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  1. Article ; Online: Enough Talk, the Time Is Now for Gender Parity of Anesthesiology Journals' Editorial Boards.

    Dunn, Lauren K / Wong, Cynthia A

    Anesthesia and analgesia

    2022  Volume 134, Issue 5, Page(s) 952–955

    MeSH term(s) Anesthesiology ; Humans ; Periodicals as Topic ; Physicians, Women
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005938
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  2. Article ; Online: Pro-Con Debate: Role of Methadone in Enhanced Recovery After Surgery Protocols-Superior Analgesic or Harmful Drug?

    D'Souza, Ryan S / Esfahani, Kamilla / Dunn, Lauren K

    Anesthesia and analgesia

    2023  Volume 137, Issue 1, Page(s) 76–82

    Abstract: Enhanced recovery after surgery (ERAS) protocols are standardized and designed to provide superior analgesia, reduce opioid consumption, improve patient recovery, and reduce hospital length of stay. Yet, moderate-to-severe postsurgical pain continues to ... ...

    Abstract Enhanced recovery after surgery (ERAS) protocols are standardized and designed to provide superior analgesia, reduce opioid consumption, improve patient recovery, and reduce hospital length of stay. Yet, moderate-to-severe postsurgical pain continues to afflict over 40% of patients and remains a major priority for anesthesia research. Methadone administration in the perioperative setting may reduce postoperative pain scores and have opioid-sparing effects, which may be beneficial for enhanced recovery. Methadone possesses a multimodal profile consisting of µ-opioid agonism, N-methyl-d-aspartate (NMDA) receptor antagonism, and reuptake inhibition of serotonin and norepinephrine. Furthermore, it may attenuate the development of chronic postsurgical pain. However, caution is advised with perioperative use of methadone in specific high-risk patient populations and surgical settings. Methadone's wide pharmacokinetic variability, opioid-related adverse effects, and potential negative impact on cost-effectiveness may also limit its use in the perioperative setting. In this PRO-CON commentary article, the authors debate whether methadone should be incorporated in ERAS protocols to provide superior analgesia with no increased risks.
    MeSH term(s) Humans ; Methadone/adverse effects ; Analgesics, Opioid/adverse effects ; Pharmaceutical Preparations ; Enhanced Recovery After Surgery ; Analgesics ; Pain, Postoperative/diagnosis ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control
    Chemical Substances Methadone (UC6VBE7V1Z) ; Analgesics, Opioid ; Pharmaceutical Preparations ; Analgesics
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anesthetic management during transsphenoidal pituitary surgery.

    Esfahani, Kamilla / Dunn, Lauren K

    Current opinion in anaesthesiology

    2021  Volume 34, Issue 5, Page(s) 575–581

    Abstract: Purpose of review: Pituitary adenoma resections comprise a large proportion of intracranial tumor surgeries. This patient population is medically and physiologically complex and requires careful perioperative planning and management on the part of the ... ...

    Abstract Purpose of review: Pituitary adenoma resections comprise a large proportion of intracranial tumor surgeries. This patient population is medically and physiologically complex and requires careful perioperative planning and management on the part of the anesthesiologist. This review will summarize anesthetic considerations for pre, intra, and postoperative management of patients undergoing transsphenoidal pituitary surgery.
    Recent findings: An endoscopic approach is favored for patients undergoing transsphenoidal pituitary surgery. Hemodynamic monitoring is important to maintain cerebral perfusion and avoid risk of bleeding; however, 'controlled' hypotension may have adverse effects. Multimodal analgesia is effective for the management of postoperative pain and may reduce the risk of postoperative complications, including respiratory depression and postoperative nausea and vomiting.
    Summary: Transsphenoidal pituitary surgery is a preferred approach for the surgical management of nonfunctioning pituitary macroadenomas with symptoms of mass effect and functioning adenomas that cannot be otherwise managed medically. Understanding tumor pathologies and systemic effects are essential for preoperative planning and providing safe anesthetic care during the perioperative period.
    MeSH term(s) Adenoma/surgery ; Anesthetics ; Humans ; Pituitary Neoplasms/surgery ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Retrospective Studies
    Chemical Substances Anesthetics
    Language English
    Publishing date 2021-07-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001035
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  4. Article ; Online: Business vs After-Hours Use of an Artificial Intelligence-Powered Digital Health Platform Among Insured Patients.

    Graham, Sarah A / Pickus, Sarah K / Lockwood, Kimberly G / Buch, Lauren S / Dunn, Patrick / Paruthi, Jason

    JAMA network open

    2023  Volume 6, Issue 9, Page(s) e2333511

    MeSH term(s) Humans ; Artificial Intelligence ; Commerce
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.33511
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  5. Article ; Online: Mind Over Matter: Reducing Perioperative Opioid Use Through Patient Education.

    Dunn, Lauren K / Sun, Eric C

    Anesthesia and analgesia

    2020  Volume 130, Issue 3, Page(s) 556–558

    MeSH term(s) Humans ; Opioid-Related Disorders ; Pain
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000004569
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  6. Article ; Online: Perioperative Precedex: Whole New Ball Game or Whole New Ball of Wax?

    Grant, Michael C / Dunn, Lauren K

    Anesthesia and analgesia

    2020  Volume 132, Issue 2, Page(s) 317–319

    MeSH term(s) Dexmedetomidine ; Double-Blind Method ; Humans ; Hyperalgesia ; Remifentanil ; Thyroidectomy
    Chemical Substances Dexmedetomidine (67VB76HONO) ; Remifentanil (P10582JYYK)
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Putative Lipoprotein Mediates Cell-Cell Contact for Type VI Secretion System-Dependent Killing of Specific Competitors.

    Speare, Lauren / Woo, Madison / Dunn, Anne K / Septer, Alecia N

    mBio

    2022  Volume 13, Issue 2, Page(s) e0308521

    Abstract: Interbacterial competition is prevalent in host-associated microbiota, where it can shape community structure and function, impacting host health in both positive and negative ways. However, the factors that permit bacteria to discriminate among their ... ...

    Abstract Interbacterial competition is prevalent in host-associated microbiota, where it can shape community structure and function, impacting host health in both positive and negative ways. However, the factors that permit bacteria to discriminate among their various neighbors for targeted elimination of competitors remain elusive. We identified a putative lipoprotein (TasL) in
    MeSH term(s) Aliivibrio fischeri/genetics ; Aliivibrio fischeri/metabolism ; Animals ; Decapodiformes/microbiology ; Lipoproteins/genetics ; Symbiosis ; Type VI Secretion Systems/genetics ; Type VI Secretion Systems/metabolism
    Chemical Substances Lipoproteins ; Type VI Secretion Systems
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03085-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis.

    Esfahani, Kamilla / Tennant, William / Tsang, Siny / Naik, Bhiken I / Dunn, Lauren K

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288988

    Abstract: Objective: To compare efficacy of oral versus intravenous (IV) methadone on postoperative pain and opioid requirements after spine surgery.: Methods: This was a retrospective, single-academic center cohort study evaluating 1010 patients who underwent ...

    Abstract Objective: To compare efficacy of oral versus intravenous (IV) methadone on postoperative pain and opioid requirements after spine surgery.
    Methods: This was a retrospective, single-academic center cohort study evaluating 1010 patients who underwent >3 level spine surgery from January 2017 to May 2020 and received a one-time dose of oral or intravenous methadone prior to surgery. The primary outcome measured was postoperative opioid use in oral morphine equivalents (ME) and verbal response scale (VRS) pain scores up to postoperative day (POD) three. Secondary outcomes were time to first bowel movement and adverse effects (reintubation, myocardial infarction, and QTc prolongation) up to POD 3.
    Results: A total of 687 patients received oral and 317 received IV methadone, six patients were excluded. The IV group received a significantly greater methadone morphine equivalent (ME) dose preoperatively (112.4 ± 83.0 mg ME versus 59.3 ± 60.9 mg ME, p < 0.001) and greater total (methadone and non-methadone) opioid dose (119.1 ± 81.4 mg ME versus 63.9 ± 62.5 mg ME, p < 0.001), intraoperatively. Although pain scores for the oral group were non-inferior to the IV group for all postoperative days (POD), non-inferiority for postoperative opioid requirements was demonstrated only on POD 3. Based on the joint hypothesis for the co-primary outcomes, oral methadone was non-inferior to IV methadone on POD 3 only. No differences in secondary outcomes, including QTc prolongation and arrhythmias, were noted between the groups.
    Conclusions: Oral methadone is a feasible alternative to IV methadone for patients undergoing spine surgery regarding both pain scores and postoperative opioid consumption.
    MeSH term(s) Humans ; Adult ; Methadone/therapeutic use ; Analgesics, Opioid/adverse effects ; Retrospective Studies ; Cohort Studies ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Morphine ; Opioid-Related Disorders/drug therapy ; Long QT Syndrome/drug therapy
    Chemical Substances Methadone (UC6VBE7V1Z) ; Analgesics, Opioid ; Morphine (76I7G6D29C)
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288988
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  9. Article ; Online: In Reply.

    Dunn, Lauren K / Durieux, Marcel E

    Anesthesiology

    2017  Volume 127, Issue 6, Page(s) 1038

    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000001914
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  10. Article ; Online: Phylogeny and Genomic Characterization of Clinical Salmonella enterica Serovar Newport Collected in Tennessee.

    Hudson, Lauren K / Andershock, William E / Qian, Xiaorong / Gibbs, Paula L / Orejuela, Kelly / Garman, Katie N / Dunn, John R / Denes, Thomas G

    Microbiology spectrum

    2023  Volume 11, Issue 1, Page(s) e0387622

    Abstract: Salmonella enterica subsp. ...

    Abstract Salmonella enterica subsp.
    MeSH term(s) United States ; Humans ; Serogroup ; Salmonella enterica ; Phylogeny ; Tennessee/epidemiology ; Genomics
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03876-22
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