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Article ; Online: Sex differences in colonic gene expression and fecal microbiota composition in a mouse model of obesity-associated colorectal cancer.

Chang, Yoo-Mee / Kang, Yoo-Ree / Lee, Yu-Gyeong / Sung, Mi-Kyung

2024 Volume 14, Issue 1, Page(s) 3576

Abstract: ... carbon metabolism in cancer. Sex-specific changes in gut microbial composition in response to HFD were ...

Abstract	This study investigated the sex-specific correlation between obesity and colorectal cancer emphasizing a more pronounced association in males. Estrogen, chromosomal genes, and gut bacteria were assessed in C57BL6/J male, female and ovariectomized (OVX) female mice, subjected to either a low-fat diet (LFD) or high-fat diet (HFD) for 14 weeks. Induction of colon tumor involved azoxymethane (10 mg/kg) administration, followed by three cycles of dextran sulfate sodium. Male mice on HFD exhibited higher final body weight and increased colon tumors compared to females. Colonic mucin 2 expression was significantly higher in females. HFD-modulated differentially expressed genes numbered 290 for males, 64 for females, and 137 for OVX females. Only one up-regulated gene (Gfra3) overlapped between females and OVX females, while two down-regulated genes (Thrsp and Gbp11) overlapped between males and OVX females. Genes up-regulated by HFD in males were linked to cytokine-cytokine interaction, HIF-1 signaling pathway, central carbon metabolism in cancer. Sex-specific changes in gut microbial composition in response to HFD were observed. These findings suggest a male-specific vulnerability to HFD-induced colon tumor formation, implicating key genes and colonic bacteria in colon tumorigenesis.
MeSH term(s)	Female ; Male ; Animals ; Mice ; Sex Characteristics ; Obesity/complications ; Obesity/genetics ; Obesity/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Diet, High-Fat/adverse effects ; Cytokines ; Microbiota ; Gene Expression ; Mice, Inbred C57BL
Chemical Substances	Cytokines
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53861-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Molecular Characterization and Fungicide Sensitivity of Jujube Pathogens

Kang, Eun Chan / Hassan, Oliul / Kim, Kyung-Min / Chang, Taehyun

Plant disease

2023 Volume 107, Issue 3, Page(s) 861–869

Abstract: Jujube ( ...

Abstract	Jujube (
MeSH term(s)	Fungicides, Industrial/pharmacology ; Colletotrichum/genetics ; Ziziphus ; Fruit ; Republic of Korea
Chemical Substances	Fungicides, Industrial ; azoxystrobin (NYH7Y08IPM)
Language	English
Publishing date	2023-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-04-22-0942-RE
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Article: The talk test as a useful tool to monitor aerobic exercise intensity in healthy population.

Kwon, Yonghyun / Kang, Kyung Woo / Chang, Jong Sung

Journal of exercise rehabilitation

2023 Volume 19, Issue 3, Page(s) 163–169

Abstract: The talk test (TT) is subjective method to measure exercise intensity in costless and feasible manner, compared to sophisticated laboratory equipment. We attempted to investigate whether the TT was a valid method for evaluation of exercise intensity, by ... ...

Abstract	The talk test (TT) is subjective method to measure exercise intensity in costless and feasible manner, compared to sophisticated laboratory equipment. We attempted to investigate whether the TT was a valid method for evaluation of exercise intensity, by comparing with values derived from various physiologic markers during cardiopulmonary exercise testing on treadmill in healthy population. A total of 17 healthy subjects (12 males and 5 females) participated in this study. The TT was applied, which consisted of 3-stages difficulties demanding respiratory load while they performed the cardiopulmonary exercise testing on treadmill. In each of the TT stages, ergospirometric and psychophysiologic response marker were collected such as heart rate, oxygen consumption, respiratory exchange ratio, minute ventilation, carbon dioxide output, tidal volume, respiratory rate, and rating of perceived exertion of breathing. Statistical analyses revealed a significant difference of all dependent variables in each of three TT stages, comparing with the resting phase before the TT. The TT showed strong correlation coefficient with all variables except for rating of perceived exertion during the resting phase before the TT. According to increase of exercise intensity, all dependent variables showed a linear tendency with the stages of the TT. Our findings indicated that each of the TT stages was strongly correlated with ergospirometric variables as well as psychophysiologic response during cardiopulmonary exercise testing on treadmill. We suggested that the TT can be used to evaluate and prescribe exercise intensity of aerobic activity in cardiovascular and pulmonary rehabilitation settings.
Language	English
Publishing date	2023-06-28
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2756291-8
ISSN	2288-1778 ; 2288-176X
ISSN (online)	2288-1778
ISSN	2288-176X
DOI	10.12965/jer.2346170.085
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Article ; Online: Effects of resistance training and nutritional support on osteosarcopenia in older, community-dwelling postmenopausal Korean females (ERTO-K study): a study protocol.

Lee, Byung Chan / Kim, Kyung Il / Cho, Kang Hee / Moon, Chang-Won

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 68

Abstract: ... the changes in skeletal muscle index and bone marrow density of the lumbar spine and femoral neck between ...

Abstract	Background: Osteosarcopenia is geriatric syndrome defined as the concomitant occurrence of osteopenia/osteoporosis, and sarcopenia. Osteosarcopenia is a relatively new concept in geriatric medicine; however, it may increase the risk of fragility fractures, several morbidities and mortalities, and socioeconomic costs. Although resistance exercises and nutritional support-including protein, calcium, and vitamin D-are potential non-pharmacological management procedures, evidence is still lacking. The objective of this study was therefore to evaluate the effect of combined resistance exercise and nutritional support on the quality and quantity of bone and muscle in postmenopausal females with osteosarcopenia. Methods: This research proposal presents the protocol for a prospective, single-center, single-blinded, two-armed randomized controlled trial. Thirty-four participants with osteosarcopenia will be recruited and randomly divided into intervention and control groups; both groups will receive nutritional supplements (protein, 40 g; vitamin D, 1600 IU; calcium, 600 mg) daily. The intervention group will undergo 24 weeks of resistance exercise of increasing intensity, achieved through a three-phase step-up process. The primary outcomes will be the changes in skeletal muscle index and bone marrow density of the lumbar spine and femoral neck between the baseline and end of intervention (24 weeks). The secondary outcomes will be the body composition, whole body phase angle, physical function assessment, quality of life, psychological assessment, and bone turnover markers of participants, surveyed at multiple time points. Discussion: This randomized controlled trial may reveal the effect of resistance exercise and nutritional support on older postmenopausal women with osteosarcopenia. The results will provide evidence for developing proper non-pharmacological management guidelines for postmenopausal women. Trial registration: Clinical Research Information Service of Republic of Korea, KCT0008291, Registered on 16 March 2023, https://cris.nih.go.kr/cris/search/detailSearch.do/25262 .
MeSH term(s)	Humans ; Female ; Aged ; Resistance Training/methods ; Calcium ; Quality of Life ; Independent Living ; Postmenopause ; Prospective Studies ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Sarcopenia/therapy ; Vitamin D ; Nutritional Support ; Randomized Controlled Trials as Topic
Chemical Substances	Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04667-1
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Article: Effect of Processing Parameters on Bonding Performance of a Carbon Fiber/Polyetheretherketone Thermoplastic Composite Prepared by Induction Welding.

Choi, Bo-Kyung / Kang, Chang-Soo / Yoo, Myeong-Han / Seo, Min-Kang

Materials (Basel, Switzerland)

2023 Volume 16, Issue 11

Abstract: Among the various welding techniques used to bond thermoplastic composites, induction welding stands out as a fast, clean, and contact-free process that shortens the welding time and prevents the weight increase of mechanical fastening, such as rivets ... ...

Abstract	Among the various welding techniques used to bond thermoplastic composites, induction welding stands out as a fast, clean, and contact-free process that shortens the welding time and prevents the weight increase of mechanical fastening, such as rivets and bolts. In this study, we manufactured polyetheretherketone (PEEK)-resin-based thermoplastic carbon fiber (CF) composite materials at different automated fiber placement laser powers (3569, 4576, and 5034 W) and investigated their bonding and mechanical characteristics after induction welding. The quality of the composite was evaluating using various techniques, including optical microscopy, C-scanning, and mechanical strength measurements, and a thermal imaging camera was used to monitor the surface temperature of the specimen during its processing. The results revealed that the preparation conditions of the polymer/carbon fiber composites, such as the laser power and surface temperature, significantly affect the quality and performance of the induction-welding-bonded composites. A lower laser power during preparation resulted in weaker bonding between components of the composite and yielded samples with a lower shear stress.
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16113954
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Article ; Online: Process optimization for microfluidic preparation of liposomes using food-grade components.

Hong, Sung-Chul / Hong, Chi Rac / Kim, Minsoo / Kang, Yue Jai / Jung, Young Hoon / Park, Kyung-Min / Choi, Jaeyoung / Chang, Pahn-Shick

Food chemistry

2024 Volume 451, Page(s) 139437

Abstract: This study explores the potential for optimizing a sustainable manufacturing process that maintains the essential characteristics of conventional liposomes using food-grade solvents and components. The focus was comparing the physicochemical, ... ...

Abstract	This study explores the potential for optimizing a sustainable manufacturing process that maintains the essential characteristics of conventional liposomes using food-grade solvents and components. The focus was comparing the physicochemical, morphological, and interfacial properties of liposomes produced with these food-grade ingredients to those made by conventional methods. It was found that there was no significant difference in particle size (195.87 ± 1.40 nm) and ζ-potential (-45.13 ± 0.65 mV) between liposomes made from food-grade and conventional materials. The manufacturing process for liposomes, utilizing food-grade solvents and components, was optimized through the application of Plackett-Burman design and response surface methodology. This approach helped identify key parameters (soy lecithin, β-sitosterol, W/O ratio) and their optimal values (3.17 g, 0.25 g, 1:2.59). These findings suggest that it is possible to enhance the use of liposomes as an effective and safe delivery system in the food industry, adhering to the strict guidelines set by regulatory agencies.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139437
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Article ; Online: Why are children less affected than adults by severe acute respiratory syndrome coronavirus 2 infection?

Kang, Chang Kyung / Shin, Hyun Mu / Park, Wan Beom / Kim, Hang-Rae

Cellular & molecular immunology

2022 Volume 19, Issue 5, Page(s) 555–557

MeSH term(s)	Adult ; COVID-19 ; Child ; Humans ; SARS-CoV-2
Language	English
Publishing date	2022-03-24
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-022-00857-2
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Article ; Online: Adverse Drug Events Associated With Remdesivir in Real-World Hospitalized Patients With COVID-19, Including Vulnerable Populations: A Retrospective Multicenter Study.

Kang, Hyein / Kang, Chang Kyung / Im, Jae Hyoung / Cho, Yoonsook / Kang, Dong Yoon / Lee, Ju-Yeun

Journal of Korean medical science

2023 Volume 38, Issue 44, Page(s) e346

Abstract: Background: Remdesivir is a US Food and Drug Administration-approved drug for coronavirus disease 2019 (COVID-19). Clinical trials were conducted under strictly controlled situations for a selected population, and their reported adverse events may not ... ...

Abstract	Background: Remdesivir is a US Food and Drug Administration-approved drug for coronavirus disease 2019 (COVID-19). Clinical trials were conducted under strictly controlled situations for a selected population, and their reported adverse events may not fully represent conditions in real-world patients. We aimed to estimate the incidence of adverse drug events (ADEs) associated with remdesivir in hospitalized patients with COVID-19, including vulnerable subpopulations, such as those with impaired renal or hepatic function and pregnant women. Methods: This retrospective observational study included hospitalized patients with confirmed COVID-19 treated with remdesivir between January and December 2021 at ten hospitals. ADEs and severe ADEs (Common Toxicity Criteria for Adverse Events grade ≥ 3) were operationally defined and analyzed through laboratory investigations. The incidence of ADEs was compared with that of each matched control in subpopulations with renal or hepatic impairment and pregnant women. Results: Among 2,140 patients, 1,416 (66.2%) and 295 (13.8%) experienced at least one ADE and severe ADE, respectively. The most frequent ADE was 'hepatic injury' (42.9%), followed by anemia (27.6%). The most common severe ADEs were 'hypokalemia' (5.3%), 'hepatic injury' (2.9%), and 'anemia' (3.6%). There was no significant difference in the incidence of ADEs in patients relative to their respective matched-control groups, including those with renal impairment (80.0% vs. control 71.8%, Conclusion: A significant proportion of patients with COVID-19 treated with remdesivir experienced ADEs and severe ADEs. Given the high incidence of severe ADEs, caution is required in patients with renal impairment. Further studies are needed to investigate ADEs in pregnant women and patients with hepatic impairment.
MeSH term(s)	Pregnancy ; Humans ; Female ; COVID-19 ; COVID-19 Drug Treatment ; Drug-Related Side Effects and Adverse Reactions ; Retrospective Studies
Chemical Substances	remdesivir (3QKI37EEHE)
Language	English
Publishing date	2023-11-13
Publishing country	Korea (South)
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2023.38.e346
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Article ; Online: Effects of physical activity participation on cognitive impairment in older adults population with disabilities.

Lim, Seung-Taek / Kwak, Hyo-Bum / Kang, Ju-Hee / Chang, Eunwook / Joa, Kyung-Lim / Park, Hee-Jung / Park, Dong-Ho

Frontiers in public health

2024 Volume 12, Page(s) 1293023

Abstract: Background: Existing research on the association between cognitive function and physical activity in the older adults population with disabilities is limited. Additionally, there is a need to explore avenues for enhancing the longevity and quality of ... ...

Abstract	Background: Existing research on the association between cognitive function and physical activity in the older adults population with disabilities is limited. Additionally, there is a need to explore avenues for enhancing the longevity and quality of life among these individuals. Objective: This study aimed to investigate the independent and joint associations between cognitive function and levels of physical activity in the older adults population with disabilities. Methods: A total of 315 older adults adults (men = 182, women = 133), identified with disabilities based on medical evaluation, were recruited from the first survey of the Korean Longitudinal Study of Aging (KLoSA). Participants underwent assessments for cognitive function, physical activity (PA), activities of daily living (ADLs), instrumental activities of daily living (IADLs), and grip strength. Results: ADLs ( Conclusion: This study provides robust evidence that disabled older adults individuals who do not meet the recommended guidelines for PA or who do not participate in PA at least once a week have an increased likelihood of cognitive impairment compared to those who are regularly active.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Longitudinal Studies ; Quality of Life ; Activities of Daily Living ; Cognitive Dysfunction/epidemiology ; Exercise ; Disabled Persons
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1293023
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Article ; Online: Analysis of the Effects of Job Policy Measures in Korea

Chang Ick Kang / Kyung Eun Lim / Junghak Kim

Asian Journal for Public Opinion Research, Vol 10, Iss

Do the Job Policy Measures Impact the Marriage and Fertility of the Youth in Korea?

2022 Volume 3

Abstract: The purpose of this study is to analyze the effects of youth job policy measures, set forth in Korea's 2016-2020 Third Basic Plan for Low Fertility and Aging Society (December 2015), on marriage and fertility among young people. Based on the results, we ... ...

Abstract	The purpose of this study is to analyze the effects of youth job policy measures, set forth in Korea's 2016-2020 Third Basic Plan for Low Fertility and Aging Society (December 2015), on marriage and fertility among young people. Based on the results, we provide theoretical explanations for the findings and suggest policy alternatives to overcome the low fertility phenomenon in Korea. Previous studies have shown that employment is an important factor for marriage among youth, and a job policy could increase marriage and fertility rates. To test this assumption, we performed an exact matching between Statistics Korea's Employee-Enterprise Linkage DB and the Newlyweds DB from 2011 to 2019, in order to identify all young people aged 15-34. Then, linear spline regression analysis was used to examine the impact of the youth job policy on marriage and fertility. Comparing the period before the implementation of the employment policy (2011-2015) and after (2016-2019), the fertility rate increased as the number of young people looking for work increased. In addition, it was found that these impacts were greater after the implementation of the measures (2016-2019) than before (2011-2015). It is interesting to note that job growth among young people did not lead to an increase in marriage. However, the number of births significantly increased when young people who occupy jobs got married, which seems to be related to the delay in marriage among young people who are employed. Survey results about the intentions to marry and views on fertility are utilized for the explanation of the study results.
Keywords	Political science (General) ; JA1-92 ; Political institutions and public administration - Asia (Asian studies only) ; JQ1-6651
Subject code	360
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	ANPOR Korea
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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