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  1. Book: Acrolein

    Stevens, Jan F.

    (Molecular nutrition & food research ; 55,9)

    2011  

    Title variant Special: Acrolein
    Author's details guest ed.: Jan F. Stevens
    Series title Molecular nutrition & food research ; 55,9
    Collection
    Language English
    Size S. 1275 - 1434 : Ill., graph. Darst.
    Publisher Wiley-Blackwell
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT016975210
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    Z 1146 (55,9) available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Profiling of Oxylipins as Markers of Oxidative Stress in Biological Samples.

    Yang, Liping / Choi, Jaewoo / Maier, Claudia S / Stevens, Jan F

    Current protocols

    2024  Volume 4, Issue 3, Page(s) e992

    Abstract: Oxylipins are oxidized metabolites of polyunsaturated fatty acids (PUFAs). They represent a class of risk markers and/or therapeutic targets for diseases associated with inflammation, including cardiovascular disease and brain disorders. Because the ... ...

    Abstract Oxylipins are oxidized metabolites of polyunsaturated fatty acids (PUFAs). They represent a class of risk markers and/or therapeutic targets for diseases associated with inflammation, including cardiovascular disease and brain disorders. Because the biological activities of free PUFAs and oxylipins depend on their chemical structures and concentrations, monitoring PUFAs and oxylipin levels in biological systems is critical for understanding their roles in health and disease. Traditionally, accurate quantification of free PUFAs and oxylipins in biological samples was performed separately, as PUFAs are often 1000-fold more abundant than the derived oxidized fatty acids (oxylipins). This article describes a liquid chromatography multiple reaction monitoring tandem mass spectrometry method for the quantitative analysis of five free PUFAs and 88 oxylipins in various biological fluids, including plasma, platelet supernatants, and tissues. The same approach can also be used in conjunction with an alkaline hydrolysis step to quantify total oxylipins in fish oils. We observed that in some samples, linoleic acid levels in plasma and eicosapentaenoic acid and arachidonic acid levels in brain tissue were above the upper limit of quantification. To address this issue, we developed a data analysis method to obtain PUFA and oxylipin concentrations in these samples without additional sample preparation, thus significantly saving time and labor. © 2024 Wiley Periodicals LLC. Basic Protocol: Quantification of polyunsaturated fatty acids (PUFAs) and oxylipins using liquid chromatography multiple reaction monitoring tandem mass spectrometry Support Protocol 1: Preparation of internal standard mixed working solution Support Protocol 2: Preparation of standard mixed stock solution Support Protocol 3: Preparation of standard mixed working solution Alternate Protocol 1: Extraction and quantitation of free PUFAs and oxylipins from mouse brain tissue Alternate Protocol 2: Extraction and quantitation of total PUFAs and oxylipins from fish oil.
    MeSH term(s) Animals ; Mice ; Oxylipins ; Fatty Acids ; Oxidative Stress ; Fatty Acids, Nonesterified ; Linoleic Acid ; Fish Oils
    Chemical Substances Oxylipins ; Fatty Acids ; Fatty Acids, Nonesterified ; Linoleic Acid (9KJL21T0QJ) ; Fish Oils
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dietary (poly)phenols mitigate inflammatory bowel disease: Therapeutic targets, mechanisms of action, and clinical observations.

    Jamieson, Paige E / Carbonero, Franck / Stevens, Jan F

    Current research in food science

    2023  Volume 6, Page(s) 100521

    Abstract: Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are a rapidly growing public health concern worldwide. These diseases are heterogeneous at the clinical, immunological, molecular, genetic, and microbial level, but ... ...

    Abstract Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are a rapidly growing public health concern worldwide. These diseases are heterogeneous at the clinical, immunological, molecular, genetic, and microbial level, but characteristically involve a disrupted immune-microbiome axis. Shortcomings in conventional treatment options warrant the need for novel therapeutic strategies to mitigate these life-long and relapsing disorders of the gastrointestinal tract. Polyphenols, a diverse group of phytochemicals, have gained attention as candidate treatments due to their array of biological effects. Polyphenols exert broad anti-inflammatory and antioxidant effects through the modulation of cellular signaling pathways and transcription factors important in IBD progression. Polyphenols also bidirectionally modulate the gut microbiome, supporting commensals and inhibiting pathogens. One of the primary means by which gut microbiota interface with the host is through the production of metabolites, which are small molecules produced as intermediate or end products of metabolism. There is growing evidence to support that modulation of the gut microbiome by polyphenols restores microbially derived metabolites critical to the maintenance of intestinal homeostasis that are adversely disrupted in IBD. This review aims to define the therapeutic targets of polyphenols that may be important for mitigation of IBD symptoms, as well as to collate evidence for their clinical use from randomized clinical trials.
    Language English
    Publishing date 2023-05-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2665-9271
    ISSN (online) 2665-9271
    DOI 10.1016/j.crfs.2023.100521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of

    Miranda, Cristobal L / Kumbi, Yadano / Wu, Wenbin / Lee, Hyi-Seung / Reed, Ralph L / Stevens, Jan F

    Natural product communications

    2022  Volume 17, Issue 7

    Abstract: Phytochemicals from the genus, ...

    Abstract Phytochemicals from the genus,
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2430442-6
    ISSN 1555-9475 ; 1934-578X
    ISSN (online) 1555-9475
    ISSN 1934-578X
    DOI 10.1177/1934578x221109426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Affinity- and activity-based probes synthesized from structurally diverse hops-derived xanthohumol flavonoids reveal highly varied protein profiling in

    Webber, Lucas C / Anderson, Lindsey N / Paraiso, Ines L / Metz, Thomas O / Bradley, Ryan / Stevens, Jan F / Wright, Aaron T

    RSC advances

    2023  Volume 13, Issue 42, Page(s) 29324–29331

    Abstract: Xanthohumol, the principle prenylflavonoid found in hops ( ...

    Abstract Xanthohumol, the principle prenylflavonoid found in hops (
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05296f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults.

    Jamieson, Paige E / Smart, Eli B / Bouranis, John A / Choi, Jaewoo / Danczak, Robert E / Wong, Carmen P / Paraiso, Ines L / Maier, Claudia S / Ho, Emily / Sharpton, Thomas J / Metz, Thomas O / Bradley, Ryan / Stevens, Jan F

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2315633

    Abstract: Xanthohumol (XN), a polyphenol found in the hop plant ( ...

    Abstract Xanthohumol (XN), a polyphenol found in the hop plant (
    MeSH term(s) Adult ; Humans ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S/genetics ; Flavonoids/pharmacology ; Prebiotics ; Propiophenones
    Chemical Substances xanthohumol (T4467YT1NT) ; RNA, Ribosomal, 16S ; Flavonoids ; Prebiotics ; Propiophenones
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2315633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study Analysis of

    Alcázar Magaña, Armando / Vaswani, Ashish / Brown, Kevin S / Jiang, Yuan / Alam, Md Nure / Caruso, Maya / Lak, Parnian / Cheong, Paul / Gray, Nora E / Quinn, Joseph F / Soumyanath, Amala / Stevens, Jan F / Maier, Claudia S

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 4

    Abstract: Rapid screening of botanical extracts for the discovery of bioactive natural products was performed using a fractionation approach in conjunction with flow-injection high-resolution mass spectrometry for obtaining chemical fingerprints of each fraction, ... ...

    Abstract Rapid screening of botanical extracts for the discovery of bioactive natural products was performed using a fractionation approach in conjunction with flow-injection high-resolution mass spectrometry for obtaining chemical fingerprints of each fraction, enabling the correlation of the relative abundance of molecular features (representing individual phytochemicals) with the read-outs of bioassays. We applied this strategy for discovering and identifying constituents of
    MeSH term(s) Humans ; Amyloid beta-Peptides/toxicity ; Alzheimer Disease/drug therapy ; Plant Extracts/pharmacology ; Cognition ; Centella/chemistry ; Triterpenes/analysis ; Biological Assay ; Computer Simulation ; Quinic Acid/analogs & derivatives
    Chemical Substances Amyloid beta-Peptides ; Plant Extracts ; Triterpenes ; caffeoylquinic acid ; Quinic Acid (058C04BGYI)
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29040838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article: Potential use of polyphenols in the battle against COVID-19.

    Paraiso, Ines L / Revel, Johana S / Stevens, Jan F

    Current opinion in food science

    2020  Volume 32, Page(s) 149–155

    Abstract: The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs ... ...

    Abstract The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. Polyphenols, a major class of bioactive compounds in nature, are known for their antiviral activity and pleiotropic effects. The aim of this review is to assess the effects of polyphenols on COVID-19 drug targets as well as to provide a perspective on the possibility to use polyphenols in the development of natural approaches against this viral disease.
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2797683-X
    ISSN 2214-7993
    ISSN 2214-7993
    DOI 10.1016/j.cofs.2020.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quantification of Caffeoylquinic Acids and Triterpenes as Targeted Bioactive Compounds of

    Yang, Liping / Marney, Luke / Magana, Armando Alcazar / Choi, Jaewoo / Wright, Kirsten / Mcferrin, Janis / Gray, Nora E / Soumyanath, Amala / Stevens, Jan F / Maier, Claudia S

    Journal of chromatography open

    2023  Volume 4

    Abstract: ... Centella ... ...

    Abstract Centella asiatica
    Language English
    Publishing date 2023-07-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-3917
    ISSN (online) 2772-3917
    DOI 10.1016/j.jcoa.2023.100091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Nitrate exposure reprograms hepatic amino acid and nutrient sensing pathways prior to exercise: A metabolomic and transcriptomic investigation in zebrafish

    Keller, Rosa M / Beaver, Laura M / Prater, Mary C / Truong, Lisa / Tanguay, Robyn L / Stevens, Jan F / Hord, Norman G

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 903130

    Abstract: Scope: ...

    Abstract Scope:
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.903130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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