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  1. Article: The Molecular Chaperone CCT/TRiC: An Essential Component of Proteostasis and a Potential Modulator of Protein Aggregation.

    Grantham, Julie

    Frontiers in genetics

    2020  Volume 11, Page(s) 172

    Abstract: Chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC) is an essential eukaryotic molecular chaperone. It is a multi-subunit oligomer of two rings of eight individual protein subunits. When ... ...

    Abstract Chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC) is an essential eukaryotic molecular chaperone. It is a multi-subunit oligomer of two rings of eight individual protein subunits. When assembled, each of the eight CCT subunits occupies a specific position within each chaperonin ring. Thus a geometrically defined binding interface is formed from the divergent sequences within the CCT subunit substrate binding domains. CCT is required for the folding of the abundant cytoskeletal proteins actin and tubulin, which in turn form assemblies of microfilaments and microtubules. CCT is also involved in the folding of some additional protein substrates and some CCT subunits have been shown to have functions when monomeric. Since observations were made in worms over a decade ago using an RNAi screen, which connected CCT subunits to the aggregation of polyglutamine tracts, a role for CCT as a potential modulator of protein aggregation has started to emerge. Here there will be a focus on how mechanistically CCT may be able to achieve this and if this potential function of CCT provides any insights and directions for developing future treatments for protein aggregation driven neurodegenerative diseases generally, many of which are associated with aging.
    Language English
    Publishing date 2020-03-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.00172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Serum S100A8/A9 May Act as Biomarker of Atherosclerosis Severity in Psoriasis.

    Grantham, Henry J / Hussain, Amaani B / Reynolds, Nick J

    The Journal of investigative dermatology

    2022  Volume 142, Issue 11, Page(s) 2848–2850

    MeSH term(s) Humans ; Calgranulin A ; Calgranulin B ; Biomarkers ; Psoriasis/diagnosis ; Atherosclerosis
    Chemical Substances Calgranulin A ; Calgranulin B ; Biomarkers
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Preoperative risk modelling for oesophagectomy: A systematic review.

    Grantham, James Paul / Hii, Amanda / Shenfine, Jonathan

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 3, Page(s) 450–470

    Abstract: Background: Oesophageal cancer is a frequently observed and lethal malignancy worldwide. Surgical resection remains a realistic option for curative intent in the early stages of the disease. However, the decision to undertake oesophagectomy is ... ...

    Abstract Background: Oesophageal cancer is a frequently observed and lethal malignancy worldwide. Surgical resection remains a realistic option for curative intent in the early stages of the disease. However, the decision to undertake oesophagectomy is significant as it exposes the patient to a substantial risk of morbidity and mortality. Therefore, appropriate patient selection, counselling and resource allocation is important. Many tools have been developed to aid surgeons in appropriate decision-making.
    Aim: To examine all multivariate risk models that use preoperative and intraoperative information and establish which have the most clinical utility.
    Methods: A systematic review of the MEDLINE, EMBASE and Cochrane databases was conducted from 2000-2020. The search terms applied were ((Oesophagectomy) AND (Risk OR predict OR model OR score) AND (Outcomes OR complications OR morbidity OR mortality OR length of stay OR anastomotic leak)). The applied inclusion criteria were articles assessing multivariate based tools using exclusively preoperatively available data to predict perioperative patient outcomes following oesophagectomy. The exclusion criteria were publications that described models requiring intra-operative or post-operative data and articles appraising only univariate predictors such as American Society of Anesthesiologists score, cardiopulmonary fitness or pre-operative sarcopenia. Articles that exclusively assessed distant outcomes such as long-term survival were excluded as were publications using cohorts mixed with other surgical procedures. The articles generated from each search were collated, processed and then reported in accordance with PRISMA guidelines. All risk models were appraised for clinical credibility, methodological quality, performance, validation, and clinical effectiveness.
    Results: The initial search of composite databases yielded 8715 articles which reduced to 5827 following the deduplication process. After title and abstract screening, 197 potentially relevant texts were retrieved for detailed review. Twenty-seven published studies were ultimately included which examined twenty-one multivariate risk models utilising exclusively preoperative data. Most models examined were clinically credible and were constructed with sound methodological quality, but model performance was often insufficient to prognosticate patient outcomes. Three risk models were identified as being promising in predicting perioperative mortality, including the National Quality Improvement Project surgical risk calculator, revised STS score and the Takeuchi model. Two studies predicted perioperative major morbidity, including the predicting postoperative complications score and prognostic nutritional index-multivariate models. Many of these models require external validation and demonstration of clinical effectiveness.
    Conclusion: Whilst there are several promising models in predicting perioperative oesophagectomy outcomes, more research is needed to confirm their validity and demonstrate improved clinical outcomes with the adoption of these models.
    Language English
    Publishing date 2023-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i3.450
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  4. Article: Combined and intraoperative risk modelling for oesophagectomy: A systematic review.

    Grantham, James Paul / Hii, Amanda / Shenfine, Jonathan

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 7, Page(s) 1485–1500

    Abstract: Background: Oesophageal cancer is the eighth most common malignancy worldwide and is associated with a poor prognosis. Oesophagectomy remains the best prospect for a cure if diagnosed in the early disease stages. However, the procedure is associated ... ...

    Abstract Background: Oesophageal cancer is the eighth most common malignancy worldwide and is associated with a poor prognosis. Oesophagectomy remains the best prospect for a cure if diagnosed in the early disease stages. However, the procedure is associated with significant morbidity and mortality and is undertaken only after careful consideration. Appropriate patient selection, counselling and resource allocation is essential. Numerous risk models have been devised to guide surgeons in making these decisions.
    Aim: To evaluate which multivariate risk models, using intraoperative information with or without preoperative information, best predict perioperative oesophagectomy outcomes.
    Methods: A systematic review of the MEDLINE, EMBASE and Cochrane databases was undertaken from 2000-2020. The search terms used were [(Oesophagectomy) AND (Model OR Predict OR Risk OR score) AND (Mortality OR morbidity OR complications OR outcomes OR anastomotic leak OR length of stay)]. Articles were included if they assessed multivariate based tools incorporating preoperative and intraoperative variables to forecast patient outcomes after oesophagectomy. Articles were excluded if they only required preoperative or any post-operative data. Studies appraising univariate risk predictors such as preoperative sarcopenia, cardiopulmonary fitness and American Society of Anesthesiologists score were also excluded. The review was conducted following the preferred reporting items for systematic reviews and meta-analyses model. All captured risk models were appraised for clinical credibility, methodological quality, performance, validation and clinical effectiveness.
    Results: Twenty published studies were identified which examined eleven multivariate risk models. Eight of these combined preoperative and intraoperative data and the remaining three used only intraoperative values. Only two risk models were identified as promising in predicting mortality, namely the Portsmouth physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) and POSSUM scores. A further two studies, the intraoperative factors and Esophagectomy surgical Apgar score based nomograms, adequately forecasted major morbidity. The latter two models are yet to have external validation and none have been tested for clinical effectiveness.
    Conclusion: Despite the presence of some promising models in forecasting perioperative oesophagectomy outcomes, there is more research required to externally validate these models and demonstrate clinical benefit with the adoption of these models guiding postoperative care and allocating resources.
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i7.1485
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  5. Article ; Online: Treat the Patient, Not the Angiogram.

    Grantham, J Aaron

    Circulation

    2017  Volume 135, Issue 15, Page(s) 1382–1384

    MeSH term(s) Angina Pectoris/diagnostic imaging ; Angina Pectoris/surgery ; Chronic Disease ; Coronary Angiography ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2017-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.116.022150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
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  6. Article ; Online: Survival and Chronic Total Occlusion Percutaneous Coronary Intervention: The Never-Ending Debate Continues.

    Grantham, J Aaron

    JACC. Cardiovascular interventions

    2017  Volume 10, Issue 9, Page(s) 876–878

    MeSH term(s) Coronary Vessels ; Heart ; Incidence ; Longitudinal Studies ; Percutaneous Coronary Intervention
    Language English
    Publishing date 2017-05-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2017.03.010
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    Zs.A 6669: Show issues Location:
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  7. Article ; Online: Functional assessment of the V390F mutation in the CCTδ subunit of chaperonin containing tailless complex polypeptide 1.

    Vallin, Josefine / Grantham, Julie

    Cell stress & chaperones

    2021  Volume 26, Issue 6, Page(s) 955–964

    Abstract: The chaperonin containing tailless complex polypeptide 1 (CCT) is a multi-subunit molecular chaperone. It is found in the cytoplasm of all eukaryotic cells, where the oligomeric form plays an essential role in the folding of predominantly the ... ...

    Abstract The chaperonin containing tailless complex polypeptide 1 (CCT) is a multi-subunit molecular chaperone. It is found in the cytoplasm of all eukaryotic cells, where the oligomeric form plays an essential role in the folding of predominantly the cytoskeletal proteins actin and tubulin. Both the CCT oligomer and monomeric subunits also display functions that extend beyond folding, which are often associated with microtubules and actin filaments. Here, we assess the functional significance of the CCTδ V390F mutation, reported in several cancer cell lines. Upon transfection into B16F1 mouse melanoma cells, GFP-CCTδ
    MeSH term(s) Actins/chemistry ; Actins/genetics ; Animals ; Cell Line, Tumor ; Chaperonin Containing TCP-1/genetics ; Chaperonins/genetics ; Dynactin Complex/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Melanoma, Experimental/genetics ; Melanoma, Experimental/pathology ; Mice ; Molecular Chaperones ; Mutation/genetics ; Protein Folding ; Protein Interaction Maps/genetics ; Protein Kinases/genetics ; Tubulin/chemistry ; Tubulin/genetics
    Chemical Substances Actins ; Dynactin Complex ; Molecular Chaperones ; Tubulin ; Protein Kinases (EC 2.7.-) ; p150 protein kinase (EC 2.7.1.-) ; Chaperonin Containing TCP-1 (EC 3.6.1.-) ; Chaperonins (EC 3.6.1.-)
    Language English
    Publishing date 2021-10-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-021-01237-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4797: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Indications and Patient Selection for Percutaneous Coronary Intervention of Chronic Total Occlusions.

    Hirai, Taishi / Grantham, J Aaron

    Interventional cardiology clinics

    2020  Volume 10, Issue 1, Page(s) 1–5

    Abstract: The most common indication for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is angina relief, which translates into improved physical function and quality of life. As the risk of the procedure is higher compared with non CTO PCI, ...

    Abstract The most common indication for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is angina relief, which translates into improved physical function and quality of life. As the risk of the procedure is higher compared with non CTO PCI, it is important for operators to understand the current state of literature and have a detailed discussion with patients regarding risks and benefits prior to the procedure. This article discusses indications for the procedure and how to appropriately select patients for CTO PCI, in hopes of inspiring the reader to consistently offer this approach to indicated patients regardless of anatomic complexity.
    MeSH term(s) Chronic Disease ; Coronary Occlusion/diagnosis ; Coronary Occlusion/surgery ; Humans ; Patient Selection ; Percutaneous Coronary Intervention ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2020-10-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2211-7466
    ISSN (online) 2211-7466
    DOI 10.1016/j.iccl.2020.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Perforation Mechanisms, Risk Stratification, and Management in the Post-Coronary Artery Bypass Grafting Patient.

    Hirai, Taishi / Grantham, J Aaron

    Interventional cardiology clinics

    2020  Volume 10, Issue 1, Page(s) 101–107

    Abstract: Coronary perforations during chronic total occlusion percutaneous coronary intervention (CTO PCI) is a most frequent major complication and the incidence is significantly higher compared with non-CTO PCI. Patients with prior history of coronary bypass ... ...

    Abstract Coronary perforations during chronic total occlusion percutaneous coronary intervention (CTO PCI) is a most frequent major complication and the incidence is significantly higher compared with non-CTO PCI. Patients with prior history of coronary bypass have more major adverse events when perforation occurs compared with patients without prior bypass surgery. In this article, the authors discuss the unique challenges in identification and timely treatment of perforations in patients with prior bypass surgery.
    MeSH term(s) Coronary Angiography ; Coronary Artery Bypass ; Coronary Occlusion ; Humans ; Percutaneous Coronary Intervention ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-10-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2211-7466
    ISSN (online) 2211-7466
    DOI 10.1016/j.iccl.2020.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Besprechung von:] Blum, Jerome: The end of the old order in rural Europe. Princeton/N.J. 1978

    Grantham, George / Blum, Jerome

    Journal of economic literature Vol. 19 , p. 574-576

    1981  Volume 19, Page(s) 574–576

    Author's details George Grantham
    Language Undetermined
    Publisher Assoc
    Publishing place Nashville, Tenn
    Document type Article
    ZDB-ID 3076-4 ; 2010159-4
    ISSN 0022-0515
    ISSN 0022-0515
    Database ECONomics Information System

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