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  1. Article ; Online: Animal hepacivirus models for hepatitis C virus immune responses and pathology.

    Kennedy, Matthew J / Fernbach, Sonja / Scheel, Troels K H

    Journal of hepatology

    2024  

    Language English
    Publishing date 2024-04-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.12.019
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  2. Article ; Online: Enhancing phage therapy through synthetic biology and genome engineering.

    Lenneman, Bryan R / Fernbach, Jonas / Loessner, Martin J / Lu, Timothy K / Kilcher, Samuel

    Current opinion in biotechnology

    2020  Volume 68, Page(s) 151–159

    Abstract: The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the inability of most phage isolates to bind and infect a broad range of clinical strains. Here, we discuss how phage ...

    Abstract The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the inability of most phage isolates to bind and infect a broad range of clinical strains. Here, we discuss how phage therapy can be improved through recent advances in genetic engineering. First, we outline how receptor-binding proteins and their relevant structural domains are engineered to redirect phage specificity and to avoid resistance. Next, we summarize how phages are reprogrammed as prokaryotic gene therapy vectors that deliver antimicrobial 'payload' proteins, such as sequence-specific nucleases, to target defined cells within complex microbiomes. Finally, we delineate big data- and novel artificial intelligence-driven approaches that may guide the design of improved synthetic phage in the future.
    MeSH term(s) Artificial Intelligence ; Bacteriophages/genetics ; Genetic Engineering ; Phage Therapy ; Synthetic Biology
    Language English
    Publishing date 2020-12-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2020.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3071: Show issues Location:
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  3. Article: Towards an understanding of urinary tract infection in children: a model for the future of paediatric radiology and urology.

    Fernbach, S K

    BJU international

    2000  Volume 86 Suppl 1, Page(s) 80–83

    MeSH term(s) Child ; Forecasting ; Humans ; Radiation Dosage ; Radiography ; Urinary Tract Infections/diagnostic imaging ; Urinary Tract Infections/etiology ; Urinary Tract Infections/therapy
    Language English
    Publishing date 2000-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1046/j.1464-410x.2000.00591.x
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  4. Article: Craniosynostosis 1998: concepts and controversies.

    Fernbach, S K

    Pediatric radiology

    1998  Volume 28, Issue 9, Page(s) 722–728

    Abstract: The diagnosis of craniosynostosis requires attention to radiologic technique, familiarity with the signs of closure at each suture, and correlation with the clinical setting. Misdiagnosis may result in unwarranted calvarial or craniofacial surgery or a ... ...

    Abstract The diagnosis of craniosynostosis requires attention to radiologic technique, familiarity with the signs of closure at each suture, and correlation with the clinical setting. Misdiagnosis may result in unwarranted calvarial or craniofacial surgery or a delay of surgery, necessitating a more extensive procedure.
    MeSH term(s) Child ; Child, Preschool ; Craniosynostoses/diagnostic imaging ; Craniosynostoses/etiology ; Humans ; Image Processing, Computer-Assisted ; Infant ; Radionuclide Imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 1998-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s002470050452
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  5. Article: Pediatric uroradiology--1997.

    Fernbach, S K

    World journal of urology

    1998  Volume 16, Issue 1, Page(s) 46–51

    Abstract: The imaging of common pediatric urological problems is in evolution. Modifications of standard techniques such as substitution of cyclic voiding cystourethrography in the neonate and infants, introduction of newer modalities (Doppler ultrasound), and new ...

    Abstract The imaging of common pediatric urological problems is in evolution. Modifications of standard techniques such as substitution of cyclic voiding cystourethrography in the neonate and infants, introduction of newer modalities (Doppler ultrasound), and new nuclear renal agents (Tc-MAG3) have enhanced our ability to detect anomalies and abnormalities. In this brief article, some of the recent developments in imaging are reviewed and the ways in which these developments interface with traditional imaging studies are presented.
    MeSH term(s) Child ; Humans ; Hydronephrosis/diagnostic imaging ; Urinary Tract Infections/diagnostic imaging ; Urography/methods ; Urography/trends
    Language English
    Publishing date 1998
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s003450050025
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  6. Article: Ascites produced by peritoneal seeding of neuroblastoma.

    Fernbach, S K

    Pediatric radiology

    1993  Volume 23, Issue 7, Page(s) 569

    Abstract: Preoperative CT and ultrasound of a 16-month-old girl with abdominal mass demonstrated the calcified mass and a copious amount of ascites. Pathological examination of the tumor revealed neuroblastoma, a tumor not usually associated with peritoneal ... ...

    Abstract Preoperative CT and ultrasound of a 16-month-old girl with abdominal mass demonstrated the calcified mass and a copious amount of ascites. Pathological examination of the tumor revealed neuroblastoma, a tumor not usually associated with peritoneal seeding or ascites.
    MeSH term(s) Abdominal Neoplasms/diagnostic imaging ; Abdominal Neoplasms/pathology ; Ascites/diagnosis ; Ascites/etiology ; Female ; Humans ; Infant ; Neoplasm Seeding ; Neuroblastoma/complications ; Neuroblastoma/diagnostic imaging ; Neuroblastoma/secondary ; Peritoneal Neoplasms/complications ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/secondary ; Tomography, X-Ray Computed
    Language English
    Publishing date 1993
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/bf02012157
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  7. Article: Pediatric gastrointestinal imaging.

    Fernbach, S K

    Current opinion in radiology

    1992  Volume 4, Issue 3, Page(s) 117–123

    Abstract: The traditional areas of interest in pediatric gastrointestinal radiology (gastroesophageal reflux, malrotation, necrotizing enterocolitis) were the source of many new and important studies in the past year. Information gleaned from correlative ... ...

    Abstract The traditional areas of interest in pediatric gastrointestinal radiology (gastroesophageal reflux, malrotation, necrotizing enterocolitis) were the source of many new and important studies in the past year. Information gleaned from correlative nonradiologic studies or from newer modalities provided the new focus of interest. The imaging and treatment of intussusception remains a topic in which literature is evolving. Pneumatic reduction is repeatedly being shown to be safe and effective. There have been a large number of studies addressing polysplenia, biliary atresia, and liver transplantation. Images of the anomalies associated with polysplenia were published in several sources. One paper reported better than previously described results of liver transplantation in the subset of patients with polysplenia and biliary atresia.
    MeSH term(s) Biliary Tract Diseases/diagnosis ; Child ; Diagnostic Imaging ; Gastrointestinal Diseases/diagnosis ; Humans
    Language English
    Publishing date 1992-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049377-3
    ISSN 1040-869X
    ISSN 1040-869X
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    Zs.A 3050: Show issues Location:
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  8. Article: The dilated urinary tract in children.

    Fernbach, S K

    Urologic radiology

    1992  Volume 14, Issue 1, Page(s) 34–42

    Abstract: Dilatation of the urinary tract is detected in a number of settings throughout childhood. Children may be asymptomatic or present with urinary tract infection, hematuria, or voiding symptoms. Evaluation of the affected urinary tract may require standard ... ...

    Abstract Dilatation of the urinary tract is detected in a number of settings throughout childhood. Children may be asymptomatic or present with urinary tract infection, hematuria, or voiding symptoms. Evaluation of the affected urinary tract may require standard radiographic techniques (VCUG, EU) complemented by ultrasound and nuclear medicine studies. The goal of imaging is to differentiate hydronephrosis (HN) from hydroureteronephrosis (HUN) and to provide the correct diagnosis so that appropriate treatment can be given. This article reviews and demonstrates the findings in some common and uncommon causes of HN and HUN.
    MeSH term(s) Adult ; Algorithms ; Child ; Diagnosis, Differential ; Dilatation, Pathologic/diagnosis ; Dilatation, Pathologic/diagnostic imaging ; Female ; Humans ; Hydronephrosis/diagnosis ; Hydronephrosis/diagnostic imaging ; Infant, Newborn ; Kidney/abnormalities ; Kidney Diseases/diagnostic imaging ; Kidney Pelvis/abnormalities ; Male ; Pregnancy ; Prune Belly Syndrome/diagnosis ; Radiography ; Ultrasonography, Prenatal ; Ureter/abnormalities ; Ureterocele/diagnosis ; Ureterocele/diagnostic imaging ; Urologic Diseases/diagnosis ; Urologic Diseases/diagnostic imaging ; Vesico-Ureteral Reflux/diagnosis ; Vesico-Ureteral Reflux/diagnostic imaging
    Language English
    Publishing date 1992
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135572-7
    ISSN 0171-1091
    ISSN 0171-1091
    DOI 10.1007/bf02926899
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    Zs.A 1511: Show issues Location:
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  9. Article: Axial torsion of Meckel's diverticulum presenting as a pelvic mass.

    Farris, S L / Fernbach, S K

    Pediatric radiology

    2001  Volume 31, Issue 12, Page(s) 886–888

    Abstract: Meckel's diverticulum is the most common congenital gastrointestinal anomaly. Axial torsion of the diverticulum is rare and may produce nonspecific abdominal signs and symptoms. We describe a case of torsion of a Meckel's diverticulum that was noted as a ...

    Abstract Meckel's diverticulum is the most common congenital gastrointestinal anomaly. Axial torsion of the diverticulum is rare and may produce nonspecific abdominal signs and symptoms. We describe a case of torsion of a Meckel's diverticulum that was noted as a pelvic mass on CT images.
    MeSH term(s) Adolescent ; Diagnosis, Differential ; Humans ; Male ; Meckel Diverticulum/diagnostic imaging ; Tomography, X-Ray Computed ; Torsion Abnormality/diagnostic imaging
    Language English
    Publishing date 2001-12
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s002470100013
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  10. Article: Imaging of neonatal renal masses.

    Fernbach, S K

    Urologic radiology

    1991  Volume 12, Issue 4, Page(s) 214–219

    Abstract: The radiologic evaluation of the neonate with a suspected or clinically palpable renal mass has evolved. There is increasing use of ultrasound and a parallel decrease of excretory urography. Postnatal imaging studies should be performed in a sequence to ... ...

    Abstract The radiologic evaluation of the neonate with a suspected or clinically palpable renal mass has evolved. There is increasing use of ultrasound and a parallel decrease of excretory urography. Postnatal imaging studies should be performed in a sequence to complement data provided by prenatal sonography, clinical examination, and family history.
    MeSH term(s) Diagnostic Imaging ; Humans ; Infant, Newborn ; Kidney/abnormalities ; Kidney Diseases/diagnosis ; Kidney Neoplasms/diagnosis ; Urethra/abnormalities ; Wilms Tumor/diagnosis
    Language English
    Publishing date 1991
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 135572-7
    ISSN 0171-1091
    ISSN 0171-1091
    DOI 10.1007/bf02924012
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