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Article ; Online: Frail Silk: Is the Hughes-Stovin Syndrome a Behçet Syndrome Subtype with Aneurysm-Involved Gene Variants?

Manole, Simona / Rancea, Raluca / Vulturar, Romana / Simon, Siao-Pin / Molnar, Adrian / Damian, Laura

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Hughes-Stovin syndrome is a rare disease characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. The etiology and pathogenesis of HSS are incompletely known. The current consensus is that vasculitis underlies the pathogenic ... ...

Abstract	Hughes-Stovin syndrome is a rare disease characterized by thrombophlebitis and multiple pulmonary and/or bronchial aneurysms. The etiology and pathogenesis of HSS are incompletely known. The current consensus is that vasculitis underlies the pathogenic process, and pulmonary thrombosis follows arterial wall inflammation. As such, Hughes-Stovin syndrome may belong to the vascular cluster with lung involvement of Behçet syndrome, although oral aphtae, arthritis, and uveitis are rarely found. Behçet syndrome is a multifactorial polygenic disease with genetic, epigenetic, environmental, and mostly immunological contributors. The different Behçet syndrome phenotypes are presumably based upon different genetic determinants involving more than one pathogenic pathway. Hughes-Stovin syndrome may have common pathways with fibromuscular dysplasias and other diseases evolving with vascular aneurysms. We describe a Hughes-Stovin syndrome case fulfilling the Behçet syndrome criteria. A
MeSH term(s)	Humans ; Aneurysm/complications ; Aneurysm/diagnosis ; Aneurysm/pathology ; Behcet Syndrome/diagnosis ; Pulmonary Artery/pathology ; Vasculitis/pathology
Language	English
Publishing date	2023-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis.

Siao-Pin, Simon / Damian, Laura-Otilia / Muntean, Laura Mirela / Rednic, Simona

Experimental and therapeutic medicine

2016 Volume 12, Issue 5, Page(s) 3459–3463

Abstract: Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast ... ...

Abstract	Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis. The hypoxia-inducible transcription factor HIF-1α and VEGF signaling has a critical role in regulating osteoclastic bone-resorption and angiogenesis, and increased osteoclastogenesis and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis. The cells of the osteoblast lineage also have important roles in angiogenic-osteogenic coupling. The research in this field might help limiting the disability associated with the disease.
Language	English
Publishing date	2016-10-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2016.3782
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Article ; Online: Posttraumatic hip bulging mimicking an abscess in a patient with hip prosthesis: the role of ultrasonography.

Damian, Laura Otilia / Simon, Siao-Pin / Felea, Ioana / Coman, Mihaela / Fodor, Daniela / Voica, Cezara Mariana

Medical ultrasonography

2019 Volume 21, Issue 2, Page(s) 191–193

Abstract: A 48-yr old female patient, with stage 4 rheumatoid arthritis, who had undergone multiple joint prostheses including four arthroplasties of the left hip, presented for a sudden-onset large bulge on the left thigh, after a minor local injury. Orthopedic ... ...

Abstract	A 48-yr old female patient, with stage 4 rheumatoid arthritis, who had undergone multiple joint prostheses including four arthroplasties of the left hip, presented for a sudden-onset large bulge on the left thigh, after a minor local injury. Orthopedic examination and radiography excluded fractures. Ultrasonography revealed a large mixed hypo- and hyperechoic collection,with no Doppler signal, but with comet tail artifacts. Repeated cultures from the collection were negative. Fluid analysis revealed increased quantities of titanium and cobalt. The sudden-onset deformity and fluid collection were in favor of a shear lesion (Morel-Lavallée). The new collection communicated with a previously asymptomatic periprosthetic aseptic abscess, mimicking an infection. To our knowledge, Morel-Lavallée shear lesions have not been described in patients with hip prostheses. Their presence may add to the difficulties of ruling out silent infections in such patients. Ultrasonography is a very effective method for the diagnosis and follow-up of collections in this setting.
MeSH term(s)	Abscess ; Degloving Injuries/diagnostic imaging ; Diagnosis, Differential ; Female ; Hip Prosthesis ; Humans ; Middle Aged ; Thigh/diagnostic imaging ; Thigh/injuries ; Ultrasonography/methods
Language	English
Publishing date	2019-05-07
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2529623-1
ISSN	2066-8643 ; 1844-4172
ISSN (online)	2066-8643
ISSN	1844-4172
DOI	10.11152/mu-1748
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Article ; Online: Bone status and aortic calcifications in chondrocalcinosis patients

Vele Paulina / Silaghi Ciprian Nicolae / Damian Laura Otilia / Simon Siao-Pin / Craciun Alexandra / Rednic Simona

Romanian Journal of Laboratory Medicine, Vol 28, Iss 2, Pp 195-

2020 Volume 204

Abstract: Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients ... ...

Abstract	Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC).
Keywords	chondrocalcinosis ; osteocalcin ; osteoprotegerin ; beta cross laps ; abdominal aortic calcifications ; Medicine ; R
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SYNOVIAL AND SERUM LEVELS OF OSTEOCALCIN, OSTEOPROTEGERIN AND Β-CROSSLAPS IN PATIENTS WITH CALCIUM PYROPHOSPHATE DEPOSITION DISEASE

Paulina Vele / Ciprian N. Silaghi / Laura O. Damian / Siao-Pin Simon / Alexandra M. Craciun / Simona Rednic

Romanian Journal of Rheumatology, Vol 28, Iss 2, Pp 71-

2019 Volume 75

Abstract: Background. Calcium pyrophosphate deposition disease is defined by deposition of calcium pyrophosphate crystals in hyaline cartilage, fibrocartilage and soft tissues. The study of bone markers is of great interest in different types of arthritis. In ... ...

Abstract	Background. Calcium pyrophosphate deposition disease is defined by deposition of calcium pyrophosphate crystals in hyaline cartilage, fibrocartilage and soft tissues. The study of bone markers is of great interest in different types of arthritis. In patients with calcium pyrophosphate deposition disease, bone turnover markers may yield additional information from many perspectives. Objectives. To measure synovial and serum levels of osteocalcin, osteoprotegerin and β-CrossLaps in patients with calcium pyrophosphate deposition disease. Material and methods. In this pilot, prospective study were enrolled eight patients with calcium pyrophosphate deposition disease. Osteocalcin, osteoprotegerin and β-CrossLaps were measured in serum and in the synovial fluid using ELISA kits. Results. Synovial fluid osteocalcin was significantly lower comparative with serum osteocalcin (2.1±0.6 versus 9.21 ±46, p=0.02). Synovial fluid osteoprotegerin was significantly higher than serum osteoprotegerin (55.5±284 versus 8.44±7; p=0.0001). Synovial fluid β-CrossLaps wasn’t statistically different from serum levels (6146±66818 versus 6077±12212; p=0.5). Ratios between synovial fluid and serum levels were 0.22 for osteocalcin, 6.57 for osteoprotegerin and 1.01 for β-CrossLaps. Conclusions. Osteocalcin was higher in serum than in the synovial fluid. β-CrossLaps had similar values in serum and synovial fluid. Osteoprotegerin was higher in synovial fluid than serum.
Keywords	calcium pyrophosphate deposition disease ; osteocalcin ; osteoprotegerin ; β-crosslaps ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
Subject code	616
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Basic calcium phosphate deposition disease – a clinical and imaging analysis

Paulina Vele / Laura Otilia Damian / Siao-Pin Simon / Ioana Felea / Laura Muntean / Ileana FilipescU / Maria Magdalena Tamas / Cristina Pamfil / Cristian Nedelcut / Simona Rednic

Romanian Journal of Rheumatology, Vol 29, Iss 2, Pp 70-

2020 Volume 74

Abstract: Background. Basic calcium phosphate (BCP) deposition disease is a frequent musculoskeletal problem characterized by the intraarticular or periarticular deposition of carbonate substituted hydroxyapatite, octacalcium phosphate and tricalcium phosphate. ... ...

Abstract	Background. Basic calcium phosphate (BCP) deposition disease is a frequent musculoskeletal problem characterized by the intraarticular or periarticular deposition of carbonate substituted hydroxyapatite, octacalcium phosphate and tricalcium phosphate. BCP and calcium pyrophosphate (CPP) crystals play an important role in the pathogenesis of osteoarthritis. Objectives. The primary aim was to evaluate the clinical and ultrasonographic characteristics of patients with BCP. The secondary aim was to compare the radiographic scores of patients with BCP, calcium pyrophosphate dihydrate (CPPD) deposition disease and degenerative disease (DD). Material and methods. 50 patients with BCP deposition disease diagnosed by imaging or by identification of BCP in synovial fluid (SF) were included in the study. The second part of the study included 20 patients with BCP crystals in SF, 20 patients with CPP crystals in SF and 20 patients with degenerative changes on radiography and without crystals in SF. Clinical, ultrasonographic and radiographic data were recorded. Results. The shoulder joint (56%), followed by the knee joint (36%) and the acute clinical presentation (84%) were the most common findings. The fragmented ultrasound appearance (54%) was the most frequent, followed by the arch-shaped (36%). The localization of the deposits was found most often in the tendons (68%), mainly in the supraspinatus tendon (55.88%). Higher K/L scores were found in patients with BCP and CPP crystals than in the patients with DD. K/L score ≥3, defining osteoarthritis was associated with the presence of BCP and CPP crystals. Conclusions. The shoulder and the fragmented ultrasound pattern are the most common findings in patients with BCP. Higher K/L scores are found in patients with BCP and CPP crystal associated disease than in the degenerative disease patients.
Keywords	basic calcium phosphate ; calcium pyrophosphate ; osteoarthritis ; kellgren-lawrence ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
Subject code	610
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and ultrasound findings in patients with calcium pyrophosphate dihydrate deposition disease.

Vele, Paulina / Simon, Siao-Pin / Damian, Laura / Felea, Ioana / Muntean, Laura / Filipescu, Ileana / Rednic, Simona

Medical ultrasonography

2018 Volume 20, Issue 2, Page(s) 159–163

Abstract: Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ... ...

Abstract	Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ultrasound (US). Material and methods: Thirty consecutive patients fulfilling McCarty diagnostic criteria for CPPD were consecutively enrolled in the study. The data registered using the US included the affected joints, the calcification site, and the pattern of calcification (thin hyperechoic bands, parallel to the surface of the hyaline cartilage, hyperechoic spots, and hyperechoic nodular or oval deposits). The presence of CPP crystals in knees was confirmed by polarized light microscopy examination of the synovial fluid and radiographs of the knees were performed in all patients. Results: In 30 patients, 390 joints were scanned, (13 joints in every patient). The mean±standard deviation number of joints with US CPPD evidence per patient was 2.93±1.8 (range 1-9). The knee was the most common joint involved both clinically and using US examination. The second US pattern (with hyperechoic spots) was the most frequent. Fibrocartilage calcifications were more common than hyaline calcification. Using radiography as reference method, the sensitivity and specificity of US for diagnosis CPPD in knees was 79.31%, 95CI(66.65%-88.83%), and 14.29%, 95CI(1.78%-42.81%), respectively. Conclusions: The knee is the most frequent joint affected by CPPD. The second ultrasound pattern is the most common. CPPD affects the fibrocartilage to a greater extent than the hyaline cartilage.
MeSH term(s)	Chondrocalcinosis/diagnostic imaging ; Chondrocalcinosis/pathology ; Female ; Humans ; Joints/diagnostic imaging ; Joints/pathology ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Synovial Fluid/diagnostic imaging ; Ultrasonography/methods
Language	English
Publishing date	2018-05-04
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2529623-1
ISSN	2066-8643 ; 1844-4172
ISSN (online)	2066-8643
ISSN	1844-4172
DOI	10.11152/mu-1193
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone mineral density, carotid artery intima-media thickness, and Klotho gene polymorphism in postmenopausal women

Muntean Laura / Simon Siao-pin / Popp Radu / Albu Adriana / Fodor Daniela

Open Medicine, Vol 9, Iss 2, Pp 315-

2014 Volume 324

Keywords	klotho ; osteoporosis ; atherosclerosis ; genetics ; carotid intima-media thickness ; Medicine ; R
Language	English
Publishing date	2014-04-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: GENERAL FEATURES OF CALCIUM PYROPHOSPHATE DEPOSITION DISEASE

Paulina Vele / Laura Damian / Siao-Pin Simon / Ioana Felea / Laura Muntean / Maria Tamas / Simona Rednic

Romanian Journal of Rheumatology, Vol 25, Iss 3, Pp 122-

2016 Volume 126

Abstract: Background. Calcium pyrophosphate deposition (CPPD) disease is due to deposition of calcium pyrophosphate to hyaline cartilage, fibrocartilage and soft tissues. Clinical presentation may be as acute arthritis, chronic arthritis and associated with ... ...

Abstract	Background. Calcium pyrophosphate deposition (CPPD) disease is due to deposition of calcium pyrophosphate to hyaline cartilage, fibrocartilage and soft tissues. Clinical presentation may be as acute arthritis, chronic arthritis and associated with osteoarthritis. CPPD can be idiopathic or secondary, due to different metabolic diseases. Objectives. The aim of this study was to evaluate the clinical characteristics, secondary causes and risk factors of symptomatic CPPD. Material and methods. Patients diagnosed with CPPD upon presentation for joint pain and/or limitation of motion in Cluj-Napoca Rheumatology Department, were prospectively included in the study. Demographic data, clinical features, laboratory parameters for secondary causes of CPPD and risk factors were recorded. Results. The study included 40 patients with CPPD. A percentage of 70% patients presented with acute arthritis. The knee was the most affected joint. During the assessment for secondary CPPD, three patients with hypomagnesaemia and one patient with hypophosphatasia were found. Screening for alkaptonuria was negative in all patients tested (30 patients). Regarding risk factors, 65% of patients were over 60 years old, osteoarthritis was associated in 80% of cases, joint injury in 2%, meniscectomy in 6%, diuretics use in 18%, family history of CPPD 2%. Conclusions. Acute arthritis of the knee is the most frequent form of CPPD presentation. Ageing and osteoarthritis are common risk factors for CPPD. Although secondary causes of CPPD are rare, screening is very important.
Keywords	cppd ; clinical features ; secondary causes ; risk factors ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607
Subject code	610 ; 616
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bone mineral density, vertebral fractures and body mass index in postmenopausal women with abdominal aortic calcification.

Simon, Siao-pin / Fodor, Daniela / Muntean, Laura / Poanta, Laura / Cristea, Paulina / Rednic, Simona

Endocrine research

2014 Volume 39, Issue 1, Page(s) 1–6

Abstract: Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases.: Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and ... ...

Abstract	Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases. Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and bone mineral density (BMD) in postmenopausal women. Methods: In this cross-sectional study were included 125 postmenopausal women 50-84 years of age. BMD of the spine and hip was measured by dual energy X-ray absorptiometry (DXA). AAC were assessed by lateral radiographs of lumbar spine (L1-L4), using the antero-posterior severity score (0-24). Vertebral fractures were evaluated from T4 to L4 using Genant's semiquantitative method. Results: Forty-one (32.8%) patients had osteoporosis and 61 (48.8%) had AAC with a mean score of 3.1. Postmenopausal women with AAC were older and had significantly lower femoral neck and trochanteric BMD than subjects without AAC (all p < 0.01). There were no significant differences in the frequency of fractures between subjects with AAC and those without AAC (p > 0.05). In univariate analysis, age, height, weight, femoral and trochanter BMD were significantly associated with the severity of AAC score. In multiple regression analysis, femoral neck BMD, but not lumbar spine, trochanter BMD or age, was an independent predictor of AAC. Conclusions: Reduced femoral neck BMD is negatively associated with the presence of AAC in postmenopausal women. The association between BMD and AAC seems to be age-independent, which suggests a common pathogenesis for bone loss and vascular calcifications.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Diseases/complications ; Aortic Diseases/physiopathology ; Body Mass Index ; Bone Density/physiology ; Calcinosis/complications ; Calcinosis/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Postmenopause/physiology ; Spinal Fractures/complications ; Spinal Fractures/physiopathology
Language	English
Publishing date	2014
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605823-1
ISSN	1532-4206 ; 0743-5800
ISSN (online)	1532-4206
ISSN	0743-5800
DOI	10.3109/07435800.2013.794425
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