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Article ; Online: Assessing Heavy Metals in the Sele River Estuary: An Overview of Pollution Indices in Southern Italy.

Di Duca, Fabiana / Montuori, Paolo / De Rosa, Elvira / De Simone, Bruna / Russo, Immacolata / Nubi, Raffaele / Triassi, Maria

Toxics

2024 Volume 12, Issue 1

Abstract: Rapid industrialization, coupled with a historical lack of understanding in toxicology, has led in an increase in estuary pollution, frequently resulting in unexpected environmental situations. Therefore, the occurrence of heavy metals (HMs) constitutes ... ...

Abstract	Rapid industrialization, coupled with a historical lack of understanding in toxicology, has led in an increase in estuary pollution, frequently resulting in unexpected environmental situations. Therefore, the occurrence of heavy metals (HMs) constitutes a major environmental issue, posing a serious risk both to aquatic ecosystems and public health. This study aimed to evaluate the levels of eight HMs (As, Hg, Cd, Cr, Cu, Ni, Pb, and Zn) in water, suspended particles, and sediment near the Sele River estuary (Italy) in order to assess their environmental impacts on the sea and health risks for humans. The results revealed an increasing order of HM concentration according to the scheme suspended particulate matter (SPM) > sediment (SED) > dissolved phase (DP) and a moderate contamination status in sediment. The health risk assessment indicated that the non-carcinogenic risk was negligible. Carcinogenic risk, expressed as the incremental lifetime cancer risk (ILCR), was negligible for Cd and Ni and within tolerable limits for As, Pb, and Cr. The findings suggested that, even if there are currently no specific limits for chemical parameters in the transitional waters of Italy, monitoring systems should be implemented to determine pollution levels and implement effective steps to improve river water quality and reduce human health risks.
Language	English
Publishing date	2024-01-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12010038
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Article ; Online: Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable "on-off" luminescence.

Pugliese, Raffaele / Montuori, Monica / Gelain, Fabrizio

Nanoscale advances

2021 Volume 4, Issue 2, Page(s) 447–456

Abstract: Significant progress has been made in peptide self-assembly over the past two decades; however, ... ...

Abstract	Significant progress has been made in peptide self-assembly over the past two decades; however, the
Language	English
Publishing date	2021-11-22
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d1na00688f
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Article ; Online: The Role of the Plasminogen Activation System in Angioedema

Filomena Napolitano / Nunzia Montuori

Journal of Clinical Medicine, Vol 10, Iss 3, p

Novel Insights on the Pathogenesis

2021 Volume 518

Abstract: The main physiological functions of plasmin, the active form of its proenzyme plasminogen, are blood clot fibrinolysis and restoration of normal blood flow. The plasminogen activation (PA) system includes urokinase-type plasminogen activator (uPA), ... ...

Abstract	The main physiological functions of plasmin, the active form of its proenzyme plasminogen, are blood clot fibrinolysis and restoration of normal blood flow. The plasminogen activation (PA) system includes urokinase-type plasminogen activator (uPA), tissue-type PA (tPA), and two types of plasminogen activator inhibitors (PAI-1 and PAI-2). In addition to the regulation of fibrinolysis, the PA system plays an important role in other biological processes, which include degradation of extracellular matrix such as embryogenesis, cell migration, tissue remodeling, wound healing, angiogenesis, inflammation, and immune response. Recently, the link between PA system and angioedema has been a subject of scientific debate. Angioedema is defined as localized and self-limiting edema of subcutaneous and submucosal tissues, mediated by bradykinin and mast cell mediators. Different forms of angioedema are linked to uncontrolled activation of coagulation and fibrinolysis systems. Moreover, plasmin itself can induce a potentiation of bradykinin production with consequent swelling episodes. The number of studies investigating the PA system involvement in angioedema has grown in recent years, highlighting its relevance in etiopathogenesis. In this review, we present the components and diverse functions of the PA system in physiology and its importance in angioedema pathogenesis.
Keywords	angioedema ; fibrinolysis ; plasmin ; uPAR ; tPA ; Medicine ; R
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Variations in Epidural Steroid Injection Practice Patterns by Pain Medicine Physicians in the United States.

Bingham, Nishan / Dhall, Raymon / Montuori, Michael / Padjen, Kristoffer / Gharibo, Christopher / Doan, Lisa

Pain physician

2022 Volume 25, Issue 6, Page(s) E857–E862

Abstract: Background: Epidural steroid injections (ESI) are one of the most commonly performed pain procedures; however, there has been variation in techniques and approaches amongst pain physicians in the United States. The formation of a multidisciplinary ... ...

Abstract	Background: Epidural steroid injections (ESI) are one of the most commonly performed pain procedures; however, there has been variation in techniques and approaches amongst pain physicians in the United States. The formation of a multidisciplinary working group was made with considerations to help guide ESI practice. Objective: Pain medicine physicians in the United States were surveyed in order to provide an update on current practices for both transforaminal and interlaminar ESI. Study design and setting: This was a cross-sectional survey of pain medicine physicians in the United States. Methods: This study was approved by the institutional review board of our institution. Based on the American Society of Interventional Pain Physicians membership database, an email list was generated, and a web-based survey was sent to interventional pain physicians at academic centers, private practices, government hospitals, and community settings across the United States. Cervical, lumbar, and caudal ESI sections were divided into questions regarding preferences for fluoroscopic views, injectates, and techniques. Results: A total of 261 responses were analyzed. All but one used fluoroscopy for lumbar ESI. There were variations in methods to detect intravascular uptake, choice of injectate, and the use of particulate steroids for lumbar transforaminal epidural steroid injection (TFESI). Limitations: The response rate is a limitation, and thus the results may not be representative of all pain medicine physicians in the United States. Conclusions: Since the 2015 multidisciplinary pain workgroup recommendations were made for ESI, there appears to be a trend towards following these guidelines compared to prior surveys looking at ESI practices. However, our survey shows there continues to be variations in ESI practice that deviates from these guidelines.
MeSH term(s)	Analgesics ; Cross-Sectional Studies ; Humans ; Injections, Epidural/methods ; Pain ; Physicians ; Steroids ; United States
Chemical Substances	Analgesics ; Steroids
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146393-1
ISSN	2150-1149 ; 1533-3159
ISSN (online)	2150-1149
ISSN	1533-3159
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Article ; Online: Behavior during aging of bone-marrow fatty-acids profile in women's calcaneus to search for early potential osteoporotic biomarkers: a 1H-MR Spectroscopy study.

Mattioli, Daniele / Vinicola, Vincenzo / Aragona, Michele / Montuori, Marco / Tarantino, Umberto / Capuani, Silvia

Bone

2022 Volume 164, Page(s) 116514

Abstract: ... Results: TL was significantly correlated with age (r = 0.73, p < 0.001). TL increases linearly with age ... in the young + perimenopausal population (r = 0.92, p < 0.001) but this trend is not significant ... in the postmenopausal subject (r = 0.48, p = 0.07). No significant correlation was found between T-Score and TL ...

Abstract	Aim: Identify new potential biomarkers of osteoporosis at an early stage, by magnetic resonance spectroscopy (MRS), studying early changes in the metabolic profile of bone-marrow fatty acids in women's calcanei during healthy aging and osteoporosis status. Methods: Single voxel MRS was performed by using a point resolved spectroscopy (PRESS) sequence at 3T. Thirty-four Caucasian women (age range: 22-59 years) were recruited to investigate calcaneus bone marrow. The cohort was constituted of four groups according to age, menopausal status, and T-score evaluated after a DXA examination on the femoral neck. Women were classified in young control (n = 11, mean age = 26.5 ± 3.8 y, age range: 22-34 years), perimenopausal groups (n = 11, mean age = 42.0 ± 3.6 y, age range: 37-47 years), postmenopausal group (n = 9, mean age = 55.4 ± 2.9 y, age range: 50-59 years, mean T-score = -1.70 ± 0.50) and osteoporotic group (n = 6, mean age = 53.0 ± 2.8 y, age range: 50-58 years, mean T-score = -2.54 ± 0.10). The total lipid content (TL), the Unsaturation Index (UI), and the fraction of unsaturated/polyunsaturated fatty acid (f Results: TL was significantly correlated with age (r = 0.73, p < 0.001). TL increases linearly with age in the young + perimenopausal population (r = 0.92, p < 0.001) but this trend is not significant in the postmenopausal subject (r = 0.48, p = 0.07). No significant correlation was found between T-Score and TL in postmenopausal and osteoporotic women, whereas a significant correlation was found between TL and time interval (t Conclusion: In the female calcaneus, f
MeSH term(s)	Absorptiometry, Photon ; Adult ; Biomarkers ; Bone Density ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Calcaneus/pathology ; Fatty Acids ; Female ; Humans ; Magnetic Resonance Spectroscopy/methods ; Middle Aged ; Osteoporosis/diagnostic imaging ; Osteoporosis/pathology ; Osteoporosis, Postmenopausal/pathology ; Young Adult
Chemical Substances	Biomarkers ; Fatty Acids
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2022.116514
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Invasive meningococcal disease epidemiology and vaccination strategies in four Southern European countries: a review of the available data.

Zografaki, Irini / Detsis, Marios / Del Amo, Maria / Iantomasi, Raffaella / Maia, Ana / Montuori, Eva Agostina / Mendez, Cristina

Expert review of vaccines

2023 Volume 22, Issue 1, Page(s) 545–562

Abstract: Introduction: Invasive meningococcal disease (IMD) is a major health concern which can be prevented through vaccination. Conjugate vaccines against serogroups A, C, W, and Y and two protein-based vaccines against serogroup B are currently available in ... ...

Abstract	Introduction: Invasive meningococcal disease (IMD) is a major health concern which can be prevented through vaccination. Conjugate vaccines against serogroups A, C, W, and Y and two protein-based vaccines against serogroup B are currently available in the European Union. Areas covered: We present epidemiologic data for Italy, Portugal, Greece, and Spain using publicly available reports from national reference laboratories and national or regional immunization programs (1999-2019), aiming to confirm risk groups, and describe time trends in overall incidence and serogroup distribution, as well as impact of immunization. Analysis of circulating MenB isolates in terms of the surface factor H binding protein (fHbp) using PubMLST is discussed as fHbp represents an important MenB vaccine antigen. Predictions of potential reactivity of the two available MenB vaccines (MenB-fHbp and 4CMenB) with circulating MenB isolates are also provided as assessed using the recently developed MenDeVAR tool. Expert opinion: Understanding dynamics of IMD and continued genomic surveillance are essential for evaluating vaccine effectiveness, but also prompting proactive immunization programs to prevent future outbreaks. Importantly, the successful design of further effective meningococcal vaccines to fight IMD relies on considering the unpredictable epidemiology of the disease and combining lessons learnt from capsule polysaccharide vaccines and protein-based vaccines.
MeSH term(s)	Humans ; Meningococcal Infections/epidemiology ; Meningococcal Infections/prevention & control ; Meningococcal Vaccines ; Neisseria meningitidis, Serogroup B ; Vaccination ; Antigens, Bacterial ; Serogroup ; Carrier Proteins
Chemical Substances	Meningococcal Vaccines ; Antigens, Bacterial ; Carrier Proteins
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2023.2225596
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Zs.A 6077: Show issues

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Article ; Online: Desarrollo Normal en Menores de Dos Años Prevención de Trastornos del Desarrollo y Accidentes

Eliana Montuori

Revista del Hospital Materno Infantil Ramón Sardá, Vol 33, Iss 1, p

2014 Volume 36

Keywords	Pediatrics ; RJ1-570 ; Medicine ; R ; Gynecology and obstetrics ; RG1-991
Language	Spanish
Publishing date	2014-01-01T00:00:00Z
Publisher	Asociación de Profesionales del Hospital Materno Infantil Ramón Sardá
Document type	Article ; Online
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Article ; Online: Perceptual learning with tactile stimuli in rats: Changes in the processing of a dimension.

Montuori, Luke M / Honey, R C

Journal of experimental psychology. Animal learning and cognition

2016 Volume 42, Issue 3, Page(s) 281–289

Abstract: Four experiments with male rats investigated perceptual learning involving a tactile dimension (A, B, C, D, E), where A denotes 1 end of the continuum (e.g., a rough floor) and E the other (e.g., a smooth floor). In Experiment 1, rats given preexposure ... ...

Abstract	Four experiments with male rats investigated perceptual learning involving a tactile dimension (A, B, C, D, E), where A denotes 1 end of the continuum (e.g., a rough floor) and E the other (e.g., a smooth floor). In Experiment 1, rats given preexposure to A and E learned an appetitive discrimination between them more readily than those not given preexposure. Experiment 2a showed that rats preexposed to B and D acquired a discrimination between A and E more readily than those preexposed to A and E; and in Experiment 2b the same preexposure treatments had no effect on the acquisition of a discrimination between B and D. In Experiments 3a and 3b, rats given preexposure to C learned a discrimination between A and E more readily than those not given preexposure. Experiment 4 demonstrated that preexposure to a texture (e.g., B) that was adjacent to the to-be-discriminated textures (e.g., C and E) facilitated a discrimination between them relative to preexposure to their midpoint (D). These novel perceptual learning effects are interpreted as reflecting a redistribution of processing between the notional elements of the texture dimension. (PsycINFO Database Record
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Journal Article
ISSN	2329-8464
ISSN (online)	2329-8464
DOI	10.1037/xan0000104
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Article ; Online: Switching of biological therapy to dupilumab in comorbid patients with severe asthma and CRSwNP.

Rosso, Cecilia / De Corso, Eugenio / Conti, Valerio / Nitro, Letizia / Saibene, Alberto Maria / Parazzini, Elena / Rinaldo, Rocco / De Pascalis, Sabrina / Arnone, Flavio / Centanni, Stefano / Montuori, Claudio / D'Auria, Leandro Maria / Felisati, Giovanni / Pipolo, Carlotta

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024

Abstract: Purpose: Nowadays, several efficacious biologic drugs are used for severe asthma with or without chronic rhinosinusitis with nasal polyps (CRSwNP). However, it has been observed that not all comorbid patients (asthma/CRSwNP) receiving biologic treatment ...

Abstract	Purpose: Nowadays, several efficacious biologic drugs are used for severe asthma with or without chronic rhinosinusitis with nasal polyps (CRSwNP). However, it has been observed that not all comorbid patients (asthma/CRSwNP) receiving biologic treatment for asthma experience satisfactory control of both conditions equally. Methods: We selected 20 patients who had both severe asthma and comorbid CRSwNP under biological treatment with benralizumab, omalizumab or mepolizumab with adequate control of asthma but inadequate control of nasal symptoms. Patients were switched to dupilumab and outcomes were evaluated at baseline (T0), at 3 months (T1), at 6 months (T2), at 12 months (T3) and finally at 18 months (T4). Data were collected at each time point including blood tests measuring eosinophil levels and total IgE, SNOT22, ACT, NPS score, rhinomanometry, olfactory testing, and nasal cytology. Results: The results showed an overall improvement in all the outcomes. Peripheral eosinophilia was observed consistently with existing literature. All patients registered an improvement in sinonasal outcomes, while only one patient had a worsening of asthma. Three patients interrupted the therapy due to various causes: poor asthma control, onset of psoriasis and thrombocytopenia. Conclusions: The response to a biologic treatment for CRSwNP control may be heterogenous and it seems that patients may benefit from switching improving control in equal measure in the upper and lower airway. Further studies to explore the endotype/phenotype which best fits with each biologic are mandatory to personalize the therapy.
Language	English
Publishing date	2024-02-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08461-y
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Article ; Online: Comentario sobre libro

Eliana Montuori

Revista del Hospital Materno Infantil Ramón Sardá, Vol 31, Iss 3, p

Desarrollo en menores de dos años. Prevención de trastornos del desarrollo y accidentes

2012 Volume 139

Keywords	Pediatrics ; RJ1-570 ; Medicine ; R ; Gynecology and obstetrics ; RG1-991
Language	Spanish
Publishing date	2012-01-01T00:00:00Z
Publisher	Asociación de Profesionales del Hospital Materno Infantil Ramón Sardá
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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