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  1. Article ; Online: Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography.

    Anwar, Ashraf M

    Heart failure reviews

    2024  Volume 29, Issue 3, Page(s) 713–727

    Abstract: Left atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered the interest with expanding research supporting the utility as a biomarker for outcomes in heart failure (HF). Echocardiography is ... ...

    Abstract Left atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered the interest with expanding research supporting the utility as a biomarker for outcomes in heart failure (HF). Echocardiography is the main imaging modality which helps in a qualitative and quantitative assessment of the LA size and function. Recent advances in probe technology and software analysis have provided a better understanding of LA anatomy, physiology, pathology, and function. A variety of parameters have been defined as markers of LA function but there is no single parameter that best defines LA function. Speckle tracking echocardiography-derived analysis of LA deformation provides a window on all phases of LA function (reservoir, conduit, and booster pump). There is accumulative published data that supported the diagnostic and prognostic values of LA deformation integration during echo assessment of LA in HF. This review article summarized the clinical utility of LA deformation that may help in prediction, diagnosis, categorization, risk stratification, and guiding the proper selection of therapy in HF patients in daily practice.
    MeSH term(s) Humans ; Heart Failure/physiopathology ; Heart Failure/diagnosis ; Heart Failure/diagnostic imaging ; Heart Atria/diagnostic imaging ; Heart Atria/physiopathology ; Prognosis ; Atrial Function, Left/physiology ; Echocardiography/methods
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-024-10392-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of Suitability for Percutaneous Mitral Commissurotomy: A Contemporary Review of Key Anatomical Criteria and Predictive Models.

    Abdelghani, Mohammad / Nunes, Maria Carmo P / Anwar, Ashraf M / Prendergast, Bernard

    European heart journal. Cardiovascular Imaging

    2024  

    Abstract: The immediate result of percutaneous balloon mitral commissurotomy (PMC) is largely determined by the anatomy of the mitral valve complex. Several scores and models have been developed to assess anatomical suitability for PMC. Although none has an ... ...

    Abstract The immediate result of percutaneous balloon mitral commissurotomy (PMC) is largely determined by the anatomy of the mitral valve complex. Several scores and models have been developed to assess anatomical suitability for PMC. Although none has an optimal predictive power, these models look at the valvular apparatus from different perspectives bearing the potential for a complementary role.
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeae052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spontaneous Coronary Sinus Thrombosis in a Patient With Pulmonary Embolism and No Prior Cardiac Instrumentation.

    Ibrahim, Islam A / Alharbi, Jamilah / Alsaadi, Ibrahim / Anwar, Ashraf M

    CASE (Philadelphia, Pa.)

    2023  Volume 7, Issue 9, Page(s) 383–388

    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Case Reports
    ISSN 2468-6441
    ISSN (online) 2468-6441
    DOI 10.1016/j.case.2023.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Insight into antioxidant and anti-inflammatory effects of marine bacterial natural exopolysaccharide (EPSSM) using carrageenan-induced paw edema in rats.

    El Awady, Mohamed E / Mohamed, Sahar S / Abo Elsoud, Mostafa M / Mahmoud, Manal G / Anwar, Mai M / Ahmed, Mahgoub M / Eltaher, Ashraf / Magdeldin, Sameh / Attallah, Ashraf / Elhagry, Ali E / Abdelhamid, Sayeda A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5113

    Abstract: Inflammation is a part of the body's intricate biological reaction to noxious stimuli and defensive reactions. So, the aim of this investigation was to study the anti-inflammatory activity of exopolysaccharide (EPSSM) using carrageenan-induced paw edema ... ...

    Abstract Inflammation is a part of the body's intricate biological reaction to noxious stimuli and defensive reactions. So, the aim of this investigation was to study the anti-inflammatory activity of exopolysaccharide (EPSSM) using carrageenan-induced paw edema in rats. A halophilic bacterial strain was isolated from marine sediments in the Red Sea in Egypt. The isolate has been visually and physiologically recognized, as well as by analyzing its 16S rRNA gene, which confirms Kocuria sp. clone Asker4. This particular isolate can be referenced using the accession number OL798051.1. EPSSM was subjected to purification and fractionation by a DEAE-cellulose column. Preliminary chemical analysis of EPSSM indicated that the monosaccharides were fructose, glucuronic acid, and xylose, with 2.0, 0.5, and 1.0, respectively. The antioxidant potential of EPSSM was investigated, and it was discovered that the level of activity increased independently of the concentrations, reaching a maximum threshold of 94.13% at 100 µg/mL of EPSSM for 120 min. Also, EPSSM at 50 mg/kg orally produced a significant anti-inflammatory effect on the carrageenan model at 2, 3, and 4 intervals. The EPSSM intervention resulted in reductions in the levels of catalase and superoxide dismutase enzymes, as well as a decrease in glutathione. Furthermore, the levels of nitric oxide, lipid peroxidation, and reactive oxygen species resulting from carrageenan-induced edema showed a significant reduction subsequent to the administration of EPSSM. Moreover, the findings indicated that the protein expression levels of cyclooxygenase-2 and interleukin-6 were reduced following treatment with EPSSM, resulting in a reduction of paw edema.
    MeSH term(s) Animals ; Rats ; Antioxidants/pharmacology ; Carrageenan ; RNA, Ribosomal, 16S ; Bacteria ; Edema/chemically induced ; Edema/drug therapy ; Inflammation ; Nitric Oxide
    Chemical Substances Antioxidants ; Carrageenan (9000-07-1) ; RNA, Ribosomal, 16S ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53502-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: Ashraf et al. Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches.

    Ashraf, Ghulam Md / DasGupta, Debarati / Alam, Mohammad Zubair / Baeesa, Saleh S / Alghamdi, Badrah S / Anwar, Firoz / Alqurashi, Thamer M A / Sharaf, Sharaf E / Al Abdulmonem, Waleed / Alyousef, Mohammed A / Alhumaydhi, Fahad A / Shamsi, Anas

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 2

    Abstract: The updated affiliation information can be seen in the affiliation part of this correction [ ... ]. ...

    Abstract The updated affiliation information can be seen in the affiliation part of this correction [...].
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28020600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Application of honeybee venom loaded nanoparticles for the treatment of chronic toxoplasmosis: parasitological, histopathological, and immunohistochemical studies.

    El Naggar, Heba M / Anwar, Mona M / Khayyal, Amira E / Abdelhameed, Reda M / Barakat, Ashraf M / Sadek, Sabry A S / Elashkar, Ayman M

    Journal of parasitic diseases : official organ of the Indian Society for Parasitology

    2023  Volume 47, Issue 3, Page(s) 591–607

    Language English
    Publishing date 2023-06-07
    Publishing country India
    Document type Journal Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-023-01602-w
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  7. Article ; Online: Surgery-first approach for correction of class III dentofacial deformity with Le Fort I osteotomy; is it advantageous?

    Anwar, Mudasir / Benington, Philip C M / Gillgrass, Toby J / Ayoub, Ashraf F

    The British journal of oral & maxillofacial surgery

    2022  Volume 60, Issue 9, Page(s) 1234–1239

    Abstract: The surgery-first approach (SFA) to orthognathic treatment aims to reduce its duration without compromising the outcome. However, the objective assessment of the achieved occlusion has been limited. This study was designed to assess the treatment ... ...

    Abstract The surgery-first approach (SFA) to orthognathic treatment aims to reduce its duration without compromising the outcome. However, the objective assessment of the achieved occlusion has been limited. This study was designed to assess the treatment duration, outpatient appointment number, and quality of occlusal outcomes for two groups of patients; one treated with the SFA and the other with an orthodontics-first approach (OFA). We carried our a retrospective cohort study of case records for twenty consecutive SFA, and 23 consecutive OFA, cases with class III malocclusions, treated with Le Fort I maxillary osteotomy only. Pre-and post-treatment study models were assessed using the Peer Assessment Rating (PAR). Significant differences (p<0.001) were found between the median active treatment durations (10.2 months for the SFA and 32.5 months for the OFA) and appointment numbers (14 for SFA and 24 for OFA). Median absolute PAR reductions were 40 for the SFA and 39 for the OFA. There was no significant difference between the groups regarding quality of occlusal correction. Treatment durations for the SFA group were significantly shorter than for the OFA group, with fewer outpatient appointments. The quality of occlusal outcome for both SFA and OFA groups were satisfactory and comparable.
    MeSH term(s) Humans ; Dentofacial Deformities/surgery ; Orthognathic Surgical Procedures ; Retrospective Studies ; Malocclusion, Angle Class III/surgery ; Maxilla/surgery ; Osteotomy, Le Fort ; Cephalometry
    Language English
    Publishing date 2022-07-22
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2022.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Echocardiographic evaluation of hypertrophic cardiomyopathy: A review of up-to-date knowledge and practical tips.

    Anwar, Ashraf M / tenCate, Folkert J

    Echocardiography (Mount Kisco, N.Y.)

    2021  Volume 38, Issue 10, Page(s) 1795–1808

    Abstract: Hypertrophic cardiomyopathy (HCM) is the most frequent cardiac disease with genetic substrate, affecting about .2%-.5% of the population. The proper diagnosis is important for optimal management and follow-up. Echocardiography plays an essential role in ... ...

    Abstract Hypertrophic cardiomyopathy (HCM) is the most frequent cardiac disease with genetic substrate, affecting about .2%-.5% of the population. The proper diagnosis is important for optimal management and follow-up. Echocardiography plays an essential role in the assessment of patients with HCM including diagnosis, screening, management formulation, prognosis, and follow up. It also helps to differentiate HCM from other diseases. The advancement of software and probe technology added many echo modalities and techniques that helped in refining the diagnostic and assessing the prognosis of patients with HCM. In this review, we briefly summarize how to integrate the different echocardiographic modalities to obtain comprehensive assessment supported by an updated knowledge of the latest guidelines and recently published articles. Many practical tips and tricks are included in this review to improve the diagnostic accuracy of echocardiography and minimize errors during interpretation.
    MeSH term(s) Cardiomyopathy, Hypertrophic/diagnostic imaging ; Echocardiography ; Humans ; Prognosis
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15200
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  9. Article: Incorporation of Plant Extracted Hydroxyapatite and Chitosan Nanoparticles on the Surface of Orthodontic Micro-Implants: An In-Vitro Antibacterial Study.

    Alhazmi, Anwar S / Syame, Sohier M / Mohamed, Wael S / Hakim, Ashraf S

    Microorganisms

    2022  Volume 10, Issue 3

    Abstract: In our study, the structural and morphological applications of hydroxyapatite and chitosan nanoparticles and coated micro-implants were assessed for their ability to combat oral pathogenic bacteria. The hydroxyapatite, as well as chitosan nanoparticles, ... ...

    Abstract In our study, the structural and morphological applications of hydroxyapatite and chitosan nanoparticles and coated micro-implants were assessed for their ability to combat oral pathogenic bacteria. The hydroxyapatite, as well as chitosan nanoparticles, were synthesized from the
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10030581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Stepwise Protocols for Scoring of Mitral Valve using Three-Dimensional Transthoracic Echocardiography in Mitral Stenosis.

    Anwar, Ashraf M / Attia, Wael M

    Journal of cardiovascular echography

    2019  Volume 29, Issue 1, Page(s) 7–13

    Abstract: Aim: This study aims to propose protocols that enable scoring of mitral valve (MV) in mitral stenosis using the three-dimensional (3D) scoring system.: Methods: A two-staged study was conducted. The first stage was designed to select the best 3D ... ...

    Abstract Aim: This study aims to propose protocols that enable scoring of mitral valve (MV) in mitral stenosis using the three-dimensional (3D) scoring system.
    Methods: A two-staged study was conducted. The first stage was designed to select the best 3D images of MV leaflets and chordae through analysis of 471 images. The second stage was designed to organize the best 3D images into protocols for complete scoring of MV. It included 35 consecutive patients; 23 had sinus rhythm (SR) and 12 had atrial fibrillation (AF). Both single- and multi-beat 3D acquisition from apical and parasternal windows were focused on MV leaflets and chordae using all 3D modalities (live, zoom, and full volume). To propose the protocols, 1563 images were analyzed.
    Results: In SR with good apical window, 2 protocols were recommended for complete scoring of leaflets and chordae (4 zoom 3D images [1 image for leaflets and 3 images for chordae] and 1 full-volume 3D image) using single- and multi-beat acquisition. In AF, the same 2 protocols using single-beat acquisition were recommended. From parasternal window, complete scoring of leaflets was obtained by 3 recommended protocols (single- or multi-beat zoom 3D images from parasternal short axis [PSAX], multibeat live 3D images from PSAX, and single- or multi-beat full-volume 3D images from parasternal long axis) in SR and 1 protocol in AF (single-beat zoom 3D images from PSAX). Scoring of chordae was incomplete in all patients by all 3D modalities.
    Conclusions: The proposed 3D-transthoracic echocardiography protocols suit all patients regardless of echo window and heart rhythm and enabled complete MV scoring.
    Language English
    Publishing date 2019-01-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2734045-4
    ISSN 2347-193X ; 2211-4122
    ISSN (online) 2347-193X
    ISSN 2211-4122
    DOI 10.4103/jcecho.jcecho_58_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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