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Article ; Online: Synthesis, characterization and ROS-mediated cytotoxic action of novel (S,S)-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and corresponding esters.

Savić, Aleksandar / Misirlić-Denčić, Sonja / Dulović, Marija / Mihajlović-Lalić, Ljiljana E / Jovanović, Maja / Grgurić-Šipka, Sanja / Marković, Ivanka / Sabo, Tibor J

Bioorganic chemistry

2014 Volume 54, Page(s) 73–80

Abstract: This study involves the synthesis and characterization of novel cyclohexyl 1,3-propanediamine-N,N' ... by reaction between (S)-2-amino-3-cyclohexylpropanoic acid and 1,3-dibromopropane, while the esters (1b-1e ... glioma (U251) cells. The esterification is required for the novel compounds' cytotoxic action since the n ...

Abstract	This study involves the synthesis and characterization of novel cyclohexyl 1,3-propanediamine-N,N'-diacetate molecules as well as investigation of their cytotoxic action. New acid 1a was synthesized by reaction between (S)-2-amino-3-cyclohexylpropanoic acid and 1,3-dibromopropane, while the esters (1b-1e) derived from this acid were obtained by reaction of the corresponding absolute alcohol, thionyl chloride and synthesized acid. All compounds were characterized by IR, ESI-MS, ((1)H, (13)C and HSQC) NMR spectroscopy and elemental analysis. The cytotoxic activity of all compounds was tested on several tumour cell lines: human (U251) and rat (C6) glioma, human promyelocytic leukaemia (HL-60), human neuroblastoma (SHSY-5Y) and mouse fibrosarcoma (L929) as well as primary rat astrocytes. The present study reveals potent antitumour activity of novel purely organic compounds (1a-1e), which was most pronounced in human glioma (U251) cells. The esterification is required for the novel compounds' cytotoxic action since the n-butyl ester 1e was the most efficient compound. Importantly, n-butyl ester 1e was more toxic to glioma cells in comparison to rat astrocytes, with 24-h IC50 values lower than those for cisplatin. n-Butyl ester 1e induced production of reactive oxygen species (ROS) and caused an oxidative-stress-derived accumulation of glioma cells in the G0/G1 phase of the cell cycle, as well as caspase activation and DNA fragmentation, suggesting that apoptosis induction plays an important role in the novel compounds' antiglioma action.
MeSH term(s)	Alanine/analogs & derivatives ; Alanine/chemical synthesis ; Alanine/chemistry ; Alanine/pharmacology ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Astrocytes/drug effects ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Esters/chemical synthesis ; Esters/chemistry ; Esters/pharmacology ; Humans ; Mice ; Molecular Structure ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Esters ; O,O'-dibutyl-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoate ; Reactive Oxygen Species ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2014.04.006
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Zs.A 4207: Show issues

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Article: Gait Characteristics during Dual-Task Walking in Elderly Subjects of Different Ages.

Nedović, Nenad / Eminović, Fadilj / Marković, Vladana / Stanković, Iva / Radovanović, Saša

Brain sciences

2024 Volume 14, Issue 2

Abstract: Background: In older age, walking ability gradually decreases due to factors including impaired balance, reduced muscle strength, and impaired vision and proprioception. Further, cognitive functions play a key role during walking and gradually decline ... ...

Abstract	Background: In older age, walking ability gradually decreases due to factors including impaired balance, reduced muscle strength, and impaired vision and proprioception. Further, cognitive functions play a key role during walking and gradually decline with age. There is greater variability in gait parameters when the demands during walking increase, in dual- and multiple-task situations. The aim of this study was to analyze gait parameters while performing a demanding cognitive and motor dual task in three different age-related healthy elderly subject groups. Method: A total of 132 healthy individuals (54 males, 78 females) were divided into three groups-55 to 65, 66 to 75, and 76 to 85 years. The subjects performed a basic walking task, dual motor task, dual mental task, and combined motor and mental task while walking. The gait parameters cycle time, stride length, swing time, and double support time were noted, as well as the variability of those parameters. Results: Cycle time was longer and stride length was shorter in the >76-year-old group than in the 51-65-year-old group in all test conditions. A comparison of all three groups did not show a significant difference in swing time, while double support time was increased in the same group. Conclusions: Changes are observed when gait is performed simultaneously with an additional motor or cognitive task. Early detection of gait disorders can help identify elderly people at increased risk of falls. Employing a dual-task paradigm during gait assessment in healthy elderly subjects may help identify cognitive impairment early in the course of the disturbance.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci14020148
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Article ; Online: Quantitative profiling and baseline intervals of trace elements in healthy lung tissues.

Stojsavljević, Aleksandar / Marković, Katarina / Lukač, Aleksandar / Ristanović, Aleksandar / Marić, Nebojša / Marković, Stefan / Šarac, Ivana / Ščančar, Janez

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2024 Volume 84, Page(s) 127440

Abstract: ... and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic ...

Abstract	Background: Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described. Methods: This study aimed to characterize the elemental composition of histologically healthy, unaffected parts of human lung tissues, associated with non-infective, non-infiltrative, and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic trace elements (Sr, Ni, As, Cd, and Pb). Additionally, we investigated the influence of personal factors (sex, age, and smoking habits) on the examined trace element profiles, as well as between the trace elements correlations in the healthy human lungs. Results: Among the analyzed trace elements, Fe was the most prevalent, while As was the least prevalent in healthy lung tissues. Stratifying by age revealed significantly higher Cr and Co (less Sr, Ni, and Pb) and lower Se levels in older individuals (above 65 years) compared to their younger counterparts. Sex-based differences were also notable, with Cu and Co 1.2- and 2.3-fold higher levels in females than in males. Exploring the impact of smoking habits revealed a striking 10-fold increase in Cd levels in the lung tissues of smokers compared to non-smokers. Correlation analyses showed significant positive associations between concentrations of certain toxic and essential trace elements in healthy lung tissues. Conclusions: This study could contribute to the establishment of baseline intervals for essential and toxic trace elements, valuable for toxicological and clinical assessment, in healthy, unaffected human lungs, and indicates the influence of sex, age, and smoking. However, further larger-scale studies are needed to make more stable conclusions.
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2024.127440
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Zs.A 2279: Show issues

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Article ; Online: Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis.

Suman, Shankar / Markovic, Svetomir N

Trends in immunology

2023 Volume 44, Issue 9, Page(s) 724–743

Abstract: The natural history of advanced malignant melanoma demonstrates that, in most cases, widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes (SLNs)]. Under physiological conditions, LNs ...

Abstract	The natural history of advanced malignant melanoma demonstrates that, in most cases, widespread tumor dissemination is preceded by regional metastases involving tumor-draining lymph nodes [sentinel lymph nodes (SLNs)]. Under physiological conditions, LNs play a central role in immunosurveillance to non-self-antigens to which they are exposed via afferent lymph. The dysfunctional immunity in SLNs is mediated by tumor secretory factors that allow the survival of metastatic melanoma cells within the LN by creating a premetastatic niche (PMN). Recent studies outline the altered microenvironment of LNs shaped by melanoma mediators. Here, we discuss tumor secretory factors involved in subverting tumor immunity and remodeling LNs and highlight emerging therapeutic strategies to reinvigorate antitumoral immunity in SLNs.
MeSH term(s)	Humans ; Lymphatic Metastasis/pathology ; Melanoma/pathology ; Skin Neoplasms/pathology ; Lymph Nodes ; Tumor Microenvironment
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2023.07.002
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects.

Milenković, Mila / Ciasca, Gabriele / Bonasera, Aurelio / Scopelliti, Michelangelo / Marković, Olivera / Verbić, Tatjana / Marković, Biljana Todorović / Jovanović, Svetlana

Journal of photochemistry and photobiology. B, Biology

2023 Volume 250, Page(s) 112818

Abstract: ... In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light ... data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms ...

Abstract	The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L-cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp
MeSH term(s)	Humans ; Quantum Dots/chemistry ; Graphite/pharmacology ; Graphite/chemistry ; Cysteine ; Escherichia coli ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Graphite (7782-42-5) ; Cysteine (K848JZ4886) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2023.112818
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Article: Kinematic parameters and metabolic power in elite soccer players: A small sided a large sided games comparison.

Zlojutro, Nemanja / Eler, Serdar / Joksimovic, Marko / Eler, Nebahat / Marković, Saša / Kukrić, Aleksandar / Goranovic, Kosta

Frontiers in physiology

2023 Volume 14, Page(s) 1150713

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1150713
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Article: Determining the Role of Acicular Ferrite Carbides in Cleavage Fracture Crack Initiation for Two Medium Carbon Microalloyed Steels.

Jovanović, Gvozden / Glišić, Dragomir / Dikić, Stefan / Međo, Bojan / Marković, Branislav / Vuković, Nikola / Radović, Nenad

Materials (Basel, Switzerland)

2023 Volume 16, Issue 22

Abstract: Two medium-carbon microalloyed steels with a predominant acicular ferrite microstructure were investigated in this study in order to determine the initial micro-crack formation mechanism and the role of acicular ferrite structure in cleavage fracture. In ...

Abstract	Two medium-carbon microalloyed steels with a predominant acicular ferrite microstructure were investigated in this study in order to determine the initial micro-crack formation mechanism and the role of acicular ferrite structure in cleavage fracture. In order to ensure cleavage fracture, samples were investigated at -196 °C for uniaxial tension and four point bending fracture. Previous investigations have shown that cleavage fracture for steels with a predominant acicular ferrite microstructure has not been initiated by the fracture of coarse TiN particles as in ferrite-pearlite, bainite, or martensitic microalloyed steels. The average maximal thickness of cementite plates measured in this work is 0.798 µm and 0.966 µm, for V and TiV steel, respectively. The corresponding stress values required for their fracture according to Griffith's equation are 1970 MPa and 1791 MPa, respectively. Estimated values of the effective surface energy for the V steel with an average cementite volume fraction of 3.8% range from 40 Jm
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16227192
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Article ; Online: Soil humic acid and arsenite binding by isothermal titration calorimetry and Dynamic Light Scattering: Thermodynamics and aggregation.

Čokeša, Đuro / Radmanović, Svjetlana / Potkonjak, Nebojša / Marković, Mirjana / Šerbula, Snežana

Chemosphere

2022 Volume 315, Page(s) 137687

Abstract: The arsenite-humic acid binding process was investigated using Isothermal Titration Calorimetry (ITC), Dynamic Light Scattering and Laser Doppler Electrophoresis techniques. The ITC data were successfully ( ... ...

Abstract	The arsenite-humic acid binding process was investigated using Isothermal Titration Calorimetry (ITC), Dynamic Light Scattering and Laser Doppler Electrophoresis techniques. The ITC data were successfully (R
MeSH term(s)	Humic Substances ; Dynamic Light Scattering ; Soil ; Arsenites ; Thermodynamics ; Calorimetry
Chemical Substances	Humic Substances ; Soil ; Arsenites
Language	English
Publishing date	2022-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137687
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Zs.A 2540: Show issues

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Article ; Online: Overview of nature, frequency and technological role of dietary fibre from cereals and pseudocereals from grain to bread.

Torbica, Aleksandra / Radosavljević, Miloš / Belović, Miona / Djukić, Nevena / Marković, Stefan

Carbohydrate polymers

2022 Volume 290, Page(s) 119470

Abstract: This review presents integrated literature data on the occurrence and type of dietary fibres present in cereals and pseudocereals, as well as their technological role in production of wheat based dough and bread. The focus on wheat based dough and bread ... ...

Abstract	This review presents integrated literature data on the occurrence and type of dietary fibres present in cereals and pseudocereals, as well as their technological role in production of wheat based dough and bread. The focus on wheat based dough and bread was in order to objectively compare the influence of the fibre and flour fractions of cereals and pseudocereals on the same food matrix. The evident heterogeneity, contradiction of scientific results and the lack of objective comparability were the main reason for compilation of systematic review. Remarkably, the literature is characterized by a large methodology gap that leads to significant knowledge gap due to the lack of the comparability of presented results on dietary fibre content, composition and influence on wheat based dough and bread properties. Based on this, the authors must emphasize the need for standardized presentation of scientific results in the future by scientific community.
MeSH term(s)	Bread ; Dietary Fiber/analysis ; Edible Grain/chemistry ; Flour/analysis ; Triticum
Chemical Substances	Dietary Fiber
Language	English
Publishing date	2022-04-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.119470
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Article ; Online: Lithium and strontium accumulation in native and invasive plants of the Sava River: Implications for bioindication and phytoremediation.

Miletić, Zorana / Marković, Milica / Jarić, Snežana / Radulović, Natalija / Sekulić, Dimitrije / Mitrović, Miroslava / Pavlović, Pavle

Ecotoxicology and environmental safety

2023 Volume 270, Page(s) 115875

Abstract: The objective of this study was to investigate the potential of native and invasive plant species for the uptake and accumulation of lithium (Li) and strontium (Sr) along the Sava River, focusing on their bioindication and phytoremediation capabilities. ... ...

Abstract	The objective of this study was to investigate the potential of native and invasive plant species for the uptake and accumulation of lithium (Li) and strontium (Sr) along the Sava River, focusing on their bioindication and phytoremediation capabilities. Sampling was carried out in riparian zones exposed to different pollution sources in Slovenia, Croatia, and Serbia. Plant samples of native (Salix alba, Populus alba, Populus nigra, Ulmus glabra, Juglans regia) and invasive (Amorpha fruticosa, Reynoutria japonica, Solidago canadensis, Impatiens glandulifera) species were collected. The content of Li and Sr was analyzed in the soils, roots, and leaves of the selected plants, as well as physical and chemical soil properties. Both Li and Sr content in the soils increased from the source to the mouth of the Sava River. The native species showed significant potential for Li and Sr accumulation based on the metal accumulation index. The highest Sr accumulation was measured in the leaves of Salix alba and the roots of Juglans regia, while the highest Li accumulation was measured in Ulmus glabra. Native species, especially Salix alba, proved to be better bioindicators of Li and Sr. Invasive species, especially Amorpha fruticosa and Impatiens glandulifera, showed a remarkable ability to translocate Sr and Li, respectively, to leaves. These results provide valuable insight into the suitability of plants for biomonitoring soil contamination and potential applications in phytoremediation strategies. In summary, the study shows the importance of native species in the context of the accumulation and bioindication of soil pollution.
MeSH term(s)	Strontium ; Biodegradation, Environmental ; Lithium ; Rivers ; Plants ; Soil/chemistry ; Populus/chemistry ; Salix ; Soil Pollutants/analysis
Chemical Substances	Strontium (YZS2RPE8LE) ; Lithium (9FN79X2M3F) ; Soil ; Soil Pollutants
Language	English
Publishing date	2023-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115875
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