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Article ; Online: The mediating effect of institutional trust in the relationship between precarity and conspiracy beliefs: A conceptual replication of Adam-Troian et al. (2023).

Adamus, Magdalena / Ballová Mikušková, Eva / Kačmár, Pavol / Guzi, Martin / Adamkovič, Matuš / Chayinska, Maria / Adam-Troian, Jais

The British journal of social psychology

2024

Abstract: ... The original study of Adam-Troian et al. (2023; British Journal of Social Psychology, 62(S1), 136-159 ...

Abstract	The paper reports the results of registered conceptual replications of the indirect effect of institutional trust in the relationship between precarity and the endorsement of conspiracy beliefs (CB). The original study of Adam-Troian et al. (2023; British Journal of Social Psychology, 62(S1), 136-159) indicated that subjective appraisals of economic hardship are associated with lower trust in governments and institutions, which in turn is associated with stronger endorsement of CB. Our Studies 1 to 3 report a series of replications using Slovak panel data. Study 4 reports a replication of the mediation model using data from the European Social Survey Round 10 collected in 17 countries. To provide a quantitative synthesis of these and previous results, we conducted mini meta-analysis (N = 50,340). Although the strength of the observed relationships differed across the studies to some degree, the original patterns of relations remained robust, supporting the original model. The study corroborates the view that to curb the spread of CB, it is necessary to address structural issues, such as growing financial insecurity, socioeconomic inequalities, and the deficit of institutional trust. Finally, we discuss the role of cultural and political settings in conditioning the mechanisms through which precarity enhances the endorsement of CB.
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	625325-8
ISSN	2044-8309 ; 0144-6665
ISSN (online)	2044-8309
ISSN	0144-6665
DOI	10.1111/bjso.12725
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Article: ADAM: A web platform for graph-based modeling and optimization of supply chains.

Hu, Yicheng / Zhang, Weiqi / Tominac, Philip / Shen, Margaret / Gorëke, Dilara / Martín-Hernández, Edgar / Martín, Mariano / Ruiz-Mercado, Gerardo J / Zavala, Victor M

Computers & chemical engineering

2022 Volume 165, Page(s) 107911

Abstract: ... optimization, and this hinders the adoption of advanced decision-making tools. In this work, we present ADAM ... a web platform that enables the modeling and optimization of SCs. ADAM facilitates modeling ... locations, products, and participants. ADAM model objects serve as repositories of experimental, technology ...

Abstract	Modeling and optimization are essential tasks that arise in the analysis and design of supply chains (SCs). SC models are essential for understanding emergent behavior such as transactions between participants, inherent value of products exchanged, as well as impact of externalities (e.g., policy and climate) and of constraints. Unfortunately, most users of SC models have limited expertise in mathematical optimization, and this hinders the adoption of advanced decision-making tools. In this work, we present ADAM, a web platform that enables the modeling and optimization of SCs. ADAM facilitates modeling by leveraging intuitive and compact graph-based abstractions that allow the user to express dependencies between locations, products, and participants. ADAM model objects serve as repositories of experimental, technology, and socio-economic data; moreover, the graph abstractions facilitate the organization and exchange of models and provides a natural framework for education and outreach. Here, we discuss the graph abstractions and software design principles behind ADAM, its key functional features and workflows, and application examples.
Language	English
Publishing date	2022-10-21
Publishing country	England
Document type	Journal Article
ISSN	0098-1354
ISSN	0098-1354
DOI	10.1016/j.compchemeng.2022.107911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study.

Pichler, Renate / Lindner, Andrea Katharina / Schäfer, Georg / Tulchiner, Gennadi / Staudacher, Nina / Mayr, Martin / Comperat, Eva / Orme, Jacob J / Schachtner, Gert / Thurnher, Martin

Journal of clinical medicine

2021 Volume 10, Issue 4

Abstract: ... ADAM) proteases, IL-10/IL-10R). A modified quick score was used for IHC semi-quantification ... raise the possibility that ADAM proteases may cleave PD-L1 from the surface of bladder TC and possibly ...

Abstract	Although Bacillus Calmette Guérin (BCG) remains a mainstay of adjuvant treatment in high-risk, non-muscle-invasive bladder cancer, BCG failure occurs in up to 40% of patients, with radical cystectomy (RC) as the inevitable therapeutic consequence. Current data suggest that PD-L1 immunosuppressive signaling is responsible for BCG failure, supporting the therapeutic rationale of combining checkpoint inhibitors with BCG. To address the immune cascade in 19 RC specimens obtained after BCG failure, we applied a small immunohistochemical (IHC) panel consisting of selected markers (PD-L1, GATA-3, a disintegrin and metalloproteinase (ADAM) proteases, IL-10/IL-10R). A modified quick score was used for IHC semi-quantification of these markers in tumor cells (TC) and immune cells (IC) within two different regions: muscle-invasive bladder cancer (MIBC) and primary/concurrent carcinoma in situ (CIS). Contrary to expectation, PD-L1 was consistently low, irrespective of tumor region and cell type. Intriguingly, expression of ADAM17, which has been reported to release membrane-bound PD-L1, was high in both tumor regions and cell types. Moreover, expression of GATA3, IL-10, and IL-10R was also increased, indicative of a generally immunosuppressive tumor microenvironment in BCG failure. ADAM10 expression was associated with advanced tumor disease at RC. Our findings raise the possibility that ADAM proteases may cleave PD-L1 from the surface of bladder TC and possibly also from IC. Therefore, IHC assessment of PD-L1 expression seems to be insufficient and should be supplemented by ADAM10/17 in patients with BCG failure.
Language	English
Publishing date	2021-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10040764
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The anatomy of the CDS market$Martin Oehmke, Adam Zawadowski

Oehmke, Martin / Zawadowski, Adam

The review of financial studies Vol. 30, No. 1 , p. 80-119

2017 Volume 30, Issue 1, Page(s) 80–119

Keywords	Kreditderivat ; Standardisierung ; Liquidität ; Hedging ; Spekulation ; USA
Language	English
Publisher	Oxford Univ. Press
Publishing place	Cary, NC
Document type	Article
Note	CDS = corporate credit default swaps
ZDB-ID	1043666-2 ; 1467494-4
ISSN	1465-7368 ; 0893-9454
ISSN (online)	1465-7368
ISSN	0893-9454
Database	ECONomics Information System

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Article ; Online: Anoctamin-6 regulates ADAM sheddase function.

Veit, Martin / Koyro, Katharina Isabelle / Ahrens, Björn / Bleibaum, Florian / Munz, Martin / Rövekamp, Hagen / Andrä, Jörg / Schreiber, Rainer / Kunzelmann, Karl / Sommer, Anselm / Bhakdi, Sucharit / Reiss, Karina

Biochimica et biophysica acta. Molecular cell research

2018 Volume 1865, Issue 11 Pt A, Page(s) 1598–1610

Abstract: ADAM17, a prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital ...

Abstract	ADAM17, a prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates including TGF-alpha, Amphiregulin (AREG) and TNF-Receptor 1 (TNFR1). We recently presented evidence that surface exposure of phosphatidylserine (PS) is pivotal for ADAM17 to exert sheddase activity. Anoctamin-6 (ANO6) has Ca
MeSH term(s)	ADAM Proteins/metabolism ; ADAM17 Protein/metabolism ; Anoctamins/metabolism ; Calcium/metabolism ; Cell Membrane/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Ionomycin/pharmacology ; Models, Biological ; Mutation ; Phosphatidylserines/metabolism ; Phospholipid Transfer Proteins/metabolism ; Phospholipids/metabolism ; Transforming Growth Factor alpha/metabolism
Chemical Substances	ANO6 protein, human ; Anoctamins ; Phosphatidylserines ; Phospholipid Transfer Proteins ; Phospholipids ; Transforming Growth Factor alpha ; Ionomycin (56092-81-0) ; ADAM Proteins (EC 3.4.24.-) ; ADAM17 Protein (EC 3.4.24.86) ; ADAM17 protein, human (EC 3.4.24.86) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-08-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2018.08.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uc I Zs.247: Show issues

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Article ; Online: Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure

Renate Pichler / Andrea Katharina Lindner / Georg Schäfer / Gennadi Tulchiner / Nina Staudacher / Martin Mayr / Eva Comperat / Jacob J. Orme / Gert Schachtner / Martin Thurnher

Journal of Clinical Medicine, Vol 10, Iss 4, p

A Pilot Study

2021 Volume 764

Abstract	Although Bacillus Calmette Guérin (BCG) remains a mainstay of adjuvant treatment in high-risk, non-muscle-invasive bladder cancer, BCG failure occurs in up to 40% of patients, with radical cystectomy (RC) as the inevitable therapeutic consequence. Current data suggest that PD-L1 immunosuppressive signaling is responsible for BCG failure, supporting the therapeutic rationale of combining checkpoint inhibitors with BCG. To address the immune cascade in 19 RC specimens obtained after BCG failure, we applied a small immunohistochemical (IHC) panel consisting of selected markers (PD-L1, GATA-3, a disintegrin and metalloproteinase (ADAM) proteases, IL-10/IL-10R). A modified quick score was used for IHC semi-quantification of these markers in tumor cells (TC) and immune cells (IC) within two different regions: muscle-invasive bladder cancer (MIBC) and primary/concurrent carcinoma in situ (CIS). Contrary to expectation, PD-L1 was consistently low, irrespective of tumor region and cell type. Intriguingly, expression of ADAM17, which has been reported to release membrane-bound PD-L1, was high in both tumor regions and cell types. Moreover, expression of GATA3, IL-10, and IL-10R was also increased, indicative of a generally immunosuppressive tumor microenvironment in BCG failure. ADAM10 expression was associated with advanced tumor disease at RC. Our findings raise the possibility that ADAM proteases may cleave PD-L1 from the surface of bladder TC and possibly also from IC. Therefore, IHC assessment of PD-L1 expression seems to be insufficient and should be supplemented by ADAM10/17 in patients with BCG failure.
Keywords	bacillus calmette guéri (BCG) failure ; bladder cancer ; a disintegrin and metalloproteinase (ADAM) proteases ; soluble PD-L1 ; PD-L1 biomarkers ; checkpoint inhibition ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: La vigencia del pensamiento de Adam Smith

Martín Aceña, Pablo

El legado de Gonzalo Anes (1931-2014) : alumnos y discípulos , p. 157-172

2015 , Page(s) 157–172

Author's details	Pablo Martín-Aceña (Catedrático de Historia e Instituciones Económicas, Universidad de Alcalá)
Language	Spanish
Publisher	Publicacions de la Universidad d'Alacant
Publishing place	Sant Vicent del Raspeig
Document type	Article
ISBN	9788497173797 ; 8497173791
Database	ECONomics Information System

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Article ; Online: Use of ADAM-C and CHA2DS2-VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study.

Nicot, Florence / Charbonnel, Clément / Jego, Christophe / Jourda, François / Vinsonneau, Ulric / Garçon, Philippe / Turlotte, Guillaume / Rivière, Jean François / Maurin, Marion / Lubret, Rémy / Meimoun, Patrick / Akret, Chrystelle / Cournot, Maxime / Sokic, Charles / Michel, Laurent / Lescure, Maryse / Kenizou, David / Melay, Marie / Fayard, Maxime /

Chauvat, Anthony / Fouché, Renaud / Cartigny, Guillaume / Dijoux, Nicolas / Martin, Anne Céline / Tho-Agostini, Aurélia / Mann, Hubert / Magnin, Dominique / Goralski, Marc / Pico, Fernando / Georges, Jean-Louis / Belle, Loïc

Echocardiography (Mount Kisco, N.Y.)

2021 Volume 38, Issue 4, Page(s) 612–622

Abstract: ... can also predict cardiovascular events in other populations, including non-AF populations. The ADAM-C score ... after BI. We aimed to evaluate the ability of CHA2DS2-VASc and ADAM-C scores to predict CAA after BI ... 6%). CHA2DS2-VASc and ADAM-C scores were significantly higher in the CAA group versus the non-CAA ...

Abstract	Background and aims: Complex aortic atheroma (CAA) is a common cause of acute brain ischemia (BI), including ischemic stroke (IS) and transient ischemic attack (TIA), and is associated with recurrence. The CHA2DS2-VASc score is a useful tool for predicting stroke in patients with atrial fibrillation (AF), and can also predict cardiovascular events in other populations, including non-AF populations. The ADAM-C score is a new risk score for predicting the diagnostic yield of transesophageal echocardiography (TEE) after BI. We aimed to evaluate the ability of CHA2DS2-VASc and ADAM-C scores to predict CAA after BI. Methods: This prospective, multicenter, observational study included 1479 patients aged over 18 years who were hospitalized for BI. CAA was defined as the presence of one or more of the following criteria: thrombus, ulcerated plaque, or plaque thickening ≥ 4 mm. Results: CAA was diagnosed in 216 patients (14.6%). CHA2DS2-VASc and ADAM-C scores were significantly higher in the CAA group versus the non-CAA group (P < .0001 for both). The CHA2DS2-VASc and ADAM-C scores appear to be good predictors of CAA (AUC 0.699 [0.635, 0.761] and 0.759 [0.702, 0.814], respectively). The sensitivity, specificity, predictive positive value (PPV), and negative predictive value (NPV) of the scores for detecting CAA were 94%, 22%, 17%, and 96%, respectively, for a CHA2DS2-VASc score < 2, and 90%, 46%, 22%, and 96%, respectively, for an ADAM-C score < 3 CONCLUSIONS: CHA2DS2-VASc and ADAM-C scores are able to predict CAA after BI. CHA2DS2-VASc < 2 and ADAM-C < 3 both have an interesting NPV of 96%.
Language	English
Publishing date	2021-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15034
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 359: Show issues

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Article ; Online: A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma.

Kanzaki, Hiroyuki / Shinohara, Fumiaki / Suzuki, Maiko / Wada, Satoshi / Miyamoto, Yutaka / Yamaguchi, Yuuki / Katsumata, Yuta / Makihira, Seicho / Kawai, Toshi / Taubman, Martin A / Nakamura, Yoshiki

Scientific reports

2016 Volume 6, Page(s) 32259

Abstract: ... bone resorption. Peptidases of the a-disintegrin and metalloproteinase (ADAM) family are implicated in cancer cell ... proliferation and tumor progression. We hypothesized that the ADAM enzymes expressed by cancer cells degrades ...

Abstract	Interferon-gamma (IFN-γ) is a pleiotropic cytokine that exerts anti-tumor and anti-osteoclastogenic effects. Although transcriptional and post-transcriptional regulation of IFN-γ is well understood, subsequent modifications of secreted IFN-γ are not fully elucidated. Previous research indicates that some cancer cells escape immune surveillance and metastasize into bone tissue by inducing osteoclastic bone resorption. Peptidases of the a-disintegrin and metalloproteinase (ADAM) family are implicated in cancer cell proliferation and tumor progression. We hypothesized that the ADAM enzymes expressed by cancer cells degrades IFN-γ and attenuates IFN-γ-mediated anti-tumorigenic and anti-osteoclastogenic effects. Recombinant ADAM17 degraded IFN-γ into small fragments. The addition of ADAM17 to the culture supernatant of stimulated mouse splenocytes decreased IFN-γ concentration. However, ADAM17 inhibition in the stimulated mouse T-cells prevented IFN-γ degradation. ADAM17-expressing human breast cancer cell lines MCF-7 and MDA-MB-453 also degraded recombinant IFN-γ, but this was attenuated by ADAM17 inhibition. Degraded IFN-γ lost the functionality including the inhibititory effect on osteoclastogenesis. This is the first study to demonstrate the extracellular proteolytic degradation of IFN-γ by ADAM17. These results suggest that ADAM17-mediated degradation of IFN-γ may block the anti-tumorigenic and anti-osteoclastogenic effects of IFN-γ. ADAM17 inhibition may be useful for the treatment of attenuated cancer immune surveillance and/or bone metastases.
Language	English
Publishing date	2016-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep32259
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Book: Worlds before Adam

Rudwick, Martin J. S

the reconstruction of geohistory in the age of reform

2008

Author's details	Martin J. S. Rudwick
Keywords	Geology/History ; Science/History
Language	English
Size	XXII, 614 S., Ill., graph. Darst., Kt., 27 cm
Publisher	Univ. of Chicago Press
Publishing place	Chicago u.a.
Document type	Book
Note	Includes bibliographical references (p. 567-603) and index
ISBN	0226731286 ; 9780226731285
Database	Former special subject collection: coastal and deep sea fishing

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