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  1. Book ; Conference proceedings: Third Acta Physiologica Scandinavica International Symposium on Signalling Mechanisms in Vascular Smooth Muscle

    Mulvany, Michael J.

    in Margretetorp, Hjärnarp, Sweden, 21 - 25 May 1998

    (Acta physiologica Scandinavica ; 164,4)

    1998  

    Event/congress Acta Physiologica Scandinavica International Symposium on Signalling Mechanisms in Vascular Smooth Muscle (3, 1998, Margretetorp)
    Author's details Michael J. Mulvaney, ... (guest eds.)
    Series title Acta physiologica Scandinavica ; 164,4
    Collection
    Language English
    Size S. 339 - 644 : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT009624193
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 229 -164- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Biomedical PhD education--an international perspective.

    Mulvany, Michael J

    Basic & clinical pharmacology & toxicology

    2013  Volume 112, Issue 5, Page(s) 289–295

    Abstract: The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, ... ...

    Abstract The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving tenured university positions. However, over the past 20-30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the 'knowledge society', and thus increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output. The situation has thus created a paradox. On the one hand, it has become essential for institutions to have many PhD students and for the research performed to be of the highest level. On the other hand, the careers of PhD students are not necessarily going to be directly related to the research performed during their PhD studies. The purpose of this article is to explore how this seeming paradox is being addressed in biomedicine and to show that far from being inconsistent that the two aspects are in fact complementary. The article is based on the author's experience as Head of Aarhus Graduate School of Health Sciences 2002-2011 and his work with graduate schools across Europe and internationally through the organization ORPHEUS.
    MeSH term(s) Biomedical Research/education ; Biomedical Technology/education ; Education, Graduate ; Humans ; Internationality
    Language English
    Publishing date 2013-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.12063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Small artery remodelling in hypertension.

    Mulvany, Michael J

    Basic & clinical pharmacology & toxicology

    2012  Volume 110, Issue 1, Page(s) 49–55

    Abstract: Increased blood pressure (essential hypertension) is associated with increased cardiovascular risk, and the condition is treated primarily with a view to reducing this parameter. However, in the early stages, the main pathological changes are increased ... ...

    Abstract Increased blood pressure (essential hypertension) is associated with increased cardiovascular risk, and the condition is treated primarily with a view to reducing this parameter. However, in the early stages, the main pathological changes are increased peripheral resistance and altered cardiovascular structure. The aim of this MiniReview was to trace the endeavours over the past several decades to translate these findings into answering the question whether normalization of resistance vessel structure should be a target for therapy. This MiniReview describes first the altered structure of the resistance vasculature in essential hypertension, where the vessels show increased media/lumen ratio because of inward eutrophic remodelling. Secondly, evidence is presented that altered small artery structure appears to have prognostic consequences. Then, the cellular mechanisms that may be involved are discussed, where there is evidence that vasoconstriction in itself can cause inward remodelling and that this can be prevented by vasodilators. This leads to a discussion of the degree to which it may be possible to rectify the abnormal structure, where it appears that this may be achieved using a therapy that causes vasodilatation in the patient concerned. Finally, the consequences of these findings are considered as regards clues for strategies that may be able to improve the outcome of antihypertensive therapy. The MiniReview concludes that there is reasonably strong evidence that improvement in abnormal resistance vessel structure requires a treatment that reduces peripheral resistance in the individual patient.
    MeSH term(s) Animals ; Antihypertensive Agents/therapeutic use ; Arterioles/drug effects ; Arterioles/pathology ; Arterioles/physiopathology ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/pathology ; Hypertension/physiopathology ; Prognosis ; Vascular Resistance/drug effects ; Vasoconstriction/drug effects ; Vasodilation/drug effects ; Vasodilator Agents/therapeutic use
    Chemical Substances Antihypertensive Agents ; Vasodilator Agents
    Language English
    Publishing date 2012-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/j.1742-7843.2011.00758.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.144: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Book ; Conference proceedings: Abstracts / Third International Symposium on Resistance Arteries

    Mulvany, Michael J.

    Rebild, Skørping, Denmark, May 21 - 25, 1991

    (Blood vessels ; 28,4)

    1991  

    Event/congress International Symposium on Resistance Arteries (3, 1991, Skørping)
    Author's details Ed.: M. J. Mulvany
    Series title Blood vessels ; 28,4
    Keywords Vascular Resistance / congresses ; Widerstandsarterie
    Language English
    Size S. [269] - 348
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT003787321
    ISBN 3-8055-5409-5 ; 978-3-8055-5409-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 513 -28- verfügbar in Königswinter Königswinter

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  5. Book ; Conference proceedings: Resistance arteries

    Mulvany, Michael J.

    structure and function ; proceedings of the Third International Symposium on Resistance Arteries, Rebild, Skörping, Denmark, 21 - 25 May 1991

    (International congress series ; 974)

    1991  

    Event/congress International Symposium on Resistance Arteries (3, 1991, Skørping)
    Author's details ed. M. J. Mulvany
    Series title International congress series ; 974
    Collection
    Keywords Arterie ; Vasomotion ; Blutdruck ; Regulation
    Subject Schlagader ; Arteria ; Arterien
    Size XV, 417 S. : Ill., graph. Darst.
    Publisher Excerpta Medica
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT003978970
    ISBN 0-444-89193-5 ; 978-0-444-89193-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 294/a -974- verfügbar in Königswinter Königswinter

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  6. Article ; Online: REMODELLING SMALL ARTERIES AND PHD TRAINING

    Michael J. Mulvany

    Artery Research, Vol

    A JOURNEY

    2016  Volume 16

    Abstract: Biomedical research is increasingly based on the efforts of PhD students. This talk will trace the development of the author’s research, and show how this experience can be used to optimize PhD training. The basis of the research has been that essential ... ...

    Abstract Biomedical research is increasingly based on the efforts of PhD students. This talk will trace the development of the author’s research, and show how this experience can be used to optimize PhD training. The basis of the research has been that essential hypertension is associated with increased peripheral resistance due to narrowing of the small arteries and arterioles. The author’s PhD training ended in 1978 with development of a technique that enabled accurate measurement of the structure and function of small arteries. The technique was adopted by many laboratories world-wide, and also formed the basis for the author to establish a research group (with 22 PhD students over the years) that elucidated excitation-contraction properties and the morphology of small arteries, and how these were altered in essential hypertension. Vessels showed increased media:lumen ratio with inward eutrophic remodelling and limited functional changes. The remodelling was found to have prognostic consequences. The inward remodelling was found to be due to the vasoconstriction itself, mediated through multiple cellular pathways. The remodelling can be prevented by vasodilators and the results have had clinical effect. While this career path points to some success, it would unlikely happen in today’s academic environment in that the author’s PhD training took about 10 years. Through being head of the faculty graduate school and vice-president of the organization ORPHEUS (Organization for PhD education in Biomedicine and Health Sciences in the European System), the author has sought to establish procedures to ensure that today’s PhD students are able to prepare for successful careers – within or outside of academia – even within the normal 3–4 year time constraints.
    Keywords Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Book: Hypertension - lipids and atherosclerosis

    Mulvany, Michael J.

    Herlev County Hospital, Copenhagen, 22nd September 1989

    (Proceedings of the ... scientific meeting of the Danish Society of Hypertension ; 37 ; The Scandinavian journal of clinical & laboratory investigation : Supplement ; 199)

    1990  

    Author's details ed. by: Michael J. Mulvany
    Series title Proceedings of the ... scientific meeting of the Danish Society of Hypertension ; 37
    The Scandinavian journal of clinical & laboratory investigation : Supplement ; 199
    The Scandinavian journal of clinical & laboratory investigation
    The Scandinavian journal of clinical & laboratory investigation ; Supplement
    Collection The Scandinavian journal of clinical & laboratory investigation
    The Scandinavian journal of clinical & laboratory investigation ; Supplement
    Keywords Atherosclerosis / complications / congresses ; Hypertension / complications / congresses ; Risk Factors / congresses ; Hypertonie ; Arteriosklerose
    Subject Arterienverkalkung ; Atherosklerose ; Arteriosclerosis ; Arterielle Hypertonie ; Arterieller Hochdruck ; Bluthochdruck ; Hochdruck ; Hypertension ; Hypertonus
    Language English
    Size 72 S. : graph. Darst.
    Publisher Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003562234
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 150 -Suppl.199- verfügbar in Königswinter Königswinter

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  8. Book: Ion transport and hypertension

    Mulvany, Michael J.

    Copenhagen, Apr. 26, 1985

    (Proceedings of the ... scientific meeting of the Danish Society of Hypertension ; 19 ; The Scandinavian journal of clinical & laboratory investigation : Supplement ; 180)

    1986  

    Author's details ed. Michael J. Mulvany
    Series title Proceedings of the ... scientific meeting of the Danish Society of Hypertension ; 19
    The Scandinavian journal of clinical & laboratory investigation : Supplement ; 180
    The Scandinavian journal of clinical & laboratory investigation
    The Scandinavian journal of clinical & laboratory investigation ; Supplement
    Collection The Scandinavian journal of clinical & laboratory investigation
    The Scandinavian journal of clinical & laboratory investigation ; Supplement
    Keywords Biological Transport / congresses ; Ion Channels / congresses ; Hypertension / congresses
    Size 103 S. : graph. Darst.
    Publisher Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT002390953
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 150 -Suppl.180- verfügbar in Königswinter Königswinter

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  9. Book ; Conference proceedings: Resistance vessels: physiology, pharmacology and hypertensive pathology

    Mulvany, Michael J.

    proceedings of a Workshop on Resistance Vessel Abnormalities in Hypertension, Sandbjerg Manor, Soenderborg, Denmark, June 12 - 15, 1984

    (Progress in applied microcirculation ; 8)

    1985  

    Event/congress Workshop on Resistance Vessel Abnormalities in Hypertension (1984, Sønderborg)
    Author's details vol. ed. M. J. Mulvany
    Series title Progress in applied microcirculation ; 8
    Collection
    Keywords Blood Vessels / physiopathology / congresses ; Hypertension / physiopathology / congresses ; Vascular Resistance / congresses ; Widerstandsgefäß ; Blutgefäß
    Subject Gefäß ; Blutgefäße ; Gefäße ; Ader ; Adern
    Size IX, 236 S. : 40 Ill. u. graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    Note Mit 40 fig. u. 14 tab. - Literaturangaben
    HBZ-ID HT002131983
    ISBN 3-8055-4052-3 ; 978-3-8055-4052-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1985 A 4094 order for loan Magazin

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  10. Article: A comparison of best practices for doctoral training in Europe and North America.

    Barnett, Joey V / Harris, Robert A / Mulvany, Michael J

    FEBS open bio

    2017  Volume 7, Issue 10, Page(s) 1444–1452

    Abstract: The PhD degree was established in Berlin 200 years ago and has since spread across the whole world. While there is general agreement that the degree is awarded in recognition of successfully completed research training, there have been significant ... ...

    Abstract The PhD degree was established in Berlin 200 years ago and has since spread across the whole world. While there is general agreement that the degree is awarded in recognition of successfully completed research training, there have been significant differences in the way doctoral training programs have developed in particular countries. There is, however, a clear global tendency to follow the programs currently used either in the United States or in Europe. To determine more clearly how US and European PhD programs are both similar and different, we have used a validated questionnaire to analyze biomedical PhD programs in four representative institutions at Vanderbilt University, University of Manitoba, Karolinska Institutet, and Graz Medical University. The analysis is based on 63 detailed questions concerning the research environment, outcomes, admission criteria, content of programs, mentoring (or supervising), the PhD thesis, assessment of the thesis, and PhD school structure. The results reveal that while there is considerable overlap in the aims and content of PhD programs, there are also considerable differences regarding the structure of PhD programs, mentoring and assessment of PhD theses. These differences are analyzed in detail in order to provide a foundation for discussion of their relative advantages and disadvantages, with a view to providing a platform for discussion of best practices. The results will be of importance in the continued development of global discussion about development of doctoral training.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ISSN 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.12305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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