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Article: Folded Pectoralis Major Myocutaneous Flap for Reconstruction of Complex Oral Commissural Defects: A Retrospective Case Series and Technical Report.

Mitra, Sandipta / Panda, Smriti / Amit Singh, Chirom / Mani, Suresh / Thakar, Alok

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 76, Issue 1, Page(s) 1251–1254

Abstract: Full thickness defects following surgical resection of locally advanced carcinoma buccal mucosa involving oral commissure often require complex microvascular procedures that are technically demanding. We present a novel technique of folded pectoralis ... ...

Abstract	Full thickness defects following surgical resection of locally advanced carcinoma buccal mucosa involving oral commissure often require complex microvascular procedures that are technically demanding. We present a novel technique of folded pectoralis major myocutaneous flap for reconstruction of such defects without the need for free flaps or additional sling support.
Language	English
Publishing date	2023-10-05
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04251-w
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Article: Modified Mustardé Flap for Lower Eyelid Reconstruction in Basal Cell Carcinoma: Revisited.

Mitra, Sandipta / Panda, Smriti / Singh, Chirom Amit / Thakar, Alok

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 3, Page(s) 2492–2495

Abstract: Background: Full thickness defects of lower eyelid, following oncological resection, often pose a formidable challenge to the operating surgeon. Although a plethora of reconstructive options have been tried, the Mustardé flap has stood the test of time.! ...

Abstract	Background: Full thickness defects of lower eyelid, following oncological resection, often pose a formidable challenge to the operating surgeon. Although a plethora of reconstructive options have been tried, the Mustardé flap has stood the test of time. Methods: Our patient, a 57-year old lady, diagnosed with basal cell carcinoma of the left lower eyelid underwent full-thickness wide local excision and reconstruction using modified Mustardé flap. The anterior part of defect was reconstructed using the flap. The posterior part was reconstructed using septal mucoperichondrial-cartilage composite graft, sutured to remnant palpebral conjunctiva. Results: The patient had an uneventful post-operative period. On serial follow-up, the patient had an acceptable scar. At 6 months follow-up, the facial scar was barely perceptible with normal lower lid disposition. Conclusion: The modified Mustardé flap is a simple and reliable reconstructive option for full-thickness lower eyelid defects following oncological resection in carefully selected cases.
Language	English
Publishing date	2023-04-21
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-03768-4
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Article ; Online: Use of free jejunal flap as a salvage procedure in the management of high corrosive esophageal re-strictures: an institutional experience and review of literature.

Dash, Nihar Ranjan / Agarwal, Lokesh / Singh, Chirom Amit / Thakar, Alok

Langenbeck's archives of surgery

2022 Volume 407, Issue 7, Page(s) 2725–2732

Abstract: Background: High pharyngo-esophageal strictures following corrosive ingestion continue to pose a challenge to the surgeon, particularly in the developing world. With the advancements and increased experience with microsurgical techniques, free jejunal ... ...

Abstract	Background: High pharyngo-esophageal strictures following corrosive ingestion continue to pose a challenge to the surgeon, particularly in the developing world. With the advancements and increased experience with microsurgical techniques, free jejunal flaps offer a viable reconstruction option in patients with high corrosive strictures with previous failed reconstruction. We review our experience with free jejunal flap in three cases with high pharyngo-esophageal stricture following corrosive ingestion, with previous failed reconstruction. Materials and methods: A total of three patients underwent salvage free jejunal flap after failed reconstruction for high pharyngo-esophageal strictures following corrosive acid ingestion. All the three patients developed anastomotic leak and subsequent stricture, two following a pharyngo-gastric anastomosis and one following a pharyngo-colic anastomosis. The strictured segment was bridged using a free jejunal graft with microvascular anastomosis to the lingual artery and common facial vein. All patients were followed-up at regular intervals. Results and conclusions: The strictured pharyngeal anastomotic segment was successfully reconstructed with free jejunal flap in all the three patients. Patients were able to take food orally and maintain nutrition without the need of jejunostomy feeding. On long-term follow-up (median: 5 years), there was no recurrence of dysphagia and all the patients had good health-related quality of life.
MeSH term(s)	Humans ; Esophageal Stenosis/chemically induced ; Esophageal Stenosis/surgery ; Caustics/toxicity ; Constriction, Pathologic/surgery ; Quality of Life ; Jejunum/surgery ; Burns, Chemical/surgery
Chemical Substances	Caustics
Language	English
Publishing date	2022-06-27
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-022-02595-5
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Article ; Online: Nano-modified screen-printed electrode-based electrochemical immunosensors for oral cancer biomarker detection in undiluted human serum and saliva samples.

Gulati, Payal / Singh, Avinash Kumar / Yadav, Amit K / Pasbola, Kiran / Pandey, Prerna / Sharma, Rinu / Thakar, Alok / Solanki, Pratima R

Nanoscale advances

2023 Volume 6, Issue 2, Page(s) 705–721

Abstract: This proposed work reports the development of in-house made conductive ink-based screen-printed electrodes (SPEs) for label-free detection of oral cancer biomarkers. Carbon ink synthesis includes graphite powder, gum arabic, and water. The selectivity ... ...

Abstract	This proposed work reports the development of in-house made conductive ink-based screen-printed electrodes (SPEs) for label-free detection of oral cancer biomarkers. Carbon ink synthesis includes graphite powder, gum arabic, and water. The selectivity test of the fabricated SPE involves immobilizing antibodies specific to biomarkers and challenges with redox-active interference, other serum molecules, and non-target biomarkers. Three different biomarkers, cytokeratin-19 fragment (CYFRA 21-1), interleukin 8 (IL-8), and tumor protein p53 (TP-53), act as target entities for the detection of oral cancer in patients' samples (serum,
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d3na00682d
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Article ; Online: Absence of SARS-CoV-2 in the air and on the surfaces within the school environment.

Thakar, Amit / Dutkiewicz, Shawn / Hoffman, Timothy / Joyce, Paul / Shah, Vishal

Journal of medical microbiology

2021 Volume 70, Issue 9

Abstract: To the best of our knowledge to date there are no scientific studies specifically investigating whether the SARS-CoV-2 virus is present in the air or on the various surfaces in the school environment. The aim of this study was to determine if SARS-CoV-2 ... ...

Abstract	To the best of our knowledge to date there are no scientific studies specifically investigating whether the SARS-CoV-2 virus is present in the air or on the various surfaces in the school environment. The aim of this study was to determine if SARS-CoV-2 is present on various high touch surfaces and in the air across the elementary, middle and high schools in the Chester County of Pennsylvania, USA. One hundred and fifty surface swab samples and 45 air samples were analysed for the presence of the virus. All the samples tested were negative for the presence of SARS-CoV-2. The results indicate that the spread of the virus through contact and through air in the school buildings across the USA is highly unlikely.
MeSH term(s)	Air Microbiology ; COVID-19/transmission ; COVID-19/virology ; Humans ; Pandemics/prevention & control ; Pennsylvania/epidemiology ; SARS-CoV-2/isolation & purification ; Schools
Language	English
Publishing date	2021-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.001424
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Article ; Online: Low-Molecular-Weight Heparin Salvage in Pedicled Flap Reconstruction in Head and Neck: A Prospective Cohort Study.

Panda, Smriti / Gautam, Vimmi / Mitra, Sandipta / Singh, Chirom Amit / M, Suresh / Palreddy, Akshara / K, Yuvanesh / Konkimalla, Abhilash / K, Dheeraj / Bagchi, Debadeep / Raveendran, Sarath / Sikka, Kapil / Kumar, Rajeev / Singh, Anup / Thakar, Alok

The Journal of laryngology and otology

2024 , Page(s) 1–24

Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215124000562
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Article ; Online: Surgical armamentarium for salvage laryngectomy closure reinforcements.

Sakthivel, Pirabu / Mani, Suresh / Panda, Smriti / Singh, Chirom Amit / Thakar, Alok

Head & neck

2021 Volume 43, Issue 8, Page(s) 2557–2558

MeSH term(s)	Cutaneous Fistula/surgery ; Humans ; Laryngectomy ; Salvage Therapy
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26760
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Article ; Online: Polymorphisms in Toll-Like Receptors (TLRs)-7 and

Shaikh, Nawaj / Nirmalkar, Amit / Thakar, Madhuri

AIDS research and human retroviruses

2019 Volume 35, Issue 6, Page(s) 577–582

Abstract: The polymorphisms in Toll-like receptor ( ...

Abstract	The polymorphisms in Toll-like receptor (
MeSH term(s)	Adult ; Alleles ; Disease Progression ; European Continental Ancestry Group ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HIV Infections/ethnology ; HIV Infections/genetics ; HIV Infections/immunology ; HIV-1/physiology ; Humans ; India ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Toll-Like Receptor 7/genetics ; Toll-Like Receptor 7/immunology ; Toll-Like Receptor 9/genetics ; Toll-Like Receptor 9/immunology ; Young Adult
Chemical Substances	TLR7 protein, human ; TLR9 protein, human ; Toll-Like Receptor 7 ; Toll-Like Receptor 9
Language	English
Publishing date	2019-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2019.0004
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Article: Prevalence of hearing loss in India.

Verma, Ravneet Ravinder / Konkimalla, Abhilash / Thakar, Alok / Sikka, Kapil / Singh, Amit Chirom / Khanna, Tripti

The National medical journal of India

2022 Volume 34, Issue 4, Page(s) 216–222

Abstract: Background Despite abundant literature, a clear and coherent understanding of hearing loss (HL) in India is limited by the wide disparity in studies. Methods We did a review of published peer-reviewed journal articles. Studies reporting the prevalence ... ...

Abstract	Background Despite abundant literature, a clear and coherent understanding of hearing loss (HL) in India is limited by the wide disparity in studies. Methods We did a review of published peer-reviewed journal articles. Studies reporting the prevalence and degree of HL in India from 1980 to 2020 were included. Information was gathered on the population characteristics, methodology applied and the prevalence of hearing impairment. The data were analysed to identify trends and at-risk sections of population in various categories. Results Four hundred and forty studies were identified after a database search; 29 full-length articles were selected for final analysis. Using a 3-step screening protocol, hearing impairment (abnormal auditory brainstem response/auditory steady state response) in neonates ranged between 1.59 and 8.8 per 1000 births. Among 'at risk' neonates, it ranged from 7 to 49.18 per 1000 births. In children the prevalence of HL was 6.6% to 16.47%. Otitis media was the most common cause of HL in children. Community-based studies (all ages) reported prevalence of HL between 6% and 26.9% and prevalence of disabling HL between 4.5% and 18.3%. Rural areas and elderly showed a higher prevalence of hearing impairment. Conclusion Despite India's improving health indices, hearing disability remains persistently high. It is a major contributor to the loss of personal potential and a financial strain for the individual and the country. A large-scale multicentric study to identify the degree and type of HL, social awareness campaigns, widespread neonatal screening, strengthening treatment facilities and well-funded rehabilitation programmes can counter the rising prevalence of hearing impairment.
MeSH term(s)	Aged ; Child ; Hearing Loss/diagnosis ; Hearing Loss/epidemiology ; Hearing Loss/etiology ; Humans ; India/epidemiology ; Infant, Newborn ; Mass Screening ; Prevalence
Language	English
Publishing date	2022-02-03
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	645116-0
ISSN	0970-258X
ISSN	0970-258X
DOI	10.25259/NMJI_66_21
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Article ; Online: Incremental value of magnification and indocyanine green for parathyroid preservation in thyroid surgery.

Shaphaba, Konthoujam / Thakar, Alok / Sakthivel, Pirabu / Sikka, Kapil / Singh, Chirom Amit / Kumar, Rajeev / Chandran, Ashwin / Goswami, Ravinder

Head & neck

2023 Volume 45, Issue 7, Page(s) 1753–1760

Abstract: Background: To assess the promise of surgical magnification and of intraoperative indocyanine green (ICG) assisted near-infrared fluorescence (NIRF) in improving parathyroid identification and viability assessment during thyroidectomy.: Methods: ... ...

Abstract	Background: To assess the promise of surgical magnification and of intraoperative indocyanine green (ICG) assisted near-infrared fluorescence (NIRF) in improving parathyroid identification and viability assessment during thyroidectomy. Methods: Prospective comparative study. Parathyroid gland identification sequentially assessed by naked eye, surgical microscopy, and by NIRF imaging following ICG administration (5 mgIV). Parathyroid perfusion/vitality reassessed end-surgery by ICG-NIRF. Results: An expected total of 104 parathyroid glands were assessed in 35 patients (17 total-thyroidectomy, 18 hemi-thyroidectomy). 54/104 (51.9%) were identified by naked eye, and sequentially greater numbers identified by microscope magnification (n = 61; 58.7%; p = 0.33), and by ICG-NIRF (n = 72; 69.2%; p = 0.01). ICG-NIRF detected additional parathyroid glands in 16/35 patients (45.7%). Confident identification of at least one parathyroid remained unachieved in 5/35 by naked eye, in 4/35 by microscopic magnification, and in no patient by ICG-NIRF. ICG-NIRF indicated end-of-surgery devascularization in 12/72 glands and informed decisions regarding gland implantation. Conclusion: Significantly greater parathyroid glands are identified and preserved with surgical magnification and with ICG-NIRF. Both techniques merit routine adoption for thyroidectomy.
MeSH term(s)	Humans ; Parathyroid Glands/diagnostic imaging ; Parathyroid Glands/surgery ; Thyroid Gland/diagnostic imaging ; Thyroid Gland/surgery ; Indocyanine Green ; Prospective Studies ; Thyroidectomy/methods
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27387
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