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  1. Article ; Online: Special issue: Cushing's disease update.

    Fleseriu, Maria

    Pituitary

    2022  Volume 25, Issue 5, Page(s) 687–688

    MeSH term(s) Humans ; Pituitary ACTH Hypersecretion/diagnosis ; Adrenalectomy ; Adrenocorticotropic Hormone
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-022-01271-7
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  2. Article ; Online: Cushing's syndrome Part 1: Journey to Improving Diagnosis and Outcomes.

    Fleseriu, Maria

    Best practice & research. Clinical endocrinology & metabolism

    2021  Volume 35, Issue 1, Page(s) 101520

    Language English
    Publishing date 2021-03-13
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2021.101520
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  3. Article ; Online: Cushing's syndrome Part 2: Advances in Treatment and in Understanding Complications' Impact.

    Fleseriu, Maria

    Best practice & research. Clinical endocrinology & metabolism

    2021  Volume 35, Issue 2, Page(s) 101523

    Language English
    Publishing date 2021-03-12
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2021.101523
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  4. Article: Pituitary Disorders and COVID-19, Reimagining Care: The Pandemic A Year and Counting.

    Fleseriu, Maria

    Frontiers in endocrinology

    2021  Volume 12, Page(s) 656025

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/therapy ; Comorbidity ; Delivery of Health Care/methods ; Delivery of Health Care/organization & administration ; Delivery of Health Care/trends ; Endocrinology/methods ; Endocrinology/organization & administration ; Endocrinology/trends ; History, 21st Century ; Humans ; Pandemics/history ; Pituitary Diseases/complications ; Pituitary Diseases/epidemiology ; Pituitary Diseases/therapy ; Risk Factors ; SARS-CoV-2/physiology ; Severity of Illness Index
    Language English
    Publishing date 2021-03-12
    Publishing country Switzerland
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2021.656025
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  5. Article ; Online: Salivary Cortisol in the Diagnosis of Cushing Syndrome, Always More Than One!

    Fleseriu, Maria

    Journal of the Endocrine Society

    2020  Volume 4, Issue 10, Page(s) bvaa109

    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvaa109
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  6. Article ; Online: Mentorship in academic medicine: truth is in the eye of the beholder.

    Fleseriu, Maria / Lim, Dawn Shao Ting

    Nature reviews. Endocrinology

    2023  Volume 19, Issue 7, Page(s) 373–374

    MeSH term(s) Humans ; Mentors
    Language English
    Publishing date 2023-05-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-023-00846-z
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  7. Article ; Online: Commentary: Cortisone or Cortisol, "the E" or "the F," That Is the Question!

    Ceccato, Filippo / Fleseriu, Maria

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 1, Page(s) e428–e429

    MeSH term(s) Humans ; Hydrocortisone ; Cortisone/therapeutic use ; Dexamethasone ; Saliva ; Adrenal Gland Neoplasms
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Cortisone (V27W9254FZ) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad348
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  8. Article ; Online: Reply to 'The shift of therapeutic strategy for prolactinomas: surgery as the first-line option'.

    Petersenn, Stephan / Fleseriu, Maria / Melmed, Shlomo

    Nature reviews. Endocrinology

    2024  Volume 20, Issue 5, Page(s) 311

    MeSH term(s) Humans ; Prolactinoma/surgery ; Prolactinoma/drug therapy ; Pituitary Neoplasms/surgery ; Pituitary Neoplasms/drug therapy ; Prolactin
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Letter
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-024-00954-4
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  9. Article ; Online: Reply to 'Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern'.

    Petersenn, Stephan / Fleseriu, Maria / Melmed, Shlomo

    Nature reviews. Endocrinology

    2024  Volume 20, Issue 5, Page(s) 315

    MeSH term(s) Humans ; Prolactinoma/drug therapy ; Prolactinoma/pathology ; Dopamine Agonists/adverse effects ; Pituitary Neoplasms/drug therapy ; Pituitary Neoplasms/pathology ; Fibrosis
    Chemical Substances Dopamine Agonists
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-024-00978-w
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  10. Article ; Online: Cushing Syndrome: A Review.

    Reincke, Martin / Fleseriu, Maria

    JAMA

    2023  Volume 330, Issue 2, Page(s) 170–181

    Abstract: Importance: Cushing syndrome is defined as a prolonged increase in plasma cortisol levels that is not due to a physiological etiology. Although the most frequent cause of Cushing syndrome is exogenous steroid use, the estimated incidence of Cushing ... ...

    Abstract Importance: Cushing syndrome is defined as a prolonged increase in plasma cortisol levels that is not due to a physiological etiology. Although the most frequent cause of Cushing syndrome is exogenous steroid use, the estimated incidence of Cushing syndrome due to endogenous overproduction of cortisol ranges from 2 to 8 per million people annually. Cushing syndrome is associated with hyperglycemia, protein catabolism, immunosuppression, hypertension, weight gain, neurocognitive changes, and mood disorders.
    Observations: Cushing syndrome characteristically presents with skin changes such as facial plethora, easy bruising, and purple striae and with metabolic manifestations such as hyperglycemia, hypertension, and excess fat deposition in the face, back of the neck, and visceral organs. Cushing disease, in which corticotropin excess is produced by a benign pituitary tumor, occurs in approximately 60% to 70% of patients with Cushing syndrome due to endogenous cortisol production. Evaluation of patients with possible Cushing syndrome begins with ruling out exogenous steroid use. Screening for elevated cortisol is performed with a 24-hour urinary free cortisol test or late-night salivary cortisol test or by evaluating whether cortisol is suppressed the morning after an evening dexamethasone dose. Plasma corticotropin levels can help distinguish between adrenal causes of hypercortisolism (suppressed corticotropin) and corticotropin-dependent forms of hypercortisolism (midnormal to elevated corticotropin levels). Pituitary magnetic resonance imaging, bilateral inferior petrosal sinus sampling, and adrenal or whole-body imaging can help identify tumor sources of hypercortisolism. Management of Cushing syndrome begins with surgery to remove the source of excess endogenous cortisol production followed by medication that includes adrenal steroidogenesis inhibitors, pituitary-targeted drugs, or glucocorticoid receptor blockers. For patients not responsive to surgery and medication, radiation therapy and bilateral adrenalectomy may be appropriate.
    Conclusions and relevance: The incidence of Cushing syndrome due to endogenous overproduction of cortisol is 2 to 8 people per million annually. First-line therapy for Cushing syndrome due to endogenous overproduction of cortisol is surgery to remove the causative tumor. Many patients will require additional treatment with medications, radiation, or bilateral adrenalectomy.
    MeSH term(s) Humans ; Adrenocorticotropic Hormone/blood ; Cushing Syndrome/blood ; Cushing Syndrome/diagnosis ; Cushing Syndrome/etiology ; Cushing Syndrome/therapy ; Hydrocortisone/blood ; Hypertension/etiology ; Pituitary Neoplasms/blood ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/surgery
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.11305
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