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  1. Book ; Online: Salud mental universitaria

    Abarzúa Cubillos, Marianella / Cifuentes Astete, Ángela / Ferreira González, Cristian / Araya Avaria, Catalina / Asún Inostroza, Rodrigo / Palma Manríquez, Irma / Cabrera Pérez, Pablo / Arensburg Castelli, Svenska / Venegas Artaza, Victoria / Hurtado Lobos, Natalia / Orellana Moraga, Valeska / Allende Mardones, Matías / Lizama Aguayo, Juan Andrés / Jiménez Meneses, Marco / Riquelme Contreras, Doris / Aceituno Morales, Roberto / Jáuregui Jinés, Gabriela / Aceituno Morales, Roberto

    Salud mental universitaria: voces, trayectorias y prácticas situadas

    2022  

    Keywords Mental health services ; mental health ; Interdisciplinary approaches ; University life ; Community-based interventions
    Language Spanish
    Size 1 electronic resource (460 pages)
    Publisher Social-ediciones
    Publishing place Santiago, Chile
    Document type Book ; Online
    Note Spanish
    HBZ-ID HT030382436
    ISBN 9789561912533 ; 9561912538
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Possible Effect of Polycystic Ovary Syndrome (PCOS) on Cardiovascular Disease (CVD): An Update.

    Profili, Nicia I / Castelli, Roberto / Gidaro, Antonio / Manetti, Roberto / Maioli, Margherita / Petrillo, Marco / Capobianco, Giampiero / Delitala, Alessandro P

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during the fertile period. Women with PCOS have an increased risk of developing major cardiovascular risk factors during the fertile period: obesity, impaired glucose ... ...

    Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during the fertile period. Women with PCOS have an increased risk of developing major cardiovascular risk factors during the fertile period: obesity, impaired glucose tolerance, diabetes mellitus, dyslipidemia, and metabolic syndrome. The possible effect of PCOS on cardiovascular disease (CVD) has been reported in different studies, but the results are not clear for several reasons. Indeed, most of the studies analyzed a cohort of fertile women who, given their relatively young age, have a low frequency of cardiovascular diseases. In addition, longitudinal studies have a short follow-up period, insufficient to draw firm conclusions on this topic. Finally, pharmacological treatment is limited by the lack of specific drugs available to specifically treat PCOS. In this review, we report on studies that analyzed the possible effect of PCOS on the most common CVD (hypertension, arterial stiffness, atherosclerosis, and cardiovascular event) and available drugs used to reduce CVD in PCOS women.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Abnormal Hemostatic Parameters and Risk of Thromboembolism Among Patients With COVID-19 Infection.

    Castelli, Roberto / Gidaro, Antonio

    Journal of hematology

    2020  Volume 9, Issue 1-2, Page(s) 1–4

    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Canada
    Document type Editorial
    ZDB-ID 2662519-2
    ISSN 1927-1220 ; 1927-1212
    ISSN (online) 1927-1220
    ISSN 1927-1212
    DOI 10.14740/jh636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A stacking-based artificial intelligence framework for an effective detection and localization of colon polyps.

    Albuquerque, Carina / Henriques, Roberto / Castelli, Mauro

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 17678

    Abstract: Polyp detection through colonoscopy is a widely used method to prevent colorectal cancer. The automation of this process aided by artificial intelligence allows faster and improved detection of polyps that can be missed during a standard colonoscopy. In ... ...

    Abstract Polyp detection through colonoscopy is a widely used method to prevent colorectal cancer. The automation of this process aided by artificial intelligence allows faster and improved detection of polyps that can be missed during a standard colonoscopy. In this work, we propose to implement various object detection algorithms for polyp detection. To improve the mean average precision (mAP) of the detection, we combine the baseline models through a stacking approach. The experiments demonstrate the potential of this new methodology, which can reduce the workload for oncologists and increase the precision of the localization of polyps. Our proposal achieves a mAP of 0.86, translated into an improvement of 34.9% compared to the best baseline model and 28.8% with respect to the weighted boxes fusion ensemble technique.
    MeSH term(s) Humans ; Artificial Intelligence ; Colonic Polyps/diagnosis ; Colonoscopy/methods ; Algorithms ; Colon ; Colorectal Neoplasms/diagnosis
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-21574-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Awake pronation with helmet CPAP in early COVID-19 ARDS patients: effects on respiratory effort and distribution of ventilation assessed by EIT.

    Fossali, Tommaso / Locatelli, Martina / Colombo, Riccardo / Veronese, Alice / Borghi, Beatrice / Ballone, Elisabetta / Castelli, Antonio / Rech, Roberto / Catena, Emanuele / Ottolina, Davide

    Internal and emergency medicine

    2024  

    Abstract: Prone positioning with continuous positive airway pressure (CPAP) is widely used for respiratory support in awake patients with COVID-19-associated acute respiratory failure. We aimed to assess the respiratory mechanics and distribution of ventilation in ...

    Abstract Prone positioning with continuous positive airway pressure (CPAP) is widely used for respiratory support in awake patients with COVID-19-associated acute respiratory failure. We aimed to assess the respiratory mechanics and distribution of ventilation in COVID-19-associated ARDS treated by CPAP in awake prone position. We studied 16 awake COVID-19 patients with moderate-to-severe ARDS. The study protocol consisted of a randomized sequence of supine and prone position with imposed positive end-expiratory pressure (PEEP) of 5 and 10 cmH
    Language English
    Publishing date 2024-03-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03572-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
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  6. Article ; Online: Modelling the impacts of water harvesting and climate change on rainfed maize yields in Senegal

    Andrea Setti / Giulio Castelli / Lorenzo Villani / Roberto Ferrise / Elena Bresci

    Journal of Agricultural Engineering (2023)

    2023  

    Abstract: Senegalese agriculture is threatened by climate change effects, affecting rainfall variability both at interannual and interdecadal timescales. Using FAO’s AquaCrop crop-growth model, we tested the efficiency of an in situ water harvesting technique - ... ...

    Abstract Senegalese agriculture is threatened by climate change effects, affecting rainfall variability both at interannual and interdecadal timescales. Using FAO’s AquaCrop crop-growth model, we tested the efficiency of an in situ water harvesting technique - tied ridges - for maize cropping in the Fatick region in Senegal, in response to changes in temperature and precipitation with different fertility levels and different soils. Results showed that, considering the current climate and soil fertility, tied ridges did not significantly impact maize yields. The rainfall amount was enough for maize production and to avoid water stress during the cropping season. Under perturbed climates and, especially, in years with low average rainfall amounts, high losses in yield were registered under optimal fertility conditions (up to 80%). The strongest effect was obtained when tied ridges were simulated on clay soil, enhancing yields by 5.6% and 13% at actual and optimal fertility conditions, respectively. Our results highlighted how the current maize production in the Fatick region in Senegal is sustainable in the current climate scenario, while it could be potentially impacted by climate change in the near future. In a pessimistic climate change scenario, in situ water harvesting has the potential to avoid excessive crop losses.
    Keywords Adaptation ; AquaCrop ; crop yield ; rainwater harvesting ; Sahel ; tied ridges ; Agriculture ; S ; Agriculture (General) ; S1-972
    Subject code 550
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: A Use Case of Patent Classification Using Deep Learning with Transfer Learning

    Henriques Roberto / Ferreira Adria / Castelli Mauro

    Journal of Data and Information Science, Vol 7, Iss 3, Pp 49-

    2022  Volume 70

    Abstract: Patent classification is one of the areas in Intellectual Property Analytics (IPA), and a growing use case since the number of patent applications has been increasing worldwide. We propose using machine learning algorithms to classify Portuguese patents ... ...

    Abstract Patent classification is one of the areas in Intellectual Property Analytics (IPA), and a growing use case since the number of patent applications has been increasing worldwide. We propose using machine learning algorithms to classify Portuguese patents and evaluate the performance of transfer learning methodologies to solve this task.
    Keywords natural language processing (nlp) ; patent classification ; transfer learning ; bi-directional encoder representations for transformers (bert) ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Endocrine Side Effects in Patients Treated with Immune Checkpoint Inhibitors: A Narrative Review.

    Profili, Nicia I / Castelli, Roberto / Gidaro, Antonio / Merella, Alessandro / Manetti, Roberto / Palmieri, Giuseppe / Maioli, Margherita / Delitala, Alessandro P

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Checkpoint inhibitors are monoclonal antibodies that elicit an anti-tumor response by stimulating immune system. Their use has improved the treatment of different types of cancer such as melanoma, breast carcinoma, lung, stomach, colon, liver, renal cell ...

    Abstract Checkpoint inhibitors are monoclonal antibodies that elicit an anti-tumor response by stimulating immune system. Their use has improved the treatment of different types of cancer such as melanoma, breast carcinoma, lung, stomach, colon, liver, renal cell carcinoma, and Hodgkin's lymphoma, but several adverse events have been reported. Although the etiology of these effects is not completely understood, an uncontrolled activation of the immune system has been postulated. Indeed, some studies showed a cross reactivity of T cells, which acted against tumor antigens as well as antigens in the tissues of patients who developed immune-related adverse events. Despite the known possibility of developing immune-related adverse events, early diagnosis, monitoring during therapy, and treatment are fundamental for the best supportive care and administration of immune checkpoint inhibitors. The aim of this review is to guide the clinician in early diagnosis, management, and treatment of the endocrinological adverse effects in the major endocrine glands (thyroid, pituitary, adrenal, endocrine pancreas, and parathyroid).
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Eltrombopag reduces bleeding complications and the need of platelet transfusions in cirrhotic thrombocytopenic patients subjected to invasive procedures.

    Castelli, Roberto / Gidaro, Antonio / Lambertenghi Deliliers, Giorgio

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

    2021  Volume 32, Issue 2, Page(s) 163–166

    MeSH term(s) Aged ; Benzoates/therapeutic use ; Female ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Hydrazines/therapeutic use ; Liver Cirrhosis/complications ; Male ; Middle Aged ; Platelet Count ; Platelet Transfusion ; Pyrazoles/therapeutic use ; Receptors, Thrombopoietin/agonists ; Thrombocytopenia/complications ; Thrombocytopenia/drug therapy ; Thrombocytopenia/therapy
    Chemical Substances Benzoates ; Hydrazines ; Pyrazoles ; Receptors, Thrombopoietin ; eltrombopag (S56D65XJ9G)
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Letter
    ZDB-ID 1033551-1
    ISSN 1473-5733 ; 0957-5235
    ISSN (online) 1473-5733
    ISSN 0957-5235
    DOI 10.1097/MBC.0000000000001001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2920: Show issues Location:
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  10. Article: ADAMTS13, von Willebrand Factor, Platelet Microparticles, Factor VIII, and Impact of Somatic Mutations in the Pathogenesis of Splanchnic Vein Thrombosis Associated with BCR-ABL-Negative Myeloproliferative Neoplasms.

    Castelli, Roberto / Berzuini, Alessandra / Manetti, Roberto / Delitala, Alessandro Palmerio / Castro, Dante / Sanna, Giuseppe / Sircana, Marta Chiara / Profili, Nicia Isabella / Bartoli, Arianna / La Cava, Leyla / Lambertenghi Deliliers, Giorgio / Donadoni, Mattia / Gidaro, Antonio

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Background: Myeloproliferative neoplasms (MPNs) are often associated with splanchnic vein thrombosis (SVT). Not all the factors involved in the thrombotic tendency are currently known.: Objectives: This study aims to evaluate a possible association ... ...

    Abstract Background: Myeloproliferative neoplasms (MPNs) are often associated with splanchnic vein thrombosis (SVT). Not all the factors involved in the thrombotic tendency are currently known.
    Objectives: This study aims to evaluate a possible association between ADAMTS13, von Willebrand factor (VWF), platelet microvesicles (MV), and factor VIII activity (FVIII:C) with thrombotic events in MPN patients.
    Materials and methods: In total, 36 consecutive MPN patients with SVT were enrolled. The MPNs were diagnosed based on clinical characteristics and one or more gene mutations among JAK-2, CALR, and MPL. As controls, 50 randomly selected patients with MPN without thrombosis, 50 patients with deep vein thrombosis without MPNs, and 50 healthy blood donors were evaluated. Complete blood count, ADAMTS13, VWF, MV, and FVIII:C in plasma were measured in all the subjects.
    Results: The JAK-2 mutation was found in 94% of the patients with SVT, but none were triple-negative for genetic mutations (JAK2 V617F, CALR, MPL, and exon 12). Compared to the normal subjects, in all the MPN patients (with or without SVT), the levels of ADAMTS13 were found to be significantly lower (
    Conclusions: The significant increase in circulating MV, VWF, and FVIII:C in the MPN patients and in the patients with thrombosis supports the role of endothelium damage in promoting thrombotic events. In particular, a significant increase in VWF and FVIII:C levels was found in the MPN patients with SVT.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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