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  1. Article ; Online: The role of high-quality systematic reviews in the nutrition literature: Creatine, a promising nutrition intervention to optimize physical function in patients at risk of functional disability.

    Besen, Bruno Adler Maccagnan Pinheiro

    JPEN. Journal of parenteral and enteral nutrition

    2024  Volume 48, Issue 4, Page(s) 375–376

    MeSH term(s) Humans ; Creatine/administration & dosage ; Systematic Reviews as Topic ; Dietary Supplements ; Nutrition Therapy/methods
    Chemical Substances Creatine (MU72812GK0)
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Editorial
    ZDB-ID 800861-9
    ISSN 1941-2444 ; 0148-6071
    ISSN (online) 1941-2444
    ISSN 0148-6071
    DOI 10.1002/jpen.2625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Biased Study Design and Statistical Analysis in a Need for Intensive Care Unit Admission Surgical Prediction Model.

    Roepke, Roberta Muriel Longo / Besen, Bruno Adler Maccagnan Pinheiro

    JAMA surgery

    2022  Volume 157, Issue 9, Page(s) 857

    MeSH term(s) Hospital Mortality ; Humans ; Intensive Care Units ; Patient Admission
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.2233
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    Uk I Zs.72: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Brazilian Contributions on Standardized Education for Brain Death Determination.

    Westphal, Glauco Adrieno / Besen, Bruno Adler Maccagnan Pinheiro / de Andrade, Joel / Sardinha, Luiz Antônio / Franke, Cristiano Augusto

    Neurocritical care

    2023  Volume 39, Issue 3, Page(s) 740–741

    MeSH term(s) Humans ; Brain Death/diagnosis ; Brazil ; Brain ; Educational Status
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Letter
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01850-x
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    Zs.A 6538: Show issues Location:
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  4. Article ; Online: Capillary leak syndrome during continuous renal replacement therapy after renal hilum ligation in a hypercapnic landrace pig.

    Santos, Yuri de Albuquerque Pessoa Dos / Cardozo Júnior, Luis Carlos Maia / Mendes, Pedro Vitale / Besen, Bruno Adler Maccagnan Pinheiro / Park, Marcelo

    Critical care science

    2024  Volume 35, Issue 4, Page(s) 413–415

    MeSH term(s) Swine ; Animals ; Continuous Renal Replacement Therapy ; Capillary Leak Syndrome ; Kidney
    Language Portuguese
    Publishing date 2024-01-24
    Publishing country Brazil
    Document type Letter
    ISSN 2965-2774
    ISSN (online) 2965-2774
    DOI 10.5935/2965-2774.20230139-en
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  5. Article ; Online: Association between piperacillin/tazobactam use and acute kidney injury in critically ill patients: a retrospective multicentre cohort study.

    Tomazini, Bruno Martins / Besen, Bruno Adler Maccagnan Pinheiro / Taniguchi, Leandro Utino / Zampieri, Fernando Godinho / Cavalcanti, Alexandre Biasi

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 3, Page(s) 552–558

    Abstract: Background: Piperacillin/tazobactam is one of the most common antibiotics prescribed in the ICU and the combination of piperacillin/tazobactam with vancomycin has been associated with acute kidney injury (AKI) in critically ill patients. However, data ... ...

    Abstract Background: Piperacillin/tazobactam is one of the most common antibiotics prescribed in the ICU and the combination of piperacillin/tazobactam with vancomycin has been associated with acute kidney injury (AKI) in critically ill patients. However, data on the risk of AKI with piperacillin/tazobactam, despite vancomycin co-exposure, are lacking.
    Objectives: To investigate the association of piperacillin/tazobactam with AKI and renal replacement therapy (RRT) among adult ICU patients.
    Methods: We analysed data from patients included in two open access databases (MIMIC-IV and eICU). Critically ill patients who received piperacillin/tazobactam or cefepime (a cephalosporin with similar broad-spectrum activity to piperacillin/tazobactam) during their first ICU stay were eligible for the study. Marginal structural Cox models, accounting for time-fixed covariates and time-dependent covariates were performed. The primary outcomes were AKI and need of RRT.
    Results: A total of 20 107 patients were included, with 11 213 in the piperacillin/tazobactam group and 8894 in the cefepime group. Exposure to piperacillin/tazobactam was associated with AKI (HR 1.77; 95% CI 1.51-2.07; P < 0.001) and with need of RRT (HR 1.31; 95% CI 1.08-1.57; P = 0.005). Tests for interaction were not statistically significant for occurrence of AKI and RRT in the subgroup of patients exposed to vancomycin or not (P = 0.26 and P = 0.6, respectively).
    Conclusions: In critically ill patients, exposure to piperacillin/tazobactam was associated with increased risk of AKI and with increased risk of RRT, regardless of combination therapy with vancomycin.
    MeSH term(s) Adult ; Humans ; Cefepime/adverse effects ; Vancomycin/adverse effects ; Cohort Studies ; Critical Illness ; Retrospective Studies ; Piperacillin, Tazobactam Drug Combination/adverse effects ; Acute Kidney Injury/chemically induced
    Chemical Substances Cefepime (807PW4VQE3) ; Vancomycin (6Q205EH1VU) ; Piperacillin, Tazobactam Drug Combination (157044-21-8)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae001
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    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  6. Article ; Online: Sulfonamide-induced acute eosinophilic pneumonia requiring extracorporeal membrane oxygenation support: a case report.

    Silva, Ana Flávia Garcia / Melro, Lívia Maria Garcia / Besen, Bruno Adler Maccagnan Pinheiro / Mendes, Pedro Vitale / Park, Marcelo

    Critical care science

    2023  Volume 35, Issue 2, Page(s) 239–242

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Pulmonary Eosinophilia/chemically induced ; Pulmonary Eosinophilia/therapy ; Sulfanilamide/adverse effects
    Chemical Substances Sulfanilamide (21240MF57M)
    Language Portuguese
    Publishing date 2023-09-15
    Publishing country Brazil
    Document type Case Reports ; Letter
    ISSN 2965-2774
    ISSN (online) 2965-2774
    DOI 10.5935/2965-2774.20230404-en
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  7. Article ; Online: Fluid management in diabetic ketoacidosis: new tricks for old dogs?

    Besen, Bruno Adler Maccagnan Pinheiro / Boer, Willem / Honore, Patrick M

    Intensive care medicine

    2021  Volume 47, Issue 11, Page(s) 1312–1314

    MeSH term(s) Diabetic Ketoacidosis/drug therapy ; Fluid Therapy ; Humans ; Insulin/therapeutic use
    Chemical Substances Insulin
    Language English
    Publishing date 2021-10-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-021-06527-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Characteristics of critically ill patients with cancer associated with intensivist's perception of inappropriateness of ICU admission: A retrospective cohort study.

    Silva, Carla Marchini Dias da / Besen, Bruno Adler Maccagnan Pinheiro / Nassar, Antônio Paulo

    Journal of critical care

    2023  Volume 79, Page(s) 154468

    Abstract: Purpose: Although admitting cancer patients to the ICU is no longer an issue, it may be valuable to identify patients perceived least likely to benefit from admission. Our objective was to investigate factors associated with potentially inappropriate ... ...

    Abstract Purpose: Although admitting cancer patients to the ICU is no longer an issue, it may be valuable to identify patients perceived least likely to benefit from admission. Our objective was to investigate factors associated with potentially inappropriate ICU admission.
    Methods: Retrospective cohort study of patients with cancer with unplanned ICU admission. We classified admissions as appropriate or potentially inappropriate according to Society of Critical Care Medicine guidelines. We used logistic regression model to assess factors associated with inappropriateness for ICU admission.
    Results: From 3384 patients, 663 (19.6%) were classified as potentially inappropriate. They received more invasive mechanical ventilation (25.3% vs 12.5%, P < 0.001) and vasopressors (34.4% vs 30.1%, P = 0.034), had higher ICU [3 (2,6) vs 2 (1,4), P < 0.001] length-of-stay, higher ICU (32.7% vs 8.4%, P < 0.001), hospital (71.9% vs 21.3%, P < 0.001), and one-year mortality (97.6% vs 54.7%, P < 0.001) compared with those considered appropriate. Performance status impairment, more severe organ dysfunctions at admission, metastatic disease, and source of ICU admission were the characteristics associated with intensivist's perception of inappropriateness of ICU admission.
    Conclusions: These findings may help guide ICU admission policies and triage criteria for end-of-life discussions among hospitalized patients with cancer.
    MeSH term(s) Humans ; Intensive Care Units ; Retrospective Studies ; Critical Illness ; Neoplasms/therapy ; Perception ; Hospital Mortality
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154468
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    Zs.A 2152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Tackling healthcare-associated infections in Brazilian intensive care units: we need more than collaboration.

    Oliveira, Renato Daltro de / Bustamante, Pedro Fortes Osório / Besen, Bruno Adler Maccagnan Pinheiro

    Revista Brasileira de terapia intensiva

    2022  Volume 34, Issue 3, Page(s) 313–315

    Title translation Infecções relacionadas à assistência à saúde no Brasil: precisamos de mais do que colaboração.
    MeSH term(s) Humans ; Brazil/epidemiology ; Intensive Care Units ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Delivery of Health Care
    Language Portuguese
    Publishing date 2022-11-04
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2732162-9
    ISSN 1982-4335 ; 1982-4335
    ISSN (online) 1982-4335
    ISSN 1982-4335
    DOI 10.5935/0103-507X.2022editorial-pt
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Validation of a low-cost continuous renal replacement therapy dialysate fluid controller for experimental purposes.

    Dos Santos, Yuri de Albuquerque Pessoa / Park, Viviane Flor / Cardozo Junior, Luis Carlos Maia / Besen, Bruno Adler Maccagnan Pinheiro / Mendes, Pedro Vitale / Park, Marcelo

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 9

    Abstract: Background: Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios, but the prohibitive cost of ... ...

    Abstract Background: Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios, but the prohibitive cost of CRRT machines limits their accessibility. This study aimed to develop and validate a low-cost and precise dialysate controller for experimental CRRT.
    Results: Our results demonstrate a commendable level of precision in affluent flow control, with a robust correlation (R
    Conclusions: The low-cost dialysate controller developed and tested in this study offers a precise means of regulating CRRT in experimental settings. Its affordability and accuracy render it a valuable instrument for studying CRRT support in unconventional clinical scenarios, particularly in middle-income countries' experimental ICU laboratories.
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00593-z
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