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Article ; Online: Is the Current Maastricht Consensus Report Applicable for H. pylori Management in Sub-Saharan Africa?

Setshedi, Mashiko

2023 Volume 41, Issue 4, Page(s) 572–573

MeSH term(s)	Humans ; Helicobacter pylori ; Consensus ; Anti-Bacterial Agents/therapeutic use ; Helicobacter Infections/drug therapy ; Africa South of the Sahara/epidemiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-01-17
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000529107
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Helicobacter pylori

Setshedi, Mashiko / Smith, Stella I

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Helicobacter ... ...

Abstract	Helicobacter pylori
Language	English
Publishing date	2023-05-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12060969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of Helicobacter pylori and intestinal helminth infections on gastric adenocarcinoma and inflammatory bowel disease in Sub-Saharan Africa

Mashiko Setshedi / Gillian Watermeyer

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: Gastric adenocarcinoma (GCA) is the 5th leading cancer globally with an estimated 1.1 million cases reported in 2020. Ninety percent of non-cardia GCAs are attributable to Helicobacter pylori (H. pylori), the most prevalent bacterial infection globally. ... ...

Abstract	Gastric adenocarcinoma (GCA) is the 5th leading cancer globally with an estimated 1.1 million cases reported in 2020. Ninety percent of non-cardia GCAs are attributable to Helicobacter pylori (H. pylori), the most prevalent bacterial infection globally. Rates of H. pylori infection are highest in Sub-Saharan Africa (SSA), yet surprisingly low numbers of GCAs are reported in the region. A similar phenomenon is seen with the inflammatory bowel diseases (IBD), Crohn’s disease, and ulcerative colitis. These disorders have risen dramatically over the past century in high income countries across the globe, with sharp increases noted more recently in newly industrialized regions. In contrast IBD is rare in most regions in SSA. For both diseases this may reflect under-reporting or limited access to diagnostic modalities, but an alternative explanation is the high burden of infection with gastrointestinal parasites endemic to SSA which may attenuate the risk of developing GCA and IBD. In this mini review we discuss the complex interplay between these microorganisms, GCA, and IBD, as well as a possible protective role of H. pylori and the development of IBD.
Keywords	Helicobacter pylori ; inflammatory bowel disease ; gastric cancer ; Africa ; helminths ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inflammatory bowel disease in sub-Saharan Africa: epidemiology, risk factors, and challenges in diagnosis.

Watermeyer, Gillian / Katsidzira, Leolin / Setshedi, Mashiko / Devani, Smita / Mudombi, Wisdom / Kassianides, Chris

The lancet. Gastroenterology & hepatology

2022 Volume 7, Issue 10, Page(s) 952–961

Abstract: Over the past century, the incidence of inflammatory bowel disease (IBD) in high-income countries has shown a sharp rise that then plateaued, and a similar trend has been observed in newly industrialised countries. IBD has long been considered uncommon ... ...

Abstract	Over the past century, the incidence of inflammatory bowel disease (IBD) in high-income countries has shown a sharp rise that then plateaued, and a similar trend has been observed in newly industrialised countries. IBD has long been considered uncommon in sub-Saharan Africa, possibly reflecting low exposure to environmental risk factors described in high-income populations. Alternatively, individuals living in sub-Saharan Africa might have a different genetic disposition. However, some cases of IBD might remain undetected in sub-Saharan Africa because of a lack of awareness, deficiencies in diagnostic and clinical capacity, and a substantial rate of misdiagnosis due to the high burden of infectious diseases. There are few published data describing the natural history of IBD in sub-Saharan Africa, and the true burden of the disease remains largely unknown, although there is some evidence that the incidence of IBD is rising in this region. This Series paper summarises the present understanding of IBD and challenges facing clinicians when diagnosing this disease in sub-Saharan Africa.
MeSH term(s)	Africa South of the Sahara/epidemiology ; Humans ; Incidence ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/epidemiology ; Risk Factors
Language	English
Publishing date	2022-06-30
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(22)00047-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Managing acute abdominal pain in the emergency centre: Lessons from a patient's experience.

Parker, Romy / Bedwell, Gill J / Hodkinson, Peter / Lourens, Andrit / Setshedi, Mashiko

African journal of emergency medicine : Revue africaine de la medecine d'urgence

2021 Volume 11, Issue 4, Page(s) 483–486

Abstract: Pain is one of the most common reasons people present to the emergency centre with 7-10% of presentations being due to acute abdominal pain. However, pain is also often neglected by clinicians in emergency centres. The well validated South African Triage ...

Abstract	Pain is one of the most common reasons people present to the emergency centre with 7-10% of presentations being due to acute abdominal pain. However, pain is also often neglected by clinicians in emergency centres. The well validated South African Triage Score (SATS) incorporates pain assessment in the prioritising of patients with the aim of guiding clinicians. Based on the SATS, severe pain (a score of ≥8 out of 10) should prompt the clinician to initiate treatment within 10 min of presentation, as unmanaged pain has multiple negative consequences, including poor outcomes of the acute incident with delayed healing and increased risk of developing chronic pain. In this commentary, we present a patient's experience when attending an emergency centre for acute abdominal pain, describe relevant pain mechanisms and highlight the stages where clinical management could have been optimised.
Language	English
Publishing date	2021-11-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4203
ISSN (online)	2211-4203
DOI	10.1016/j.afjem.2021.06.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Helicobacter pylori diagnosis and treatment in Africa: The First Lagos Consensus Statement of the African Helicobacter and Microbiota Study Group (AHMSG).

Smith, Stella I / Schulz, Christian / Ugiagbe, Rose / Ndip, Roland / Dieye, Yakhya / Leja, Marcis / Onyekwere, Charles / Ndububa, Dennis / Ajayi, Abraham / Jolaiya, Tolulope Funbi / Jaka, Hyasinta / Setshedi, Mashiko / Gunturu, Revathi / Otegbayo, Jesse Abiodun / Lahbabi-Amrani, Naima / Arigbabu, Anthony Oluwole / Kayamba, Violet / Nashidengo, Pueya Abdulrashid

Digestive diseases (Basel, Switzerland)

2024

Abstract: Background: Helicobacter pylori (H. pylori) infection is the most prevalent type of bacterial infection. Current guidelines from different regions of the world neglect specific African conditions and requirements. The African Helicobacter and Microbiota ...

Abstract	Background: Helicobacter pylori (H. pylori) infection is the most prevalent type of bacterial infection. Current guidelines from different regions of the world neglect specific African conditions and requirements. The African Helicobacter and Microbiota Study Group (AHMSG), founded in 2022, aims to create an Africa-specific consensus report reflecting Africa-specific issues. Summary: Eighteen experts from nine African countries and two European delegates supported by nine African collaborators from eight other countries prepared statements on the most important African issues in four working groups: (1) epidemiology, (2) diagnosis, (3) indications and prevention, and (4) treatment. Limited resources, restricted access to medical systems, and underdeveloped diagnostic facilities differ from those of other regions. The results of the individual working groups were presented for the final consensus voting, which included all board members. Key messages: There is need for further studies on H. pylori prevalence in Africa, with diagnosis hinged on specific African situation. Treatment of H. pylori in the African setting should be based on accessibility and reimbursement, while indication and prevention should be defined in specific African countries.
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	632798-9
ISSN	1421-9875 ; 0257-2753
ISSN (online)	1421-9875
ISSN	0257-2753
DOI	10.1159/000537878
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Rechallenge after anti-tuberculosis drug-induced liver injury in a high HIV prevalence cohort.

Moosa, Muhammed Shiraz / Maartens, Gary / Gunter, Hannah / Allie, Shaazia / Chughlay, Mohamed F / Setshedi, Mashiko / Wasserman, Sean / Stead, David F / Cohen, Karen

Southern African journal of HIV medicine

2022 Volume 23, Issue 1, Page(s) 1376

Abstract: Background: There are limited data on the outcomes of rechallenge with anti-tuberculosis therapy (ATT) following anti-tuberculosis drug-induced liver injury (AT-DILI) in a high HIV prevalence setting.: Objectives: To describe the outcomes of ... ...

Abstract	Background: There are limited data on the outcomes of rechallenge with anti-tuberculosis therapy (ATT) following anti-tuberculosis drug-induced liver injury (AT-DILI) in a high HIV prevalence setting. Objectives: To describe the outcomes of rechallenge with first-line ATT. Method: Hospitalised participants with AT-DILI who were enrolled into a randomised controlled trial of N-acetylcysteine in Cape Town, South Africa, were followed up until completion of ATT rechallenge. We described rechallenge outcomes, and identified associations with recurrence of liver injury on rechallenge (positive rechallenge). Results: Seventy-nine participants were rechallenged of whom 41 (52%) were female. Mean age was 37 years (standard deviation [s.d.] ±10). Sixty-eight (86%) were HIV-positive, of whom 34 (50%) were on antiretroviral therapy (ART) at time of AT-DILI presentation. Five participants had serious adverse reactions to an aminoglycoside included in the alternate ATT regimen given after first-line ATT interruption: acute kidney injury in three and hearing loss in two. The median time from first-line ATT interruption to start of first-line ATT rechallenge was 13 days (interquartile range [IQR]: 8-18 days). Antiretroviral therapy was interrupted for a median of 32 days (IQR: 17-58) among HIV-positive participants on ART before AT-DILI. Fourteen participants had positive rechallenge (18%). Positive rechallenge was associated with pyrazinamide rechallenge ( Conclusion: Rechallenge was successful in most of our cohort. Pyrazinamide rechallenge should be carefully considered.
Language	English
Publishing date	2022-06-14
Publishing country	South Africa
Document type	Journal Article
ZDB-ID	2259791-8
ISSN	2078-6751 ; 2078-6751
ISSN (online)	2078-6751
ISSN	2078-6751
DOI	10.4102/sajhivmed.v23i1.1376
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Article ; Online: Challenges in the management of inflammatory bowel disease in sub-Saharan Africa.

Watermeyer, Gillian / Awuku, Yaw / Fredericks, Ernst / Epstein, David / Setshedi, Mashiko / Devani, Smita / Mudombi, Wisdom / Kassianides, Chris / Katsidzira, Leolin

The lancet. Gastroenterology & hepatology

2022 Volume 7, Issue 10, Page(s) 962–972

Abstract: Inflammatory bowel disease (IBD) is generally considered a disease of high-income countries and is regarded as rare in sub-Saharan Africa. However, this assumption is almost certainly an underestimate, and the high burden of communicable diseases makes ... ...

Abstract	Inflammatory bowel disease (IBD) is generally considered a disease of high-income countries and is regarded as rare in sub-Saharan Africa. However, this assumption is almost certainly an underestimate, and the high burden of communicable diseases makes IBD in sub-Saharan Africa difficult to detect. Furthermore, some gastrointestinal infections can closely mimic IBD, contributing to delays in diagnosis and complicating therapeutic decision making. Constraints in endoscopic capacity alongside a scarcity of qualified diagnostic pathologists add to the difficulties. Implementing evidence-based guidelines recommended by international societies is challenging, mostly due to high costs and unavailability of medication. However, cost-effective approaches can still be implemented to manage IBD in sub-Saharan Africa as the predominant disease phenotype is mild-to-moderate ulcerative colitis, which often responds to treatment with basic medication. In this Series paper, we summarise the current management of IBD in sub-Saharan Africa and propose how it can be tailored to suit the epidemiological and socioeconomic specificities of the region. We also discuss measures required to address existing challenges, such as educating health-care workers about the diagnosis and management of IBD or improving endoscopic capacity.
MeSH term(s)	Africa South of the Sahara/epidemiology ; Chronic Disease ; Colitis, Ulcerative ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/therapy
Language	English
Publishing date	2022-06-30
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(22)00048-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Managing acute abdominal pain in the emergency centre

Romy Parker / Gill J. Bedwell / Peter Hodkinson / Andrit Lourens / Mashiko Setshedi

African Journal of Emergency Medicine, Vol 11, Iss 4, Pp 483-

Lessons from a patient's experience

2021 Volume 486

Abstract	Pain is one of the most common reasons people present to the emergency centre with 7-10% of presentations being due to acute abdominal pain. However, pain is also often neglected by clinicians in emergency centres. The well validated South African Triage Score (SATS) incorporates pain assessment in the prioritising of patients with the aim of guiding clinicians. Based on the SATS, severe pain (a score of ≥8 out of 10) should prompt the clinician to initiate treatment within 10 min of presentation, as unmanaged pain has multiple negative consequences, including poor outcomes of the acute incident with delayed healing and increased risk of developing chronic pain. In this commentary, we present a patient's experience when attending an emergency centre for acute abdominal pain, describe relevant pain mechanisms and highlight the stages where clinical management could have been optimised.
Keywords	Acute abdominal pain ; Assessment ; SATS ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma

Mankgopo M. Kgatle / Mashiko Setshedi / Henry N. Hairwadzi

BioMed Research International, Vol

2016 Volume 2016

Abstract: Hepatocellular carcinoma (HCC) is a major public health concern and one of the leading causes of tumour-related deaths worldwide. Extensive evidence endorses that HCC is a multifactorial disease characterised by hepatic cirrhosis mostly associated with ... ...

Abstract	Hepatocellular carcinoma (HCC) is a major public health concern and one of the leading causes of tumour-related deaths worldwide. Extensive evidence endorses that HCC is a multifactorial disease characterised by hepatic cirrhosis mostly associated with chronic inflammation and hepatitis B/C viral infections. Interaction of viral products with the host cell machinery may lead to increased frequency of genetic and epigenetic aberrations that cause harmful alterations in gene transcription. This may provide a progressive selective advantage for neoplastic transformation of hepatocytes associated with phenotypic heterogeneity of intratumour HCC cells, thus posing even more challenges in HCC treatment development. Epigenetic aberrations involving DNA methylation, histone modifications, and noncoding miRNA dysregulation have been shown to be intimately linked with and play a critical role in tumour initiation, progression, and metastases. The current review focuses on the aberrant hepatoepigenetics events that play important roles in hepatocarcinogenesis and their utilities in the development of HCC therapy.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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