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  1. Article ; Online: Looking Back, Looking Forward: Current Medications and Innovative Potential Medications to Treat Alcohol Use Disorder.

    Mason, Barbara J

    Alcohol research : current reviews

    2022  Volume 42, Issue 1, Page(s) 11

    Abstract: This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent ... ...

    Abstract This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent institute of the National Institutes of Health, NIAAA today is the world's largest funding agency for alcohol research. In addition to its own intramural research program, NIAAA supports the entire spectrum of innovative basic, translational, and clinical research to advance the diagnosis, prevention, and treatment of alcohol use disorder and alcohol-related problems. To celebrate the anniversary, NIAAA hosted a 2-day symposium, "Alcohol Across the Lifespan: 50 Years of Evidence-Based Diagnosis, Prevention, and Treatment Research," devoted to key topics within the field of alcohol research. This article is based on Dr. Mason's presentation at the event. NIAAA Director George F. Koob, Ph.D., serves as editor of the Festschrift.
    MeSH term(s) United States ; Humans ; Alcoholism/diagnosis ; National Institute on Alcohol Abuse and Alcoholism (U.S.) ; Alcohol Drinking ; Alcohol-Related Disorders ; National Institutes of Health (U.S.) ; Alcohol Deterrents/therapeutic use ; Naltrexone/therapeutic use
    Chemical Substances Alcohol Deterrents ; Naltrexone (5S6W795CQM)
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2677485-9
    ISSN 2169-4796 ; 1930-0573 ; 2168-3492 ; 0090-838X
    ISSN (online) 2169-4796 ; 1930-0573
    ISSN 2168-3492 ; 0090-838X
    DOI 10.35946/arcr.v42.1.11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Medications to Treat Alcohol Use Disorder: Targeting the Dark Side.

    Mason, Barbara J

    The American journal of psychiatry

    2021  Volume 178, Issue 5, Page(s) 375–377

    MeSH term(s) Alcoholism/drug therapy ; Humans ; Substance Withdrawal Syndrome
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2021.21030286
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  3. Article: Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats.

    Illenberger, Jessica M / Flores-Ramirez, Francisco J / Matzeu, Alessandra / Mason, Barbara J / Martin-Fardon, Rémi

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1127735

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1127735
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  4. Article ; Online: Alcohol Use Disorder: The Role of Medication in Recovery.

    Mason, Barbara J / Heyser, Charles J

    Alcohol research : current reviews

    2021  Volume 41, Issue 1, Page(s) 7

    Abstract: The misuse of alcohol in the United States continues to take a large toll on society, resulting in the deaths of about 88,000 Americans per year. Moreover, it is estimated that nearly 14.6 million Americans currently meet diagnostic criteria for current ... ...

    Abstract The misuse of alcohol in the United States continues to take a large toll on society, resulting in the deaths of about 88,000 Americans per year. Moreover, it is estimated that nearly 14.6 million Americans currently meet diagnostic criteria for current alcohol use disorder (AUD). However, very few individuals receive treatment, with an even smaller portion receiving medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of AUD, despite scientifically rigorous evidence showing the benefits of combining medication approved for treating AUD with evidence-based behavioral therapy. These benefits include higher rates of abstinence and less risk of relapse to heavy drinking, with associated improvements in medical and mental health and in quality of life. This review provides an overview of FDA-approved medications and "off-label" drugs for the treatment of AUD. The article emphasizes that AUD medical advice and prescription recommendations should come from professionals with training in the treatment of AUD and that treatment plans should consider medication in conjunction with evidence-based behavioral therapy. Finally, this review notes the limited number of medications available and the continued need for the development of new pharmacotherapies to optimize AUD recovery goals.
    MeSH term(s) Acamprosate ; Alcoholism/drug therapy ; Humans ; Naltrexone ; Pharmaceutical Preparations ; Quality of Life ; United States
    Chemical Substances Pharmaceutical Preparations ; Naltrexone (5S6W795CQM) ; Acamprosate (N4K14YGM3J)
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2677485-9
    ISSN 2169-4796 ; 1930-0573 ; 2168-3492 ; 0090-838X
    ISSN (online) 2169-4796 ; 1930-0573
    ISSN 2168-3492 ; 0090-838X
    DOI 10.35946/arcr.v41.1.07
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  5. Article ; Online: Emerging pharmacotherapies for alcohol use disorder.

    Mason, Barbara J

    Neuropharmacology

    2017  Volume 122, Page(s) 244–253

    Abstract: The identification of different stages within the alcohol use disorder (AUD) cycle that are linked to neurocircuitry changes in pathophysiology associated with the negative emotional states of abstinence has provided a view of medication development for ... ...

    Abstract The identification of different stages within the alcohol use disorder (AUD) cycle that are linked to neurocircuitry changes in pathophysiology associated with the negative emotional states of abstinence has provided a view of medication development for AUD that emphasizes changes in the brain reward and stress systems. Alcohol use disorder can be defined as a chronic relapsing disorder that involves compulsive alcohol seeking and taking, loss of control over alcohol intake, and emergence of a negative emotional state during abstinence. The focus of early medications development was to block the motivation to seek alcohol in the binge/intoxication stage. More recent work has focused on reversing the motivational dysregulations associated with the withdrawal/negative affect and preoccupation/anticipation stages during protracted abstinence. Advances in our understanding of the neurocircuitry and neuropharmacological mechanisms that are involved in the development and maintenance of the withdrawal/negative affect stage using validated animal models have provided viable targets for future medications. Another major advance has been proof-of-concept testing of potential therapeutics and clinical validation of relevant pharmacological targets using human laboratory models of protracted abstinence. This review focuses on future targets for medication development associated with reversal of the loss of reward function and gain in brain stress function that drive negative reinforcement in the withdrawal/negative affect stage of addiction. Basic research has identified novel neurobiological targets associated with the withdrawal/negative affect stage and preoccupation/anticipation stage, with a focus on neuroadaptive changes within the extended amygdala that account for the transition to dependence and vulnerability to relapse. This article is part of the Special Issue entitled "Alcoholism".
    MeSH term(s) Alcoholism/complications ; Alcoholism/drug therapy ; Animals ; Brain/drug effects ; Brain/physiopathology ; Humans ; Motivation/drug effects ; Reward ; Substance Withdrawal Syndrome/complications ; Substance Withdrawal Syndrome/drug therapy
    Language English
    Publishing date 2017-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2017.04.032
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  6. Article ; Online: Acamprosate, alcoholism, and abstinence.

    Mason, Barbara J

    The Journal of clinical psychiatry

    2015  Volume 76, Issue 2, Page(s) e224–5

    MeSH term(s) Alcoholism/rehabilitation ; Ethanol/adverse effects ; Female ; Humans ; Male ; Substance Withdrawal Syndrome/rehabilitation ; Taurine/analogs & derivatives
    Chemical Substances Taurine (1EQV5MLY3D) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2015-02
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.14com09632
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  7. Article ; Online: Media competencies for nurses: A Delphi study.

    Myers, Carole R / Muñoz, Lauren R / Mason, Diana J / Glickstein, Barbara

    Nursing outlook

    2022  Volume 70, Issue 4, Page(s) 625–638

    Abstract: Background: Media raises awareness of important health issues, provides guidance to promote health, and shapes health policies. However, nurses are poorly represented in media.: Purpose: To propose competencies that can be used to advance nurses' ... ...

    Abstract Background: Media raises awareness of important health issues, provides guidance to promote health, and shapes health policies. However, nurses are poorly represented in media.
    Purpose: To propose competencies that can be used to advance nurses' knowledge and skills in using media to advance health.
    Methods: A Delphi study design of three successive surveys was employed. The Round 1 survey was sent to 70 nurse media leaders, and 28 (40%) responded. Seventeen respondents (61%) participated in Round 2. The Round 3 survey was not needed.
    Discussion: These competencies provide direction for academia, healthcare organizations, nursing associations and others who seek to develop the leadership and population health skills of nurses. Ways the competencies can be used are outlined.
    Conclusion: There is an urgent need to improve population health outcomes by reducing disparities and promoting equity in health and health care. Media engagmeent is an importnat strategy for promoting population health. Additionally, promotion of better media representation of nurses and improved media engagement by nurses and nursing organizations all speak to the importance of advancing media competence.
    MeSH term(s) Clinical Competence ; Delphi Technique ; Health Promotion ; Humans ; Leadership ; Nurses
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 300568-9
    ISSN 1528-3968 ; 0029-6554
    ISSN (online) 1528-3968
    ISSN 0029-6554
    DOI 10.1016/j.outlook.2022.03.008
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  8. Book ; Conference proceedings: Pharmacotherapy of alcoholism update

    Mason, Barbara J.

    [presented on June 23, 1994, at a Symposium Entitled Pharmacotherapy of Alcoholism Update ... held during the annual meeting of the Research Society on Alcoholism in Maui, Hawaii]

    (Alcoholism ; 20,7, Suppl.)

    1996  

    Institution Symposium Entitled Pharmacotherapy of Alcoholism Update
    Research Society on Alcoholism
    Author's details guest ed.: Barbara J. Mason
    Series title Alcoholism ; 20,7, Suppl.
    Collection
    Keywords Alcoholism / drug therapy / congresses
    Language English
    Size 29A S. : graph. Darst.
    Publisher Williams & Wilkins
    Publishing place Baltimore, MD
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007441596
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1375 -20,7,Suppl.- not available for loan Zeitschriften-Lesesaal

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  9. Article: A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder.

    Mason, Barbara J / Estey, David / Roberts, Amanda / de Guglielmo, Giordano / George, Olivier / Light, John / Stoolmiller, Mike / Quello, Susan / Skinner, Michael / Shadan, Farhad / Begovic, Adnan / Kyle, Mark C / Harris, R Adron

    Neurobiology of stress

    2024  Volume 29, Page(s) 100604

    Abstract: Alcohol Use Disorder (AUD) is a chronic relapsing disorder affecting an estimated 283 million individuals worldwide, with substantial health and economic consequences. Peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α and PPAR-γ, ... ...

    Abstract Alcohol Use Disorder (AUD) is a chronic relapsing disorder affecting an estimated 283 million individuals worldwide, with substantial health and economic consequences. Peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α and PPAR-γ, have shown promise in preclinical studies as potential therapeutic targets for AUD. In this human laboratory study, we aimed to translate preclinical findings on the PPAR-α agonist fenofibrate to a human population with current AUD. We hypothesized that, relative to placebo, fenofibrate at the highest FDA-approved dose of 145 mg/d would attenuate responsiveness to
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2816500-7
    ISSN 2352-2895
    ISSN 2352-2895
    DOI 10.1016/j.ynstr.2023.100604
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  10. Article: Alternative use of suvorexant (Belsomra

    Flores-Ramirez, Francisco J / Illenberger, Jessica M / Pascasio, Glenn E / Matzeu, Alessandra / Mason, Barbara J / Martin-Fardon, Rémi

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 1085882

    Abstract: Alcohol use disorder (AUD) is one of the most treatment-resistant medical conditions globally. The orexin (Orx) system regulates diverse physiological processes, including stress, and is a system of interest for the development of pharmaceuticals to ... ...

    Abstract Alcohol use disorder (AUD) is one of the most treatment-resistant medical conditions globally. The orexin (Orx) system regulates diverse physiological processes, including stress, and is a system of interest for the development of pharmaceuticals to treat substance use disorders, particularly AUD. The present study tested the ability of the dual orexin receptor antagonist suvorexant (SUV), marketed by Merck as Belsomra
    Language English
    Publishing date 2022-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.1085882
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