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  1. Article: The Effect of Subinhibitory Concentration of Metronidazole on the Growth and Biofilm Formation on Toxigenic

    Wultańska, Dorota / Karpiński, Paweł / Piotrowski, Michał / Pituch, Hanna

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 10

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2023-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12101244
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  2. Article ; Online: CpG Island Methylator Phenotype-A Hope for the Future or a Road to Nowhere?

    Paweł, Karpiński / Maria Małgorzata, Sąsiadek

    International journal of molecular sciences

    2022  Volume 23, Issue 2

    Abstract: The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. ... ...

    Abstract The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathological characteristics of CIMP in CRC and other tumour types has rapidly expanded. Concordant and widespread hypermethylation of multiple CpG islands observed in CIMP in multiple cancers raised hopes for future epigenetically based diagnostics and treatments of solid tumours. However, studies on CIMP in solid tumours were hampered by a lack of generalisability and reproducibility of epigenetic markers. Moreover, CIMP was not a satisfactory marker in predicting clinical outcomes. The idea of targeting epigenetic abnormalities such as CIMP for cancer therapy has not been implemented for solid tumours, either. Twenty-one years after its discovery, we aim to cover both the fundamental and new aspects of CIMP and its future application as a diagnostic marker and target in anticancer therapies.
    MeSH term(s) Animals ; Biomarkers ; Biomarkers, Tumor ; Computational Biology/methods ; CpG Islands ; DNA Methylation ; Drug Development ; Epigenesis, Genetic ; Gene Expression Profiling ; Gene Expression Regulation ; Humans ; Molecular Targeted Therapy ; Oligonucleotide Array Sequence Analysis ; Phenotype
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23020830
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  3. Article ; Online: THE INFLUENCE OF THE INJECTION TIMING ON THE PERFORMANCE OF TWO-STROKE OPPOSED-PISTON DIESEL ENGINE

    Paweł KARPIŃSKI

    Applied Computer Science, Vol 14, Iss 2, Pp 69-

    2018  Volume 81

    Abstract: The performance of the engine strongly depends on the parameters of the combustion process. In compression ignition engines, the fuel injection timing has a significant influence on this process. The moment of its occurrence and its duration should be ... ...

    Abstract The performance of the engine strongly depends on the parameters of the combustion process. In compression ignition engines, the fuel injection timing has a significant influence on this process. The moment of its occurrence and its duration should be chosen so that the maximum pressure value occurs several degrees after TDC. In order to analyze the effect of the fuel injection timing on the performance of the tested two-stroke opposed-piston diesel engine, a zero-dimensional model was developed in the AVL BOOST program. Next, a series of simulations were performed based on the defined calculation points for maximum continuous power, which resulted in power, specific fuel consumption and mean in-cylinder pressure. Finally, the engine map was made as a function of the start of combustion angle.
    Keywords diesel engine ; opposed piston engine ; two-stroke engine ; injection timing ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 600
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Polish Association for Knowledge Promotion
    Document type Article ; Online
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  4. Article ; Online: CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere?

    Karpiński Paweł / Sąsiadek Maria Małgorzata

    International Journal of Molecular Sciences, Vol 23, Iss 830, p

    2022  Volume 830

    Abstract: The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. ... ...

    Abstract The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers (CRC) and gliomas. Consequently, knowledge on molecular and pathological characteristics of CIMP in CRC and other tumour types has rapidly expanded. Concordant and widespread hypermethylation of multiple CpG islands observed in CIMP in multiple cancers raised hopes for future epigenetically based diagnostics and treatments of solid tumours. However, studies on CIMP in solid tumours were hampered by a lack of generalisability and reproducibility of epigenetic markers. Moreover, CIMP was not a satisfactory marker in predicting clinical outcomes. The idea of targeting epigenetic abnormalities such as CIMP for cancer therapy has not been implemented for solid tumours, either. Twenty-one years after its discovery, we aim to cover both the fundamental and new aspects of CIMP and its future application as a diagnostic marker and target in anticancer therapies.
    Keywords epigenetics ; methylator phenotype ; CIMP ; DNA methylation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Epigenetic Findings in Twins with Esophageal Atresia.

    Błoch, Michal / Gasperowicz, Piotr / Gerus, Sylwester / Rasiewicz, Katarzyna / Lebioda, Arleta / Skiba, Pawel / Płoski, Rafal / Patkowski, Dariusz / Karpiński, Pawel / Śmigiel, Robert

    Genes

    2023  Volume 14, Issue 9

    Abstract: Esophageal atresia (EA) is the most common malformation of the upper gastrointestinal tract. The estimated incidence of EA is 1 in 3500 births. EA is more frequently observed in boys and in twins. The exact cause of isolated EA remains unknown; a ... ...

    Abstract Esophageal atresia (EA) is the most common malformation of the upper gastrointestinal tract. The estimated incidence of EA is 1 in 3500 births. EA is more frequently observed in boys and in twins. The exact cause of isolated EA remains unknown; a multifactorial etiology, including epigenetic gene expression modifications, is considered. The study included six pairs of twins (three pairs of monozygotic twins and three pairs of dizygotic twins) in which one child was born with EA as an isolated defect, while the other twin was healthy. DNA samples were obtained from the blood and esophageal tissue of the child with EA as well as from the blood of the healthy twin. The reduced representation bisulfite sequencing (RRBS) technique was employed for a whole-genome methylation analysis. The analyses focused on comparing the CpG island methylation profiles between patients with EA and their healthy siblings. Hypermethylation in the promoters of 219 genes and hypomethylation in the promoters of 78 genes were observed. A pathway enrichment analysis revealed the statistically significant differences in methylation profile of 10 hypermethylated genes in the Rho GTPase pathway, previously undescribed in the field of EA (
    MeSH term(s) Male ; Child ; Humans ; Esophageal Atresia/genetics ; Twins, Monozygotic/genetics ; Twins, Dizygotic ; CpG Islands/genetics ; Epigenesis, Genetic ; Proto-Oncogene Proteins ; Guanine Nucleotide Exchange Factors ; Rho Guanine Nucleotide Exchange Factors
    Chemical Substances MCF2 protein, human ; Proto-Oncogene Proteins ; Guanine Nucleotide Exchange Factors ; ARHGEF9 protein, human ; Rho Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14091822
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  6. Article ; Online: The CRK5 and WRKY53 Are Conditional Regulators of Senescence and Stomatal Conductance in

    Burdiak, Paweł / Mielecki, Jakub / Gawroński, Piotr / Karpiński, Stanisław

    Cells

    2022  Volume 11, Issue 22

    Abstract: ... ...

    Abstract In
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/metabolism ; Gene Expression Regulation, Plant ; Chlorophyll A/metabolism ; Plants, Genetically Modified/metabolism ; DNA-Binding Proteins/metabolism ; Receptors, Cell Surface/metabolism ; Protein Serine-Threonine Kinases
    Chemical Substances Arabidopsis Proteins ; Chlorophyll A (YF5Q9EJC8Y) ; DNA-Binding Proteins ; WRKY53 protein, Arabidopsis ; CRK5 protein, Arabidopsis (EC 2.7.1.-) ; Receptors, Cell Surface ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11223558
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  7. Article ; Online: Further Delineation of Clinical Phenotype of

    Bodetko, Aleksandra / Chrzanowska, Joanna / Rydzanicz, Malgorzata / Borys-Iwanicka, Agnieszka / Karpinski, Pawel / Bladowska, Joanna / Ploski, Rafal / Smigiel, Robert

    Genes

    2024  Volume 15, Issue 2

    Abstract: Intellectual disability with speech delay and behavioural abnormalities, as well as hypotonia, seizures, feeding difficulties and craniofacial dysmorphism, are the main symptoms associated with pathogenic variants of ... ...

    Abstract Intellectual disability with speech delay and behavioural abnormalities, as well as hypotonia, seizures, feeding difficulties and craniofacial dysmorphism, are the main symptoms associated with pathogenic variants of the
    MeSH term(s) Child ; Humans ; Abnormalities, Multiple/genetics ; Abnormalities, Multiple/diagnosis ; Cell Cycle Proteins/genetics ; Co-Repressor Proteins/genetics ; DNA-Binding Proteins/genetics ; Intellectual Disability/genetics ; Intellectual Disability/diagnosis ; Mutation, Missense ; Phenotype ; Syndrome
    Chemical Substances Cell Cycle Proteins ; Co-Repressor Proteins ; DNA-Binding Proteins ; ZMYND11 protein, human
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15020256
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  8. Article ; Online: Optically Controlled Development of a Waveguide from a Reservoir of Microparticles.

    Karpinski, Pawel / Sznitko, Lech / Wisniewska-Belej, Monika / Miniewicz, Andrzej / Antosiewicz, Tomasz J

    Small methods

    2023  Volume 7, Issue 7, Page(s) e2201545

    Abstract: Light can be guided without diffraction in prefabricated structures: optical fibers and waveguides or in actively created spatial solitons in optically nonlinear media. Here, an approach in which a self-stabilized optical waveguide develops from a ... ...

    Abstract Light can be guided without diffraction in prefabricated structures: optical fibers and waveguides or in actively created spatial solitons in optically nonlinear media. Here, an approach in which a self-stabilized optical waveguide develops from a reservoir of building blocks-spherical polymer microparticles (MPs)-and is pushed through an optically passive medium-water-is presented. The optical waveguide, formed by a chain of these microparticles and one microsphere wide, is self-stabilized and propelled by the guided light, while its geometrical and dynamical properties depend on the diameter-to-wavelength ratio. The smallest investigated particles, 500 nm in diameter, form single-mode waveguides up to tens of micrometers long, with the length limited only by optical losses. In contrast, waveguides constructed of larger MPs, 1 and 2.5 µm in diameter, are limited in length to only a few particles due to interference of different modes and beating of light intensity.
    Language English
    Publishing date 2023-04-19
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202201545
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  9. Article ; Online: Experimental Investigation of Performance of the Rotorcraft Directional Rudder

    Andrej Novák / Karol Ścisłowski / Rafał Kliza / Robert Bąbel / Zbigniew Czyż / Paweł Karpiński

    Communications, Vol 26, Iss 1, Pp A1-A

    2024  Volume 10

    Abstract: The paper presents the results of gyrocopter fuselage experiment testing in a wind tunnel. The model subjected to testing was made in 1:8 scale by 3D printing. The tests included the measurement of forces and aerodynamic moments acting on the model, for ... ...

    Abstract The paper presents the results of gyrocopter fuselage experiment testing in a wind tunnel. The model subjected to testing was made in 1:8 scale by 3D printing. The tests included the measurement of forces and aerodynamic moments acting on the model, for a variable fuselage sideslip angle (-20º to 20º), and for three different positions of the rudder setting (0º, +5º, +10º). The measurement was carried out at an airspeed of 25 to 26 m/s. Based on the measured values, aerodynamic drag coefficients, lift coefficient and aerodynamic moment coefficients with respect to all axes of the reference system, were determined. The measurements carried out have facilitated the derivation of diverse characteristics, validating our conclusions. The results and conclusions drawn from these experiments can be valuable in enhancing the design and functionality of rotorcraft rudders.
    Keywords gyrocopter ; wind tunnel ; aerodynamic research ; directional rudder ; sideslip angle ; Transportation and communications ; HE1-9990 ; Science ; Q ; Transportation engineering ; TA1001-1280
    Subject code 621
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher University of Žilina
    Document type Article ; Online
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  10. Article ; Online: Current Achievements and Applications of Transcriptomics in Personalized Cancer Medicine.

    Supplitt, Stanislaw / Karpinski, Pawel / Sasiadek, Maria / Laczmanska, Izabela

    International journal of molecular sciences

    2021  Volume 22, Issue 3

    Abstract: Over the last decades, transcriptome profiling emerged as one of the most powerful approaches in oncology, providing prognostic and predictive utility for cancer management. The development of novel technologies, such as revolutionary next-generation ... ...

    Abstract Over the last decades, transcriptome profiling emerged as one of the most powerful approaches in oncology, providing prognostic and predictive utility for cancer management. The development of novel technologies, such as revolutionary next-generation sequencing, enables the identification of cancer biomarkers, gene signatures, and their aberrant expression affecting oncogenesis, as well as the discovery of molecular targets for anticancer therapies. Transcriptomics contribute to a change in the holistic understanding of cancer, from histopathological and organic to molecular classifications, opening a more personalized perspective for tumor diagnostics and therapy. The further advancement on transcriptome profiling may allow standardization and cost reduction of its analysis, which will be the next step for transcriptomics to become a canon of contemporary cancer medicine.
    MeSH term(s) Biomarkers, Tumor/genetics ; Gene Expression Profiling ; Humans ; Medical Oncology ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine ; Prognosis ; Transcriptome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22031422
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