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Article: Glisoprenins C, D and E, new inhibitors of appressorium formation in Magnaporthe grisea, from cultures of Gliocladium roseum. 2. Structure determination.

Sterner, O / Thines, E / Eilbert, F / Anke, H

1998 Volume 51, Issue 2, Page(s) 228–231

MeSH term(s)	Enzyme Inhibitors/chemistry ; Fatty Alcohols/chemistry ; Molecular Structure
Chemical Substances	Enzyme Inhibitors ; Fatty Alcohols ; glisoprenin C ; glisoprenin D ; glisoprenin E
Language	English
Publishing date	1998-02
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.7164/antibiotics.51.228
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Article: Glisoprenins C, D and E, new inhibitors of appressorium formation in Magnaporthe grisea, from cultures of Gliocladium roseum. 1. Production and biological activities.

Thines, E / Eilbert, F / Anke, H / Sterner, O

The Journal of antibiotics

1998 Volume 51, Issue 2, Page(s) 117–122

Abstract: Glisoprenins C, D, and E, new glisoprenin derivatives, were isolated together with glisoprenin ...

Abstract	Glisoprenins C, D, and E, new glisoprenin derivatives, were isolated together with glisoprenin A from submerged cultures of the deuteromycete Gliocladium roseum HA190-95. All glisoprenins inhibited appressorium formation in Magnaporthe grisea on inductive (hydrophobic) surfaces. The compounds exhibited moderate cytotoxic, but no antifungal, antibacterial or phytotoxic activities.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/isolation & purification ; Ascomycota/drug effects ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/pharmacology ; Fatty Alcohols/isolation & purification ; Fatty Alcohols/pharmacology ; Fermentation ; Lactams ; Microbial Sensitivity Tests ; Mitosporic Fungi ; Tumor Cells, Cultured/drug effects
Chemical Substances	Anti-Bacterial Agents ; Enzyme Inhibitors ; Fatty Alcohols ; Lactams ; cremimycin ; glisoprenin C ; glisoprenin D ; glisoprenin E ; glisoprenin A (144376-62-5)
Language	English
Publishing date	1998-02
Publishing country	Japan
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390800-8
ISSN	1881-1469 ; 0021-8820 ; 0368-3532
ISSN (online)	1881-1469
ISSN	0021-8820 ; 0368-3532
DOI	10.7164/antibiotics.51.117
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Article ; Online: Understanding Regional Patterns of Overdose Deaths Related to Opioids and Psychostimulants.

Segel, Joel E / Shearer, Riley D / Jones, Abenaa A / Khatri, Utsha G / Howell, Benjamin A / Crowley, D Max / Sterner, Glenn / Vest, Noel / Teixeira da Silva, Daniel / Winkelman, Tyler N A

Substance use & misuse

2024 Volume 59, Issue 4, Page(s) 558–566

Abstract: ... opioid and psychostimulant overdose mortality rates. Counties with higher SVI scores (i.e. higher social ...

Abstract	Background: As overdose rates increase for multiple substances, policymakers need to identify geographic patterns of substance-specific deaths. In this study, we describe county-level opioid and psychostimulant overdose patterns and how they correlate with county-level social vulnerability measures. Methods: A cross-sectional observational study, we used nationwide 2016-2018 restricted access Centers for Disease Prevention and Control county-level mortality files for 1,024 counties. We estimated quartiles of opioid and psychostimulant overdose mortality and provided estimates of their association with county-level Social Vulnerability Index (SVI) percentile. Results: There was high opioid and psychostimulant overdose mortality in the Middle Atlantic, South Atlantic, East North Central, and Mountain regions. The Central US had the lowest opioid and psychostimulant overdose mortality rates. Counties with higher SVI scores (i.e. higher social vulnerability) were significantly more likely to experience high opioid and high psychostimulant overdose (high-high) mortality. A 10-percentile increase in SVI score was associated with a 3.1 percentage point increase in the likelihood of being a high-high county (p < 0.001) in unadjusted models and a 1.5 percentage point increase (p < 0.05) in models adjusting for region. Conclusion: Our results illustrated the heterogenous geographic distribution of the growing concurrent opioid and psychostimulant overdose crisis. The substantial regional variation we identified highlights the need for local data to guide policymaking and treatment planning. The association of opioid-psychostimulant overdose mortality with social vulnerability demonstrates the critical need in impacted counties for tailored treatment that addresses the complex medical and social needs of people who use both opioids and psychostimulants.
MeSH term(s)	Humans ; Analgesics, Opioid/therapeutic use ; Opioid-Related Disorders/drug therapy ; Cross-Sectional Studies ; Drug Overdose/prevention & control ; Central Nervous System Stimulants/therapeutic use ; Opiate Overdose/drug therapy
Chemical Substances	Analgesics, Opioid ; Central Nervous System Stimulants
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2023.2287220
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Article: Das Konfidenz-/Signifikanzniveau impliziert ein bestimmtes Kostenverhältnis zwischen Fehler 1. Art und Fehler 2. Art. Für ein stärkeres Einbeziehen der Entscheidungstheorie in die psychologische Einzelfalldiagnostik

Sterner, Philipp / Friemelt, Benedikt / Goretzko, David / Kraus, Elisabeth / Bühner, Markus / Pargent, Florian

Diagnostica

2024 , Page(s) 1–13

Abstract: Die psychologische Einzelfalldiagnostik erfordert oft konkrete Entscheidungen, z. B. ob Personen in einem psychologischen Bereich "unterdurchschnittlich" sind. Alle deutschen Lehrbücher empfehlen, die Messunsicherheit von psychologischen Tests zu ... ...

Title translation	The confidence/significance level implies a certain cost ratio between type I error and type II error. An appeal for a stronger focus on decisiontheory in psychological assessment
Abstract	Die psychologische Einzelfalldiagnostik erfordert oft konkrete Entscheidungen, z. B. ob Personen in einem psychologischen Bereich "unterdurchschnittlich" sind. Alle deutschen Lehrbücher empfehlen, die Messunsicherheit von psychologischen Tests zu berücksichtigen, z. B. durch kritische Differenzen, Hypothesentests oder Konfidenzintervalle. Diese Empfehlungen ähneln jedoch Heuristiken ohne eine nachvollziehbare Begründung, wie das geeignete Signifikanz- oder Konfidenzniveau zu wählen ist. Die statistische Entscheidungstheorie ist ein mathematischer Rahmen, um rationale Entscheidungen zu treffen. Obwohl sie bereits früh in der Psychologie behandelt wurde, findet sie heute wenig Beachtung. Aus einer entscheidungstheoretischen Perspektive betrachtet, lassen sich die impliziten Annahmen aktueller Entscheidungsheuristiken aufzeigen. Die Verwendung zweiseitiger Hypothesentests und Konfidenzintervalle mit einem Signifikanzniveau von Alpha = 0.05 impliziert beispielsweise, dass Fehler 1. Art 39-mal schwerwiegender eingestuft werden als Fehler 2. Art. In diesem Artikel geben wir eine kurze Einführung in die Entscheidungstheorie und nutzen dieses Framework, um die Auswirkungen auf die derzeitige Praxis zu erörtern. Außerdem stellen wir eine Umfrage unter klinischen Neuropsychologinnen und -psychologen vor, die für ein Fallbeispiel ihre internen Kostenverhältnisse angaben. Obwohl die Kostenverhältnisse der Praktikerinnen und Praktiker variierten, wählte die Mehrheit weniger extreme Verhältnisse als die üblichen Heuristiken vermuten ließen. Wir argumentieren, dass die Einzelfalldiagnostik von einer expliziten Berücksichtigung entscheidungstheoretischer Implikationen profitieren würde und skizzieren mögliche zukünftige Forschungsrichtungen.
Keywords	Alpha-Fehler (Statistik) ; Bayesian Analysis ; Bayessche Analyse ; Beta-Fehler (Statistik) ; Confidence Limits (Statistics) ; Decision Theory ; Entscheidungstheorie ; Error of Measurement ; Konfidenzgrenzen (Statistik) ; Messfehler ; Neuropsychologie ; Neuropsychology ; Psychological Assessment ; Psychologinnen und Psychologen ; Psychologische Messung ; Psychologists ; Type I Errors ; Type II Errors
Language	German
Document type	Article
ZDB-ID	212493-2
ISSN	0012-1924 ; 0012-1924
ISSN (online)	0012-1924
ISSN	0012-1924
DOI	10.1026/0012-1924/a000329
Database	PSYNDEX

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Zs.B 1191: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 47: Show issues

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Article ; Online: Cytotoxic and other bioactivities of a novel and known sesquiterpene lactones isolated from

Tuasha, Nigatu / Escobar, Zilma / Seifu, Daniel / Gadisa, Endalamaw / Petros, Beyene / Sterner, Olov / Oredsson, Stina

Toxicology reports

2022 Volume 9, Page(s) 382–392

Abstract: ... Vernonia ... ...

Abstract	Vernonia leopoldi
Language	English
Publishing date	2022-03-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2022.02.011
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Article: Association of CSF biomarkers with MRI brain changes in Alzheimer's disease.

Seidu, Nazib M / Kern, Silke / Sacuiu, Simona / Sterner, Therese Rydberg / Blennow, Kaj / Zetterberg, Henrik / Lindberg, Olof / Ferreira, Daniel / Westman, Eric / Zettergren, Anna / Skoog, Ingmar

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 1, Page(s) e12556

Abstract: The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants' ( ...

Abstract	The relation between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures is poorly understood in cognitively healthy individuals from the general population. Participants' (
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12556
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Article ; Online: Human and African ape myosin heavy chain content and the evolution of hominin skeletal muscle.

Queeno, Samantha R / Reiser, Peter J / Orr, Caley M / Capellini, Terence D / Sterner, Kirstin N / O'Neill, Matthew C

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

2023 Volume 281, Page(s) 111415

Abstract: ... in our skeletal muscle biology towards a predominance of myosin heavy chain (MyHC) I isoforms (i.e. slow fibers) across ... and exercise, can induce modest decreases and increases in human MyHC I content (i.e. -9.3% to 2.3%, n ... 2033 subjects), but these shifts are much smaller than the mean human-African ape differential (i.e. 31 ...

Abstract	Humans are unique among terrestrial mammals in our manner of walking and running, reflecting 7 to 8 Ma of musculoskeletal evolution since diverging with the genus Pan. One component of this is a shift in our skeletal muscle biology towards a predominance of myosin heavy chain (MyHC) I isoforms (i.e. slow fibers) across our pelvis and lower limbs, which distinguishes us from chimpanzees. Here, new MyHC data from 35 pelvis and hind limb muscles of a Western gorilla (Gorilla gorilla) are presented. These data are combined with a similar chimpanzee dataset to assess the MyHC I content of humans in comparison to African apes (chimpanzees and gorillas) and other terrestrial mammals. The responsiveness of human skeletal muscle to behavioral interventions is also compared to the human-African ape differential. Humans are distinct from African apes and among a small group of terrestrial mammals whose pelvis and lower limb muscle is slow fiber dominant, on average. Behavioral interventions, including immobilization, bed rest, spaceflight and exercise, can induce modest decreases and increases in human MyHC I content (i.e. -9.3% to 2.3%, n = 2033 subjects), but these shifts are much smaller than the mean human-African ape differential (i.e. 31%). Taken together, these results indicate muscle fiber content is likely an evolvable trait under selection in the hominin lineage. As such, we highlight potential targets of selection in the genome (e.g. regions that regulate MyHC content) that may play an important role in hominin skeletal muscle evolution.
MeSH term(s)	Humans ; Animals ; Myosin Heavy Chains/genetics ; Hominidae ; Pan troglodytes ; Muscle, Skeletal ; Muscle Fibers, Skeletal ; Protein Isoforms ; Mammals
Chemical Substances	Myosin Heavy Chains (EC 3.6.4.1) ; Protein Isoforms
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	121246-1
ISSN	1531-4332 ; 0300-9629 ; 1095-6433
ISSN (online)	1531-4332
ISSN	0300-9629 ; 1095-6433
DOI	10.1016/j.cbpa.2023.111415
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Article ; Online: Natural marine cloud brightening in the Southern Ocean

G. G. Mace / S. Benson / R. Humphries / P. M. Gombert / E. Sterner

Atmospheric Chemistry and Physics, Vol 23, Pp 1677-

2023 Volume 1685

Abstract: The number of cloud droplets per unit volume ( N d ) is a fundamentally important property ... controls on albedo. Past work has shown that regional N d has a direct correlation to marine ... we examine N d variability derived from 5 years of MODIS Level 2-derived cloud properties in a broad region ...

Abstract	The number of cloud droplets per unit volume ( N d ) is a fundamentally important property of marine boundary layer (MBL) liquid clouds that, at constant liquid water path, exerts considerable controls on albedo. Past work has shown that regional N d has a direct correlation to marine primary productivity (PP) because of the role of seasonally varying, biogenically derived precursor gases in modulating secondary aerosol properties. These linkages are thought to be observable over the high-latitude oceans, where strong seasonal variability in aerosol and meteorology covary in mostly pristine environments. Here, we examine N d variability derived from 5 years of MODIS Level 2-derived cloud properties in a broad region of the summer eastern Southern Ocean and adjacent marginal seas. We demonstrate latitudinal, longitudinal and temporal gradients in N d that are strongly correlated with the passage of air masses over high-PP waters that are mostly concentrated along the Antarctic Shelf poleward of 60 ∘ S. We find that the albedo of MBL clouds in the latitudes south of 60 ∘ S is significantly higher than similar liquid water path (LWP) clouds north of this latitude.
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Motor Cortex Function in APOE4 Carriers and Noncarriers.

Yasen, Alia L / Eick, Geeta N / Sterner, Kirstin N / Christie, Anita D

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

2020 Volume 38, Issue 6, Page(s) 553–557

Abstract: Purpose: The ε4 allele of the apolipoprotein-E gene has been associated with disease activity ...

Abstract	Purpose: The ε4 allele of the apolipoprotein-E gene has been associated with disease activity including Alzheimer disease, multiple sclerosis, and cardiovascular disease. Individuals who possess the ε4 variant of this gene (ε4 carriers) also demonstrate higher levels of cognitive impairment and lower motor scores compared with noncarriers. The purpose of this study was to establish whether there is a difference in motor cortex function between apoε4 carriers and noncarriers. We hypothesized that carriers would have lower levels of excitability and excitatory transmitter (glutamate) and similar levels of intracortical inhibition and inhibitory neurotransmitter (gamma-aminobutyric acid) than noncarriers. Methods: Fifty-two participants provided saliva samples to determine apoε4 carrier status. Measures of motor cortex excitability and inhibition were obtained using transcranial magnetic stimulation, and measures of glutamate and gamma-aminobutyric acid concentrations were obtained using proton magnetic resonance spectroscopy. Results: No significant differences in transcranial magnetic stimulation (P ≥ 0.19) or proton magnetic resonance spectroscopy measures (P ≥ 0.90) were found between carriers and noncarriers. Conclusions: The results from this study suggest that motor cortex function, as assessed by transcranial magnetic stimulation measures of excitability and inhibition, and MRS measures of excitatory and inhibitory neurotransmitter are similar in those who possess an apoε4 allele and those who do not.
MeSH term(s)	Alzheimer Disease ; Apolipoprotein E4/genetics ; Humans ; Motor Cortex ; Transcranial Magnetic Stimulation ; gamma-Aminobutyric Acid
Chemical Substances	Apolipoprotein E4 ; gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	605640-4
ISSN	1537-1603 ; 0736-0258
ISSN (online)	1537-1603
ISSN	0736-0258
DOI	10.1097/WNP.0000000000000738
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Article ; Online: Action selection in early stages of psychosis: an active inference approach.

Knolle, Franziska / Sterner, Elisabeth / Moutoussis, Michael / Adams, Rick A / Griffin, Juliet D / Haarsma, Joost / Taverne, Hilde / Goodyer, Ian M / Fletcher, Paul C / Murray, Graham K

Journal of psychiatry & neuroscience : JPN

2023 Volume 48, Issue 1, Page(s) E78–E89

Abstract: Background: To interact successfully with their environment, humans need to build a model to make sense of noisy and ambiguous inputs. An inaccurate model, as suggested to be the case for people with psychosis, disturbs optimal action selection. Recent ... ...

Abstract	Background: To interact successfully with their environment, humans need to build a model to make sense of noisy and ambiguous inputs. An inaccurate model, as suggested to be the case for people with psychosis, disturbs optimal action selection. Recent computational models, such as active inference, have emphasized the importance of action selection, treating it as a key part of the inferential process. Based on an active inference framework, we sought to evaluate previous knowledge and belief precision in an action-based task, given that alterations in these parameters have been linked to the development of psychotic symptoms. We further sought to determine whether task performance and modelling parameters would be suitable for classification of patients and controls. Methods: Twenty-three individuals with an at-risk mental state, 26 patients with first-episode psychosis and 31 controls completed a probabilistic task in which action choice (go/no-go) was dissociated from outcome valence (gain or loss). We evaluated group differences in performance and active inference model parameters and performed receiver operating characteristic (ROC) analyses to assess group classification. Results: We found reduced overall performance in patients with psychosis. Active inference modelling revealed that patients showed increased forgetting, reduced confidence in policy selection and less optimal general choice behaviour, with poorer action-state associations. Importantly, ROC analysis showed fair-to-good classification performance for all groups, when combining modelling parameters and performance measures. Limitations: The sample size is moderate. Conclusion: Active inference modelling of this task provides further explanation for dysfunctional mechanisms underlying decision-making in psychosis and may be relevant for future research on the development of biomarkers for early identification of psychosis.
MeSH term(s)	Humans ; Psychotic Disorders/diagnosis ; Task Performance and Analysis ; Choice Behavior ; Models, Psychological
Language	English
Publishing date	2023-02-21
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1077443-9
ISSN	1488-2434 ; 1180-4882
ISSN (online)	1488-2434
ISSN	1180-4882
DOI	10.1503/jpn.220141
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