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  1. Article: Hepatitis B prophylaxis of infants born to mothers with no antenatal care: Understanding the nuances in Canada.

    Bitnun, Ari / Baron-Forbes, Michelle / Sauvé, Laura / Fanella, Sergio

    Paediatrics & child health

    2024  Volume 29, Issue 2, Page(s) 71

    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2106767-3
    ISSN 1918-1485 ; 1205-7088
    ISSN (online) 1918-1485
    ISSN 1205-7088
    DOI 10.1093/pch/pxad092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global importance of new treatment strategies to efforts to control hepatitis B virus.

    Forbes, Carol / Lavoie, Louis / Satram, Sacha / Shen, Ling / Thanawala, Vaidehi / Arizpe, Andre / Terrault, Norah

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 8, Page(s) 847–862

    Abstract: Introduction: Hepatitis B Virus (HBV) infection can progress to chronic HBV (CHB) disease, thereby ...

    Abstract Introduction: Hepatitis B Virus (HBV) infection can progress to chronic HBV (CHB) disease, thereby increasing the risk of severe forms of liver disease (i.e. liver cirrhosis and hepatocellular carcinoma) and resulting in a high global burden of morbidity, mortality, and health-care utilization.
    Areas covered: We discuss how future therapeutic strategies and treatment guidelines may address the large unmet medical needs among patients with CHB.
    Expert opinion: Complexity and a lack of consensus in current CHB treatment guidelines may limit their effective implementation. To minimize poor outcomes in patients not currently receiving treatment (including immune-tolerant and inactive carriers), a simplified harmonized treatment approach is needed across guidelines. Current treatment recommendations focus on nucleot(s)ide analogs (NAs) and pegylated interferon (Peg-IFN), both of which have limitations. NAs provide clinical benefits, but treatment is prolonged and has little impact on functional cure rates. Peg-IFN offers the potential for functional cure but has notable safety and tolerability issues. A shift toward finite treatments with acceptable safety and tolerability profiles is needed.
    Conclusion: The key to achieving World Health Organization targets for the global eradication of HBV involves enhanced diagnosis with new treatments and/or combinations of existing treatments alongside globally aligned and simplified treatment guidelines for untreated/inadequately treated populations.
    MeSH term(s) Humans ; Hepatitis B virus ; Antiviral Agents/adverse effects ; Interferon-alpha ; Hepatitis B, Chronic ; Liver Neoplasms/prevention & control ; Hepatitis B/drug therapy ; Hepatitis B/prevention & control
    Chemical Substances Antiviral Agents ; Interferon-alpha
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2225771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A2/A2B to B kidney transplantation outcomes: A single center 7-year experience.

    El Chediak, Alissar / Shawar, Saed / Fallahzadeh, Mohammad K / Forbes, Rachel / Schaefer, Heidi M / Feurer, Irene D / Rega, Scott / Triozzi, Jefferson L / Shaffer, David

    Clinical transplantation

    2024  Volume 38, Issue 4, Page(s) e15295

    Abstract: Introduction: Data on long-term outcomes following A2/A2B to B kidney transplants since the 2014 ... experience with A2/A2B to B kidney transplants and to compare post-transplant outcomes of A2/A2B ... to a concurrent group of B to B kidney transplants. Additionally, the study evaluates the impact of pre-transplant ...

    Abstract Introduction: Data on long-term outcomes following A2/A2B to B kidney transplants since the 2014 kidney allocation system (KAS) changes are few. The primary aim of this study is to report our 7-year experience with A2/A2B to B kidney transplants and to compare post-transplant outcomes of A2/A2B to a concurrent group of B to B kidney transplants. Additionally, the study evaluates the impact of pre-transplant anti-A1 titers on survival outcomes in A2/A2B transplants.
    Methods: This retrospective, single-center analysis included all adults who received A2/A2B to B deceased donor kidney transplants from December 2014 to June 2021 compared to B to B recipients. The effects of pre-transplant IgM/IgG titers, stratified as ≤1:8 and ≥1:16, on death-censored, rejection-free, and overall graft survival were tested.
    Results: Fifty-three A2/A2B and 114 B to B adults were included with a median follow-up time of 32 months. Overall graft survival, patient survival, and rejection-free graft survival did not differ between the two groups. There were no differences between the groups' overall kidney function values (p > .80) or their temporal trajectories (time by group interaction p > .11). Unadjusted death-censored graft survival was lower in A2/A2B to B compared to B recipients (p = .03), but the effect was not significant (p = .195) after adjusting for any readmissions (p = .96), rejection episodes (p < .001) or BK infection (p = .76). We did not detect an effect of pre-transplant titer group on death-censored (p = .59), rejection-free (p = .61), or overall graft survival (p = .26) CONCLUSIONS: A2/A2B to B kidney transplants have comparable overall patient and graft survival, rejection-free graft survival, and longitudinal renal function compared to B to B transplants at our center. Allograft survival outcomes were not significantly different between patients with low and high pre-transplant anti-A1 IgM/IgG titers.
    MeSH term(s) Adult ; Humans ; Kidney Transplantation ; Retrospective Studies ; Blood Group Incompatibility ; Graft Rejection/etiology ; Isoantibodies ; Immunoglobulin G ; Immunoglobulin M ; Graft Survival ; ABO Blood-Group System
    Chemical Substances Isoantibodies ; Immunoglobulin G ; Immunoglobulin M ; ABO Blood-Group System
    Language English
    Publishing date 2024-04-16
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15295
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  4. Article ; Online: Interaction between Metformin, Folate and Vitamin B

    Owen, Manon D / Baker, Bernadette C / Scott, Eleanor M / Forbes, Karen

    International journal of molecular sciences

    2021  Volume 22, Issue 11

    Abstract: ... associated with maternal vitamin B ...

    Abstract Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence suggests metformin can cross the placenta during pregnancy, thereby exposing the fetus to high concentrations of metformin and potentially restricting placental and fetal growth. Offspring exposed to metformin during gestation are at increased risk of being born small for gestational age (SGA) and show signs of 'catch up' growth and obesity during childhood which increases their risk of future cardiometabolic diseases. The mechanisms by which metformin impacts on the fetal growth and long-term health of the offspring remain to be established. Metformin is associated with maternal vitamin B
    MeSH term(s) Carbon/metabolism ; Diabetes Mellitus, Type 2 ; Diabetes, Gestational/metabolism ; Drug Interactions ; Female ; Fetal Development/drug effects ; Fetus ; Folic Acid/metabolism ; Folic Acid/pharmacology ; Humans ; Metformin/metabolism ; Metformin/pharmacology ; Obesity/metabolism ; Placenta/metabolism ; Pregnancy ; Pregnancy Complications ; Pregnancy in Diabetics/chemically induced ; Pregnancy in Diabetics/drug therapy ; Pregnancy in Diabetics/metabolism ; Vitamin B 12/metabolism ; Vitamin B 12/pharmacology
    Chemical Substances Carbon (7440-44-0) ; Metformin (9100L32L2N) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22115759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis.

    Pelham, Simon J / Caldirola, Maria Soledad / Avery, Danielle T / Mackie, Joseph / Rao, Geetha / Gothe, Florian / Peters, Timothy J / Guerin, Antoine / Neumann, David / Vokurkova, Doris / Hwa, Vivian / Zhang, Wenming / Lyu, Shu-Chen / Chang, Iris / Manohar, Monali / Nadeau, Kari C / Gaillard, Maria Isabel / Bezrodnik, Liliana / Iotova, Violeta /
    Zwirner, Norberto Walter / Gutierrez, Mavel / Al-Herz, Waleed / Goodnow, Christopher C / Vargas-Hernández, Alexander / Forbes Satter, Lisa R / Hambleton, Sophie / Deenick, Elissa K / Ma, Cindy S / Tangye, Stuart G

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 4, Page(s) 931–946

    Abstract: ... B cells into memory cells and antibody-secreting cells. While STAT1 is largely nonessential and STAT3 is ... unique roles of STAT5 in activation and differentiation of human naive and memory B cells.: Methods ... determined by RNA-sequencing and quantitative PCR. The requirement for STAT5B in B-cell and CD4: Results ...

    Abstract Background: Lymphocyte differentiation is regulated by coordinated actions of cytokines and signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the differentiation of human B cells into memory cells and antibody-secreting cells. While STAT1 is largely nonessential and STAT3 is critical for this process, the role of STAT5 is unknown.
    Objectives: This study sought to delineate unique roles of STAT5 in activation and differentiation of human naive and memory B cells.
    Methods: STAT activation was assessed by phospho-flow cytometry cell sorting. Differential gene expression was determined by RNA-sequencing and quantitative PCR. The requirement for STAT5B in B-cell and CD4
    Results: IL-21 activated STAT5 and strongly induced SOCS3 in human naive, but not memory, B cells. Deletion of STAT5B in B-cell lines diminished IL-21-mediated SOCS3 induction. PBMCs from STAT5B-null individuals contained expanded populations of immunoglobulin class-switched B cells, CD21
    Conclusions: These findings reveal novel roles for STAT5B in regulating IL-21-induced human B-cell differentiation. This is achieved by inducing SOCS3 to attenuate IL-21 signaling, and BCL6 to repress class switching and plasma cell generation. Thus, STAT5B is critical for restraining IL-21-mediated B-cell differentiation. These findings provide insights into mechanisms underpinning B-cell responses during primary and subsequent antigen encounter and explain autoimmunity and dysfunctional humoral immunity in STAT5B deficiency.
    MeSH term(s) Cell Differentiation ; Cytokines/metabolism ; Homeostasis ; Humans ; Immunoglobulin Isotypes/metabolism ; RNA ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism
    Chemical Substances Cytokines ; Immunoglobulin Isotypes ; STAT5 Transcription Factor ; STAT5B protein, human ; RNA (63231-63-0)
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Real-Time RT-PCR Allelic Discrimination Assay for Detection of N501Y Mutation in the Spike Protein of SARS-CoV-2 Associated with B.1.1.7 Variant of Concern.

    Abdulnoor, Mariana / Eshaghi, AliReza / Perusini, Stephen J / Broukhanski, George / Corbeil, Antoine / Cronin, Kirby / Fittipaldi, Nahuel / Forbes, Jessica D / Guthrie, Jennifer L / Kus, Julianne V / Li, Ye / Majury, Anna / Mallo, Gustavo V / Mazzulli, Tony / Melano, Roberto G / Olsha, Romy / Sullivan, Ashleigh / Tran, Vanessa / Patel, Samir N /
    Allen, Vanessa G / Gubbay, Jonathan B

    Microbiology spectrum

    2022  Volume 10, Issue 1, Page(s) e0068121

    Abstract: ... of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possessed by three variants of concern (VOCs), B.1.1.7, B.1.351, and ...

    Abstract The N501Y amino acid mutation caused by a single point substitution A23063T in the spike gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is possessed by three variants of concern (VOCs), B.1.1.7, B.1.351, and P.1. A rapid screening tool using this mutation is important for surveillance during the coronavirus disease 2019 (COVID-19) pandemic. We developed and validated a single nucleotide polymorphism real-time reverse transcription PCR assay using allelic discrimination of the spike gene N501Y mutation to screen for potential variants of concern and differentiate them from SARS-CoV-2 lineages without the N501Y mutation. A total of 160 clinical specimens positive for SARS-CoV-2 were characterized as mutant (N501Y) or N501 wild type by Sanger sequencing and were subsequently tested with the N501Y single nucleotide polymorphism real-time reverse transcriptase PCR assay. Our assay, compared to Sanger sequencing for single nucleotide polymorphism detection, demonstrated positive percent agreement of 100% for all 57 specimens displaying the N501Y mutation, which were confirmed by Sanger sequencing to be typed as A23063T, including one specimen with mixed signal for wild type and mutant. Negative percent agreement was 100% in all 103 specimens typed as N501 wild type, with A23063 identified as wild type by Sanger sequencing. The identification of circulating SARS-CoV-2 lineages carrying an N501Y mutation is critical for surveillance purposes. Current identification methods rely primarily on Sanger sequencing or whole-genome sequencing, which are time consuming, labor intensive, and costly. The assay described herein is an efficient tool for high-volume specimen screening for SARS-CoV-2 VOCs and for selecting specimens for confirmatory Sanger or whole-genome sequencing.
    MeSH term(s) Alleles ; Amino Acid Substitution ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; Genes, Viral ; Humans ; Mass Screening ; Mutation, Missense ; Ontario/epidemiology ; Point Mutation ; Polymorphism, Single Nucleotide ; Population Surveillance ; Prevalence ; Real-Time Polymerase Chain Reaction/methods ; Reproducibility of Results ; SARS-CoV-2/genetics ; Sensitivity and Specificity ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00681-21
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  7. Article ; Online: The new Society for Vascular Surgery and Society of Thoracic Surgeons reporting standards for type B aortic dissections.

    Forbes, Thomas L

    Journal of vascular surgery

    2020  Volume 71, Issue 3, Page(s) 721–722

    MeSH term(s) Aneurysm, Dissecting ; Humans ; Surgeons ; Vascular Surgical Procedures
    Language English
    Publishing date 2020-02-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2019.11.025
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  8. Article ; Online: A2 to B Blood Type Incompatible Deceased Donor Kidney Transplantation in a Recipient Infected with the Human Immunodeficiency Virus: A Case Report.

    Forbes, R C / DeMers, A / Concepcion, B P / Moore, D R / Schaefer, H M / Shaffer, D

    Transplantation proceedings

    2017  Volume 49, Issue 1, Page(s) 206–209

    Abstract: ... 2014, transplant centers can list eligible B blood type recipients for A2 organ offers. There have been ... no prior reports of ABO incompatible A2 to B deceased donor kidney transplantation ... in human immunodeficiency virus-positive (HIV+) recipients to guide clinicians on enrolling or performing A2 to B transplantations ...

    Abstract Background: With the introduction of the Kidney Allocation System in the United States in December 2014, transplant centers can list eligible B blood type recipients for A2 organ offers. There have been no prior reports of ABO incompatible A2 to B deceased donor kidney transplantation in human immunodeficiency virus-positive (HIV+) recipients to guide clinicians on enrolling or performing A2 to B transplantations in HIV+ candidates. We are the first to report a case of A2 to B deceased donor kidney transplantation in an HIV+ recipient with good intermediate-term results.
    Methods and results: We describe an HIV+ 39-year-old African American man with end-stage renal disease who underwent A2 to B blood type incompatible deceased donor kidney transplantation. Prior to transplantation, he had an undetectable HIV viral load. The patient was unsensitized, with his most recent anti-A titer data being 1:2 IgG and 1:32 IgG/IgM. Induction therapy of basiliximab and methylprednisolone was followed by a postoperative regimen of plasma exchange, intravenous immunoglobulin, and rituximab with maintenance on tacrolimus, mycophenolate mofetil, and prednisone. He had delayed graft function without rejection on allograft biopsy. Nadir serum creatinine was 2.0 mg/dL. He continued to have an undetectable viral load on the same antiretroviral therapy adjusted for renal function.
    Conclusions: To our knowledge, this is the first report of A2 to B deceased donor kidney transplantation in an HIV+ recipient with good intermediate-term results, suggesting that A2 donor kidneys may be considered for transplantation into HIV+ B-blood type wait list candidates.
    MeSH term(s) ABO Blood-Group System ; Adult ; Blood Group Incompatibility ; Delayed Graft Function/blood ; Delayed Graft Function/virology ; HIV Infections/blood ; HIV Infections/surgery ; HIV Infections/virology ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/virology ; Kidney Transplantation/methods ; Male ; Tissue Donors ; Treatment Outcome
    Chemical Substances ABO Blood-Group System
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2016.11.033
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  9. Book ; Online ; E-Book: Parasites of cattle and sheep

    Forbes, Andrew B.

    a practical guide to their biology and control

    2021  

    Author's details by Andrew B. Forbes
    Keywords Cattle-Parasites ; Sheep-Parasites ; Electronic books
    Language English
    Size 1 Online-Ressource (553 Seiten), Illustrationen
    Publisher CAB International
    Publishing place Wallingford
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021150696
    ISBN 978-1-78924-517-2 ; 9781789245158 ; 1-78924-517-6 ; 178924515X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Outcomes of Primary Rhegmatogenous Retinal Detachment Repair in Eyes With Preoperative Grade B or C Proliferative Vitreoretinopathy.

    Peck, Travis J / Starr, Matthew R / Yonekawa, Yoshihiro / Khan, M Ali / Obeid, Anthony / Ryan, Edwin H / Ryan, Claire / Ammar, Michael / Patel, Luv G / Forbes, Nora J / Capone, Antonio / Emerson, Geoffrey G / Joseph, Daniel P / Eliott, Dean / Regillo, Carl D / Hsu, Jason / Gupta, Omesh P / Kuriyan, Ajay E

    Journal of vitreoretinal diseases

    2021  Volume 6, Issue 3, Page(s) 194–200

    Abstract: ... retinal detachments (RRDs) with preoperative grade B and C proliferative vitreoretinopathy (PVR) vs eyes without PVR ... the visual acuity (VA) outcomes and single-surgery anatomic success rates (SSAS) of patients with primary grade B ... during the study period, of which 153 eyes (6.2%) had documented preoperative PVR grade B or C. Eyes ...

    Abstract Purpose: This work evaluates the anatomic and functional outcomes of primary rhegmatogenous retinal detachments (RRDs) with preoperative grade B and C proliferative vitreoretinopathy (PVR) vs eyes without PVR.
    Methods: As a multi-institutional, interventional, retrospective study of all patients undergoing primary RRD surgical procedures from January 1, 2015, through December 31, 2015, this study evaluated the visual acuity (VA) outcomes and single-surgery anatomic success rates (SSAS) of patients with primary grade B and C PVR at the time of RRD repair.
    Results: A total of 2486 eyes underwent primary RD surgery during the study period, of which 153 eyes (6.2%) had documented preoperative PVR grade B or C. Eyes without PVR had better SSAS compared with eyes with grade B or C PVR (87% vs 83% vs 75%, respectively,
    Conclusions: Eyes with primary preoperative grade B and C PVR appear to have significantly worse VA outcomes and lower surgical success rates. Surgical approach and management of PVR membranes did not appear to affect VA or success rates, indicating that preoperative PVR severity may dictate these outcomes.
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/24741264211046770
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