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  1. AU=Filocamo Giovanni
  2. AU="Andrea Terán-Valdez"
  3. AU=Cleverley Joanne AU=Cleverley Joanne
  4. AU="Feng, Shiguang"
  5. AU="De Falco, Antonio"
  6. AU="Plenter, R J"
  7. AU="Malarz, Janusz"

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  1. Artikel ; Online: Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review.

    Bertoni, Camilla / Mazzocchi, Alessandra / Leone, Ludovica / Agostoni, Carlo / Filocamo, Giovanni

    Frontiers in immunology

    2024  Band 15, Seite(n) 1380372

    Abstract: Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid ... ...

    Abstract Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppressants increase the state of dyslipidemia. Several studies have shown that autoimmune diseases with an inflammatory substrate also share abnormalities in lipid profile and increased cardiovascular risk. Specifically, associations have been found between Juvenile Systemic Connective Tissue Diseases and elevated triglycerides, TC-C (Total Cholesterol), LDL-C (Low-Density Lipoprotein), low HDL-C (High-Density Lipoprotein), and increased risk of developing diseases such as myocardial infarction, peripheral vascular disease, pulmonary and arterial hypertension, and atrial fibrillation. Supplementation with alpha-linolenic acid (ALA) on the other hand has also been analyzed with positive results in reducing inflammatory parameters, such as IL-6 (Interleukin-6), CRP (C-reactive protein), and fasting glucose, in subjects with dyslipidemia. These observations suggest that supplementation with ALA, an omega-3 precursor, may positively modulate both the inflammatory status and dyslipidemic conditions in patients with autoimmune disorders.
    Mesh-Begriff(e) Child ; Humans ; Risk Factors ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Inflammation ; Lipoproteins, LDL ; Heart Disease Risk Factors ; Dyslipidemias/epidemiology ; Connective Tissue Diseases
    Chemische Substanzen Lipoproteins, LDL
    Sprache Englisch
    Erscheinungsdatum 2024-03-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1380372
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Standardising measures in pediatric rheumatology: the experience of the international consensus dataset for juvenile dermatomyositis.

    Filocamo, Giovanni

    Annals of translational medicine

    2017  Band 6, Heft Suppl 1, Seite(n) S33

    Sprache Englisch
    Erscheinungsdatum 2017-11-21
    Erscheinungsland China
    Dokumenttyp Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.09.43
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  3. Artikel ; Online: Is the parent global assessment a reliable quality of life measure in juvenile idiopathic arthritis?

    Filocamo, Giovanni / Consolaro, Alessandro / Ravelli, Angelo

    Rheumatology (Oxford, England)

    2022  Band 62, Heft 6, Seite(n) 2023–2024

    Mesh-Begriff(e) Humans ; Quality of Life ; Arthritis, Juvenile/diagnosis ; Surveys and Questionnaires ; Parents ; Health Status ; Psychometrics ; Reproducibility of Results ; Disability Evaluation ; Patient Reported Outcome Measures ; Translating
    Sprache Englisch
    Erscheinungsdatum 2022-10-21
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac600
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  4. Artikel: Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience.

    Cappellari, Alberto Maria / Rogani, Greta / Filocamo, Giovanni / Petaccia, Antonella

    Children (Basel, Switzerland)

    2023  Band 10, Heft 2

    Abstract: Objective: The purpose of this study was to investigate the effectiveness of corticosteroid therapy for children suffering from Sydenham chorea (SC).: Methods: The design of the study was observational, retrospective and conducted at the single ... ...

    Abstract Objective: The purpose of this study was to investigate the effectiveness of corticosteroid therapy for children suffering from Sydenham chorea (SC).
    Methods: The design of the study was observational, retrospective and conducted at the single center of the Rheumatology Unit of Policlinic Hospital of Milan, Italy, from May 1995 to May 2022. All data about the patients were collected from medical records.
    Results: From a total of 59 patients enrolled in the study (44 females and 15 males; median age 9.3 years, range 7.4-10.6 years), 49 were eligible for primary outcome analysis (10 patients were excluded due to incomplete data). Overall, 75% of patients received steroid therapy, while the remaining cases were treated with symptomatic drugs, including neuroleptics and antiseizure drugs. We found that the duration of chorea was significantly shorter in patients treated with corticosteroids in comparison to those receiving symptomatic treatment (median time: 31 vs. 41 days,
    Conclusions: The study suggests that corticosteroid therapy can lead to a faster resolution of SC when compared to neuroleptics and antiseizure drugs treatment.
    Sprache Englisch
    Erscheinungsdatum 2023-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10020262
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  5. Artikel ; Online: Novel heterozygous

    Rossano, Martina / Conti, Emilio Amleto / Bocca, Paola / Volpi, Stefano / Mastrangelo, Antonio / Cavalli, Riccardo / Gattorno, Marco / Minoia, Francesca / Filocamo, Giovanni

    Frontiers in immunology

    2023  Band 14, Seite(n) 1288675

    Abstract: Juvenile systemic lupus erythematosus (jSLE) is a complex inflammatory autoimmune disorder. In the last decades, genetic factors and activation pathways have been increasingly studied to understand their potential pathogenetic role better. Genetic and ... ...

    Abstract Juvenile systemic lupus erythematosus (jSLE) is a complex inflammatory autoimmune disorder. In the last decades, genetic factors and activation pathways have been increasingly studied to understand their potential pathogenetic role better. Genetic and transcriptional abnormalities directly involved in the type I interferon (IFN) signaling cascade have been identified through family-based and genome-wide association studies. IFNs trigger signaling pathways that initiate gene transcription of IFN-stimulated genes through the activation of JAK1, TYK2, STAT1, and STAT2. Thus, the use of therapies that target the IFN pathway would represent a formidable advance in SLE. It is well known that JAK inhibitors have real potential for the treatment of rheumatic diseases, but their efficacy in the treatment of SLE remains to be elucidated. We report the case of a 13-year-old girl affected by jSLE, carrying a novel heterozygous missense variant on Three prime Repair EXonuclease 1 (
    Mesh-Begriff(e) Female ; Humans ; Adolescent ; Janus Kinase Inhibitors/therapeutic use ; Genome-Wide Association Study ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics ; Mutation ; Interferon Type I/genetics
    Chemische Substanzen Janus Kinase Inhibitors ; three prime repair exonuclease 1 (EC 3.1.16.-) ; Interferon Type I
    Sprache Englisch
    Erscheinungsdatum 2023-12-06
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1288675
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Predictors of lack of response to methotrexate in juvenile idiopathic arthritis associated uveitis.

    Mapelli, Chiara / Miserocchi, Elisabetta / Nassisi, Marco / Beretta, Gisella B / Marelli, Luca / Leone, Gaia / Marino, Achille / Chighizola, Cecilia / Cincinelli, Gilberto / Giani, Teresa / Nucci, Paolo / Viola, Francesco / Filocamo, Giovanni / Minoia, Francesca

    Rheumatology (Oxford, England)

    2024  

    Abstract: Objectives: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U).: Methods: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables ... ...

    Abstract Objectives: To investigate clinical features associated with lack of response to MTX in juvenile idiopathic arthritis associated uveitis (JIA-U).
    Methods: Clinical records of JIA-U patients were retrospectively reviewed. Differences among variables were assessed by Mann-Whitney and χ 2 or Fisher's exact tests as appropriate. Association between predictors and requirement of a biological disease modifying antirheumatic drug (bDMARD) was evaluated by univariate Cox regression analysis and Kaplan-Meier curves. A multivariable logistic model was applied to estimate strength of association, adjusting for potential confounders.
    Results: Data from 99 JIA-U patients treated with MTX were analysed (82.8% female), with a mean follow up of 9.2 years and a mean age at uveitis onset of 5.7 years. In 65 patients (65.7%) at least one bDMARD to control uveitis was required. Children requiring a bDMARD for uveitis had lower age at JIA and uveitis onset, more frequent polyarticular course, higher frequency of bilateral uveitis at onset and higher prevalence of systemic steroids' use. Despite similar frequency of ocular damage at onset, MTX non responders showed a higher percentage of ocular damage at last visit. Younger age at JIA onset, polyarticular course and a history of systemic steroids' use resulted independent factors associated to lack of response to MTX at Cox regression analysis. Kaplan-Meier curves and the multivariate model confirms the independent role of both polyarticular course and systemic steroids' use.
    Conclusions: Younger age at JIA onset, polyarticular course and a history of systemic steroids' use are predictors of a worse response to MTX in JIA-U.
    Sprache Englisch
    Erscheinungsdatum 2024-02-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae079
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  7. Artikel: Henoch-Schönlein purpura with renal and gastrointestinal involvement in course of COVID-19: a case report.

    Barbetta, Laura / Filocamo, Giovanni / Passoni, Emanuela / Boggio, Francesca / Folli, Christian / Monzani, Valter

    Clinical and experimental rheumatology

    2021  Band 39 Suppl 129, Heft 2, Seite(n) 191–192

    Mesh-Begriff(e) COVID-19 ; Gastrointestinal Tract ; Humans ; IgA Vasculitis/complications ; IgA Vasculitis/diagnosis ; Kidney ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-03-24
    Erscheinungsland Italy
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/5epvob
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  8. Artikel ; Online: Development and Preliminary Validation of an Electromyography-Scoring Protocol for the Assessment and Grading of Muscle Involvement in Patients With Juvenile Idiopathic Inflammatory Myopathies.

    Cappellari, Alberto M / Minoia, Francesca / Consonni, Dario / Petaccia, Antonella / Picca, Isabella / Filocamo, Giovanni

    Pediatric neurology

    2021  Band 124, Seite(n) 6–10

    Abstract: Introduction: We performed a pilot study in order to investigate the feasibility of an electromyography (EMG)-scoring protocol for the assessment of disease activity in juvenile idiopathic inflammatory myopathies (JIIM).: Methods: Children with JIIM ... ...

    Abstract Introduction: We performed a pilot study in order to investigate the feasibility of an electromyography (EMG)-scoring protocol for the assessment of disease activity in juvenile idiopathic inflammatory myopathies (JIIM).
    Methods: Children with JIIM followed up in a tertiary-level care center underwent standardized clinical, laboratory, and EMG assessment. An EMG-scoring protocol was devised by a consensus panel including a pediatric neurophysiologist and two pediatric rheumatologists, based on a combined score obtained as the sum of (1) the presence of denervation signs (fibrillation potentials) and (2) motor unit remodeling (mixed pattern of short- and long-duration motor unit action potentials). The EMG-scoring protocol was then validated following the Outcome Measures in Rheumatoid Arthritis Clinical Trials filter for outcome measures in rheumatology and the consensus-based standards for the selection of health measurement instruments methodology.
    Results: Thirteen children (77% females) were included in the study, with a median age of 10 years (interquartile range: 7-17 years) and median disease duration of 11.8 months (interquartile range: 2.1-44.5). A total of 39 EMG examinations were evaluated. A strong positive association between a standardized tool for muscle strength assessment and the combined score was observed. No significant associations were found with both creatine kinase and erythrocyte sedimentation rate levels.
    Discussion: Our EMG-scoring protocol is the first standardized and reproducible tool for the neurophysiologic evaluation and grading of muscle involvement in patients with JIIM and could provide relevant additional information in the assessment and follow-up of these rare conditions.
    Mesh-Begriff(e) Adolescent ; Child ; Clinical Protocols/standards ; Dermatomyositis/diagnosis ; Electromyography/standards ; Feasibility Studies ; Female ; Humans ; Male ; Muscle, Skeletal/physiopathology ; Myositis/diagnosis ; Pilot Projects ; Polymyositis/diagnosis ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2021-08-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Validation Study
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2021.07.017
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  9. Artikel: Acute Retinal Necrosis: Clinical Features, Diagnostic Pitfalls, Treatment, and Outcome of an Insidious Disease in Children. Case Report and Review of the Literature.

    Mapelli, Chiara / Milella, Paolo / Donà, Caterina / Nassisi, Marco / Osnaghi, Silvia / Viola, Francesco / Agostoni, Carlo / Minoia, Francesca / Filocamo, Giovanni

    Frontiers in pediatrics

    2022  Band 10, Seite(n) 854325

    Abstract: Objective: This study aims to explore clinical features, diagnostic work-up, treatment, and outcomes of pediatric patients with acute retinal necrosis (ARN), and to propose a standardized management of this condition in childhood.: Methods: Clinical ... ...

    Abstract Objective: This study aims to explore clinical features, diagnostic work-up, treatment, and outcomes of pediatric patients with acute retinal necrosis (ARN), and to propose a standardized management of this condition in childhood.
    Methods: Clinical manifestations, diagnostic work-up, and treatment of three pediatric cases with ARN were analyzed. Furthermore, a review of the literature was performed from January 1990 to November 2021, focused on 1) clinical presentation; 2) differential diagnosis, including both infectious and non-infectious conditions; 3) key role of diagnostic techniques; and 4) currently available treatments.
    Results: Data from 72 children with ARN (69 from literature and 3 from our center) were analyzed. The most frequent presenting symptoms were red eye resistant to topical treatment (57%) and altered vision (58%), 25 patients had bilateral involvement. In 30% a known history of herpetic infection was reported. PCR testing on anterior chamber and/or vitreous sampling was performed in 46 cases (64%) and was diagnostic in 88% of them, with herpes simplex virus (HSV) 2 being the most frequently identified pathogen (57%). All patients underwent systemic antiviral therapy (16% only oral); adjunctive intravitreal injections were performed in 21% of them.
    Conclusions: ARN is a rare but severe ocular infection presenting as a panuveitis with occlusive retinal vasculitis and peripheral retinal necrosis. Varicella-zoster virus and HSV 1-2 are most frequently implicated. Due to a high incidence of rhegmatogenous retinal detachment and optic atrophy, ARN has a poor prognosis with a potentially severe impact on visual function. Although a prompt recognition is crucial to prevent complications, ARN diagnosis in children is still challenging.
    Sprache Englisch
    Erscheinungsdatum 2022-04-01
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.854325
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  10. Artikel: Absence of Severe Complications From SARS-CoV-2 Infection in Children With Rheumatic Diseases Treated With Biologic Drugs.

    Filocamo, Giovanni / Minoia, Francesca / Carbogno, Simone / Costi, Stefania / Romano, Micol / Cimaz, Rolando

    The Journal of rheumatology

    2020  Band 48, Heft 8, Seite(n) 1343–1344

    Mesh-Begriff(e) Antirheumatic Agents/adverse effects ; Biological Products/therapeutic use ; COVID-19 ; Child ; Humans ; Rheumatic Diseases/drug therapy ; SARS-CoV-2
    Chemische Substanzen Antirheumatic Agents ; Biological Products
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-25
    Erscheinungsland Canada
    Dokumenttyp Letter ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.200483
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