeng / Weinstein, Michael / Lukacz, Emily S / Karstens, Lisa / Wolfe, Alan J

    mSystems

    2021  Volume 6, Issue 4, Page(s) e0137120

    Abstract: Urobiome research has the potential to advance the understanding of a wide range of diseases, including lower urinary tract symptoms and kidney disease. Many scientific areas have benefited from early research method consensus to facilitate the greater, ... ...

    Abstract Urobiome research has the potential to advance the understanding of a wide range of diseases, including lower urinary tract symptoms and kidney disease. Many scientific areas have benefited from early research method consensus to facilitate the greater, common good. This consensus document, developed by a group of expert investigators currently engaged in urobiome research (UROBIOME 2020 conference participants), aims to promote standardization and advances in this field by the adoption of common core research practices. We propose a standardized nomenclature as well as considerations for specimen collection, preservation, storage, and processing. Best practices for urobiome study design include our proposal for standard metadata elements as part of core metadata collection. Although it is impractical to follow fixed analytical procedures when analyzing urobiome data, we propose guidelines to document and report data originating from urobiome studies. We offer this first consensus document with every expectation of subsequent revision as our field progresses.
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.01371-20
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  9. Article ; Online: Measuring Bladder Health: Development and Cognitive Evaluation of Items for a Novel Bladder Health Instrument.

    Rickey, Leslie M / Constantine, Melissa L / Lukacz, Emily S / Lowder, Jerry L / Newman, Diane K / Brubaker, Linda / Rudser, Kyle / Lewis, Cora E / Low, Lisa K / Palmer, Mary H / Rockwood, Todd

    The Journal of urology

    2020  Volume 205, Issue 5, Page(s) 1407–1414

    Abstract: Purpose: We describe the item development and cognitive evaluation process used in creating the Prevention of Lower Urinary Tract Symptoms Bladder Health Instrument (PLUS-BHI).: Materials and methods: Questions assessing bladder health were developed ...

    Abstract Purpose: We describe the item development and cognitive evaluation process used in creating the Prevention of Lower Urinary Tract Symptoms Bladder Health Instrument (PLUS-BHI).
    Materials and methods: Questions assessing bladder health were developed using reviews of published items, expert opinion, and focus groups' transcript review. Candidate items were tested through cognitive interviews with community-dwelling women and an online panel survey. Items were assessed for comprehension, language, and response categories and modified iteratively to create the PLUS-BHI.
    Results: Existing measures of bladder function (storage, emptying, sensation components) and bladder health impact required modification of time frame and response categories to capture a full range of bladder health. Of the women 167 (18-80 years old) completed individual interviews and 791 women (18-88 years) completed the online panel survey. The term "bladder health" was unfamiliar for most and was conceptualized primarily as absence of severe urinary symptoms, infection, or cancer. Coping mechanisms and self-management strategies were central to bladder health perceptions. The inclusion of prompts and response categories that captured infrequent symptoms increased endorsement of symptoms across bladder function components.
    Conclusions: Bladder health measurement is challenged by a lack of awareness of normal function, use of self-management strategies to mitigate impact on activities, and a common tendency to overlook infrequent lower urinary tract symptoms. The PLUS-BHI is designed to characterize the full spectrum of bladder health in women and will be validated for research use.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cognition ; Diagnostic Self Evaluation ; Female ; Health Status ; Humans ; Interviews as Topic ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/prevention & control ; Middle Aged ; Urinary Bladder/physiology ; Young Adult
    Language English
    Publishing date 2020-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001581
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  10. Article ; Online: School Toileting Environment, Bullying, and Lower Urinary Tract Symptoms in a Population of Adolescent and Young Adult Girls: Preventing Lower Urinary Tract Symptoms Consortium Analysis of Avon Longitudinal Study of Parents and Children.

    Shoham, David A / Wang, Zhenxun / Lindberg, Sarah / Chu, Haitao / Brubaker, Linda / Brady, Sonya S / Coyne-Beasley, Tamera / Fitzgerald, Colleen M / Gahagan, Sheila / Harlow, Bernard L / Joinson, Carol / Low, Lisa Kane / Markland, Alayne D / Newman, Diane K / Smith, Ariana L / Stapleton, Ann / Sutcliffe, Siobhan / Berry, Amanda

    Urology

    2020  Volume 151, Page(s) 86–93

    Abstract: Objectives: To examine whether the school toilet environment at age 13, including bullying at toilets, is associated with female lower urinary tract symptoms (LUTS) at ages 13 and 19, as little is known about the association among school toilet ... ...

    Abstract Objectives: To examine whether the school toilet environment at age 13, including bullying at toilets, is associated with female lower urinary tract symptoms (LUTS) at ages 13 and 19, as little is known about the association among school toilet environment, voiding behaviors, and LUTS in adolescent girls.
    Methods: The sample comprised 3962 female participants from the Avon Longitudinal Study of Parents and Children. At age 13, participants reported on 7 school toilet environment characteristics and a range of LUTS items. At age 19, participants completed the Bristol Female Lower Urinary Tract Symptoms questionnaire.
    Results: All toilet environmental factors were associated with at least 1 LUTS outcome at age 13. Holding behavior was associated with all school toilet environmental factors, with odds ratios ranging from 1.36 (95% confidence interval [CI]: 1.05, 1.76) for dirty toilets to 2.38 (95% CI: 1.60, 3.52) for feeling bullied at toilets. Bullying was associated with all daytime LUTS symptoms and nocturia; odds ratios ranged from 1.60 (95% CI: 1.04, 2.07) for nocturia to 2.90 (95% CI: 1.77, 4.75) for urgency. Associations between age 13 school toilets and age 19 LUTS were in the same direction as age 13 LUTS.
    Conclusion: This is the first examination of associations between school toilets and LUTS. Toileting environments were cross-sectionally associated with LUTS in adolescent girls. While further work is needed to determine whether these associations are causal, school toilet environments are modifiable and thus a promising target for LUTS prevention.
    MeSH term(s) Adolescent ; Bathroom Equipment ; Bullying ; Child ; Female ; Humans ; Longitudinal Studies ; Lower Urinary Tract Symptoms/epidemiology ; Nocturia/epidemiology ; Schools ; Toilet Facilities ; United Kingdom/epidemiology ; Urinary Incontinence, Urge/epidemiology
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2020.06.060
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