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  1. Book: Basic and clinical frontiers of cancer epigenetics

    Ushijima, Toshikazu

    November 17 - 19, 2010 Tokyo, Japan

    (Extended abstracts for the ... international symposium of the Princess Takamatsu Cancer Research Fund ; 41)

    2011  

    Institution Takamatsu-No-Miya-Hi-Gan-Kenkyū-Kikin
    Author's details ed. by Toshikazu Ushijima
    Series title Extended abstracts for the ... international symposium of the Princess Takamatsu Cancer Research Fund ; 41
    Collection
    Language English
    Size V, 154 S. : Ill., graph. Darst.
    Publisher Princess Takamatsu Cancer Research Fund
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT017076617
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 5569 order for loan Magazin

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  2. Book ; Collection: Epigenetics and cancer

    Herceg, Zdenko / Ushijima, Toshikazu

    (Advances in genetics ; ...)

    2010  

    Author's details ed. by Zdenko Herceg ; Toshikazu Ushijima
    Series title Advances in genetics
    ...
    Language English
    Dates of publication 2010-9999
    Publisher Elsevier/Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Collection (display volumes)
    HBZ-ID HT016611207
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Epigenetics and cancer / Pt. A

    Herceg, Zdenko / Ushijima, Toshikazu

    (Advances in genetics ; 70)

    2010  

    Author's details ed. by Zdenko Herceg ; Toshikazu Ushijima
    Series title Advances in genetics ; 70
    Epigenetics and cancer
    Collection Epigenetics and cancer
    Language English
    Size XIV, 396 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier/Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016611213
    ISBN 978-0-12-380866-0 ; 0-12-380866-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 836 -70- verfügbar in Königswinter Königswinter

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  4. Book: Epigenetics and cancer / Pt. B

    Herceg, Zdenko / Ushijima, Toshikazu

    (Advances in genetics ; 71)

    2010  

    Author's details ed. by Zdenko Herceg ; Toshikazu Ushijima
    Series title Advances in genetics ; 71
    Epigenetics and cancer
    Collection Epigenetics and cancer
    Language English
    Size XII, 302 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier/Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016618516
    ISBN 978-0-12-380864-6 ; 0-12-380864-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 836 -71- verfügbar in Königswinter Königswinter

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  5. Article ; Online: DNA Methylation Analysis.

    Hattori, Naoko / Liu, Yu-Yu / Ushijima, Toshikazu

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2691, Page(s) 165–183

    Abstract: DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene expression. DNA methylation alterations in normal and diseased cells provide rich information, such as ... ...

    Abstract DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene expression. DNA methylation alterations in normal and diseased cells provide rich information, such as tissue origin, disease risk, patient response, and prognosis. DNA methylation status is detected by bisulfite conversion, which converts unmethylated cytosines into uracils but methylated cytosines very inefficiently. A genome-wide DNA methylation analysis is conducted by a BeadChip microarray or next-generation sequencing (NGS) of bisulfite-treated DNA. A region-specific DNA methylation analysis can be conducted by various methods, such as methylation-specific PCR (MSP), quantitative MSP, and bisulfite sequencing. This chapter provides protocols for bisulfite-mediated conversion, a BeadChip array-based method (Infinium), quantitative MSP, and bisulfite sequencing.
    MeSH term(s) Humans ; DNA Methylation ; Sequence Analysis, DNA/methods ; Sulfites ; CpG Islands
    Chemical Substances hydrogen sulfite (OJ9787WBLU) ; Sulfites
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3331-1_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Cancer epigenetics: now harvesting fruit and seeding for common diseases.

    Ushijima, Toshikazu

    Biochemical and biophysical research communications

    2014  Volume 455, Issue 1-2, Page(s) 1–2

    MeSH term(s) Epigenesis, Genetic ; Epigenomics/trends ; Humans ; Neoplasms/genetics
    Language English
    Publishing date 2014-12-05
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2014.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Epigenetic field for cancerization: its cause and clinical implications.

    Ushijima, Toshikazu

    BMC proceedings

    2013  Volume 7 Suppl 2, Page(s) K22

    Language English
    Publishing date 2013-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411867-9
    ISSN 1753-6561
    ISSN 1753-6561
    DOI 10.1186/1753-6561-7-S2-K22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Origin of CIMP, At Last.

    Ushijima, Toshikazu / Suzuki, Hiromu

    Cancer cell

    2019  Volume 35, Issue 2, Page(s) 165–167

    Abstract: In this issue of Cancer Cell, Tao et al. provide compelling evidence that aging-like DNA methylation of multiple CpG islands, the CpG island methylator phenotype (CIMP), produces a cellular context that can tolerate BRAF activation avoiding senescence by ...

    Abstract In this issue of Cancer Cell, Tao et al. provide compelling evidence that aging-like DNA methylation of multiple CpG islands, the CpG island methylator phenotype (CIMP), produces a cellular context that can tolerate BRAF activation avoiding senescence by dedicating 5-month culture of colon-derived organoids to epigenomic and stemness analysis.
    MeSH term(s) Carcinogenesis ; CpG Islands ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Mutation ; Phenotype ; Proto-Oncogene Proteins B-raf/genetics
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2019.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5650: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 104: Show issues

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  9. Article ; Online: Mapping genomic and epigenomic evolution in cancer ecosystems.

    Ushijima, Toshikazu / Clark, Susan J / Tan, Patrick

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6562, Page(s) 1474–1479

    Abstract: Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data integration in understanding the molecular evolution of malignant cell states across the cancer life ... ...

    Abstract Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data integration in understanding the molecular evolution of malignant cell states across the cancer life cycle. The widespread presence of driver mutations and epigenetic alterations in normal-appearing tissues is prompting a reassessment of how cancer initiation is defined. In later-stage cancers, studying the roles of clonal selection, epigenomic adaptation, and persister cells in metastasis and therapy resistance is an emerging field. Finally, the importance of tumor ecosystems in driving cancer development is being unraveled by single-cell and spatial technologies at unprecedented resolution. Improving cancer risk assessment and accelerating therapeutic discovery for patients will require robust, comprehensive, and integrated temporal, spatial, and multilevel tumor atlases across the cancer life cycle.
    MeSH term(s) Carcinogenesis ; Epigenesis, Genetic ; Epigenome ; Evolution, Molecular ; Humans ; Mutation ; Neoplasm Metastasis ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Precancerous Conditions/genetics ; Precancerous Conditions/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abh1645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  10. Article: Accumulation of genetic and epigenetic alterations in normal cells and cancer risk.

    Takeshima, Hideyuki / Ushijima, Toshikazu

    NPJ precision oncology

    2019  Volume 3, Page(s) 7

    Abstract: Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; whereas, epigenetic alterations are mainly by aging and chronic ... ...

    Abstract Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; whereas, epigenetic alterations are mainly by aging and chronic inflammation. The accumulation and patterns of alterations in normal cells reflect our past exposure levels and life history. Most accumulated alterations are considered as passengers, but their accumulation is correlated with cancer drivers. This has been shown for aberrant DNA methylation but has only been speculated for genetic alterations. However, recent technological advancements have enabled measurement of rare point mutations, and studies have shown that their accumulation levels are indeed correlated with cancer risk. When the accumulation levels of aberrant DNA methylation and point mutations are combined, risk prediction becomes even more accurate. When high levels of alterations accumulate, the tissue has a high risk of developing cancer or even multiple cancers and is considered as a "cancerization field", with or without expansion of physiological patches of clonal cells. In this review, we describe the formation of a cancerization field and how we can apply its detection in precision cancer risk diagnosis.
    Language English
    Publishing date 2019-03-06
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-019-0079-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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