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  1. Article: Acidified sodium chlorite solution: A potential prophylaxis to mitigate impact of multiple exposures to COVID-19 in frontline health-care providers.

    Karnik-Henry, Meghana S

    Hospital practice (1995)

    2020  Volume 48, Issue 4, Page(s) 165–168

    Abstract: Limited availability of personal protective equipment is endangering first-line health-care providers treating patients with presumed or confirmed COVID-19 infections. This editorial has multiple objectives in regard to this reality: First, to raise ... ...

    Abstract Limited availability of personal protective equipment is endangering first-line health-care providers treating patients with presumed or confirmed COVID-19 infections. This editorial has multiple objectives in regard to this reality: First, to raise awareness of the need for safe and effective prophylaxis to protect health-care providers with insufficient personal protective equipment from repeated exposures to COVID-19. Second, to summarize the scientific evidence in support of solutions of acidified sodium chlorite (ASC) and its daughter compounds, chlorous acid and chlorine dioxide, as potential targets for said prophylactic use. Third, to propose a regimented protocol using commercially available solutions of ASC having sufficient concentrations of chlorine dioxide for virucidal activity to support safe and effective prophylactic use. And fourth, to raise awareness of and compare other potential prophylactic options currently under investigation.
    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Chlorides/administration & dosage ; Chlorides/chemistry ; Chlorides/pharmacology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Drug Tolerance ; Humans ; Medical Staff, Hospital ; Pandemics ; Pneumonia, Viral/transmission ; Pre-Exposure Prophylaxis/standards ; SARS-CoV-2
    Chemical Substances Chlorides
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Editorial
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.1080/21548331.2020.1778908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acidified sodium chlorite solution

    Karnik-Henry, Meghana S.

    Hospital Practice

    A potential prophylaxis to mitigate impact of multiple exposures to COVID-19 in frontline health-care providers

    2020  , Page(s) 1–4

    Keywords General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.1080/21548331.2020.1778908
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Acidified sodium chlorite solution: A potential prophylaxis to mitigate impact of multiple exposures to COVID-19 in frontline health-care providers

    Karnik-Henry, Meghana S

    Hosp Pract (1995)

    Abstract: Limited availability of personal protective equipment is endangering first-line health-care providers treating patients with presumed or confirmed COVID-19 infections. This editorial has multiple objectives in regard to this reality: First, to raise ... ...

    Abstract Limited availability of personal protective equipment is endangering first-line health-care providers treating patients with presumed or confirmed COVID-19 infections. This editorial has multiple objectives in regard to this reality: First, to raise awareness of the need for safe and effective prophylaxis to protect health-care providers with insufficient personal protective equipment from repeated exposures to COVID-19. Second, to summarize the scientific evidence in support of solutions of acidified sodium chlorite (ASC) and its daughter compounds, chlorous acid and chlorine dioxide, as potential targets for said prophylactic use. Third, to propose a regimented protocol using commercially available solutions of ASC having sufficient concentrations of chlorine dioxide for virucidal activity to support safe and effective prophylactic use. And fourth, to raise awareness of and compare other potential prophylactic options currently under investigation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #526932
    Database COVID19

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  4. Article ; Online: Early clinical experience with eptinezumab: results of a retrospective observational study of patient response in the United States.

    Starling, Amaal J / Kymes, Steven / Asher, Divya / Soni-Brahmbhatt, Seema / Karnik-Henry, Meghana

    BMC neurology

    2023  Volume 23, Issue 1, Page(s) 158

    Abstract: Background: The efficacy and safety of eptinezumab for preventive migraine treatment in adults have been demonstrated in multiple, large-scale clinical trials. This non-interventional, retrospective, observational chart review was conducted to examine ... ...

    Abstract Background: The efficacy and safety of eptinezumab for preventive migraine treatment in adults have been demonstrated in multiple, large-scale clinical trials. This non-interventional, retrospective, observational chart review was conducted to examine patient response to eptinezumab 100 mg or 300 mg every 12 weeks for 6 months in the clinical setting.
    Methods: Eight headache specialists who reported early clinical experience with eptinezumab enrolled the first adults (1-6 adults per clinician; age ≥ 18 years) who met predefined selection criteria (including ≥ 12-month history of migraine, ≥ 4 migraine days/month prior to eptinezumab initiation, receipt of ≥ 2 consecutive eptinezumab doses, and ≥ 12-week follow-up period), and provided detailed patient, disease, treatment, and outcome information via SurveyMonkey and standardized case-report forms.
    Results: Charts from 31 adults (median age, 49 years) with migraine (93.6% chronic) who received eptinezumab for the preventive treatment of migraine were reviewed. Most patients (26/31 [83.9%]) were initiated at 100 mg. Eptinezumab reduced mean headache frequency (24.3 monthly headache days [MHDs] at baseline; 17.1 MHDs at Month 6); mean migraine frequency (17.3 monthly migraine days [MMDs] at baseline; 9.1 MMDs at Month 6); attack severity (17/31 [54.8%] patients); acute headache medication use (12.5 acute medication days at baseline; 7.4 at Month 6); and patient-reported disability (11/22 [50.0%] severe at baseline; 7/19 [36.8%] at Month 6). More than three-quarters of patients (24/31 [77.4%]) perceived improved disability/function and most (30/31 [96.8%]) perceived eptinezumab to be well tolerated after 6 months. Most of the headache specialists reported that eptinezumab was well tolerated by patients (30/31 [96.8%]) and that the intravenous infusion experience was not challenging.
    Conclusions: Patients with migraine who received 6 months of preventive treatment with eptinezumab experienced reductions in migraine and headache frequency, disability, and acute medication use during the course of treatment.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Middle Aged ; Adolescent ; Retrospective Studies ; Treatment Outcome ; Double-Blind Method ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Headache/drug therapy ; Headache/epidemiology
    Chemical Substances eptinezumab (8202AY8I7H)
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-023-03204-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterization of the changes in supine blood pressure with long-term use of droxidopa in patients with neurogenic orthostatic hypotension.

    Hewitt, L Arthur / Lindsten, Annika / Gorny, Stephen / Karnik-Henry, Meghana / Kymes, Steven / Favit, Antonella

    Health science reports

    2021  Volume 4, Issue 1, Page(s) e227

    Abstract: Background and aims: Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] ≥140 mmHg). Because pressor agents used to improve nOH ... ...

    Abstract Background and aims: Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] ≥140 mmHg). Because pressor agents used to improve nOH symptoms by increasing standing blood pressure (BP) may exacerbate or cause supine hypertension, changes in supine BP with nOH treatments are of interest.
    Methods: This post hoc study examined changes in SBP in patients receiving droxidopa (100-600 mg, three times daily) during a 12-month long-term extension study based on whether patients had supine hypertension (ie, supine SBP ≥140 mmHg) at baseline. Shifts from baseline in supine hypertension categorization and mean supine and standing SBP after 6 and 12 months of treatment with droxidopa were determined.
    Results: At baseline, 64 patients did not have supine hypertension (mean supine SBP, 120 mmHg) and 38 patients had supine hypertension (mean supine SBP, 157 mmHg). A similar percentage of patients shifted from their respective baseline supine hypertension categorization (ie, with or without supine hypertension) to the other category after receiving droxidopa for 6 or 12 months. After 12 months of droxidopa treatment, patients with supine hypertension at baseline had a mean supine SBP decrease of 3 mmHg and a mean standing SBP increase of 9 mmHg. Patients without supine hypertension at baseline had mean supine and standing SBP increases of 12 and 15 mmHg, respectively.
    Conclusions: There was no consistent or progressive elevation in supine SBP over time during the 12-month treatment with droxidopa in patients either with or without supine hypertension at baseline. These data suggest that long-term droxidopa treatment for nOH does not adversely affect supine BP.
    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.227
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  6. Article ; Online: Patient preferences for attributes of injected or infused preventive migraine medications: Findings from a discrete choice experiment.

    Schwedt, Todd J / Martin, Ashley / Kymes, Steven / Talon, Brian / Lee, Xin Ying / Cady, Roger / Asher, Divya / Karnik-Henry, Meghana / Mulvihill, Emily / Bates, Dawn / Beusterien, Kathleen

    Headache

    2023  Volume 63, Issue 4, Page(s) 484–493

    Abstract: Objective: To assess preferences among adults with migraine for differentiating attributes of injected or infused preventive treatment options and evaluate their importance in determining a treatment choice.: Background: Adults with migraine and ... ...

    Abstract Objective: To assess preferences among adults with migraine for differentiating attributes of injected or infused preventive treatment options and evaluate their importance in determining a treatment choice.
    Background: Adults with migraine and health-care providers consider many factors when making treatment decisions. Injected or infused preventive migraine treatment options differ in several attributes, including mode of administration and dosing frequency, which may be preferentially selected or avoided by patients. Understanding a patient's preference is important for clinicians as they advise on various treatment options.
    Methods: A total of 604 US adults diagnosed with migraine participated in an online survey that captured information on demographics, migraine history, and treatment preferences. A discrete choice experiment (DCE) was used to evaluate participants' preferences for specific attributes of injected/infused preventive migraine therapies. The DCE data were utilized to estimate attribute importance (expressed as a percentage) and identify subgroups that had different distributions of preferences.
    Results: In the overall migraine population, mode of administration (28.8%), durability of effectiveness (27.0%), and speed of onset (25.5%) had the highest relative importance, whereas administration setting (9.9%) and dosing frequency (8.8%) had the lowest. Four distinct subgroups were identified: Group 1 (n = 128) preferred self-injection administration and durability of effectiveness; Group 2 (n = 189) expressed aversion to cranial injections; Group 3 (n = 158) prioritized rapid speed of onset; and Group 4 (n = 129) favored health-care provider administration and durability of effectiveness.
    Conclusions: Speed of onset, durability of effectiveness, and mode of administration are key moderators of treatment preference among US adults with migraine. Certain segments of the migraine population prioritize specific treatment attributes over others, with intravenous infusion not considered a barrier in three of four identified segments. Clinicians can best help their patients find the right medication if they understand which medication attributes are most and least important to them.
    MeSH term(s) Adult ; Humans ; Patient Preference ; Choice Behavior ; Decision Making ; Injections ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
    DOI 10.1111/head.14476
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    Zs.B 539: Show issues Location:
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  7. Article ; Online: Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings.

    Karnik-Henry, Meghana S / Wang, Lei / Barch, Deanna M / Harms, Michael P / Campanella, Carolina / Csernansky, John G

    Schizophrenia research

    2012  Volume 138, Issue 2-3, Page(s) 128–135

    Abstract: Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies suggest that individuals with schizophrenia have deficits in episodic memory as well as structural abnormalities of the medial temporal lobe (MTL). While ... ...

    Abstract Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies suggest that individuals with schizophrenia have deficits in episodic memory as well as structural abnormalities of the medial temporal lobe (MTL). While correlations have been reported between MTL volume loss and episodic memory deficits in such individuals, it is not clear whether such correlations reflect the influence of the disease state or of underlying genetic influences that might contribute to risk. We used high resolution magnetic resonance imaging and probabilistic algorithms for image analysis to determine whether MTL structure, episodic memory performance and the relationship between the two differed among groups of 47 healthy control subjects, 50 control siblings, 39 schizophrenia subjects, and 33 siblings of schizophrenia subjects. High-dimensional large deformation brain mapping was used to obtain volume measures of the hippocampus. Cortical distance mapping was used to obtain volume and thickness measures of the parahippocampal gyrus (PHG) and its substructures: the entorhinal cortex (ERC), the perirhinal cortex (PRC), and the parahippocampal cortex (PHC). Neuropsychological data was used to establish an episodic memory domain score for each subject. Both schizophrenia subjects and their siblings displayed abnormalities in episodic memory performance. Siblings of individuals with schizophrenia, and to a lesser extent, individuals with schizophrenia themselves, displayed abnormalities in measures of MTL structure (volume loss or cortical thinning) as compared to control groups. Further, we observed correlations between structural measures and memory performance in both schizophrenia subjects and their siblings, but not in their respective control groups. These findings suggest that disease-specific genetic factors present in both patients and their relatives may be responsible for correlated abnormalities of MTL structure and memory impairment. The observed attenuated effect of such factors on MTL structure in individuals with schizophrenia may be due to non-genetic influences related to the development and progression of the disease on global brain structure and cognitive processing.
    MeSH term(s) Adolescent ; Adult ; Case-Control Studies ; Female ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Memory Disorders/pathology ; Memory Disorders/physiopathology ; Memory, Episodic ; Neuropsychological Tests ; Organ Size ; Parahippocampal Gyrus/pathology ; Parahippocampal Gyrus/physiopathology ; Psychotic Disorders/genetics ; Psychotic Disorders/pathology ; Schizophrenia/genetics ; Schizophrenia/pathology ; Schizophrenia/physiopathology ; Siblings ; Temporal Lobe/pathology ; Temporal Lobe/physiopathology
    Language English
    Publishing date 2012-04-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2012.03.015
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