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Article ; Online: Can

Tong, Feizhou / Wu, Chaoming / Wang, Lili / Jing, Xiaolu / Wu, Shiyun / Sun, Junzhi / Hu, Yong / Li, Jie / Wang, Yanlei / Li, Yinghui

Sports medicine and health science

2023 Volume 5, Issue 3, Page(s) 245–250

Abstract: To explore the appropriate exercise methods and means for astronauts in confined and small isolation conditions, a set ... ...

Abstract	To explore the appropriate exercise methods and means for astronauts in confined and small isolation conditions, a set of
Language	English
Publishing date	2023-07-25
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-3376
ISSN (online)	2666-3376
DOI	10.1016/j.smhs.2023.07.009
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Article ; Online: Can

Du, Bulin / Wang, Shu / Cui, Yan / Liu, Guanghui / Li, Xuena / Li, Yaming

BMJ open

2021 Volume 11, Issue 6, Page(s) e044313

Abstract: Objectives: This study aimed to explore the diagnostic significance of : Design: A systematic review and meta-analysis.: Data sources: The PubMed, EMBASE and Cochrane library databases were searched from the earliest available date to December ... ...

Abstract	Objectives: This study aimed to explore the diagnostic significance of Design: A systematic review and meta-analysis. Data sources: The PubMed, EMBASE and Cochrane library databases were searched from the earliest available date to December 2020. Eligibility criteria for selecting studies: The review included primary studies that compared the mean maximum of standard uptake value (SUV Data extraction and synthesis: The main analysis was to assess the sensitivity and specificity, the positive diagnostic likelihood ratio (DLR+) and DLR-, as well as the diagnostic OR (DOR) of SUV Results: Across 15 studies (3574 patients), the pooled sensitivity for Conclusion: Meta-analysis results showed
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors/genetics ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/genetics ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; Sensitivity and Specificity
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2021-06-08
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-044313
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Article ; Online: Can

Yin, Haoli / Chen, Mengxia / Qiu, Xuefeng / Qiu, Li / Gao, Jie / Li, Danyan / Fu, Yao / Huang, Haifeng / Guo, Suhan / Zhang, Qing / Ai, Shuyue / Wang, Feng / Guo, Hongqian

European journal of nuclear medicine and molecular imaging

2021 Volume 48, Issue 11, Page(s) 3693–3701

Abstract: Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) is an ideal tool for staging and restaging of prostate cancer (PCa). This study was designed to investigate the prognostic role of preoperative : Methods: A ... ...

Abstract	Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) is an ideal tool for staging and restaging of prostate cancer (PCa). This study was designed to investigate the prognostic role of preoperative Methods: A total of 67 biopsy-confirmed localized PCa patients with mpMRI and Results: Pathological upgrading from mpMRI-TB to final RP specimens occurred in 38.8% (26/67) of the patients. Multivariable logistic regression analysis showed SUV Conclusion: 68
MeSH term(s)	Biopsy ; Edetic Acid ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Magnetic Resonance Imaging ; Male ; Positron Emission Tomography Computed Tomography ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Tomography, X-Ray Computed
Chemical Substances	Gallium Isotopes ; Gallium Radioisotopes ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2021-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-021-05217-2
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Article ; Online: Can

Peng, Lei / Li, Jinze / Meng, Chunyang / Li, Jinming / You, Chengyu / Tang, Dandan / Wei, Tangqiang / Xiong, Wei / Li, Yunxiang

Radiation oncology (London, England)

2020 Volume 15, Issue 1, Page(s) 227

Abstract: Objective: This article aims to evaluate the diagnostic value of : Methods: We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 ...

Abstract	Objective: This article aims to evaluate the diagnostic value of Methods: We systematically retrieved articles from Web of Science, EMBASE, Cochrane Database, PubMed. The time limit is from the creation of the database until June 2019, and Stata 15 was used for calculation and statistical analyses. Results: Sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CI) be used to evaluate the diagnostic value. A total of 10 studies were included in our meta-analysis, which included 701 individuals. The results of each consolidated summary are as follows: sensitivity of 0.84 (95% CI 0.55-0.95), specificity of 0.95 (95% CI 0.87-0.98), PLR and NLR was 17.19 (95% CI 6.27, 47.17) and 0.17 (95% CI 0.05-0.56), respectively. DOR of 100 (95% CI 18-545), AUC of 0.97 (95% CI 0.95-0.98). Conclusion: Our study demonstrates that
MeSH term(s)	Edetic Acid/analogs & derivatives ; Edetic Acid/metabolism ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Oligopeptides/metabolism ; Positron Emission Tomography Computed Tomography ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Radiopharmaceuticals/metabolism
Chemical Substances	Oligopeptides ; Radiopharmaceuticals ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2020-10-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ISSN	1748-717X
ISSN (online)	1748-717X
DOI	10.1186/s13014-020-01675-4
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Book ; Online: CAN

Hu, Mengting / Zhao, Shiwan / Zhang, Li / Cai, Keke / Su, Zhong / Cheng, Renhong / Shen, Xiaowei

Constrained Attention Networks for Multi-Aspect Sentiment Analysis

2018

Abstract: Aspect level sentiment classification is a fine-grained sentiment analysis task, compared to the sentence level classification. A sentence usually contains one or more aspects. To detect the sentiment towards a particular aspect in a sentence, previous ... ...

Abstract	Aspect level sentiment classification is a fine-grained sentiment analysis task, compared to the sentence level classification. A sentence usually contains one or more aspects. To detect the sentiment towards a particular aspect in a sentence, previous studies have developed various methods for generating aspect-specific sentence representations. However, these studies handle each aspect of a sentence separately. In this paper, we argue that multiple aspects of a sentence are usually orthogonal based on the observation that different aspects concentrate on different parts of the sentence. To force the orthogonality among aspects, we propose constrained attention networks (CAN) for multi-aspect sentiment analysis, which handles multiple aspects of a sentence simultaneously. Experimental results on two public datasets demonstrate the effectiveness of our approach. We also extend our approach to multi-task settings, outperforming the state-of-the-arts significantly.
Keywords	Computer Science - Computation and Language
Subject code	004
Publishing date	2018-12-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Label-Free Fluorescent Determination of Sunset Yellow in Soft Drinks Based on an Indicator-Displacement Assay

Li, Can-Peng

Journal of food quality, 2018:6302345

2018

Abstract: This work reported a fluorescence sensing platform for Sunset Yellow (SY) determination based on competitive host-guest interaction between cucurbit[7]uril (CB7) and signal probe/target molecules. Luteolin/epigallocatechin gallate (EGCG) and SY were ... ...

Abstract	This work reported a fluorescence sensing platform for Sunset Yellow (SY) determination based on competitive host-guest interaction between cucurbit[7]uril (CB7) and signal probe/target molecules. Luteolin/epigallocatechin gallate (EGCG) and SY were selected as the probe and target molecules, respectively. When luteolin or EGCG entered the CB7 host, its fluorescence significantly improved. However, upon the presence of SY in the performed luteolin·CB7 or EGCG·CB7 complex, this led to a remarkable decrease in fluorescence. This result was due to the fact that the binding constant of CB7/SY (4.9 x 10^4 M−1) was greater than that of CB7/luteolin (3.2 x 10³ M−1) or CB7/EGCG (4.8 x 10³ M−1). The fluorescence intensities of CB7/luteolin and CB7/EGCG complexes decreased linearly with increased SY concentration ranges of 0.5–50.0 and 2.0–50.0 μM. The proposed method had detection limits of 0.12 and 0.45 μM and was successfully used to determine SY samples with good recoveries ranging from 96.3% to 103.8%. This competitive mode provided a promising fluorescence assay strategy for potential applications in food safety.
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article: [Inhibition of connexin 43-mediated hemichannel activity promotes odontoblast differentiation of human dental pulp cells induced by lipopolysaccharide].

Zhang, An-Ni / Ding, Can-Can / Huang, Li-Ping / Li, Shi-Ting

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2024 Volume 33, Issue 1, Page(s) 22–29

Abstract: Purpose: To investigate the role and mechanism of connexin 43（Cx43）in odontoblast differentiation of human dental pulp cells (hDPCs) induced by lipopolysaccharide (LPS).: Methods: The maxillary first molar injury model of SD rats was established. The ...

Abstract	Purpose: To investigate the role and mechanism of connexin 43（Cx43）in odontoblast differentiation of human dental pulp cells (hDPCs) induced by lipopolysaccharide (LPS). Methods: The maxillary first molar injury model of SD rats was established. The expression pattern of Cx43 in dental pulp repair after injury was detected by immunofluorescence(IF) staining. hDPCs was respectively stimulated with 0, 1, 10, 100 and 1 000 ng/mL LPS for 6 h to screen the optimal concentration, and then the expression of Cx43 was inhibited and overexpressed in hDPCs. Quantitative real-time PCR(qRT-PCR) and Western blot(WB) were used to detect the expression of Cx43 and dentin sialophosphoprotein (DSPP), dental matrix protein-1 (DMP-1), osterix (Osx) and extracellular signal-regulated kinase (ERK) activity. Furthermore, hDPCs were treated with specific Cx43 channel inhibitors to investigate the effect of Cx43-mediated channel activity in odontoblast differentiation of hDPCs, and to explore the role and mechanism of Cx43 in regulating odontoblast differentiation of hDPCs induced by LPS. Statistical analysis was performed with SPSS 26.0 software package. Results: IF results showed that Cx43 was mainly expressed in the odontoblast layer in healthy dental pulp tissues. At 3-24 h after tooth injury, the expression of Cx43 decreased and then gradually increased to the normal level; from 3 days to 2 weeks after injury, the expression of Cx43 tended to be down-regulated which was in the odontoblast layer and pulp proper. The expression of DSPP mRNA was significantly up-regulated in the hDPCs stimulated with 10 ng/mL LPS for 6 h(P＜0.01). Inhibition of Cx43 significantly up-regulated the expression of DSPP, DMP-1 and Osx mRNA induced by LPS in hDPCs(P＜0.05), while overexpression of Cx43 obviously inhibited the expression of factors related to LPS-induced odontoblast differentiation(P＜0.01) and the fluorescence intensity of DSPP. 10 ng/mL LPS activated ERK signal in hDPCs, and overexpression of Cx43 significantly attenuated the activity of ERK signal induced by LPS(P＜0.01). Inhibition of Cx43-mediated hemichannel (HC) promoted mRNA expression of factors related to odontoblast differentiation in hDPCs and the activity of ERK signal induced by LPS(P＜0.05), while blocking Cx43-mediated gap junction channel (GJC) inhibited odontoblast differentiation. Conclusions: Cx43 participates in the regulation of dental pulp repair after injury, and its expression shows a downward trend as a whole. Inhibition of Cx43 or blocking of HC promotes LPS-induced ERK signal activity and odontoblast differentiation of hDPCs.
MeSH term(s)	Animals ; Humans ; Rats ; Cell Differentiation/physiology ; Cells, Cultured ; Connexin 43/metabolism ; Dental Pulp/metabolism ; Extracellular Matrix Proteins/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Odontoblasts/metabolism ; Rats, Sprague-Dawley ; RNA, Messenger/metabolism
Chemical Substances	Connexin 43 ; Extracellular Matrix Proteins ; Lipopolysaccharides ; RNA, Messenger ; Gja1 protein, rat
Language	Chinese
Publishing date	2024-04-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical features of omicron SARS-CoV-2 variants infection associated with co-infection and ICU-acquired infection in ICU patients

Dong-Jie Li / Can-Can Zhou / Fang Huang / Fu-Ming Shen / Ying-Chuan Li

Frontiers in Public Health, Vol

2024 Volume 11

Abstract: BackgroundAlthough the decreasing rate of hospital admission in the omicron wave has led countries to loosen control, still the patients requires ICU admission. It is common for viral respiratory infections to be co-infected with bacteria. However, the ... ...

Abstract	BackgroundAlthough the decreasing rate of hospital admission in the omicron wave has led countries to loosen control, still the patients requires ICU admission. It is common for viral respiratory infections to be co-infected with bacteria. However, the difference between co-infection and ICU-acquired infection on their clinical characteristics and outcomes during the Omicron wave was little reported.MethodsClinical and microbiological data were collected from ICU patients with omicron infection between April 1st, 2022, and May 31th, 2022 and a comprehensive comparative study of the clinical characteristics and endpoint were conducted.ResultsThe Omicron SARS-CoV-2 variants-infected patients requiring intensive care had high rates of co-infection (42.55%). Additionally, the ICU COVID-19 patients with co-infection showed more severe clinical features compared to those with ICU-acquired infection. Furthermore, Multivariate Cox analysis demonstrated that co-infection (hazard ratio: 4.670, p = 0.018) was a significant risk factor for poor outcomes in ICU patients with COVID-19. Besides, Kaplan–Meier survival curve analysis revealed that COVID-19 patients with co-infection had a significantly shorter 28-Day survival time compared to those with ICU-acquired infection (p < 0.001). Finally, our investigation identified a significant association between the presence of Candida app. in the broncho-alveolar lavage and an elevated risk of mortality (OR: 13.80, p = 0.002) and invasive ventilation (OR: 5.63, p = 0.01).ConclusionCo-infection is prevalent among patients requiring intensive care and is linked to unfavorable outcomes in the Omicron wave. Consequently, more attention may be needed for the empirical antibacterial treatment in ICU patients within the COVID-19 Omicron variant, especially anti-fungi.
Keywords	COVID-19 ; Omicron ; co-infection ; ICU-acquired infection ; Candida app ; Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Incidence and risk factors of acute kidney injury in patients with malignant tumors: a systematic review and meta-analysis.

Can, Wang / Rong, Li / Lixia, Liu

BMC cancer

2023 Volume 23, Issue 1, Page(s) 1123

Abstract: Background: There are significant differences in the incidence and risk factors of tumor patients, and there is no relevant statistical data. Therefore, this study aims to clarify the incidence and risk factors of acute kidney injury (AKI) in malignant ... ...

Abstract	Background: There are significant differences in the incidence and risk factors of tumor patients, and there is no relevant statistical data. Therefore, this study aims to clarify the incidence and risk factors of acute kidney injury (AKI) in malignant tumor patients and compare critically ill patients with non-critically ill patients. Methods: Relevant literature on the occurrence of AKI in malignant tumors was retrieved from databases. Two authors independently screened and evaluated the eligibility and quality of the literature and extracted the data. The Stata 12.0 software was used for meta-analysis. Results: A total of 3922 articles were initially retrieved, and 24 articles were finally included, 8 of which were about critically ill malignant tumor patients, and 16 were about malignant tumor patients. Among the 4107 patients included in the 8 studies on critically ill malignant tumors, 1932 developed AKI, with an incidence rate of 52% (95%CI 34-70%, I2 = 99%). The risk factors for AKI in critically ill malignant tumor patients were sepsis and hypovolemia, which were different from those in non-critically ill patients. Among the 292,874 patients included in the 16 studies on malignant tumors, 51,211 developed AKI, and the combined incidence rate was 24% (95%CI 17-30%, I2 = 100%). The risk factors for AKI in critical malignant tumor patients were sepsis and hypovolemia. Conclusion: This meta-analysis shows that the incidence of AKI in critically ill malignant tumor patients is consistent with that in other critically ill patients, and independent risk factors are sepsis and hypovolemia. The incidence of AKI in malignant tumor patients is higher than that in other patients, and tumor is a risk factor for AKI. This study has been registered in INPLASY (INPLASY202320079),Registered February 18,2023.
MeSH term(s)	Humans ; Intensive Care Units ; Incidence ; Critical Illness ; Retrospective Studies ; Hypovolemia ; Sepsis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Risk Factors ; Neoplasms/complications ; Neoplasms/epidemiology
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11561-3
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Article ; Online: Clinical features of omicron SARS-CoV-2 variants infection associated with co-infection and ICU-acquired infection in ICU patients.

Li, Dong-Jie / Zhou, Can-Can / Huang, Fang / Shen, Fu-Ming / Li, Ying-Chuan

Frontiers in public health

2024 Volume 11, Page(s) 1320340

Abstract: Background: Although the decreasing rate of hospital admission in the omicron wave has led countries to loosen control, still the patients requires ICU admission. It is common for viral respiratory infections to be co-infected with bacteria. However, ... ...

Abstract	Background: Although the decreasing rate of hospital admission in the omicron wave has led countries to loosen control, still the patients requires ICU admission. It is common for viral respiratory infections to be co-infected with bacteria. However, the difference between co-infection and ICU-acquired infection on their clinical characteristics and outcomes during the Omicron wave was little reported. Methods: Clinical and microbiological data were collected from ICU patients with omicron infection between April 1st, 2022, and May 31th, 2022 and a comprehensive comparative study of the clinical characteristics and endpoint were conducted. Results: The Omicron SARS-CoV-2 variants-infected patients requiring intensive care had high rates of co-infection (42.55%). Additionally, the ICU COVID-19 patients with co-infection showed more severe clinical features compared to those with ICU-acquired infection. Furthermore, Multivariate Cox analysis demonstrated that co-infection (hazard ratio: 4.670, Conclusion: Co-infection is prevalent among patients requiring intensive care and is linked to unfavorable outcomes in the Omicron wave. Consequently, more attention may be needed for the empirical antibacterial treatment in ICU patients within the COVID-19 Omicron variant, especially anti-fungi.
MeSH term(s)	Humans ; Coinfection/epidemiology ; COVID-19/epidemiology ; SARS-CoV-2 ; Intensive Care Units
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1320340
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