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Article: Microbiology and Antimicrobial Susceptibility in Adult Dacryocystitis.

Chi, Yi-Chun / Lin, Chia-Ching / Chiu, Tzu-Yu

Clinical ophthalmology (Auckland, N.Z.)

2024 Volume 18, Page(s) 575–582

Abstract: Purpose: To investigate the microbiology and antimicrobial susceptibility of dacryocystitis in adults and identify the changing trends over time in Taiwan.: Methods: This is a single-centered, retrospective study. We retrospectively reviewed adult ... ...

Abstract	Purpose: To investigate the microbiology and antimicrobial susceptibility of dacryocystitis in adults and identify the changing trends over time in Taiwan. Methods: This is a single-centered, retrospective study. We retrospectively reviewed adult patients with dacryocystitis from January 2012 to December 2021 in a tertiary medical center in Taiwan. The pathogens and in vitro antimicrobial susceptibility of the pus cultures from the lacrimal sac were collected. Results: Thirty-five cultures in acute and 211 cultures in chronic dacryocystitis were collected. Of the 220 isolates, a similar proportion of gram-positive (44%) and gram-negative (43%) aerobes were demonstrated in chronic dacryocystitis and more gram-negative aerobes (50%) than gram-positive aereobes (41%) in acute dacryocystitis. The most common pathogens were methicillin-resistant Conclusion: More gram-negative pathogens and more resistant species are rising in adult dacryocystitis. Understanding the bacteriology and antimicrobial susceptibility of the region is crucial for the empirical antibiotic selection in clinical practice.
Language	English
Publishing date	2024-02-23
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S452707
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Article: Case report: dengue fever associated acute macular neuroretinopathy.

Wang, How-Chen / Lin, Chia-Ching / Chang, Chia-Hsin / Tsai, Jih-Jin

Frontiers in medicine

2024 Volume 11, Page(s) 1379429

Abstract: Dengue fever (DF), which is caused by the dengue virus (DENV) and transmitted through Aedes mosquitoes, is well recognized for its systemic manifestations, with its ocular involvement gaining recent attention. We present a case of a 41-year-old Taiwanese ...

Abstract	Dengue fever (DF), which is caused by the dengue virus (DENV) and transmitted through Aedes mosquitoes, is well recognized for its systemic manifestations, with its ocular involvement gaining recent attention. We present a case of a 41-year-old Taiwanese female who developed acute macular neuroretinopathy (AMN) following a DF diagnosis related to DENV-1, emphasizing the need for awareness of this complication. The patient, with a history of completely resolved optic neuritis (ON) and comorbidities, experienced blurred vision on day 10 after the onset of DF. The ophthalmic examination revealed macular edema, ellipsoid zone (EZ) infiltration, and choriocapillaris involvement. Despite pulse therapy with corticosteroids, visual disturbances persisted, highlighting the challenge of managing ocular complications. Ocular manifestations in DF include hemorrhages, inflammation, and vascular complications. DF-associated AMN, a rare presentation, poses challenges in diagnosis and treatment response evaluation. While most patients recover spontaneously, some face persistent visual impairment, especially with AMN. Our case emphasizes the importance of recognizing ocular complications in DF, necessitating a multidisciplinary approach for optimal management and further research to delineate treatment strategies and outcomes.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1379429
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Article: First report of

Hsu, Wen-Yu / Lee, Yi-Jin / Lin, Che-Hung / Chu, Chia-Ching

Plant disease

2023

Abstract: Bougainvilleas ( ...

Abstract	Bougainvilleas (
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-01-23-0099-PDN
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Article ; Online: RNA therapeutics for metabolic disorders.

Vu, Thuy-Duong / Lin, Sheng-Che / Wu, Chia-Ching / Chu, Dinh-Toi

Progress in molecular biology and translational science

2024 Volume 203, Page(s) 181–196

Abstract: The prevalence of metabolic disorders is increasing exponentially and has recently reached epidemic levels. Over the decades, a large number of therapeutic options have been proposed to manage these diseases but still show several limitations. In this ... ...

Abstract	The prevalence of metabolic disorders is increasing exponentially and has recently reached epidemic levels. Over the decades, a large number of therapeutic options have been proposed to manage these diseases but still show several limitations. In this circumstance, RNA therapeutics have rapidly emerged as a new hope for patients with metabolic diseases. 57 years have elapsed from the discovery of mRNA, a large number of RNA-based drug candidates have been evaluated for their therapeutic effectiveness and clinical safety under clinical studies. To date, there are seven RNA drugs for treating metabolic disorders receiving official approval and entering the global market. Their targets include hereditary transthyretin-mediated amyloidosis (hATTR), familial chylomicronemia syndrome, acute hepatic porphyria, primary hyperoxaluria type 1 and hypercholesterolemia, which are all related to liver proteins. All of these seven RNA drugs are antisense oligonucleotides (ASO) and small interfering RNA (siRNA). These two types of treatment are both based on oligonucleotides complementary to target RNA through Watson-Crick base-pairing, but their mechanisms of action include different nucleases. Such treatments show greatest potential among all types of RNA therapeutics due to consecutive achievements in chemical modifications. Another method, mRNA therapeutics also promise a brighter future for patients with a handful of drug candidates currently under development.
MeSH term(s)	Humans ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/therapeutic use ; RNA, Small Interfering/genetics ; RNA, Small Interfering/therapeutic use ; RNA, Messenger ; Amyloid Neuropathies, Familial
Chemical Substances	Oligonucleotides ; Oligonucleotides, Antisense ; RNA, Small Interfering ; RNA, Messenger
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.12.014
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Article ; Online: Comparison of the correlation between serum autoantibodies against aldehyde dehydrogenase 2 and thyrotropin receptor in patients with Graves' ophthalmopathy.

Lin, Chia-Ching / Chiu, Li-Wen / Lee, Po-Yen / Chen, Kuo-Jen / Cheng, Kai-Chun

Indian journal of ophthalmology

2024 Volume 72, Issue 2, Page(s) 298–299

MeSH term(s)	Humans ; Aldehyde Dehydrogenase ; Autoantibodies ; Graves Ophthalmopathy/diagnosis ; Receptors, Thyrotropin
Chemical Substances	Aldehyde Dehydrogenase (EC 1.2.1.3) ; Autoantibodies ; Receptors, Thyrotropin
Language	English
Publishing date	2024-01-25
Publishing country	India
Document type	Comparative Study ; Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_673_23
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Article ; Online: RNA therapeutics for regenerative medicine.

Nguyen Thi, Yen Vy / Ngo, Anh Dao / Chu, Dinh-Toi / Lin, Sheng-Che / Wu, Chia-Ching

Progress in molecular biology and translational science

2024 Volume 204, Page(s) 163–176

Abstract: It is estimated that millions of people around the world experience various types of tissue injuries every year. Regenerative medicine was born and developed for understanding and application with the aim of replacing affected organs or some cells. The ... ...

Abstract	It is estimated that millions of people around the world experience various types of tissue injuries every year. Regenerative medicine was born and developed for understanding and application with the aim of replacing affected organs or some cells. The research, manufacture, production, and distribution of RNA in cells have acted as a basic foundation for the development and testing of therapies and treatments that are widely applied in different fields of medicine. Vaccines against COVID-19 are considered one of the brilliant and outstanding successes of RNA therapeutics research. With the characteristics of bio-derived RNA therapeutics, the mechanism of rapid implementation, safe production, and flexibility to create proteins depending on actual requirements. Based on the advantages above in this review, we discuss RNA therapeutics for regenerative medicine, and the types of RNA therapies currently being used for regenerative medicine. The relationship between disease and regenerative medicine is currently being studied or tested in RNA therapeutics. We have also covered the mechanisms of action of RNA therapy for regenerative medicine and some of the limitations in our current understanding of the effects of RNA therapy in this area. Additionally, we have also covered developing RNA therapeutics for regenerative medicine, focusing on RNA therapeutics for regenerative medicine. As a final point, we discuss potential applications for therapeutics for regenerative medicine in the future, as well as their mechanisms.
MeSH term(s)	Humans ; Regenerative Medicine ; RNA/therapeutic use ; COVID-19 Vaccines
Chemical Substances	RNA (63231-63-0) ; COVID-19 Vaccines
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.12.002
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Article ; Online: Performance management algorithm of financial shared service center based on Internet of Things public cloud privacy protection.

Yu, Zhen / Lin, Sheng-Huang / Cho, Chia-Ching / Chen, Changping

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 7, Page(s) 12510–12528

Abstract: The Internet of Things (IoT) refers to the use of various communication technologies to achieve the interconnection of everything in cyberspace, and to achieve smart home and intelligent transportation, thus generating unprecedented amounts of data. In ... ...

Abstract	The Internet of Things (IoT) refers to the use of various communication technologies to achieve the interconnection of everything in cyberspace, and to achieve smart home and intelligent transportation, thus generating unprecedented amounts of data. In the financial sharing center, all businesses can extract effective data from these massive databases for analysis, and use data analysis tools to collect business, financial, human, process, knowledge and social data. At present, various types of IT (Internet Technology) systems have been widely used in financial sharing centers. However, a large number of sensitive data have also been generated. In order to protect these sensitive data, there is a high requirement for the personal information of IT system operation and financial sharing center personnel. In order to protect user data privacy, the optimal and most effective use of IT systems is an important issue that must be considered in privacy management. At present, there are many algorithms to protect data and privacy, but the effect is not ideal. Considering the balance between privacy issues, this paper proposed a K-means clustering algorithm based on IoT public cloud privacy protection technology to analyze the performance management of financial sharing center. The research results showed that before the improvement, the average number of employees who were dissatisfied with the post training ability and information platform construction ability of the financial sharing center was 57.9 and 57.8% respectively, more than half of them. After the improvement of IoT based public cloud privacy protection, the average number of employees dissatisfied with the post training ability and information platform construction ability of the financial sharing center was 5 and 3.9%, far less than the data prior to the improvement. It showed that IoT public cloud privacy protection was conducive to the performance management of the financial sharing center, and the relationship between the two was positive.
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023557
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Article ; Online: Leiomyomatosis peritonealisis disseminata resembling intra-abdominal malignancy

Chia-Ching Chang / Yi-Hsin Lin / Kuo-Min Su / Mu-Hsien Yu

Journal of Medical Sciences, Vol 43, Iss 2, Pp 87-

2023 Volume 89

Abstract: Leiomyomatosis peritonealisis disseminata (LPD) is a rare benign tumor characterized by the dissemination of smooth muscle-like cell nodules within the peritoneal cavity. Diagnosing LPD is challenging for clinicians due to its nonspecific clinical ... ...

Abstract	Leiomyomatosis peritonealisis disseminata (LPD) is a rare benign tumor characterized by the dissemination of smooth muscle-like cell nodules within the peritoneal cavity. Diagnosing LPD is challenging for clinicians due to its nonspecific clinical presentation and its dissemination throughout the peritoneal cavity, which mimics intra-abdominal malignancy. In the present study, we present the case of a 47-year-old woman with severe abdominal pain and fever initially diagnosed with intra-abdominal abscess or peritoneal carcinomatosis. Exploratory laparotomy was performed to resect several leiomyoma-like tumors in the subperitoneal space. LPD was confirmed histopathologically.
Keywords	leiomyomatosis peritonealisis disseminata ; carcinomatosis ; leiomyoma ; Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Improving Limited Supervised Foot Ulcer Segmentation Using Cross-Domain Augmentation

Kuo, Shang-Jui / Huang, Po-Han / Lin, Chia-Ching / Li, Jeng-Lin / Chang, Ming-Ching

2024

Abstract: Diabetic foot ulcers pose health risks, including higher morbidity, mortality, and amputation rates. Monitoring wound areas is crucial for proper care, but manual segmentation is subjective due to complex wound features and background variation. Expert ... ...

Abstract	Diabetic foot ulcers pose health risks, including higher morbidity, mortality, and amputation rates. Monitoring wound areas is crucial for proper care, but manual segmentation is subjective due to complex wound features and background variation. Expert annotations are costly and time-intensive, thus hampering large dataset creation. Existing segmentation models relying on extensive annotations are impractical in real-world scenarios with limited annotated data. In this paper, we propose a cross-domain augmentation method named TransMix that combines Augmented Global Pre-training AGP and Localized CutMix Fine-tuning LCF to enrich wound segmentation data for model learning. TransMix can effectively improve the foot ulcer segmentation model training by leveraging other dermatology datasets not on ulcer skins or wounds. AGP effectively increases the overall image variability, while LCF increases the diversity of wound regions. Experimental results show that TransMix increases the variability of wound regions and substantially improves the Dice score for models trained with only 40 annotated images under various proportions. Comment: 5 pages, 2 figures, accepted by ICASSP 2024
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2024-01-16
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bilateral radial keratoneuritis resulting from acanthamoeba keratitis

Po‐Yu Lee / Chia‐Ching Lin / Li‐Yi Chiu / Po‐Yen Lee

Kaohsiung Journal of Medical Sciences, Vol 38, Iss 1, Pp 79-

2022 Volume 80

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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