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  1. Book ; Online: Visions of Electric Media : Television in the Victorian and Machine Ages

    Roberts, Ivy

    2019  

    Keywords TV & society ; History of engineering & technology ; Television, media, history, culture, technology
    Size 1 electronic resource (265 pages)
    Publisher Amsterdam University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021050906
    ISBN 9789048537877 ; 9048537878
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Neonatal haematology

    Roberts, Irene / Bain, Barbara J.

    a practical guide

    2022  

    Author's details Irene Roberts, Barbara J. Bain
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 285 Seiten), Illustrationen, Diagramme
    Publisher Wiley Blackwell
    Publishing place Hoboken, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021406297
    ISBN 978-1-119-37149-6 ; 9781119371588 ; 1-119-37149-X ; 1119371589
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Leukemogenesis in infants and young children with trisomy 21.

    Roberts, Irene

    Hematology. American Society of Hematology. Education Program

    2022  Volume 2022, Issue 1, Page(s) 1–8

    Abstract: Children with Down syndrome (DS) have a greater than 100-fold increased risk of developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of acute lymphoblastic leukemia (ALL) before their fifth birthday. ML-DS originates in ... ...

    Abstract Children with Down syndrome (DS) have a greater than 100-fold increased risk of developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of acute lymphoblastic leukemia (ALL) before their fifth birthday. ML-DS originates in utero and typically presents with a self-limiting, neonatal leukemic syndrome known as transient abnormal myelopoiesis (TAM) that is caused by cooperation between trisomy 21-associated abnormalities of fetal hematopoiesis and somatic N-terminal mutations in the transcription factor GATA1. Around 10% of neonates with DS have clinical signs of TAM, although the frequency of hematologically silent GATA1 mutations in DS neonates is much higher (~25%). While most cases of TAM/silent TAM resolve without treatment within 3 to 4 months, in 10% to 20% of cases transformation to full-blown leukemia occurs within the first 4 years of life when cells harboring GATA1 mutations persist and acquire secondary mutations, most often in cohesin genes. By contrast, DS-ALL, which is almost always B-lineage, presents after the first few months of life and is characterized by a high frequency of rearrangement of the CRLF2 gene (60%), often co-occurring with activating mutations in JAK2 or RAS genes. While treatment of ML-DS achieves long-term survival in approximately 90% of children, the outcome of DS-ALL is inferior to ALL in children without DS. Ongoing studies in primary cells and model systems indicate that the role of trisomy 21 in DS leukemogenesis is complex and cell context dependent but show promise in improving management and the treatment of relapse, in which the outcome of both ML-DS and DS-ALL remains poor.
    MeSH term(s) Infant ; Infant, Newborn ; Child ; Humans ; Child, Preschool ; Down Syndrome/genetics ; Down Syndrome/complications ; Leukemoid Reaction/complications ; Leukemoid Reaction/genetics ; GATA1 Transcription Factor/genetics ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mutation
    Chemical Substances GATA1 Transcription Factor
    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/hematology.2022000395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Maternal anaemia and postpartum haemorrhage.

    Mansukhani, Raoul / Roberts, Ian

    The Lancet. Global health

    2023  Volume 11, Issue 10, Page(s) e1516

    MeSH term(s) Female ; Humans ; Postpartum Hemorrhage/epidemiology ; Anemia/epidemiology
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(23)00350-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Governing digital health for infectious disease outbreaks.

    Roberts, Stephen / Kelman, Ilan

    Global public health

    2023  Volume 18, Issue 1, Page(s) 2241894

    Abstract: ... ...

    Abstract ABSTRACT
    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Big Data ; Disease Outbreaks
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1706
    ISSN (online) 1744-1706
    ISSN 1744-1706
    DOI 10.1080/17441692.2023.2241894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Structural racism and iron deficiency anaemia.

    Roberts, Ian / Jones, Camara Phyllis

    Lancet (London, England)

    2023  Volume 402, Issue 10405, Page(s) 834–835

    MeSH term(s) Humans ; Anemia, Iron-Deficiency/etiology ; Systemic Racism ; Iron ; Risk Factors
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2023-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01350-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prehospital tranexamic acid for trauma victims.

    Omori, Kazuhiko / Roberts, Ian

    Journal of intensive care

    2023  Volume 11, Issue 1, Page(s) 12

    Abstract: The public enquiry into the mass casualty incident at the Manchester Arena in the UK in which 23 people died and over 1000 were injured, identified the need for timely intramuscular administration of tranexamic acid to trauma patients. Since then, a ... ...

    Abstract The public enquiry into the mass casualty incident at the Manchester Arena in the UK in which 23 people died and over 1000 were injured, identified the need for timely intramuscular administration of tranexamic acid to trauma patients. Since then, a number of studies and trials have been carried out and UK paramedics are now authorized to give intramuscular tranexamic acid in the pre-hospital setting. In Japan, pre-hospital administration by emergency life-saving technicians is not yet authorized, despite the fact that tranexamic acid was invented by Japanese scientists. In Japan, the need for the pre-hospital administration of tranexamic acid has been raised on several occasions, where a patient died from traumatic bleeding prior to hospital admission. This paper summarizes the evidence on the use of tranexamic acid in patients with traumatic bleeding, including new evidence on the intramuscular route.
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-023-00661-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tranexamic Acid for Trauma Patients - More Lives to Save and Outcomes to Consider.

    Shakur-Still, Haleema / Roberts, Ian

    The New England journal of medicine

    2023  Volume 389, Issue 2, Page(s) 181–183

    MeSH term(s) Humans ; Antifibrinolytic Agents/therapeutic use ; Tranexamic Acid/therapeutic use ; Wounds and Injuries/drug therapy
    Chemical Substances Antifibrinolytic Agents ; Tranexamic Acid (6T84R30KC1)
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2305075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: Semantic congruency modulates the speed-up of multisensory responses.

    Roberts, Kalvin / Jentzsch, Ines / Otto, Thomas U

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 567

    Abstract: Responses to multisensory signals are often faster compared to their unisensory components. This speed-up is typically attributed to target redundancy in that a correct response can be triggered by one or the other signal. In addition, semantic ... ...

    Abstract Responses to multisensory signals are often faster compared to their unisensory components. This speed-up is typically attributed to target redundancy in that a correct response can be triggered by one or the other signal. In addition, semantic congruency of signals can also modulate multisensory responses; however, the contribution of semantic content is difficult to isolate as its manipulation commonly changes signal redundancy as well. To disentangle the effects of redundancy and semantic congruency, we manipulated semantic content but kept redundancy constant. We presented semantically congruent/incongruent animal pictures and sounds and asked participants to respond with the same response to two target animals (cats and dogs). We find that the speed-up of multisensory responses is larger for congruent (e.g., barking dogs) than incongruent combinations (e.g., barking cats). We then used a computational modelling approach to analyse audio-visual processing interferences that may underlie the effect. Our data is best described by a model that explains the semantic congruency modulation with a parameter that was previously linked to trial sequence effects, which in our experiment occur from the repetition/switching of both sensory modality and animal category. Yet, a systematic analysis of such trial sequence effects shows that the reported congruency effect is an independent phenomenon. Consequently, we discuss potential contributors to the semantic modulation of multisensory responses.
    MeSH term(s) Humans ; Animals ; Dogs ; Cats ; Semantics ; Acoustic Stimulation ; Photic Stimulation ; Visual Perception/physiology ; Computer Simulation
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50674-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Automated Image Analysis for Detection of Coccidia in Poultry.

    Kellogg, Isaac / Roberts, David L / Crespo, Rocio

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 2

    Abstract: Coccidiosis, caused by the ... ...

    Abstract Coccidiosis, caused by the protozoan
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14020212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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