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Article: Diagnostic and Therapeutic Particularities of Symptomatic Melanoma Brain Metastases from Case Report to Literature Review.

Avino, Adelaida / Ion, Daniela-Elena / Gheoca-Mutu, Daniela-Elena / Abu-Baker, Abdalah / Țigăran, Andrada-Elena / Peligrad, Teodora / Hariga, Cristian-Sorin / Balcangiu-Stroescu, Andra-Elena / Jecan, Cristian-Radu / Tudor, Adrian / Răducu, Laura

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 7

Abstract: The recent introduction of immunotherapy and targeted therapy has substantially enriched the therapeutic landscape of metastatic melanoma. However, cerebral metastases remain unrelenting entities with atypical metabolic and genetic profiles compared to ... ...

Abstract	The recent introduction of immunotherapy and targeted therapy has substantially enriched the therapeutic landscape of metastatic melanoma. However, cerebral metastases remain unrelenting entities with atypical metabolic and genetic profiles compared to extracranial metastases, requiring combined approaches with local ablative treatment to alleviate symptoms, prevent recurrence and restore patients' biological and psychological resources for fighting malignancy. This paper aims to provide the latest scientific evidence about the rationale and timing of treatment, emphasizing the complementary roles of surgery, radiotherapy, and systemic therapy in eradicating brain metastases, with a special focus on the distinct response of intracranial and extracranial disease, which are regarded as separate molecular entities. To illustrate the complexity of designing individualized therapeutic schemes, we report a case of delayed BRAF-mutant diagnosis, an aggressive forearm melanoma, in a presumed psychiatric patient whose symptoms were caused by cerebral melanoma metastases. The decision to administer molecularly targeted therapy was dictated by the urgency of diminishing the tumor burden for symptom control, due to potentially life-threatening complications caused by the flourishing of extracranial disease in locations rarely reported in living patients, further proving the necessity of multidisciplinary management.
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14070688
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enhanced Perception for Autonomous Driving Using Semantic and Geometric Data Fusion.

Florea, Horatiu / Petrovai, Andra / Giosan, Ion / Oniga, Florin / Varga, Robert / Nedevschi, Sergiu

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 13

Abstract: Environment perception remains one of the key tasks in autonomous driving for which solutions have yet to reach maturity. Multi-modal approaches benefit from the complementary physical properties specific to each sensor technology used, boosting overall ... ...

Abstract	Environment perception remains one of the key tasks in autonomous driving for which solutions have yet to reach maturity. Multi-modal approaches benefit from the complementary physical properties specific to each sensor technology used, boosting overall performance. The added complexity brought on by data fusion processes is not trivial to solve, with design decisions heavily influencing the balance between quality and latency of the results. In this paper we present our novel real-time, 360∘ enhanced perception component based on low-level fusion between geometry provided by the LiDAR-based 3D point clouds and semantic scene information obtained from multiple RGB cameras, of multiple types. This multi-modal, multi-sensor scheme enables better range coverage, improved detection and classification quality with increased robustness. Semantic, instance and panoptic segmentations of 2D data are computed using efficient deep-learning-based algorithms, while 3D point clouds are segmented using a fast, traditional voxel-based solution. Finally, the fusion obtained through point-to-image projection yields a semantically enhanced 3D point cloud that allows enhanced perception through 3D detection refinement and 3D object classification. The planning and control systems of the vehicle receives the individual sensors' perception together with the enhanced one, as well as the semantically enhanced 3D points. The developed perception solutions are successfully integrated onto an autonomous vehicle software stack, as part of the UP-Drive project.
MeSH term(s)	Algorithms ; Automobile Driving ; Perception ; Semantics
Language	English
Publishing date	2022-07-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22135061
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Article: Extremely Rare Type of Breast Cancer-Dedifferentiated Breast Liposarcoma-Diagnosis and Treatment.

Țigăran, Andrada-Elena / Abu-Baker, Abdalah / Ion, Daniela-Elena / Peligrad, Teodora / Gheoca-Mutu, Daniela-Elena / Avino, Adelaida / Anghel, Andrei-Wilhelm / Balcangiu-Stroescu, Andra-Elena / Toma, Anca / Răducu, Laura

Journal of personalized medicine

2023 Volume 13, Issue 10

Abstract: Primary liposarcoma of the breast is an uncommon soft tissue malignant tumor, comprising only 0.003% of all malignant breast tumors. The main differential diagnosis of this mass consists of malignant phyllodes tumor and metaplastic breast carcinoma. The ... ...

Abstract	Primary liposarcoma of the breast is an uncommon soft tissue malignant tumor, comprising only 0.003% of all malignant breast tumors. The main differential diagnosis of this mass consists of malignant phyllodes tumor and metaplastic breast carcinoma. The objective of this paper is to report a case of dedifferentiated breast liposarcoma, therapeutic approach and outcome. We present a case of a 79-year-old woman complaining of a large mass in her left breast which had increased in size over the last 6 months. Physical examination revealed an enlarged left breast, and a total body CT scan showed a large tumor in contact with the musculature of the anterior thoracic wall, with no metastatic lesions. The histopathology report of a fine needle biopsy described a high-grade sarcoma. The Oncological Tumor Board recommended neoadjuvant radiotherapy sessions and reevaluation by MRI and CT scans. The patient underwent radical mastectomy with latissimus dorsi myo-cutaneous flap reconstruction. The final histopathology diagnosis was a grade 3 dedifferentiated liposarcoma (FNCLCC), with certain response to radiotherapy and positive MDM2, CDK4 markers. The postoperative period was uneventful; 12 months after surgery, the follow-up CT scan showed multiple pulmonary lesions with metastatic characteristics. Liposarcoma is a very rare type of breast cancer, and the most important treatment for breast sarcoma is surgery, the role of axillary lymph node removal, chemotherapy and radiotherapy still being controversial. Considering such cases are scarce and the development of surgical guidelines is difficult, reporting any new case is crucial.
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13101451
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Article ; Online: The Relationship between Advanced Oxidation Protein Products, Vascular Calcifications and Arterial Stiffness in Predialysis Chronic Kidney Disease Patients.

Vinereanu, Ion-Vlad / Peride, Ileana / Niculae, Andrei / Tiron, Andreea Taisia / Caragheorgheopol, Andra / Manda, Dana / Checherita, Ionel Alexandru

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 5

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Advanced Oxidation Protein Products ; Humans ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/complications ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/etiology ; Vascular Stiffness
Chemical Substances	Advanced Oxidation Protein Products
Language	English
Publishing date	2021-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57050452
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Article: Non-Pharmacological Interventions for Pain Management in Hemodialysis: A Narrative Review.

Kassim, Mustafa Ali Kassim / Pantazi, Alexandru Cosmin / Nori, Wassan / Tuta, Liliana Ana / Balasa, Adriana Luminita / Mihai, Cristina Maria / Mihai, Larisia / Frecus, Corina Elena / Lupu, Vasile Valeriu / Lupu, Ancuta / Andrusca, Antonio / Iorga, Andra Maria / Litrin, Radu Mihai / Ion, Irina / Ciciu, Elena / Chirila, Sergiu Ioachim / Chisnoiu, Tatiana

Journal of clinical medicine

2023 Volume 12, Issue 16

Abstract: This narrative review aims to summarize non-pharmacological interventions for pain management in hemodialysis patients, assessing their potential benefits and limitations in enhancing patient well-being and quality of life. We reviewed the current ... ...

Abstract	This narrative review aims to summarize non-pharmacological interventions for pain management in hemodialysis patients, assessing their potential benefits and limitations in enhancing patient well-being and quality of life. We reviewed the current literature on five primary non-pharmacological interventions: acupuncture, cognitive behavioral therapy, relaxation techniques, virtual reality, and alternative methods such as transcutaneous electrical nerve stimulation, music therapy, and aromatherapy. We analyzed the evidence regarding their effectiveness, feasibility, and optimal implementation strategies. The existing evidence supports the potential benefits of these interventions in managing pain and improving the well-being of hemodialysis patients. However, further high-quality research is needed to confirm their effectiveness, establish implementation best practices, and assess their long-term impact on patient outcomes. Non-pharmacological interventions hold promise for pain management in hemodialysis patients. Additional research is required to optimize these interventions and validate their effectiveness, contributing to comprehensive pain management strategies for this vulnerable patient population.
Language	English
Publishing date	2023-08-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12165390
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Article ; Online: The Relationship between Advanced Oxidation Protein Products, Vascular Calcifications and Arterial Stiffness in Predialysis Chronic Kidney Disease Patients

Ion-Vlad Vinereanu / Ileana Peride / Andrei Niculae / Andreea Taisia Tiron / Andra Caragheorgheopol / Dana Manda / Ionel Alexandru Checherita

Medicina, Vol 57, Iss 452, p

2021 Volume 452

Abstract: Background and Objectives : Cardiovascular morbidity and mortality are increased in patients with chronic kidney disease (CKD). It is likely that the accumulation of uremic toxins resulting in increased oxidative stress (OS) is a major contributing ... ...

Abstract	Background and Objectives : Cardiovascular morbidity and mortality are increased in patients with chronic kidney disease (CKD). It is likely that the accumulation of uremic toxins resulting in increased oxidative stress (OS) is a major contributing factor, but no clear link has been identified. The purpose of this research is to establish if advanced oxidation protein product (AOPP) levels in the serum of predialysis patients are a contributing factor to vascular calcification and increased arterial stiffness. Materials and Methods : After obtaining the informed consent, 46 predialysis patients (CKD stages G3–G5) were included in the study. In order to identify vascular calcifications, hand and pelvic radiographs were performed. Valvular calcifications were identified using cardiac ultrasound. AOPP were measured using a commercially available ELISA kit. The relationships between serum AOPP values and biochemical parameters relevant in the evaluation of CKD patients were analyzed. In addition to identifying the differences in AOPP levels between patients with/without vascular or valvular calcifications, the research focused on describing the relationship between OS and arterial stiffness assessed by oscillometric pulse-wave velocity (PWV) measurement. Results : No significant relationship between serum AOPP and vascular or valvular calcifications was highlighted, but significant correlations of AOPP with C-reactive protein ( p = 0.025), HDL-cholesterol levels ( p = 0.04), HbA1c ( p = 0.05) and PWV values ( p = 0.02) were identified. Conclusions : The usefulness of (OS) measurement in clinical practice remains debatable; however, the relationship between AOPP and arterial stiffness could be valuable in improving cardiovascular risk assessment of patients with CKD.
Keywords	CKD ; arterial stiffness ; oxidative stress ; AOPP ; vascular calcification ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Assessment of the metal pollution in surface sediments of coastal Tasaul Lake (Romania)

Vasiliu, Dan / Bucse, Andra / Lupascu, Naliana / Ispas, Bogdan / Gheablau, Catalin / Stanescu, Ion

Environmental monitoring and assessment. 2020 Dec., v. 192, no. 12

2020

Abstract: Forty-three surface sediment samples were collected in September 2019 from Tasaul Lake (Black Sea coast, Romania) to examine the metal distribution patterns, assess the level of metal contamination, and identify the pollutant sources. The determined mean ...

Abstract	Forty-three surface sediment samples were collected in September 2019 from Tasaul Lake (Black Sea coast, Romania) to examine the metal distribution patterns, assess the level of metal contamination, and identify the pollutant sources. The determined mean metal concentrations were as follows: Al 49,772 mg/kg, Zn 84.40 mg/kg, Cr 83.70 mg/kg, V 76.45 mg/kg, Ni 42.53 mg/kg, Cu 34.27 mg/kg, Pb 26.30 mg/kg, As 12.49 mg/kg, and Hg 0.06 mg/kg. The metals in the surface sediments of Tasaul Lake displayed moderate spatial variation, with higher metal concentrations mainly occurring in the south and southeast (As, Pb, and Hg), southwest (Cu and Zn), and west of the lake (Cr, Ni, and V). Heavy metal contamination in sediments is assessed using pollution indices such as enrichment factor, contamination factor, and pollution load index. The highest CFs and EFs were determined for As (moderate to high pollution), followed by Pb (low to moderate pollution). The Cu, Zn, and Hg pollution indices showed values corresponding to low pollution levels, while Ni, Cr, and V presented the lowest indices, suggesting unpolluted sediments. Multivariate statistical analyses were performed to identify the origin of the analyzed heavy metals. Cr was predominantly sourced from lithogenic components, Ni and V originated from both natural and anthropogenic sources, and As, Cu, Zn, Pb, and Hg showed mainly anthropogenic sources such as agricultural runoff, domestic and industrial wastewater discharges, and quarrying activities.
Keywords	agricultural runoff ; coasts ; heavy metals ; industrial wastewater ; lakes ; pollutants ; pollution load ; sediments ; Black Sea ; Romania
Language	English
Dates of publication	2020-12
Size	p. 749.
Publishing place	Springer International Publishing
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-020-08698-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Assessment of the metal pollution in surface sediments of coastal Tasaul Lake (Romania).

Vasiliu, Dan / Bucse, Andra / Lupascu, Naliana / Ispas, Bogdan / Gheablau, Catalin / Stanescu, Ion

Environmental monitoring and assessment

2020 Volume 192, Issue 12, Page(s) 749

Abstract	Forty-three surface sediment samples were collected in September 2019 from Tasaul Lake (Black Sea coast, Romania) to examine the metal distribution patterns, assess the level of metal contamination, and identify the pollutant sources. The determined mean metal concentrations were as follows: Al 49,772 mg/kg, Zn 84.40 mg/kg, Cr 83.70 mg/kg, V 76.45 mg/kg, Ni 42.53 mg/kg, Cu 34.27 mg/kg, Pb 26.30 mg/kg, As 12.49 mg/kg, and Hg 0.06 mg/kg. The metals in the surface sediments of Tasaul Lake displayed moderate spatial variation, with higher metal concentrations mainly occurring in the south and southeast (As, Pb, and Hg), southwest (Cu and Zn), and west of the lake (Cr, Ni, and V). Heavy metal contamination in sediments is assessed using pollution indices such as enrichment factor, contamination factor, and pollution load index. The highest CFs and EFs were determined for As (moderate to high pollution), followed by Pb (low to moderate pollution). The Cu, Zn, and Hg pollution indices showed values corresponding to low pollution levels, while Ni, Cr, and V presented the lowest indices, suggesting unpolluted sediments. Multivariate statistical analyses were performed to identify the origin of the analyzed heavy metals. Cr was predominantly sourced from lithogenic components, Ni and V originated from both natural and anthropogenic sources, and As, Cu, Zn, Pb, and Hg showed mainly anthropogenic sources such as agricultural runoff, domestic and industrial wastewater discharges, and quarrying activities.
MeSH term(s)	China ; Environmental Monitoring ; Geologic Sediments ; Lakes ; Metals, Heavy/analysis ; Risk Assessment ; Romania ; Water Pollutants, Chemical/analysis
Chemical Substances	Metals, Heavy ; Water Pollutants, Chemical
Language	English
Publishing date	2020-11-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-020-08698-0
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Article: Trends in Minimally Invasive Approaches for Liver Resections-A Systematic Review.

Graur, Florin / Ciocan, Razvan Alexandru / Ciocan, Andra / Puia, Ion Cosmin / Mois, Emil / Furcea, Luminita / Zaharie, Florin / Popa, Calin / Schlanger, Diana / Vaida, Calin / Pisla, Doina / Al Hajjar, Nadim

Journal of clinical medicine

2022 Volume 11, Issue 22

Abstract: Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entrance site and ... ...

Abstract	Background: SILS (single incision laparoscopic surgery) and NOTES (natural orifice transluminal endoscopic surgery) are considered breakthroughs in minimally invasive surgery, the first consisting in the surgeon working via a single entrance site and the second via a natural orifice (e.g., oral cavity). Methods: Since 2000 until 2022, the original articles published in the online databases were analyzed. Eligible studies included information about the current therapy of patients with liver surgical pathology and how the two new techniques improve the surgical approach. Results: A total of 798 studies were identified. By applying the exclusion criteria, nine studies remained to be included in the review. Two out of nine studies examined the NOTES approach in liver surgery, whereas the other seven focused on the SILS technique. The age of the patients ranged between 24 and 83 years. Liver resections for hepatocellular carcinoma or colorectal metastases were undertaken and biliary or hydatid cysts were removed. The mean procedure time was 95 to 205 min and the average diameter of the lesions was 5 cm. Conclusions: When practiced by multidisciplinary teams, transvaginal liver resection is feasible and safe. The goals of SILS and NOTES are to be less intrusive, more easily tolerated and aesthetic.
Language	English
Publishing date	2022-11-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11226721
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Article: Clinical and therapeutic features of acute cholecystitis in diabetic patients.

Serban, Dragos / Balasescu, Simona Andreea / Alius, Catalin / Balalau, Cristian / Sabau, Alexandru Dan / Badiu, Cristinel Dumitru / Socea, Bogdan / Trotea, Andra Maria / Dascalu, Ana Maria / Motofei, Ion / Ardeleanu, Valeriu / Spataru, Radu Iulian / Sabau, Dan / Smarandache, Gabriel Catalin

Experimental and therapeutic medicine

2021 Volume 22, Issue 1, Page(s) 758

Abstract: The present study aimed to compare the clinical, paraclinical, intraoperative findings, and postoperative complications in acute cholecystitis in diabetic patients vs. non-diabetic patients. A 2-year retrospective study was performed on the patients who ... ...

Abstract	The present study aimed to compare the clinical, paraclinical, intraoperative findings, and postoperative complications in acute cholecystitis in diabetic patients vs. non-diabetic patients. A 2-year retrospective study was performed on the patients who underwent emergency cholecystectomy for acute cholecystitis between 2017 and 2019 at the 4th Department of Surgery, Emergency University Hospital Bucharest. The diabetic subgroup numbered 46 eligible patients and the non-diabetic one 287 patients. Demographics, the severity of the clinical forms, biological variables (including white cell count, urea, creatinine, coagulation and liver function tests) comorbidity status, surgical approach, postoperative complications, and hospital stay were analyzed. Statistical analyses were performed to assess comparative results between the aforementioned data (SPSS V 13.0). The CCI and ASA risk classes were increased in the diabetic group, with 34.78% of patients having 3 or more associated comorbidities. No statistically significant associations were demonstrated between diabetes and the severity of the cholecystitis and risk for conversion. Postoperatively both minor complications such as surgical site infections and major cardiovascular events were more common in the diabetic subgroup (P=0.0254), well associated with the preoperative status and baseline cardiovascular comorbidities. Laparoscopic cholecystectomy is a safe procedure for diabetic patients, which can provide the best outcomes, by decreasing the risks of surgical wounds. Attentive perioperative care and good glycemic control must be provided to minimize the risk of complications.
Language	English
Publishing date	2021-05-13
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2021.10190
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