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Article: Pefloxacin.

Bergogne-Bérézin, E

International journal of antimicrobial agents

2008 Volume 1, Issue 1, Page(s) 29–46

Language	English
Publishing date	2008-05-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/0924-8579(91)90020-e
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Article: Interpretation of pharmacologic data in respiratory tract infections.

Bergogne-Bérézin, E

International journal of antimicrobial agents

2008 Volume 3 Suppl 1, Page(s) S3–S14

Abstract: Few serum pharmacokinetic parameters of antibiotics are predictors of tissue distribution and, for instance, more useful are studies of tissue concentrations in the respiratory tree. Significant antibiotic concentrations can be obtained at various sites ... ...

Abstract	Few serum pharmacokinetic parameters of antibiotics are predictors of tissue distribution and, for instance, more useful are studies of tissue concentrations in the respiratory tree. Significant antibiotic concentrations can be obtained at various sites of potential infection: lung parenchyma; alveolar macrophages; and bronchial mucosa and secretions. New models using broncho-alveolar lavage allow studies of antibiotic concentrations in epithelial lining fluid that are good predictors of antibiotic activity in lung infections. In studies in human respiratory tissues for superinfected bronchitis, concentrations of macrolides, quinolones or beta-lactans in bronchial secretions, or mucosa, correlated with satisfactory clinical response, and eradication of pathogens. Pulmonary kinetics of aminoglycosides or beta-lactams have been studied using a canine model. Also in murine models of pneumonia, pharmacokinetic parameters have been determined for quinolones and newer macrolides.
Language	English
Publishing date	2008-05-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/0924-8579(93)90030-9
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Article: Infections urinaires basses: épidémiologie bactérienne et recommandations.

Bergogne-Bérézin, Eugénie

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2008 Volume 18, Issue 1 Suppl FMC, Page(s) F11–4

Abstract: ... To analyze elements in presence i.e. infecting bacteria and antibiotics still active or identification ...

Title translation	Lower urinary tract infections: bacterial epidemiology and recommendations.
Abstract	Lower urinary tract infection remains frequent particularly in women, despite improvement in therapeutic means. It seems likely to revisit bacterial epidemiology and therapeutic available strategies. To analyze elements in presence i.e. infecting bacteria and antibiotics still active or identification of acquired resistance mechanisms should permit to establish the evolution during the last 10 years. The study shows that bacterial epidemiology in urinary tract infection has not changed significantly, despite antibiotic selective pressure expected from overused antibiotics. However few enterobacteriaceae more resistant than Escherichia coli have emerged, but the latter remains predominant. Development of resistance has concerned Negram, amoxicillin and Augmentin, but several active molecules such as ciprofloxacin, Monuril remain available. Duration of treatments are still discussed but there is a tend toward short durations and even mono-doses. The control of lower urinary tract infections remains relatively easy provided that a good therapeutic choice is based on well documented bacteriologic data (infecting species susceptible to the available antibiotics).
MeSH term(s)	Amoxicillin/administration & dosage ; Amoxicillin/pharmacology ; Amoxicillin/therapeutic use ; Amoxicillin-Potassium Clavulanate Combination/administration & dosage ; Amoxicillin-Potassium Clavulanate Combination/pharmacology ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/therapeutic use ; Ciprofloxacin/administration & dosage ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Drug Resistance, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Escherichia coli Infections/drug therapy ; Female ; Fosfomycin/administration & dosage ; Fosfomycin/pharmacology ; Fosfomycin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Male ; Microbial Sensitivity Tests ; Proteus Infections/drug therapy ; Proteus mirabilis/drug effects ; Time Factors ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Fosfomycin (2N81MY12TE) ; Ciprofloxacin (5E8K9I0O4U) ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Amoxicillin (804826J2HU)
Language	French
Publishing date	2008-02
Publishing country	France
Document type	Comparative Study ; English Abstract ; Journal Article ; Review
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Zs.A 3959: Show issues

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Article: The Increasing Role of Acinetobacter Species As Nosocomial Pathogens.

Bergogne-Bérézin, Eugénie

Current infectious disease reports

2007 Volume 3, Issue 5, Page(s) 440–444

Abstract: Among gram-negative organisms playing a significant role in nosocomial infections, Acinetobacter species have attracted increasing attention in intensive care units during the past two decades. Acinetobacter species are implicated in a wide spectrum of ... ...

Abstract	Among gram-negative organisms playing a significant role in nosocomial infections, Acinetobacter species have attracted increasing attention in intensive care units during the past two decades. Acinetobacter species are implicated in a wide spectrum of infections (eg, bacteremia, nosocomial pneumonia, urinary tract infections, secondary meningitis, superinfections in burn patients). One of the most striking features of Acinetobacter species is their extraordinary ability to develop multiple resistance mechanisms against major antibiotic classes. They have become resistant to broad-spectrum beta-lactams (third-generation cephalosporins, carboxypenicillins, and increasingly to carbapenems); they produce a wide range of aminoglycoside-inactivating enzymes; and most strains are resistant to fluoroquinolones. In Acinetobacter nosocomial infections, the major problems confronting clinicians in intensive care units are related to the severity of Acinetobacter nosocomial infections and to resistance to major antibiotic classes of these organisms.
Language	English
Publishing date	2007-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
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Article ; Online: Treatment of Acinetobacter infections.

Bergogne-Bérézin, E

Expert opinion on investigational drugs

2005 Volume 6, Issue 2, Page(s) 119–127

Abstract: Gram-negative non-fermentative aerobic bacilli are becoming increasingly more involved in nosocomial infections. It has generally been recognised that the members of the Acinetobacter genus are among the most common agents responsible for severe hospital ...

Abstract	Gram-negative non-fermentative aerobic bacilli are becoming increasingly more involved in nosocomial infections. It has generally been recognised that the members of the Acinetobacter genus are among the most common agents responsible for severe hospital infections; their clinical importance has increased due to the development of antibacterial resistance mechanisms by these organisms. Over the last two decades the antibacterial armamentarium has progressed significantly and newer broad spectrum antibiotics have been used during therapy of hospital infections due to drug-resistant Acinetobacter spp. Despite various mechanisms of resistance to beta-lactams, aminoglycosides, fluoroquinolones developed by these organisms, the control of Acinetobacter infections can be effected by the use of several antibiotic combinations in 'conventional' antibiotic therapy. Recent surveys have pointed out the importance of using combinations of 2-amino-5-thiazolyl cephalosporins, or imipenem with aminoglycosides, or alpha-carboxy- penicillins (ticarcillin) combined with beta-lactamase inhibitors. Amongst the latter drugs, the place of sulbactam should be redefined thanks to its intrinsic activity against the Acinetobacter species, associated with its inhibitory power against beta-lactamases. The fluoroquinolones were initially very active against Acinetobacter infections, but resistance to this major class of drugs has occurred very rapidly. However, newer compounds of this class with increased anti-Acinetobacter activities can be used in combinations with beta-lactams or aminoglycosides. The potential role of rifampicin is still underestimated for the treatment of Acinetobacter infections despite promising in vitro activity. Novel derivatives of cephalosporins, carbapenems, fluoroquinolones, or completely new antibiotic classes, of which several investigational drugs seem promising, may constitute the future of antibiotic therapy and hence the treatment of Acinetobacter infections.
Language	English
Publishing date	2005-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1517/13543784.6.2.119
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Article: Après l'ère des antibiotiques, l'ère de la résistance.

Bergogne-Bérézin, E

Presse medicale (Paris, France : 1983)

2004 Volume 33, Issue 12 Pt 1, Page(s) 772–774

Title translation	After the "era of antibiotics", the "era of resistance".
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Communication ; Drug Resistance, Microbial ; Humans ; Practice Patterns, Physicians'
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2004-08-15
Publishing country	France
Document type	Editorial
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
DOI	10.1016/s0755-4982(04)98741-6
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Article: Comment améliorer la prescription des antibiotiques?

Bergogne-Bérézin, Eugénie

Presse medicale (Paris, France : 1983)

2004 Volume 33, Issue 13, Page(s) 896–901

Title translation	How can we improve the prescription of antibiotics?.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Microbial ; Humans ; Population Surveillance ; Practice Patterns, Physicians'
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2004-09-08
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
DOI	10.1016/s0755-4982(04)98780-5
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Article: Innovations pharmacologiques, le modèle des fluoroquinolones.

Bergogne-Bérézin, E

Presse medicale (Paris, France : 1983)

2003 Volume 32, Issue 10, Page(s) 466–469

Abstract: Objectives: Like all the disciplines involved in infectious diseases and antibiotic therapy, pharmacokinetics and pharmacodynamics (PK/PD) of antibiotics have evolved significantly. They include new investigation procedures like in vitro models and new ... ...

Title translation	Pharmacologic innovations, the fluoroquinolone model.
Abstract	Objectives: Like all the disciplines involved in infectious diseases and antibiotic therapy, pharmacokinetics and pharmacodynamics (PK/PD) of antibiotics have evolved significantly. They include new investigation procedures like in vitro models and new animal models. There is a current trend towards better methods, newer definitions and improved quality of research in this particular field. Definitions: The current evolution of pharmacology of antibiotics is mainly characterized by the development of pharmacodynamics (PD) which offers the advantage of including microbiology data. New PD parameters have been defined. It is recommended to working groups involved in PK/PD research to compare their results and tend to a consensus on the methods to be used. Conclusion: Benefiting from such progress, preclinical phases of PK/PD studies of new molecules as well as revision of older antibiotics permit a rigorous and clinical approach to the use of antibiotics.
MeSH term(s)	Animals ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/pharmacokinetics ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Fluoroquinolones ; Humans ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Treatment Outcome
Chemical Substances	Anti-Infective Agents ; Fluoroquinolones
Language	French
Publishing date	2003-03-15
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
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Article: Pharmacodynamics of antibiotics in the respiratory tree.

Bergogne-Bérézin, Eugénie

Expert opinion on pharmacotherapy

2003 Volume 5, Issue 1, Page(s) 15–23

Abstract: For an antibiotic to be active in vivo, the concept of high tissue concentrations at infected sites has been popular for a long time, but has recently been criticised. The measurement of antibiotic tissue levels in humans is restricted by ethical issues, ...

Abstract	For an antibiotic to be active in vivo, the concept of high tissue concentrations at infected sites has been popular for a long time, but has recently been criticised. The measurement of antibiotic tissue levels in humans is restricted by ethical issues, the cost of investigations and doubtful clinical significance. In the respiratory tree (RT), antibiotic concentrations have been studied. It has been shown that the antibiotic concentrations in both the lung tissue and fluids are related to three factors: the frequency of community and severe hospital respiratory infections; the wide prescription of antibiotics in cases of respiratory infections; and the easy access of sampling different areas of the RT. Due to the controversial perception of these studies, new pharmacological approaches have been developed using animal models, in vitro simulation of antibiotic kinetics in human serum and the involvement of pathogens, thus resulting in new pharmacodynamic parameters. This review looks at the concepts in antibiotic concentrations and the pharmacodynamics of the RT.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Bacterial Infections/drug therapy ; Bacterial Infections/metabolism ; Bacterial Infections/physiopathology ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/metabolism ; Community-Acquired Infections/physiopathology ; Cross Infection/drug therapy ; Cross Infection/metabolism ; Cross Infection/physiopathology ; Humans ; Models, Biological ; Respiratory System/metabolism ; Respiratory System/microbiology ; Respiratory System/physiopathology ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/metabolism ; Respiratory Tract Infections/physiopathology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2003-11-05
Publishing country	England
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1465-6566
ISSN	1465-6566
DOI	10.1517/14656566.5.1.15
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Zs.A 5130: Show issues

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Article: Anti-infectieux et résistances bactériennes, surveiller, vaincre ou contourner les résistances?

Bergogne-Bérézin, E

Presse medicale (Paris, France : 1983)

2002 Volume 31, Issue 38, Page(s) 1779

Title translation	Anti-infective agents and bacterial resistance, monitor, eradicate or avoid resistance?.
MeSH term(s)	Anti-Infective Agents/pharmacology ; Drug Resistance, Microbial ; Evidence-Based Medicine ; Global Health ; Humans ; Population Surveillance ; Practice Patterns, Physicians'
Chemical Substances	Anti-Infective Agents
Language	French
Publishing date	2002-11-30
Publishing country	France
Document type	Editorial
ZDB-ID	120943-7
ISSN	2213-0276 ; 0755-4982 ; 0032-7867 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0755-4982 ; 0032-7867 ; 0301-1518
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