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  1. Article ; Online: The use of esketamine in the treatment of patients with severe depression and suicidal ideation: systematic review and meta-analysis.

    Floriano, Idevaldo / Silvinato, Antônio / Bernardo, Wanderley Marques

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 4, Page(s) e2023D694

    MeSH term(s) Humans ; Suicidal Ideation ; Depression/drug therapy ; Depressive Disorder, Major ; Ketamine/therapeutic use
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-05-15
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.2023D694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The use of esketamine in the treatment of patients with oral antidepressant-resistant depression: systematic review and meta-analysis.

    Floriano, Idevaldo / Silvinato, Antônio / Bernardo, Wanderley Marques

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue 6, Page(s) e2023D696

    Abstract: The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field to standardize how to conduct, and to assist in the reasoning and decision-making of doctors. The information provided by this ... ...

    Abstract The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field to standardize how to conduct, and to assist in the reasoning and decision-making of doctors. The information provided by this project must be critically evaluated by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical condition of each patient. Guideline conclusion: April 2023. Societies: Brazilian Medical Association.
    MeSH term(s) Humans ; Depression ; Brazil
    Chemical Substances Esketamine (50LFG02TXD)
    Language English
    Publishing date 2023-06-26
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.2023D696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nitinol double-layer stent versus closed single-layer stent: a systematic review.

    Silvinato, Antonio / Floriano, Idevaldo / Bernardo, Wanderley

    Revista da Associacao Medica Brasileira (1992)

    2022  Volume 68, Issue 11, Page(s) 1490–1495

    MeSH term(s) Humans ; Alloys ; Stents
    Chemical Substances nitinol (2EWL73IJ7F) ; Alloys
    Language English
    Publishing date 2022-11-28
    Publishing country Brazil
    Document type Systematic Review ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.222D6811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effectiveness of wearing masks during the COVID-19 outbreak in cohort and case-control studies: a systematic review and meta-analysis.

    Floriano, Idevaldo / Silvinato, Antônio / Bacha, Hélio Arthur / Barbosa, Alexandre Naime / Tanni, Suzana / Bernardo, Wanderley Marques

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2024  Volume 49, Issue 6, Page(s) e20230003

    Abstract: Objective: To evaluate the efficacy of wearing a mask to prevent COVID-19 infection.: Methods: This was a systematic review and meta-analysis of cohort and case-control studies, considering the best level of evidence available. Electronic databases ( ... ...

    Abstract Objective: To evaluate the efficacy of wearing a mask to prevent COVID-19 infection.
    Methods: This was a systematic review and meta-analysis of cohort and case-control studies, considering the best level of evidence available. Electronic databases (MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Clinical Trials.gov) were searched to identify studies that evaluated the effectiveness of wearing masks compared with that of not wearing them during the COVID-19 pandemic. Risk of bias and quality of evidence were assessed using the Cochrane risk of bias tool and the Grading of Recommendations Assessment, Development, and Evaluation.
    Results: Of the 1,028 studies identified, 9 met the inclusion criteria (2 cohort studies and 7 case-control studies) and were included in the analysis. The meta-analysis using cohort studies alone showed statistically significant differences, wearing a cloth mask decreased by 21% [RD = -0.21 (95% CI, -0.34 to -0.07); I2 = 0%; p = 0,002] the risk of COVID-19 infection, but the quality of evidence was low. Regarding case-control studies, wearing a surgical mask reduced the chance of COVID-19 infection [OR = 0.51 (95% CI, 0.37-0.70); I2 = 47%; p = 0.0001], as did wearing an N95 respirator mask [OR = 0.31 (95% CI, 0.20-0.49); I2 = 0%; p = 0.00001], both with low quality of evidence.
    Conclusions: In this systematic review with meta-analysis, we showed the effectiveness of wearing masks in the prevention of SARS-CoV-2 infection regardless of the type of mask (disposable surgical mask, common masks, including cloth masks, or N95 respirators), although the studies evaluated presented with low quality of evidence and important biases.
    MeSH term(s) Humans ; COVID-19/prevention & control ; Pandemics/prevention & control ; SARS-CoV-2 ; Case-Control Studies ; Disease Outbreaks
    Language Portuguese
    Publishing date 2024-01-05
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20230003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex.

    Silvinato, Antônio / Floriano, Idevaldo / Bernardo, Wanderley Marques

    Revista da Associacao Medica Brasileira (1992)

    2022  Volume 68, Issue 10, Page(s) 1345–1357

    Abstract: Objective: The objective of this systematic review with meta-analysis was to evaluate the efficacy, safety, and short- and long-term tolerability of cannabidiol (CBD), as an adjunct treatment, in children and adults with Dravet syndrome (SD), Lennox- ... ...

    Abstract Objective: The objective of this systematic review with meta-analysis was to evaluate the efficacy, safety, and short- and long-term tolerability of cannabidiol (CBD), as an adjunct treatment, in children and adults with Dravet syndrome (SD), Lennox-Gataut syndrome (LGS), or tuberous sclerosis complex (TSC), with inadequate control of seizures.
    Methods: This systematic review was conducted through a search for scientific evidence in the Mediline/PubMed, Central Cochrane, and ClinicalTrials.gov databases until April 2022. Selected randomized clinical trials (RCTs) that presented the outcomes: reduction in the frequency of seizures and total seizures (all types), number of patients with a response greater than or equal to 50%, change in caregiver global impression of change (CGIC) (improvement ≥1 category on the initial scale), adverse events (AEs), and tolerability to treatment. This review followed Preferred Reporting Items for Systematic reviews and Meta-Analyses.
    Results: Notably, six RCTs were included, with a total of 1,034 patients with SD, LGS, and TSC, of which 3 were open-label extension RCTs. The meta-analysis of the studies showed that the use of CBD as compared with placebo, in patients with convulsive seizures refractory to the use of medications, reduces the frequency of seizures by 33%; increases the number of patients with a reduction ≥50% in the frequency of seizures by 20%; increases the number of patients with absence of seizures by 3%; improves the clinical impression evaluated by the caregiver or patient (S/CGIC) in 21%; increases total AEs by 12%; increases serious AE by 16%; increases the risk of treatment abandonment by 12%; and increases the number of patients with transaminase elevation (≥3 times the referral) by 15%.
    Conclusions: This systematic review, with meta-analysis, supports the use of CBD in the treatment of patients with seizures, originated in DS, LGS, and TSC, who are resistant to the common medications, presenting satisfactory benefits in reducing seizures and tolerable toxicity.
    MeSH term(s) Adult ; Child ; Humans ; Anticonvulsants/therapeutic use ; Anticonvulsants/adverse effects ; Cannabidiol/therapeutic use ; Cannabidiol/adverse effects ; Epilepsies, Myoclonic/drug therapy ; Epilepsies, Myoclonic/chemically induced ; Epilepsy ; Lennox Gastaut Syndrome/drug therapy ; Seizures/etiology ; Seizures/chemically induced ; Tuberous Sclerosis/complications ; Tuberous Sclerosis/drug therapy ; Tuberous Sclerosis/chemically induced
    Chemical Substances Anticonvulsants ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2022-11-21
    Publishing country Brazil
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.2022D689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis.

    Santos, Clara Lucato Dos / Barreto, Indyanara Inacio / Floriano, Idevaldo / Tristão, Luca Schiliró / Silvinato, Antonio / Bernardo, Wanderley Marques

    Clinics (Sao Paulo, Brazil)

    2024  Volume 79, Page(s) 100323

    Abstract: Introduction: Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder, with main manifestations related to communication, social interaction, and behavioral patterns. The slight dynamics of change in the child over time require ... ...

    Abstract Introduction: Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder, with main manifestations related to communication, social interaction, and behavioral patterns. The slight dynamics of change in the child over time require that the onset of clinical manifestations presented by the child be more valued, with the aim of stabilizing the condition. Faced with a variety of methods for diagnosing ASD, the question arises as to which method should be used. This systematic review aims to recommend the best tools to perform screening and diagnosis.
    Methodology: This systematic review followed the PRISMA guidelines. The databases MEDLINE, Embase, CENTRAL (Cochrane), and Lilacs were accessed, and gray and manual searches were performed. The search strategy was created with terms referring to autism and the diagnosis/broad filter. The studies were qualitatively evaluated and quantitatively. Statistical analysis was performed using Meta-diSc-2.0 software, the confidence interval was 95 %.
    Results: The M-CHAT-R/F tool demonstrated a sensitivity of 78 % (95 % CI 0.57‒0.91) and specificity of 0.98 (95 % CI 0.88-1.00). The diagnostic tools demonstrated sensitivity and specificity respectively of: ADOS, sensitivity of 87 % (95 % CI 0.79‒0.92) and specificity 75 % (95 % CI 0.73‒0.78); ADI-R demonstrated test sensitivity of 77 % (95 % CI 0.56‒0.90) and specificity 68 % (95 % CI 0.52‒0.81), CARS test sensitivity was 89 % (95 % CI 0.78‒0.95) and specificity 79 % (95 % CI 0.65‒0.88).
    Conclusion: It is mandatory to apply a screening test, the most recommended being the M-CHAT-R/F. For diagnosis CARS and ADOS are the most recommended tools.
    MeSH term(s) Child ; Humans ; Autism Spectrum Disorder/diagnosis ; Sensitivity and Specificity ; Mass Screening/methods ; Communication ; Research Design
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.1016/j.clinsp.2023.100323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multiple lidocaine infusions for relief of neuropathic pain: systematic review and meta-analysis.

    Silvinato, Antonio / Floriano, Idevaldo / Bernardo, Wanderley Marques

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 5, Page(s) 583–588

    MeSH term(s) Anesthetics, Local ; Humans ; Infusions, Intravenous ; Lidocaine/administration & dosage ; Neuralgia/drug therapy
    Chemical Substances Anesthetics, Local ; Lidocaine (98PI200987)
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.5.583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Use of anticoagulants in patients with COVID-19: an update of a living systematic review and meta-analysis.

    Batista, Diane R / Floriano, Idevaldo / Silvinato, Antonio / Bacha, Hélio A / Barbosa, Alexandre Naime / Tanni, Suzana E / Bernardo, Wanderley M

    Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

    2023  Volume 49, Issue 3, Page(s) e20230095

    MeSH term(s) Humans ; COVID-19 ; Anticoagulants/therapeutic use ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Language Portuguese
    Publishing date 2023-06-05
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Letter ; Comment
    ZDB-ID 2223157-2
    ISSN 1806-3756 ; 1806-3713
    ISSN (online) 1806-3756
    ISSN 1806-3713
    DOI 10.36416/1806-3756/e20230095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antibiotics in the prophylaxis of COVID or in the treatment of mild COVID.

    Barbosa, Alexandre Naime / Silvinato, Antonio / Bacha, Hélio / Floriano, Idevaldo / Tanni, Suzana / Bernardo, Wanderley

    Revista da Associacao Medica Brasileira (1992)

    2022  Volume 68, Issue 5, Page(s) 553–556

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-18
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.2022D685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Multiple lidocaine infusions for relief of neuropathic pain

    Antônio Silvinato / Idevaldo Floriano / Wanderley Marques Bernardo

    Revista da Associação Médica Brasileira, Vol 66, Iss 7, Pp 889-

    systematic review and meta-analysis

    2020  Volume 889

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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