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Article ; Online: Optimal quality of vitamin K antagonist therapy in Japanese patients with venous thromboembolism.

Hiramori, Seiichi / Yamashita, Yugo / Morimoto, Takeshi / Kadota, Kazushige / Takase, Toru / Kim, Kitae / Oi, Maki / Akao, Masaharu / Kobayashi, Yohei / Toyofuku, Mamoru / Inoko, Moriaki / Tada, Tomohisa / Izumi, Toshiaki / Chen, Po-Min / Murata, Koichiro / Tsuyuki, Yoshiaki / Saga, Syunsuke / Nishimoto, Yuji / Sasa, Tomoki /

Matsuda, Mitsuo / Sakamoto, Jiro / Kinoshita, Minako / Togi, Kiyonori / Mabuchi, Hiroshi / Takabayashi, Kensuke / Nakagawa, Yoshihisa / Kato, Takao / Ono, Koh / Ando, Kenji / Kimura, Takeshi

Journal of cardiology

2022 Volume 80, Issue 5, Page(s) 487–494

Abstract: Background: Vitamin K antagonist (VKA) remains an essential option for venous thromboembolism (VTE ...

Abstract	Background: Vitamin K antagonist (VKA) remains an essential option for venous thromboembolism (VTE), although direct oral anticoagulants have become available. However, there is a paucity of data on the optimal intensity and quality of control for VKA in Japanese. Methods: The COMMAND VTE Registry is a multicenter registry enrolling consecutive 3027 patients with acute symptomatic VTE among 29 centers in Japan. The current study population consisted of 1938 patients who received VKA with prothrombin time-international normalized ratio (PT-INR) measurement >5 times. The primary outcome measure was a composite of symptomatic VTE recurrence or major bleeding at 1 year. The presumed optimal quality of VKA therapy was defined as the combination of PT-INR range and time in therapeutic range (TTR) with the numerically lowest event rate. Results: The group with TTR ≥70 % based on PT-INR range ≥1.5 and <2.0 showed the lowest cumulative incidence rate. The cumulative 1-year incidence and the adjusted risk for the primary outcome measure were significantly lower in the optimal quality group than in the non-optimal quality group (5.2 % vs. 11.7 %, p = 0.001, and HR 0.49, 95%CI 0.28-0.81). Similarly, the cumulative 1-year incidences of a recurrent VTE, major bleeding, and all-cause death were significantly lower in the optimal quality group (recurrent VTE: 2.5 % vs. 6.0 %, p = 0.02; major bleeding: 2.8 % vs. 7.0 %, p = 0.008; and all-cause death: 2.8 % vs. 12.6 %, p < 0.0001). The lower risk of the optimal quality group relative to non-optimal quality group for the clinical outcomes was consistent regardless of the etiology of VTE (active cancer, transient risk factor, and unprovoked). Conclusions: The current VTE registry showed the optimal intensity of VKA therapy was target PT-INR range ≥1.5 and <2.0, which could support the current Japanese guideline recommendation, and the good quality of control for VKA therapy of TTR ≥70 % was independently associated with better outcomes.
MeSH term(s)	Anticoagulants/adverse effects ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Japan/epidemiology ; Recurrence ; Venous Thromboembolism/drug therapy ; Vitamin K
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
Language	English
Publishing date	2022-07-23
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2022.07.001
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Article ; Online: Effect of current smoking on ischemic events in patients with atrial fibrillation taking vitamin K antagonist.

Arai, Hideki / Ueda, Shinichiro / Uchida, Kazutaka / Sakakibara, Fumihiro / Kinjo, Norito / Nezu, Mari / Morimoto, Takeshi

International journal of cardiology. Cardiovascular risk and prevention

2022 Volume 14, Page(s) 200135

Abstract: ... with atrial fibrillation (AF) prescribed vitamin K antagonist (VKA).: Methods: We conducted a retrospective study at 71 ...

Abstract	Purpose: We investigated the association between current smoking and clinical outcomes in patients with atrial fibrillation (AF) prescribed vitamin K antagonist (VKA). Methods: We conducted a retrospective study at 71 centers in Japan. The inclusion criterion was taking a VKA for AF. Exclusion criteria were mechanical heart valves or history of pulmonary thrombosis or deep vein thrombosis. Consecutive patients were registered in February 2013 and followed until February 2017. The primary outcomes included ischemic events and major bleedings. The secondary outcomes were ischemic stroke, hemorrhagic stroke, and all-cause mortality. Results: A total of 7826 patients were included, with a mean age of 73 years; 5274 (67%) were men. The adjusted hazard ratios (HRs; 95% confidence intervals [CIs]) of current smokers relative to non-current smokers for ischemic events and major bleedings were 1.64 (1.05-2.57) and 1.09 (0.72-1.65), respectively. The adjusted HRs (95% CIs) of current smokers relative to non-current smokers for ischemic stroke, hemorrhagic stroke, and all-cause mortality were 1.65 (1.03-2.64), 0.52 (0.12-2.15), and 1.26 (0.83-1.92), respectively. Conclusions: There were significant associations between current smoking and ischemic events or ischemic stroke in patients with AF on VKA.
Language	English
Publishing date	2022-05-26
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-4875
ISSN (online)	2772-4875
DOI	10.1016/j.ijcrp.2022.200135
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Article ; Online: Increased door-to-puncture time during off-duty hours results in poor treatment outcomes for acute ischemic stroke: A subanalysis of the K-NET registry.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2023 , Page(s) 15910199231205050

Abstract: ... comprised 1571 patients listed in the multicenter stroke registry (K-NET) who had undergone endovascular ...

Abstract	Background: For patients who undergo endovascular treatment for acute ischemic stroke, the total time for treatment may increase during off-duty hours leading to worse outcomes. The present study compared endovascular treatment outcomes for on-duty and off-duty hours and examined factors that could be responsible for the prolonged treatment of patients in a multicenter registry. Methods: The study group comprised 1571 patients listed in the multicenter stroke registry (K-NET) who had undergone endovascular treatment between January 2018 and June 2020. The modified Rankin Scale (mRS), evaluated at 90 days after stroke onset, was utilized as the primary outcome. Patients were divided into on-duty and off-duty patients based on admission time. Multivariate logistic regression analysis was used to identify the independent factors that increased the time from admission to puncture during the off-duty period. Results: The mean mRS score at 90 days after stroke onset was 2.9, similar in both on-duty and off-duty patients, with no significant difference ( Conclusion: Door-to-puncture time >60 min during off-duty hours was associated with poor outcomes related to low NIHSS, high pre-mRS, posterior circulation, and diabetes.
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199231205050
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Zs.A 6325: Show issues

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Article ; Online: Primary results of mechanical thrombectomy for acute ischemic stroke: The K-NET registry in the Japanese metropolitan area.

Ueda, Toshihiro / Hasegawa, Yasuhiro / Takeuchi, Masataka / Morimoto, Masafumi / Tsuboi, Yoshifumi / Yamamoto, Ryoo / Kaku, Shogo / Ayabe, Junichi / Akiyama, Takekazu / Ishima, Daisuke / Mori, Kentaro / Kagami, Hiroshi / Ito, Hidemichi / Onodera, Hidetaka / Doi, Hiroshi / Tsumoto, Tomoyuki / Hataoka, Shunsuke / Noda, Masayuki / Tomura, Nagatsuki /

Masuo, Osamu / Yoshida, Yoichi / Kaga, Yasuyuki / Tatsuno, Kentaro / Yoshie, Tomohide / Takaishi, Satoshi / Yamano, Yoshihisa

International journal of stroke : official journal of the International Stroke Society

2022 Volume 18, Issue 5, Page(s) 607–614

Abstract: Background: Endovascular treatment (EVT) for acute large vessel occlusion has proven to be effective in randomized controlled trials. We conducted a prospective cohort study to evaluate the real-world efficacy of EVT in a metropolitan area with a large ... ...

Abstract	Background: Endovascular treatment (EVT) for acute large vessel occlusion has proven to be effective in randomized controlled trials. We conducted a prospective cohort study to evaluate the real-world efficacy of EVT in a metropolitan area with a large number of comprehensive stroke centers and to compare it with the results of other registries and randomized controlled trials (RCTs). Methods: We analyzed the Kanagawa Intravenous and Endovascular Treatment of Acute Ischemic Stroke registry, a prospective, multicenter observational study of patients treated by EVT and/or intravenous tissue-type plasminogen activator (tPA). Of the 2488 patients enrolled from January 2018 to June 2020, 1764 patients treated with EVT were included. The primary outcome was a good outcome, which was defined as a modified Rankin Scale (mRS) of 0-2 at 90 days. Secondary analysis included predicting a good outcome using multivariate logistic regression analysis. Results: The median age was 77 years, and the median National Institute of Health Stroke Scale (NIHSS) score was 18. Pretreatment mRS score 0-2 was 87%, and direct transport was 92%. The rate of occlusion in anterior circulation was 90.3%. Successful recanalization was observed in 88.7%. The median time from onset to recanalization was 193 min. Good outcomes at 90 days were 43.3% in anterior circulation and 41.9% in posterior circulation. Overall mortality was 12.6%. Significant predictors for a good outcome were as follows: age, male, direct transfer, NIHSS score, Alberta Stroke Program Early Computed Tomography Score, intravenous tPA, and successful recanalization. Conclusion: EVT in routine clinical use in a metropolitan area showed comparable good outcomes and lower mortality compared to previous studies, despite the high proportion of patients with older age, pretreatment mRS score of >2, posterior circulation occlusion, and higher NIHSS. Those results may have been associated with more direct transport and faster onset-to-recanalization times.
MeSH term(s)	Male ; Humans ; Aged ; Stroke/surgery ; Stroke/etiology ; Treatment Outcome ; East Asian People ; Thrombectomy/methods ; Endovascular Procedures/methods ; Ischemic Stroke/etiology ; Registries ; Brain Ischemia/surgery ; Brain Ischemia/etiology ; Retrospective Studies ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1177/17474930221138014
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Zs.A 6582: Show issues

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Article ; Online: Letter to the Editor concerning "T1 pelvic angle is associated with rapid progression of hip arthrosis" by Nakamura K, et al. (Eur Spine J [2023] https://doi.org/10.1007/s00586-023-07580-0).

Yamada, Yuta / Morimoto, Tadatsugu / Hirata, Hirohito / Mawatari, Masaaki

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2023 Volume 32, Issue 7, Page(s) 2622

MeSH term(s)	Humans ; Spine ; Osteoarthritis, Hip ; Pelvis ; Spinal Fusion
Language	English
Publishing date	2023-04-24
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-023-07722-4
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Zs.A 3437: Show issues

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Article ; Online: Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine.

Sasaki, Shogo / Izumi, Hiroto / Morimoto, Yasuo / Sakurai, Kazuo / Mochizuki, Shinichi

Bioorganic & medicinal chemistry

2020 Volume 28, Issue 18, Page(s) 115668

Abstract: Antisense oligonucleotides (AS-ODNs) specifically hybridize with target mRNAs, resulting in interference with the splicing mechanism or the regulation of protein translation. In our previous reports, we demonstrated that β-glucan schizophyllan (SPG) can ... ...

Abstract	Antisense oligonucleotides (AS-ODNs) specifically hybridize with target mRNAs, resulting in interference with the splicing mechanism or the regulation of protein translation. In our previous reports, we demonstrated that β-glucan schizophyllan (SPG) can form a complex with AS-ODNs attached with oligo deoxyadenosine dA
MeSH term(s)	Amino Acid Sequence ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cells, Cultured ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/chemistry ; Deoxycytidine/pharmacology ; Drug Delivery Systems ; Drug Liberation ; Drug Therapy, Combination ; Humans ; Lectins, C-Type/genetics ; Lectins, C-Type/metabolism ; Lung Neoplasms/drug therapy ; Oligonucleotides, Antisense/chemistry ; Oligonucleotides, Antisense/pharmacology ; Sizofiran/chemistry ; Sizofiran/pharmacology
Chemical Substances	Antineoplastic Agents ; Lectins, C-Type ; Oligonucleotides, Antisense ; dectin 1 ; Deoxycytidine (0W860991D6) ; Sizofiran (7F763NNC9X) ; gemcitabine (B76N6SBZ8R)
Language	English
Publishing date	2020-07-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2020.115668
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Zs.A 3815: Show issues

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Article: Search for the Decay K L0-->pi0nu nu[over].

Ahn, J K / Akune, Y / Baranov, V / Chen, K F / Comfort, J / Doroshenko, M / Fujioka, Y / Hsiung, Y B / Inagaki, T / Ishibashi, S / Ishihara, N / Ishii, H / Iwai, E / Iwata, T / Kato, I / Kobayashi, S / Komatsubara, T K / Kurilin, A S / Kuzmin, E /

Lednev, A / Lee, H S / Lee, S Y / Lim, G Y / Ma, J / Matsumura, T / Moisseenko, A / Morii, H / Morimoto, T / Nakano, T / Nanjo, H / Nix, J / Nomura, T / Nomachi, M / Okuno, H / Omata, K / Perdue, G N / Podolsky, S / Sakashita, K / Sasaki, T / Sasao, N / Sato, H / Sato, T / Sekimoto, M / Shinkawa, T / Sugaya, Y / Sugiyama, A / Sumida, T / Suzuki, S / Tajima, Y / Takita, S / Tsamalaidze, Z / Tsukamoto, T / Tung, Y C / Wah, Y W / Watanabe, H / Wu, M L / Yamaga, M / Yamanaka, T / Yoshida, H Y / Yoshimura, Y

Physical review letters

2008 Volume 100, Issue 20, Page(s) 201802

Abstract: We performed a search for the K L0-->pi0nu nu[over] decay at the KEK 12-GeV proton synchrotron. No ...

Abstract	We performed a search for the K L0-->pi0nu nu[over] decay at the KEK 12-GeV proton synchrotron. No candidate events were observed. An upper limit on the branching ratio for the decay was set to be 6.7 x 10(-8) at the 90% confidence level.
Language	English
Publishing date	2008-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.100.201802
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Article ; Online: Distinct chemotactic behavior in the original Escherichia coli K-12 depending on forward-and-backward swimming, not on run-tumble movements.

Kinosita, Yoshiaki / Ishida, Tsubasa / Yoshida, Myu / Ito, Rie / Morimoto, Yusuke V / Goto, Kazuki / Berry, Richard M / Nishizaka, Takayuki / Sowa, Yoshiyuki

Scientific reports

2020 Volume 10, Issue 1, Page(s) 15887

Abstract: ... in E. coli ATCC10798, which is one of the original K-12 clones. High-speed tracking of single ATCC10798 ... which is a derivative of K-12 and a wild-type for chemotaxis. The single point mutation of N87K in FliC ...

Abstract	Most motile bacteria are propelled by rigid, helical, flagellar filaments and display distinct swimming patterns to explore their favorable environments. Escherichia coli cells have a reversible rotary motor at the base of each filament. They exhibit a run-tumble swimming pattern, driven by switching of the rotational direction, which causes polymorphic flagellar transformation. Here we report a novel swimming mode in E. coli ATCC10798, which is one of the original K-12 clones. High-speed tracking of single ATCC10798 cells showed forward and backward swimming with an average turning angle of 150°. The flagellar helicity remained right-handed with a 1.3 μm pitch and 0.14 μm helix radius, which is consistent with the feature of a curly type, regardless of motor switching; the flagella of ATCC10798 did not show polymorphic transformation. The torque and rotational switching of the motor was almost identical to the E. coli W3110 strain, which is a derivative of K-12 and a wild-type for chemotaxis. The single point mutation of N87K in FliC, one of the filament subunits, is critical to the change in flagellar morphology and swimming pattern, and lack of flagellar polymorphism. E. coli cells expressing FliC(N87K) sensed ascending a chemotactic gradient in liquid but did not spread on a semi-solid surface. Based on these results, we concluded that a flagellar polymorphism is essential for spreading in structured environments.
MeSH term(s)	Chemotaxis/physiology ; Escherichia coli K12/physiology ; Flagella/physiology ; Models, Biological ; Mutation
Language	English
Publishing date	2020-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-72429-1
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Article ; Online: Tooth extraction in patients taking nonvitamin K antagonist oral anticoagulants.

Morimoto, Yoshinari / Yokoe, Chizuko / Imai, Yuko / Sugihara, Megumi / Futatsuki, Toshiko

Journal of dental sciences

2015 Volume 11, Issue 1, Page(s) 59–64

Abstract: Background/purpose: The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor ...

Abstract	Background/purpose: The nonvitamin K antagonist oral anticoagulants direct-thrombin inhibitor dabigatran and the Xa inhibitors rivaroxaban and apixaban are now being used clinically. The course of the patients on these anticoagulants who underwent tooth extraction was assessed. Materials and methods: The medical charts of these patients were investigated. Tooth extraction was performed while maintaining conventional anticoagulant therapy. Results: Twenty-three teeth were extracted in 19 patients, including two surgical extractions. Among the 19 patients, nine patients ingested rivaroxaban, six apixaban, and four dabigatran. One patient on rivaroxaban showed persistent postoperative bleeding following two surgical extractions. Mild oozing was observed in five patients (two on rivaroxaban and three on apixaban). There was no bleeding episode in the patients on dabigatran. Conclusion: The patients on rivaroxaban with a prolonged prothrombin time value have a higher risk of bleeding, especially undergoing surgical extraction. Apixaban correlates to neither activated partial thromboplastin time nor prothrombin time values and the countermeasures should be employed based on the clinical findings.
Language	English
Publishing date	2015-11-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	2213-8862
ISSN (online)	2213-8862
DOI	10.1016/j.jds.2015.09.002
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Article: Dominant honeybee colony infestation by Varroa destructor (Acari: Varroidae) K haplotype in Japan

Ogihara, Mari H / Yoshiyama, Mikio / Morimoto, Nobuo / Kimura, Kiyoshi

Applied entomology and zoology. 2020 May, v. 55, no. 2

2020

Abstract: ... i.e., Korea (K) and Japan (J), based on mtDNA sequences. Among these, V. destructor K haplotype is ... from 14 Japanese apiaries, and all mites were classified as V. destructor K haplotype ... Varroa destructor K haplotype was predominant in A. cerana colonies. Despite the different host species ...

Abstract	Varroa destructor Anderson and Trueman (Acari: Varroidae) are ectoparasitic mites found in the western honeybee Apis mellifera Linnaeus (Hymenoptera: Apidae). Varroa destructor is classified into two haplotypes, i.e., Korea (K) and Japan (J), based on mtDNA sequences. Among these, V. destructor K haplotype is possibly a more severe threat to A. mellifera colonies. Previous studies collected both V. destructor haplotypes from honeybee colonies in Japan. However, no detailed surveillance of infestation of Japanese apiaries by V. destructor or identification of their genetic structure has been conducted to date. We surveyed V. destructor at 15 different Japanese apiaries of A. mellifera. Varroa destructor was collected from 14 Japanese apiaries, and all mites were classified as V. destructor K haplotype. Varroa destructor infestation of the Japanese honeybee A. cerana japonica Radoszkawsi (Hymenoptera: Apidae) was also analyzed. Varroa destructor K haplotype was predominant in A. cerana colonies. Despite the different host species, all collected V. destructor K haplotype samples were classified into a single haplogroup, i.e., K1-1/K1-2. These results indicate that A. mellifera and A. cerana were infested by the same V. destructor haplogroup. This is the first report detailing a survey on V. destructor prevalence and haplogroups among Japanese apiaries.
Keywords	Apis cerana ; Apis mellifera ; Varroa destructor ; apiaries ; ectoparasites ; genetic structure ; haplotypes ; honey bee colonies ; honey bees ; hosts ; mite infestations ; mites ; monitoring ; nucleotide sequences ; surveys ; Japan ; Korean Peninsula
Language	English
Dates of publication	2020-05
Size	p. 189-197.
Publishing place	Springer Japan
Document type	Article
ZDB-ID	820195-x
ISSN	1347-605X ; 0003-6862
ISSN (online)	1347-605X
ISSN	0003-6862
DOI	10.1007/s13355-020-00667-w
Database	NAL-Catalogue (AGRICOLA)

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