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  1. Article ; Online: Generation of Radioresistant Prostate Cancer Cells.

    Marignol, Laure

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2645, Page(s) 129–138

    Abstract: The development of in vitro isogenic models of radioresistance through exposure to fractionated radiation is an increasingly used approach to investigate the mechanisms of radioresistance in cancer cells. Owing to the complex nature of the biological ... ...

    Abstract The development of in vitro isogenic models of radioresistance through exposure to fractionated radiation is an increasingly used approach to investigate the mechanisms of radioresistance in cancer cells. Owing to the complex nature of the biological effect of ionizing radiation, the generation and validation of these models requires the careful consideration of radiation exposure protocols and cellular endpoints. This chapter presents a protocol we used to derive and characterize an isogenic model of radioresistant prostate cancer cells. This protocol may be applicable to other cancer cell lines.
    MeSH term(s) Male ; Humans ; Radiation Tolerance ; Cell Line, Tumor ; Prostatic Neoplasms/radiotherapy ; Radiation, Ionizing
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3056-3_5
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  2. Article ; Online: Prehabilitation for Patients with Cancer Undergoing Radiation Therapy: a Scoping Review.

    Harris, E / Marignol, L

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2024  Volume 36, Issue 4, Page(s) 254–264

    Abstract: Aims: Prehabilitation is a process of identifying and assessing factors that could compromise the physical and psychological health of patients undergoing cancer treatment and implementing an intervention to combat such concerns. The use of ... ...

    Abstract Aims: Prehabilitation is a process of identifying and assessing factors that could compromise the physical and psychological health of patients undergoing cancer treatment and implementing an intervention to combat such concerns. The use of prehabilitation in cancer surgery has yielded positive outcomes in rectal, lung and abdominal cancers. Prehabilitation strategies have potential to improve the management of patients receiving radiation therapy or chemoradiation. The aim of the present study was to map the evidence of the assessment and evaluation of prehabilitation for radiation therapy patients.
    Materials and methods: A database search using EMBASE and PubMed was conducted. The PRISMA guidelines were adhered to. Keywords included prehabilitation, radiation therapy/radiotherapy, chemoradiotherapy/chemoradiation, intervention and exercise. Types of prehabilitation strategy, their purposes and impact, according to cancer site, were analysed.
    Results: Prehabilitation is most commonly evaluated in head and neck cancer, whereby unimodal, physical interventions manage dysphagia. Prehabilitation for lung cancer demonstrated its ability to widen treatment options for patients. Physical prehabilitation is administered to combat adverse effects of neoadjuvant chemoradiation therapy in patients with rectal cancer.
    Conclusion: Prehabilitation is adaptive and tailored to specific patient and site needs; thus it is applied across a wide range of cancer sites. More interventions by which radiation therapy is the definitive treatment modality and larger sample sizes within these studies are warranted to increase prehabilitation utilisation for patients undergoing radiation therapy.
    MeSH term(s) Humans ; Head and Neck Neoplasms/therapy ; Preoperative Care ; Preoperative Exercise ; Rectal Neoplasms/therapy ; Lung Neoplasms/therapy
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2024.02.002
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    Zs.A 2774: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Investigating the Needs and Concerns of Lesbian, Gay, Bisexual, Transgender, Queer, or Questioning Cancer Patients.

    Zazzera, S K / Poole, C / Marignol, L

    Journal of homosexuality

    2024  , Page(s) 1–29

    Abstract: The needs and concerns of lesbian, gay, bisexual, transgender, queer, or questioning (LGBTQ+) patients with cancer remain poorly understood. This is important as LGBTQ+ patients have an elevated risk of developing certain cancers and have poorer ... ...

    Abstract The needs and concerns of lesbian, gay, bisexual, transgender, queer, or questioning (LGBTQ+) patients with cancer remain poorly understood. This is important as LGBTQ+ patients have an elevated risk of developing certain cancers and have poorer oncologic outcomes compared to non-LGBTQ+ patients. The lack of research may be linked to the complexity of studying the needs and concerns of this patient population. This review aimed to describe the evidence that sought to identify the needs and concerns of LGBTQ+ cancer patients. Studies were extracted using keywords such as "LGBTQ" and "Oncology." Patient participants were excluded if they did not identify as LGBTQ+ and if they did not have cancer or were not cancer survivors. Healthcare professionals were excluded if they were not oncology specific. A total of 22 studies met our inclusion criteria. LGBTQ+ cancer patients expressed concerns surrounding heteronormative assumptions made by healthcare professionals, a lack of LGBTQ±specific cancer support groups, and psychosexual concerns such as erectile dysfunction following cancer treatment. Oncology healthcare professionals lacked the knowledge and education that are required to manage this patient cohort. Further research is required to investigate the needs and concerns of LGBTQ+ cancer patients specifically in the radiation oncology setting.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193138-6
    ISSN 1540-3602 ; 0091-8369
    ISSN (online) 1540-3602
    ISSN 0091-8369
    DOI 10.1080/00918369.2024.2321240
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    Zs.A 1141: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: In silico analysis of overall survival with YBX1 in male and female solid tumours.

    Grimes, David Robert / Rassamegevanon, Treewut / Marignol, Laure

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7218

    Abstract: The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are ... ...

    Abstract The Y-box binding protein-1 (YBX1) gene codes for a multifunctional oncoprotein that is increasingly being linked to the regulations of many aspects of cancer cell biology. Disparities in treatment outcomes between male and female cancer patients are increasingly reported. This study aimed to examine the relationship between YBX1 expression and overall survival in male and female patients with solid tumours. Overall survival and YBX1 expression data for cohorts of male and female cancer patients obtained from freely available databases were analysed with a cox proportional hazard model with covariates of biological sex and YBX1 expression. Kaplan-Meier curves and Violin plots were constructed for segregated male and female cohorts. High YBX1 expression was significantly associated with poor survival in 2 female-only and 4 mixed-sex cancer sites. In female lung cancer patients, better survival and lower YBX1 expression were identified. The clinical importance of YBX1 expression in cancer ought to be evaluated in a sex-specific manner, especially in lung cancer.
    MeSH term(s) Humans ; Male ; Female ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Y-Box-Binding Protein 1/genetics ; Y-Box-Binding Protein 1/metabolism ; Gene Expression Regulation, Neoplastic ; Cell Proliferation
    Chemical Substances Y-Box-Binding Protein 1 ; YBX1 protein, human
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57771-y
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  5. Article ; Online: Predicting Treatment Outcomes: The Case for Hypoxia Gene Signatures.

    Marignol, Laure

    EBioMedicine

    2018  Volume 32, Page(s) 3–4

    MeSH term(s) Gene Expression Regulation, Neoplastic ; Humans ; Male ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy ; Transcriptome ; Treatment Outcome ; Tumor Hypoxia/genetics
    Language English
    Publishing date 2018-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2018.05.016
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    Zs.A 7090: Show issues Location:
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  6. Article ; Online: Pro-con of proton: Dosimetric advantages of intensity-modulation over passive scatter for thoracic malignancies.

    Jie, Ang Wei / Marignol, Laure

    Technical innovations & patient support in radiation oncology

    2020  Volume 15, Page(s) 37–46

    Abstract: The use of passively scattered proton therapy (PSPT) or intensity modulated proton therapy (IMPT) opens the potential for dose escalation or critical structure sparing in thoracic malignancies. While the latter offers greater dose conformality, dose ... ...

    Abstract The use of passively scattered proton therapy (PSPT) or intensity modulated proton therapy (IMPT) opens the potential for dose escalation or critical structure sparing in thoracic malignancies. While the latter offers greater dose conformality, dose distributions are subjected to greater uncertainties, especially due to interplay effects. Exploration in this area is warranted to determine if there is any dosimetric advantages in using IMPT for thoracic malignancies. This review aims to both compare organs-at-risk sparing and plan robustness between PSPT and IMPT and examine the mitigation strategies for the reduction of interplay effects currently available. Early evidence suggests that IMPT is dosimetrically superior to PSPT in thoracic malignancies. Randomised control trials are required before any clinical benefit of IMPT can be confirmed.
    Language English
    Publishing date 2020-09-07
    Publishing country England
    Document type Journal Article
    ISSN 2405-6324
    ISSN (online) 2405-6324
    DOI 10.1016/j.tipsro.2019.11.005
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  7. Article ; Online: The radiotherapy cancer patient: female inclusive, but male dominated.

    Meunier, Armelle / Marignol, Laure

    International journal of radiation biology

    2020  Volume 96, Issue 7, Page(s) 851–856

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Clinical Trials as Topic ; Female ; Humans ; Male ; Neoplasms/radiotherapy ; Sex Distribution
    Language English
    Publishing date 2020-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2020.1741720
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    Ue I Zs.280: Show issues Location:
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  8. Article ; Online: Targeting notch in prostate cancer--combination is the key.

    Marignol, Laure

    Nature reviews. Urology

    2014  Volume 11, Issue 7, Page(s) 419

    MeSH term(s) Animals ; Humans ; Male ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Receptors, Notch/physiology ; Signal Transduction/physiology
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2014-07-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/nrurol.2013.110-c3
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    Zs.A 6030: Show issues Location:
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  9. Article ; Online: In vitro and in vivo characterization of [

    Liu, Tengzhi / Dahle, Maria Aanesland / Lystad, Mathilde Hirsum / Marignol, Laure / Karlsen, Morten / Redalen, Kathrine Røe

    European journal of nuclear medicine and molecular imaging

    2023  Volume 50, Issue 12, Page(s) 3576–3588

    Abstract: Purpose: Hypoxic tumors are associated with therapy resistance and poor cancer prognosis, but methods to detect and counter tumor hypoxia remain insufficient. Our purpose was to investigate : Methods: Cu-64 was produced using a biomedical cyclotron ... ...

    Abstract Purpose: Hypoxic tumors are associated with therapy resistance and poor cancer prognosis, but methods to detect and counter tumor hypoxia remain insufficient. Our purpose was to investigate
    Methods: Cu-64 was produced using a biomedical cyclotron at 12 MeV with the reaction
    Results: In vitro and in vivo studies demonstrated that [
    Conclusion: To the best of our knowledge, this is the first time that ES is radiolabeled with [
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-023-06310-4
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    Zs.A 1227: Show issues Location:
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  10. Article ; Online: Influence of inter-observer delineation variability on radiomic features of the parotid gland.

    Forde, E / Leech, M / Robert, C / Herron, E / Marignol, L

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2021  Volume 82, Page(s) 240–248

    Abstract: Purpose: This study aimed to quantify the variability in the values of radiomic features extracted from a right parotid gland (RPG) delineated by a series of independent observers.: Methods: This was a secondary analysis of anonymous data from a ... ...

    Abstract Purpose: This study aimed to quantify the variability in the values of radiomic features extracted from a right parotid gland (RPG) delineated by a series of independent observers.
    Methods: This was a secondary analysis of anonymous data from a delineation workshop. Inter-observer variability of the RPG from 40 participants was quantified using DICE similarity coefficient (DSC) and Hausdorff distance (HD). An additional contour was generated using Varian SmartSegmentation. Radiomic features extracted include four shape features, six histogram features, and 32 texture features. The absolute mean paired percentage difference (PPD) in feature values from the expert and participants were ranked . Feature robustness was classified using pre- determined thresholds.
    Results: 63% of participants achieved a DSC > 0.7, the auto- segmentation DSC was 0.76. The average HD for the participants was 16.16 mm ± 0.66 mm, and 15.16 mm for the auto-segmentation. 48% (n = 20) and 33% (n = 14) of features were deemed to be robust with a mean absolute PPD < 5%, for the auto-segmentation and manual delineations respectively; the majority of which were from the grey-run length matrix family. 7% (n = 3) of features from the auto- segmentation and 10% (n = 4) from the manual contours were deemed to be unstable with a mean absolute PPD > 50%. The value of the most robust feature was not related to DSC and HD.
    Conclusion: Inter-observer delineation variability affects the value of the radiomic features extracted from the RPG. This study identifies the radiomic features least sensitive to these uncertainties. Further investigation of the clinical relevance of these features in prediction of xerostomia is warranted.
    MeSH term(s) Humans ; Observer Variation ; Parotid Gland/diagnostic imaging
    Language English
    Publishing date 2021-03-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2021.01.084
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