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  1. Article ; Online: Targeting Alzheimer's Disease: Evaluating the Efficacy of C-1 Functionalized N-Aryl-Tetrahydroisoquinolines as Cholinergic Enzyme Inhibitors and Promising Therapeutic Candidates.

    Jovanović, Dunja / Filipović, Ana / Janjić, Goran / Lazarević-Pašti, Tamara / Džambaski, Zdravko / Bondžić, Bojan P / Bondžić, Aleksandra M

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: We have synthesized 22 C-1 functionalized- ...

    Abstract We have synthesized 22 C-1 functionalized-
    MeSH term(s) Humans ; Alzheimer Disease/drug therapy ; Butyrylcholinesterase ; Kinetics ; Molecular Docking Simulation ; Enzyme Inhibitors ; Tetrahydroisoquinolines/pharmacology
    Chemical Substances Butyrylcholinesterase (EC 3.1.1.8) ; Enzyme Inhibitors ; Tetrahydroisoquinolines
    Language English
    Publishing date 2024-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021033
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  2. Book ; Online ; E-Book: Cardiovascular and respiratory bioengineering

    Filipovic, Nenad

    2022  

    Author's details Nenad Filipovic
    Keywords Bioengineering
    Subject code 612.1
    Language English
    Size 1 online resource (314 pages)
    Publisher Bloomsbury Academic
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-824229-9 ; 9780128239568 ; 978-0-12-824229-2 ; 0128239565
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; E-Book: Computational modeling in bioengineering and bioinformatics

    Filipovic, Nenad

    2020  

    Author's details Nenad Filipovic
    Keywords Bioinformatics / Computer simulation ; Biomedical engineering / Computer simulation
    Language English
    Size 1 Online-Ressource (xi, 430 Seiten), Illustrationen
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020329094
    ISBN 978-0-12-819584-0 ; 9780128195833 ; 0-12-819584-3 ; 0128195835
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain.

    Moparthi, Lavanya / Sinica, Viktor / Moparthi, Vamsi K / Kreir, Mohamed / Vignane, Thibaut / Filipovic, Milos R / Vlachova, Viktorie / Zygmunt, Peter M

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6113

    Abstract: ... recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), was more sensitive to cold ...

    Abstract TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In patch-clamp bilayer recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), was more sensitive to cold and heat, whereas ∆1-854 hTRPA1, also lacking the S1-S4 voltage sensing-like domain (VSLD), gained sensitivity to cold but lost its heat sensitivity. In hTRPA1 intrinsic tryptophan fluorescence studies, cold and heat evoked rearrangement of VSLD and the C-terminus domain distal to the transmembrane pore domain S5-S6 (CTD). In whole-cell electrophysiology experiments, replacement of the CTD located cysteines 1021 and 1025 with alanine modulated hTRPA1 cold responses. It is proposed that hTRPA1 CTD harbors cold and heat sensitive domains allosterically coupled to the S5-S6 pore region and the VSLD, respectively.
    MeSH term(s) Alanine ; Ankyrin Repeat ; Hot Temperature ; Humans ; TRPA1 Cation Channel/genetics ; TRPA1 Cation Channel/metabolism ; Thermosensing ; Tryptophan
    Chemical Substances TRPA1 Cation Channel ; TRPA1 protein, human ; Tryptophan (8DUH1N11BX) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33876-8
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  5. Book ; Thesis: Verletzungen des N. radialis

    Filipovic, Miodrag

    1992  

    Author's details vorgelegt von Miodrag Filipovic
    Size II, 73 Bl. : graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Univ., Diss., 1992
    HBZ-ID HT004425452
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    93 E 550 order for loan Magazin

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  6. Article ; Online: In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid.

    Zmejkovski, Bojana B / Pantelić, Nebojša / Filipović, Lana / Aranđelović, Sandra / Radulović, Siniša / Sabo, Tibor J / Kaluđerović, Goran N

    Anti-cancer agents in medicinal chemistry

    2017  Volume 17, Issue 8, Page(s) 1136–1143

    Abstract: Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)2eddip}] (n = 2, 4: 1, 2 ... respectively; (S,S)-(i-Am)2eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized ...

    Abstract Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)2eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)2eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy and mass spectrometry.
    Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant 13C NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay.
    Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 μM), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.
    MeSH term(s) Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Esters/chemistry ; Esters/pharmacology ; Ethylenediamines/chemistry ; Ethylenediamines/pharmacology ; Humans ; Molecular Structure ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/pharmacology ; Quantum Theory ; Structure-Activity Relationship ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; Esters ; Ethylenediamines ; Organoplatinum Compounds ; ethylenediamine-N,N'-di-2-propanoic acid diisoamyl ester ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520616666161207155634
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    Zs.A 5583: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online: Miniaturized Transistors, Volume II

    Filipovic, Lado / Grasser, Tibor

    2022  

    Keywords Research & information: general ; Mathematics & science ; FinFETs ; CMOS ; device processing ; integrated circuits ; silicon carbide (SiC) metal-oxide-semiconductor field-effect transistors (MOSFETs) ; solid state circuit breaker (SSCB) ; prototype ; circuit design ; GaN ; HEMT ; high gate ; multi-recessed buffer ; power density ; power-added efficiency ; 4H-SiC ; MESFET ; IMRD structure ; power added efficiency ; 1200 V SiC MOSFET ; body diode ; surge reliability ; silvaco simulation ; floating gate transistor ; control gate ; CMOS device ; active noise control ; vacuum channel ; mean free path ; vertical air-channel diode ; vertical transistor ; field emission ; particle trajectory model ; F-N plot ; space-charge-limited currents ; 4H-SiC MESFET ; simulation ; power added efficiency (PAE) ; new device ; three-input transistor ; T-channel ; compact circuit style ; CMOS compatible technology ; avalanche photodiode ; SPICE model ; bandwidth ; high responsivity ; silicon photodiode ; AlGaN/GaN HEMTs ; thermal simulation ; transient channel temperature ; pulse width ; gate structures ; band-to-band tunnelling (BTBT) ; tunnelling field-effect transistor (TFET) ; germanium-around-source gate-all-around TFET (GAS GAA TFET) ; average subthreshold swing ; direct source-to-drain tunneling ; transport effective mass ; confinement effective mass ; multi-subband ensemble Monte Carlo ; non-equilibrium Green's function ; DGSOI ; FinFET ; core-insulator ; gate-all-around ; field effect transistor ; GAA ; nanowire ; one-transistor dynamic random-access memory (1T-DRAM) ; polysilicon ; grain boundary ; electron trapping ; flexible transistors ; polymers ; metal oxides ; nanocomposites ; dielectrics ; active layers ; nanotransistor ; quantum transport ; Landauer-Büttiker formalism ; R-matrix method ; nanoscale ; mosfet ; quantum current ; surface transfer doping ; 2D hole gas (2DHG) ; diamond ; MoO3 ; V2O5 ; MOSFET ; reliability ; random telegraph noise ; oxide defects ; SiO2 ; split-gate trench power MOSFET ; multiple epitaxial layers ; specific on-resistance ; device reliability ; nanoscale transistor ; bias temperature instabilities (BTI) ; defects ; single-defect spectroscopy ; non-radiative multiphonon (NMP) model ; time-dependent defect spectroscopy ; n/a
    Language 0|e
    Size 1 electronic resource (352 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021619493
    ISBN 9783036541709 ; 3036541705
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: The effect of non-specific binding of Pd(II) complexes with N-heteroaromatic hydrazone ligands on the protein structure

    Mijin Nemanja D. / Milošević Jelica / Filipović Nenad R. / Mitić Dragana / Anđelković Katarina / Polović Natalija Đ. / Todorović Tamara R.

    Journal of the Serbian Chemical Society, Vol 87, Iss 10, Pp 1143-

    2022  Volume 1156

    Abstract: Previously, the cytotoxic actions of five Pd(II) complexes with bidentate N-heteroaromatic ...

    Abstract Previously, the cytotoxic actions of five Pd(II) complexes with bidentate N-heteroaromatic chelators (complexes 1–5) on a palette of several cancer cell lines were investigated. However, the results of the cytotoxic activity did not correlate with the hydrophobic character of the complexes. To gain further insight into the structure–activity relationship, essential for the design of novel potential drugs, other factors, such as non-specific interactions with cellular proteins, have to be taken into account. To explore the potential non-specific influence of the complexes on protein structures, ovalbumin (OVA) was chosen as a model system to mimic cellular non-specific crowding environments with high protein concentrations. A Fourier-transform infrared spectroscopy study implied that the binding of 3 and 4 led to only moderate alternations in the secondary structures of the protein, without the possibility to penetrate into hydrophobic core of the protein and disruption of protein native fold. Contrary, the effect of complex 5 on OVA secondary structures was concentration- dependent. While the lower concentration of complex 5 had no effect on OVA structure, a doubled concentration of complex 5 led to complete disruption of the content native-like secondary structures. The concentration-dependent effect of complex 5 on the changes in secondary structures and considerable increase in the exposure of OVA hydrophobic surfaces to water may be related to a potential crosslinking that leads to OVA aggregation.
    Keywords ovalbumin model system ; protein aggregation ; dmso effect ; ligand hydrophobicity ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pd(II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification.

    Bjelogrlić, Snežana K / Todorović, Tamara R / Kojić, Milan / Senćanski, Milan / Nikolić, Milan / Višnjevac, Aleksandar / Araškov, Jovana / Miljković, Marija / Muller, Christian D / Filipović, Nenad R

    Journal of inorganic biochemistry

    2019  Volume 199, Page(s) 110758

    Abstract: Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was ...

    Abstract Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional layer and three-dimensional spheroid tumor model) cell lines. For the Pd(II) complexes with condensation products of ethyl hydrazainoacetate and quinoline-8-carboxaldehyde (complex 1) and 2-formylpyridine (complex 3), for which apoptosis was determined as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce generation of reactive oxygen species and inhibit Topoisomerase I in vitro. In silico studies corroborate experimental findings that these complexes show topoisomerase inhibition activity in the micromolar range and indicate binding to a DNA's minor groove as another potential target. Based on the results obtained by circular dichroism and fluorescence spectroscopy measurements, the most active complexes are suitable to be delivered to a blood stream via human serum albumin.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cisplatin/pharmacology ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Crystallography, X-Ray ; DNA Damage/drug effects ; DNA Topoisomerases, Type I/metabolism ; Humans ; Hydrazones/chemistry ; MCF-7 Cells ; Molecular Structure ; Palladium/chemistry ; Protein Binding ; Serum Albumin, Human/metabolism ; Structure-Activity Relationship ; THP-1 Cells
    Chemical Substances Antineoplastic Agents ; Coordination Complexes ; Hydrazones ; Palladium (5TWQ1V240M) ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; Cisplatin (Q20Q21Q62J) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2019.110758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1730: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Catalyzed ester synthesis using Candida rugosa lipase entrapped by poly(N-isopropylacrylamide-co-itaconic acid) hydrogel.

    Milašinović, Nikola / Jakovetić, Sonja / Knežević-Jugović, Zorica / Milosavljević, Nedeljko / Lučić, Marija / Filipović, Jovanka / Kalagasidis Krušić, Melina

    TheScientificWorldJournal

    2014  Volume 2014, Page(s) 142123

    Abstract: This study reports the synthesis of polymeric matrices based on N-isopropylacrylamide and ...

    Abstract This study reports the synthesis of polymeric matrices based on N-isopropylacrylamide and itaconic acid and its application for immobilization of lipase from Candida rugosa. The lipase was immobilized by entrapment method. Free and immobilized lipase activities, pH and temperature optima, and storage stability were investigated. The optimum temperature for free and entrapped lipase was found to be 40 and 45 °C, while the optimum pH was observed at pH 7 and 8, respectively. Both hydrolytic activity in an aqueous medium and esterolytic activity in an organic medium have been evaluated. Maximum reaction rate (V max) and Michaelis-Menten constants (K m ) were also determined for immobilized lipase. Storage stability of lipase was increased as a result of immobilization process. Furthermore, the operational stability and reusability of the immobilized lipase in esterification reaction have been studied, and it was observed that after 10 cycles, the residual activity for entrapped lipase was as high as 50%, implying that the developed hydrogel and immobilized system could provide a promising solution for the flavor ester synthesis at the industrial scale.
    MeSH term(s) Acrylamides/chemistry ; Candida/chemistry ; Candida/enzymology ; Catalysis ; Esterification/physiology ; Esters ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Lipase/analysis ; Lipase/metabolism ; Succinates/chemistry
    Chemical Substances Acrylamides ; Esters ; Succinates ; Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5) ; N-isopropylacrylamide (B7GFF17L9U) ; Lipase (EC 3.1.1.3) ; itaconic acid (Q4516562YH)
    Language English
    Publishing date 2014-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075968-X
    ISSN 1537-744X ; 1537-744X
    ISSN (online) 1537-744X
    ISSN 1537-744X
    DOI 10.1155/2014/142123
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