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  1. Article ; Online: More than a key-the pathological roles of SARS-CoV-2 spike protein in COVID-19 related cardiac injury.

    Lin, Zhiqiang

    Sports medicine and health science

    2023  

    Abstract: Cardiac injury is common in hospitalized coronavirus disease 2019 (COVID-19) patients and cardiac abnormalities have been observed in a significant number of recovered COVID-19 patients, portending long-term health issues for millions of infected ... ...

    Abstract Cardiac injury is common in hospitalized coronavirus disease 2019 (COVID-19) patients and cardiac abnormalities have been observed in a significant number of recovered COVID-19 patients, portending long-term health issues for millions of infected individuals. To better understand how Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CoV-2 for short) damages the heart, it is critical to fully comprehend the biology of CoV-2 encoded proteins, each of which may play multiple pathological roles. For example, CoV-2 spike glycoprotein (CoV-2-S) not only engages angiotensin converting enzyme II (ACE2) to mediate virus infection but also directly activates immune responses. In this work, the goal is to review the known pathological roles of CoV-2-S in the cardiovascular system, thereby shedding lights on the pathogenesis of COVID-19 related cardiac injury.
    Language English
    Publishing date 2023-03-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2666-3376
    ISSN (online) 2666-3376
    DOI 10.1016/j.smhs.2023.03.004
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  2. Article: Elderly onset of MELAS carried an M.3243A >G mutation in a female with deafness and visual deficits: A case report.

    Zijun, Lin / Xu, Yi / Yujia, Yang / Zhiqiang, Xu

    Clinical case reports

    2024  Volume 12, Issue 3, Page(s) e8438

    Abstract: Key clinical message: MELAS is a disorder with clinical variability that also responsible for a significant portion of unexplained hereditary or childhood-onset hearing loss. Although patients typically present in childhood, the first stroke-like ... ...

    Abstract Key clinical message: MELAS is a disorder with clinical variability that also responsible for a significant portion of unexplained hereditary or childhood-onset hearing loss. Although patients typically present in childhood, the first stroke-like episode can occur later in life in some patients, potentially related to a lower heteroplasmy level. It is crucial to consider MELAS as a potential cause of stroke-like events if age at presentation and symptoms are atypical, especially among middle-aged patients without vascular risk factors.
    Abstract: MELAS syndrome (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes) is a rare genetic condition that most patients develop stroke-like episodes before the age of 40. We report a 52-year-old female with a documented 40-year history of progressive sensorineural hearing loss, developed a visual field deficit and stroke-like events in her middle age who finally diagnosed was MELAS. The patient was started on vitamin E, l-carnitine, l-arginine, and coenzyme Q10 that gradually improved before dismissal from the hospital. This case highlights the importance of considering MELAS as a potential cause of stroke-like events if imaging findings are atypical for cerebral infarction, especially among middle-aged patients without vascular risk factors and an unusual cause of progressive sensorineural hearing loss.
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8438
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  3. Article ; Online: A kinetic model reveals the critical gating motifs for donor-substrate loading into

    Hao, Zhiqiang / Guo, Qiang / Peng, Wenjie / Da, Lin-Tai

    Physical chemistry chemical physics : PCCP

    2024  

    Abstract: ... ...

    Abstract Soluble
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06034a
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  4. Article ; Online: Insight into the role of reactive species on catalyst surface underlying peroxymonosulfate activation by P-Fe

    Feng, Meiyun / Xu, Zhiqiang / Li, Jianan / Wang, Ning / Lin, Kuangfei / Zhang, Meng

    Chemosphere

    2024  Volume 357, Page(s) 141943

    Abstract: In this study, bentonite supporting phosphorus-doped ... ...

    Abstract In this study, bentonite supporting phosphorus-doped Fe
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141943
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  5. Article ; Online: Immunomodulatory effect of locoregional therapy in the tumor microenvironment.

    Xie, Lin / Meng, Zhiqiang

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 31, Issue 4, Page(s) 951–969

    Abstract: Cancer immunotherapy appears to be a promising treatment option; however, only a subset of patients with cancer responds favorably to treatment. Locoregional therapy initiates a local antitumor immune response by disrupting immunosuppressive components, ... ...

    Abstract Cancer immunotherapy appears to be a promising treatment option; however, only a subset of patients with cancer responds favorably to treatment. Locoregional therapy initiates a local antitumor immune response by disrupting immunosuppressive components, releasing immunostimulatory damage-associated molecular patterns, recruiting immune effectors, and remodeling the tumor microenvironment. Many studies have shown that locoregional therapy can produce specific antitumor immunity alone; nevertheless, the effect is relatively weak and transient. Furthermore, increasing research efforts have explored the potential synergy between locoregional therapy and immunotherapy to enhance the long-term systemic antitumor immune effect and improve survival. Therefore, further research is needed into the immunomodulatory effects of locoregional therapy and immunotherapy to augment antitumor effects. This review article summarizes the key components of the tumor microenvironment, discusses the immunomodulatory role of locoregional therapy in the tumor microenvironment, and emphasizes the therapeutic potential of locoregional therapy in combination with immune checkpoint inhibitors.
    MeSH term(s) Humans ; Tumor Microenvironment ; Neoplasms/pathology ; Immunotherapy ; Immunity
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.01.017
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  6. Article ; Online: Digestive and Absorptive Properties of the Antarctic Krill Tripeptide Phe-Pro-Phe (FPF) and Its Auxiliary Memory-Enhancing Effect.

    Yang, Jingqi / Ding, Jie / Lu, Zhiqiang / Zhu, Beiwei / Lin, Songyi

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 15, Page(s) 8491–8505

    Abstract: Aging and stress have contributed to the development of memory disorders. Phe-Pro-Phe (FPF) was identified with high stability by mass spectrometry from simulated gastrointestinal digestion and everted gut sac products of the Antarctic krill peptide Ser- ... ...

    Abstract Aging and stress have contributed to the development of memory disorders. Phe-Pro-Phe (FPF) was identified with high stability by mass spectrometry from simulated gastrointestinal digestion and everted gut sac products of the Antarctic krill peptide Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg (SSDAFFPFR) which was found to have a positive impact on memory enhancement. This study investigated the digestive stability, absorption, and memory-enhancing effects of FPF using nuclear magnetic resonance spectroscopy, simulated gastrointestinal digestion,
    MeSH term(s) Animals ; Mice ; Amino Acid Sequence ; Euphausiacea ; Peptides/chemistry ; Acetylcholine ; Memory Disorders
    Chemical Substances Peptides ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c08158
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  7. Article ; Online: Risk factors for early subsidence of 3D Printed Artificial vertebral after anterior cervical corpectomy and fusion.

    Mei, Jun / Wang, Zhiqiang / Tian, Xuefeng / Liu, Qingqing / Sun, Lin / Liu, Qiang

    World neurosurgery

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.02.044
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  8. Article ; Online: Corrigendum to "Tirapazamine suppress osteosarcoma cells in part through SLC7A11 mediated ferroptosis" [Biochem. Biophys. Res. Commun. 567 (2021) 118-124 118e124].

    Shi, Yihua / Gong, Ming / Deng, Zhouming / Liu, Huifan / Chang, Yiqiang / Yang, Zhiqiang / Cai, Lin

    Biochemical and biophysical research communications

    2024  Volume 703, Page(s) 149630

    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149630
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    Zs.A 116: Show issues Location:
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  9. Article ; Online: High-Performance Ir

    Wang, Zhiqiang / Zhou, Xiaomei / Wang, Gehui / Tong, Qing / Wan, Haiqin / Dong, Lin

    Inorganic chemistry

    2024  Volume 63, Issue 16, Page(s) 7241–7254

    Abstract: The elimination of toluene is an obligatory target with increasing VOC emission in recent years. This study successfully prepared a single-atom Ir catalyst ( ... ...

    Abstract The elimination of toluene is an obligatory target with increasing VOC emission in recent years. This study successfully prepared a single-atom Ir catalyst (Ir
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c04589
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  10. Article ; Online: Human endogenous retrovirus type K encoded Np9 oncoprotein induces DNA damage response.

    Chen, Jungang / Fan, Jiaojiao / Lin, Zhen / Dai, Lu / Qin, Zhiqiang

    Journal of medical virology

    2024  Volume 96, Issue 3, Page(s) e29534

    Abstract: Human endogenous retrovirus sequences (HERVs) constitute up to 8% of the human genome, yet not all HERVs remain silent passengers within our genomes. Some HERVs, especially the HERV type K (HERV-K), have been found to be frequently transactivated in a ... ...

    Abstract Human endogenous retrovirus sequences (HERVs) constitute up to 8% of the human genome, yet not all HERVs remain silent passengers within our genomes. Some HERVs, especially the HERV type K (HERV-K), have been found to be frequently transactivated in a variety of inflammatory diseases and human cancers. Np9, a 9-kDa HERV-K encoded protein, has been reported as an oncoprotein and found present in a variety of tumors and transformed cells. In the current study, we for the first time reported that ectopic expression of Np9 protein was able to induce DNA damage response from host cells especially through upregulation of γH2AX. Furthermore, we found that direct knockdown of Np9 by RNAi in Kaposi's Sarcoma-associated herpesvirus (KSHV) infected cells effectively reduced LANA expression, the viral major latent oncoprotein in vitro and in vivo, which may represent a novel strategy against virus-associated malignancies.
    MeSH term(s) Humans ; Endogenous Retroviruses/genetics ; Neoplasms ; Herpesvirus 8, Human/physiology ; Oncogene Proteins/genetics ; Oncogene Proteins/metabolism ; DNA Repair
    Chemical Substances Oncogene Proteins
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29534
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