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Article: Letter to the Editor: The Role of D-Dimers in the Initial Evaluation of COVID-19 [Letter].

Patel, Sachin

Therapeutics and clinical risk management

2022 Volume 18, Page(s) 511–512

Language	English
Publishing date	2022-04-28
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186560-7
ISSN	1178-203X ; 1176-6336
ISSN (online)	1178-203X
ISSN	1176-6336
DOI	10.2147/TCRM.S369820
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Zs.A 6067: Show issues

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Article ; Online: Impact of Frailty on Outcomes in Patients Who Underwent Transcatheter Mitral Valve Replacement.

Agarwal, Siddharth / Thakkar, Samarthkumar / Zaid, Syed / Bansal, Agam / Patel, Harsh / Akhtar, Khawaja / Khosla, Jagjit / Goel, Sachin S / Baber, Usman

The American journal of cardiology

2023 Volume 203, Page(s) 301–303

MeSH term(s)	Humans ; Mitral Valve/surgery ; Frailty/complications ; Frailty/epidemiology ; Heart Valve Prosthesis Implantation/adverse effects ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome ; Aortic Valve Stenosis/surgery ; Aortic Valve/surgery ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/etiology ; Heart Valve Prosthesis ; Cardiac Catheterization
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.07.047
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Ui IV Zs.73: Show issues

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Article ; Online: 1-D MOF [Ag

Socha, Bhavesh N / Pandya, Sachin B / Patel, Urmila H / Patel, R H / Bhatt, Bhupesh S / Bhakhar, Sanjay / Vekariya, Nikhil / Valand, Jignesh / Thakor, Parth / Thakkar, Anjali B

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–16

Abstract: Newly synthesized dinuclear crystalline polymer, the silver complex of bidentate Sulfamethoxazole (Ag-SMX) in the presence of secondary ligand pyrrolidine has been characterized by elemental, spectral ( ...

Abstract	Newly synthesized dinuclear crystalline polymer, the silver complex of bidentate Sulfamethoxazole (Ag-SMX) in the presence of secondary ligand pyrrolidine has been characterized by elemental, spectral (
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2236732
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Zs.A 2093: Show issues

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Article ; Online: Treatment pattern and outcomes of re-induction therapy prior to stem cell transplantation in patients with relapsed/refractory multiple myeloma in Germany.

Sauer, Sandra / Engelhardt, Monika / Trautmann-Grill, Karolin / Kimmich, Christoph / Hänel, Mathias / Schmidt-Hieber, Martin / Salwender, Hans / Flossmann, Carmen / Heckmann, Hiltrud / Ertel, Franziska / Friederich, Andrea / Patel, Sachin / Thun, Barbara / Raab, Marc S

Bone marrow transplantation

2024

Abstract: There are limited data guiding choice of re-induction therapies for patients with relapsed/refractory multiple myeloma (RRMM) prior to stem cell transplantation (SCT). We performed a retrospective medical chart review of 171 patients with RRMM in Germany ...

Abstract	There are limited data guiding choice of re-induction therapies for patients with relapsed/refractory multiple myeloma (RRMM) prior to stem cell transplantation (SCT). We performed a retrospective medical chart review of 171 patients with RRMM in Germany who received re-induction therapy in second line (78%; n = 134) or third line (22%; n = 37) prior to re-SCT. Index therapy was defined as first completed re-induction therapy for planned myeloablative conditioning and SCT in second/third line within the eligibility period (1/2016-12/2019). Most common pre-index first line and maintenance therapy used were bortezomib-based combinations (91%; n = 155/171) and lenalidomide (55%; n = 29/53), respectively. Median duration of index therapy line was 9 months; carfilzomib-based combinations were the most widely used in second/third line re-induction therapy (49%; n = 83/171), followed by daratumumab-based combinations (21%; n = 36/171). Overall response rates in second/third line were 87% after re-induction and 96% after SCT; median time to next treatment line after start of index therapy was 31 months; median progression-free survival (PFS) was 29 months; and median overall survival after index date was not reached. Based on these data, re-induction therapy with salvage SCT appears to be beneficial in selected patients with RRMM in clinical practice in Germany, translating into deep responses, long PFS and prolonged time to next treatment.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632854-4
ISSN	1476-5365 ; 0268-3369 ; 0951-3078
ISSN (online)	1476-5365
ISSN	0268-3369 ; 0951-3078
DOI	10.1038/s41409-024-02208-3
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Zs.A 2168: Show issues

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Article ; Online: Interactions Between Endocannabinoid and Endogenous Opioid Systems Prospectively Influence Postoperative Opioid Use in Pregnant Patients Undergoing Cesarean Delivery.

Stone, Amanda L / Pham, Amelie / Osmundson, Sarah S / Pedowitz, Alex / Kingsley, Philip J / Marnett, Larry J / Patel, Sachin / Wickersham, Nancy / Sorabella, Laura L / Bruehl, Stephen

The journal of pain

2024 , Page(s) 104548

Abstract: Both endocannabinoid (EC) and endogenous opioid systems are involved in nociceptive processing and may work together synergistically based on preclinical models. This study evaluated the interactive effects of preoperative beta-endorphin concentrations ( ... ...

Abstract	Both endocannabinoid (EC) and endogenous opioid systems are involved in nociceptive processing and may work together synergistically based on preclinical models. This study evaluated the interactive effects of preoperative beta-endorphin concentrations (a key analgesic endogenous opioid) in cerebrospinal fluid (CSF) and ECs (CSF and plasma 2-arachidonoylglycerol [2-AG] and plasma anandamide [AEA]) on postoperative opioid use and pain intensity in a prospective cohort of n = 112 pregnant patients undergoing scheduled cesarean delivery. Maternal blood and CSF samples were collected preoperatively for beta-endorphin and EC assays. Patients completed measures of outpatient opioid use (number of tablets used and days of use) and average pain intensity at 2 weeks postoperatively. Results of general linear model analyses controlling for maternal age, BMI at time of delivery, and race revealed significant multiplicative interactions between EC and beta-endorphin concentrations on number of opioid tablets used (based on pill count), days of opioid use, and total milligram morphine equivalents used in the 2 week follow-up period. Elevated preoperative plasma and CSF 2-AG predicted reduced outpatient opioid analgesic use particularly for patients low in CSF beta-endorphin. Similar analyses for pain intensity at 2-week follow-up indicated a significant interaction (p<.02) characterized by higher preoperative beta-endorphin concentrations being associated with lower subsequent pain only for individuals with low preoperative plasma AEA concentrations. Further exploration of interactions between EC and endogenous opioid inhibitory systems as they influence responses to opioid analgesics in other clinical pain populations may help guide development of precision pain management approaches. PERSPECTIVE: In the postoperative setting of patients undergoing cesarean delivery, elevated endocannabinoids were linked to reduced outpatient opioid analgesic use in individuals who had low endogenous opioid concentrations in cerebrospinal fluid. Further exploration of interactions between these two inhibitory systems as they impact on responses to pain management interventions appears warranted.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2018789-0
ISSN	1528-8447 ; 1526-5900
ISSN (online)	1528-8447
ISSN	1526-5900
DOI	10.1016/j.jpain.2024.104548
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Zs.A 5237: Show issues

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Article ; Online: E-cigarette use and prevalence of lung diseases among the U.S. population: a NHANES survey.

Dirisanala, Sudha / Laller, Srishti / Ganti, Naga / Taj, Shafaq / Patel, Neel / Singh Arora, Kunwardeep / Williams, Inemesit / Hameed, Ayesha / Kuditipudi, Aasa Deepika / Lei, Yadanar Win / Tirupathi, Raghavendra / Gupta, Sachin / Patel, Urvish / Venkata, Vikramaditya Samala

Journal of investigative medicine : the official publication of the American Federation for Clinical Research

2023 Volume 71, Issue 6, Page(s) 613–622

Abstract: The primary aim of this study was to evaluate epidemiological characteristics and prevalence of lung disease among e-cigarettes users in the United States. A population-based, cross-sectional survey was performed using the National Health and Nutrition ... ...

Abstract	The primary aim of this study was to evaluate epidemiological characteristics and prevalence of lung disease among e-cigarettes users in the United States. A population-based, cross-sectional survey was performed using the National Health and Nutrition Examination Survey (NHANES) of 2015-2018. Adults using e-cigarettes (SMQ900), traditional smoking (SMQ020: > 100 cigarettes in lifetime or SMQ040: current cigarettes use), and dual smoking (e-cigarettes and traditional smoking) were identified and compared in their sociodemographic characteristics and prevalence of lung diseases (Asthma: MCQ010 and COPD: MCQ160O). We used the chi square test (categorical variables) and Mann-Whitney test and unpaired-student
MeSH term(s)	Adult ; Humans ; Female ; United States/epidemiology ; Child, Preschool ; Child ; Electronic Nicotine Delivery Systems ; Nutrition Surveys ; Prevalence ; Vaping/epidemiology ; Cross-Sectional Studies ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Asthma/epidemiology ; Asthma/diagnosis
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1217870-6
ISSN	1708-8267 ; 0009-9279 ; 1081-5589
ISSN (online)	1708-8267
ISSN	0009-9279 ; 1081-5589
DOI	10.1177/10815589231167357
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Zs.A 307: Show issues

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Article ; Online: Transcending the challenge of evolving resistance mechanisms in

Hujer, Andrea M / Marshall, Steven H / Mack, Andrew R / Hujer, Kristine M / Bakthavatchalam, Yamuna Devi / Umarkar, Kushal / Palwe, Snehal R / Takalkar, Swapna / Joshi, Prashant R / Shrivastava, Rahul / Periasamy, Hariharan / Bhagwat, Sachin S / Patel, Mahesh V / Veeraraghavan, Balaji / Bonomo, Robert A

mBio

2023 , Page(s) e0111823

Abstract: Multi-drug resistant (MDR) ...

Abstract	Multi-drug resistant (MDR)
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01118-23
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Article ; Online: Visible light-driven photocatalysts, quantum chemical calculations, ADMET-SAR parameters, and DNA binding studies of nickel complex of sulfadiazine.

Pandya, Sachin B / Socha, Bhavesh N / Dubey, Rahul P / Patel, Urmila H / Patel, R H / Bhatt, Bhupesh S / Thakor, Parth / Bhakhar, Sanjay / Vekariya, Nikhil / Valand, Jignesh

Scientific reports

2023 Volume 13, Issue 1, Page(s) 15275

Abstract: ... utilizing UV-Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality ...

Abstract	A 3D-supramolecular nickel integrated Ni-SDZ complex was synthesized using sodium salt of sulfadiazine as the ligand and nickel(II) acetate as the metal salt using a condensation process and slow evaporation approach to growing the single crystal. The metal complex was characterized for its composition, functional groups, surface morphology as well as complex 3D structure, by resorting to various analytical techniques. The interacting surface and stability as well as reactivity of the complex were carried out using the DFT platform. From ADMET parameters, human Intestinal Absorbance data revealed that the compound has the potential to be well absorbed, and also Ni-SDZ complex cannot cross the blood-brain barrier (BBB). Additionally, the complex's DNA binding affinity and in-vivo and in-vitro cytotoxic studies were explored utilizing UV-Vis absorbance titration, viscosity measurements, and S. pombe cells and brine shrimp lethality tests. In visible light radiation, the Ni-SDZ complex displayed exceptional photo-degradation characteristics of approximately 70.19% within 70 min against methylene blue (MB).
MeSH term(s)	Humans ; Nickel ; Sulfadiazine/pharmacology ; Light ; Methylene Blue ; DNA
Chemical Substances	Nickel (7OV03QG267) ; Sulfadiazine (0N7609K889) ; Methylene Blue (T42P99266K) ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-42668-z
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Article ; Online: Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

Yang, Moua / Chiu, Joyce / Scartelli, Christina / Ponzar, Nathan / Patel, Sachin / Patel, Anika / Ferreira, Renan B / Keyes, Robert F / Carroll, Kate S / Pozzi, Nicola / Hogg, Philip J / Smith, Brian C / Flaumenhaft, Robert

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 8, Page(s) 2137–2150

Abstract: Background: Oxidative stress contributes to thrombosis in atherosclerosis, inflammation, infection, aging, and malignancy. Oxidant-induced cysteine modifications, including sulfenylation, can act as a redox-sensitive switch that controls protein ... ...

Abstract	Background: Oxidative stress contributes to thrombosis in atherosclerosis, inflammation, infection, aging, and malignancy. Oxidant-induced cysteine modifications, including sulfenylation, can act as a redox-sensitive switch that controls protein function. Protein disulfide isomerase (PDI) is a prothrombotic enzyme with exquisitely redox-sensitive active-site cysteines. Objectives: We hypothesized that PDI is sulfenylated during oxidative stress, contributing to the prothrombotic potential of PDI. Methods: Biochemical and enzymatic assays using purified proteins, platelet and endothelial cell assays, and in vivo murine thrombosis studies were used to evaluate the role of oxidative stress in PDI sulfenylation and prothrombotic activity. Results: PDI exposure to oxidants resulted in the loss of PDI reductase activity and simultaneously promoted sulfenylated PDI generation. Following exposure to oxidants, sulfenylated PDI spontaneously converted to disulfided PDI. PDI oxidized in this manner was able to transfer disulfides to protein substrates. Inhibition of sulfenylation impaired disulfide formation by oxidants, indicating that sulfenylation is an intermediate during PDI oxidation. Agonist-induced activation of platelets and endothelium resulted in the release of sulfenylated PDI. PDI was also sulfenylated by oxidized low-density lipoprotein (oxLDL). In an in vivo model of thrombus formation, oxLDL markedly promoted platelet accumulation following an arteriolar injury. PDI oxidoreductase inhibition blocked oxLDL-mediated augmentation of thrombosis. Conclusion: PDI sulfenylation is a critical posttranslational modification that is an intermediate during disulfide PDI formation in the setting of oxidative stress. Oxidants generated by vascular cells during activation promote PDI sulfenylation, and interference with PDI during oxidative stress impairs thrombus formation.
MeSH term(s)	Animals ; Mice ; Cysteine/metabolism ; Disulfides ; Oxidants ; Oxidative Stress ; Oxidoreductases/metabolism ; Protein Disulfide-Isomerases/metabolism ; Thrombosis/metabolism
Chemical Substances	Cysteine (K848JZ4886) ; Disulfides ; Oxidants ; Oxidoreductases (EC 1.-) ; Protein Disulfide-Isomerases (EC 5.3.4.1)
Language	English
Publishing date	2023-04-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.03.034
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 295: Show issues

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Article ; Online: Alcohol and Cannabinoids - From the Editors.

Metrik, Jane / Patel, Sachin

Alcohol research : current reviews

2022 Volume 42, Issue 1, Page(s) 10

MeSH term(s)	Accidents, Traffic ; Cannabinoids/adverse effects ; Ethanol ; Humans
Chemical Substances	Cannabinoids ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2677485-9
ISSN	2169-4796 ; 1930-0573 ; 2168-3492 ; 0090-838X
ISSN (online)	2169-4796 ; 1930-0573
ISSN	2168-3492 ; 0090-838X
DOI	10.35946/arcr.v42.1.10
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