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  1. Article ; Online: Clathrin coated pits as signaling platforms for Akt signaling.

    Smythe, Elizabeth

    The Journal of cell biology

    2022  Volume 221, Issue 4

    Abstract: Signaling by the activated epidermal growth factor receptor (EGFR) results in diverse cell fates. In this issue, Cabral-Dias et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.201808181) demonstrate how plasma membrane clathrin coated pits can act as ...

    Abstract Signaling by the activated epidermal growth factor receptor (EGFR) results in diverse cell fates. In this issue, Cabral-Dias et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.201808181) demonstrate how plasma membrane clathrin coated pits can act as a signaling platform for one branch of EGFR downstream signaling.
    MeSH term(s) Clathrin/metabolism ; Clathrin-Coated Vesicles/metabolism ; Coated Pits, Cell-Membrane/metabolism ; Endocytosis/physiology ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Proto-Oncogene Proteins c-akt/metabolism
    Chemical Substances Clathrin ; ErbB Receptors (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202203026
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  2. Article ; Online: Commentary on: 'A critical analysis of articles using a Gadamerian-based research method' (Fleming & Robb).

    Smythe, Elizabeth

    Nursing inquiry

    2019  Volume 26, Issue 2, Page(s) e12287

    MeSH term(s) Research Design
    Language English
    Publishing date 2019-04-16
    Publishing country Australia
    Document type Journal Article ; Comment
    ZDB-ID 1483798-5
    ISSN 1440-1800 ; 1320-7881
    ISSN (online) 1440-1800
    ISSN 1320-7881
    DOI 10.1111/nin.12287
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    Zs.A 5087: Show issues Location:
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  3. Article ; Online: Occupational therapy's oversight: How science veiled our humanity.

    Reid, Heleen / Hocking, Clare / Smythe, Elizabeth

    Scandinavian journal of occupational therapy

    2024  Volume 31, Issue 1, Page(s) 2306585

    Abstract: Background: Occupational therapy's connection to positivist science predates the profession's formal beginning, with important contributing knowledge sources coming from mathematics, physics, psychology, and systems theory. While these sources of ... ...

    Abstract Background: Occupational therapy's connection to positivist science predates the profession's formal beginning, with important contributing knowledge sources coming from mathematics, physics, psychology, and systems theory. While these sources of objective knowledge provide a rational, defendable position for practice, they can only explain a portion of what it means to exist as an occupational being.
    Aims/objectives: This article aims to reveal some of the history of science within occupational therapy and reveal the subjective, ontological nature of doing everyday activities that the profession's preoccupation with positivist science has obscured.
    Methods: This research used a history of ideas methodology to uncover how occupational therapy perceived people and how practice was conceptualised and conducted between 1800 and 1980s, as depicted in writing of the time.
    Conclusion: Analysis showed that, through history, people were increasingly categorised and delimited. Practice also became systematically controlled, moving occupational therapy into a theoretical, scientific, and abstract realm.
    Significance: The emphasis placed on objectivity diminishes the attention given to human ways of practicing, where the subjective experience is central to our thinking.
    MeSH term(s) Humans ; Occupational Therapy
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2144132-7
    ISSN 1651-2014 ; 1103-8128
    ISSN (online) 1651-2014
    ISSN 1103-8128
    DOI 10.1080/11038128.2024.2306585
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  4. Article ; Online: A Heideggerian analysis of good care in an acute hospital setting: Insights from healthcare workers, patients and families.

    Dewar, Jan / Cook, Catherine / Smythe, Elizabeth / Spence, Deborah

    Nursing inquiry

    2023  Volume 30, Issue 4, Page(s) e12561

    Abstract: This study articulates the relational constituents of good care beyond techno-rational competence. Neoliberal healthcare means that notions of care are readily commodified and reduced to quantifiable assessments and checklists. This novel research ... ...

    Abstract This study articulates the relational constituents of good care beyond techno-rational competence. Neoliberal healthcare means that notions of care are readily commodified and reduced to quantifiable assessments and checklists. This novel research investigated accounts of good care provided by nursing, medical, allied and auxiliary staff. The Heideggerian phenomenological study was undertaken in acute medical-surgical wards, investigating the contextual, communicative nature of care. The study involved interviews with 17 participants: 3 previous patients, 3 family members and 11 staff. Data were analysed iteratively, dwelling with stories and writing and rewriting to surface the phenomenality of good care. The data set highlighted the following essential constituents: authentic care: caring encompassing solicitude (fürsorge); impromptu care: caring beyond role category; sustained care: caring beyond specialist parameters; attuned care: caring encompassing family and culture; and insightful care: caring beyond assessment and diagnosis. The findings are clinically significant because they indicate the importance of nurse leaders and educators harnessing the potential capacity of all healthcare workers to participate in good care. Healthcare workers reported that participating in or witnessing good care was uplifting and added meaning to their work, contributing to a sense of shared humanity.
    Language English
    Publishing date 2023-05-17
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1483798-5
    ISSN 1440-1800 ; 1320-7881
    ISSN (online) 1440-1800
    ISSN 1320-7881
    DOI 10.1111/nin.12561
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    Zs.A 5087: Show issues Location:
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  5. Article ; Online: An analysis of time conceptualisations and good care in an acute hospital setting.

    Dewar, Jan / Cook, Catherine / Smythe, Elizabeth / Spence, Deborah

    Nursing inquiry

    2023  Volume 31, Issue 2, Page(s) e12613

    Abstract: This study articulates the relationship between conceptualisations of time and the accounts of good care in an acute setting. Neoliberal healthcare services, with their focus on efficiencies, predominantly calculate quality care based on time-on-the- ... ...

    Abstract This study articulates the relationship between conceptualisations of time and the accounts of good care in an acute setting. Neoliberal healthcare services, with their focus on efficiencies, predominantly calculate quality care based on time-on-the-clock workforce management planning systems. However, the ways staff conceptualise and then relate to diverse meanings of time have implications for good care and for staff morale. This phenomenological study was undertaken in acute medical-surgical wards, investigating the contextual, temporal nature of care embedded in human relations. The study interviews involved 17 participants: 11 staff, 3 previous patients and 3 family members. Data were analysed iteratively to surface the phenomenality of temporality and good care. The following constituents of the data set are explored that together illustrate the relationship between the conceptualisations of time and the accounts of good care in an acute setting: patient time as a relational journey; patient time, sovereign time and time ethics and time, teamwork and flow. The findings are clinically significant because they offer a contrasting narrative about the relationship between time and care quality. The experiences of giving and receiving good care are indivisible from how temporality is experienced and the social relations within which care is embedded. Healthcare staff experience temporality differently from patients and families, a point that healthcare participants in this study appeared to comprehend and accommodate. For all parties involved in providing care or being the recipient of care, however, the capacity to be present was valued as a humanising ethic of care. Our study reinforces the importance of not creating presumptive binaries about which temporal structures are more or less humanising-there is a place for a fast-paced tempo, which can be experienced as being in the flow of human relations with one's team and on behalf of patients.
    MeSH term(s) Humans ; Concept Formation ; Qualitative Research ; Family ; Quality of Health Care ; Hospitals
    Language English
    Publishing date 2023-11-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1483798-5
    ISSN 1440-1800 ; 1320-7881
    ISSN (online) 1440-1800
    ISSN 1320-7881
    DOI 10.1111/nin.12613
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  6. Article ; Online: Review of A History of the World in Seven Cheap Things

    Elizabeth Smythe

    Journal of World-Systems Research, Vol 24, Iss 2, Pp 473-

    A Guide to Capitalism, Nature and the Future of the Planet by Raj Patel and Jason Moore. 2017. Oakland, CA: University of California Press. 328 pages, ISBN 978-0-5202-9993-1 Paper ($24.95)

    2018  Volume 477

    Abstract: ... N/ ... ...

    Abstract N/A
    Keywords Political science ; J ; Social Sciences ; H
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher University Library System, University of Pittsburgh
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Water loss regulates cell and vesicle volume.

    King, Jason S / Smythe, Elizabeth

    Science (New York, N.Y.)

    2020  Volume 367, Issue 6475, Page(s) 246–247

    MeSH term(s) Cell Size ; Cytoplasmic Vesicles ; Lipids ; Water
    Chemical Substances Lipids ; Water (059QF0KO0R)
    Language English
    Publishing date 2020-01-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aba3623
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  8. Article ; Online: Heideggerian phenomenological hermeneutics: Working with the data.

    Smythe, Elizabeth / Spence, Deb

    Nursing philosophy : an international journal for healthcare professionals

    2020  Volume 21, Issue 4, Page(s) e12308

    Abstract: It is one thing to read about the methodology and methods of Heideggerian hermeneutic phenomenological research, the ontic description. It is quite another thing to be faced with an interview transcript. This article draws on a study that asked doctoral ... ...

    Abstract It is one thing to read about the methodology and methods of Heideggerian hermeneutic phenomenological research, the ontic description. It is quite another thing to be faced with an interview transcript. This article draws on a study that asked doctoral students about their experience of doing such research. How did they become "phenomenological/hermeneutic" in their thinking and writing? What helped them to find their way? We offer this article as a means of letting others learn from our own experiences. We support our insights with the writings of Heidegger and Gadamer to show the methodological congruence that is essential to Heideggerian phenomenological hermeneutic research.
    MeSH term(s) Data Analysis ; Hermeneutics ; Humans ; Physicians/psychology ; Qualitative Research ; Research Design/trends ; Writing/standards
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2029286-7
    ISSN 1466-769X ; 1466-7681
    ISSN (online) 1466-769X
    ISSN 1466-7681
    DOI 10.1111/nup.12308
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  9. Article ; Online: Role of the rab5 guanine nucleotide exchange factor, Rme-6, in the regulation of clathrin-coated vesicle uncoating.

    Smythe, Elizabeth

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1298, Page(s) 283–293

    Abstract: Clathrin-coated pits are major ports of entry into eukaryotic cells. Following scission of clathrin-coated pits to form coated vesicles, the peripheral membrane proteins that form the coat need to be removed. Here we describe an assay that provides a ... ...

    Abstract Clathrin-coated pits are major ports of entry into eukaryotic cells. Following scission of clathrin-coated pits to form coated vesicles, the peripheral membrane proteins that form the coat need to be removed. Here we describe an assay that provides a measure of the extent of clathrin coat uncoating in intact cells. This assay has been used to investigate rab5-dependent modulation of uncoating. Specifically, it has been used to identify functional differences between rab5 guanine nucleotide exchange factors.
    MeSH term(s) Biological Assay/methods ; Cell Culture Techniques ; Clathrin-Coated Vesicles/metabolism ; Fluorescent Antibody Technique ; Gene Knockdown Techniques ; Guanine Nucleotide Exchange Factors/deficiency ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; HEK293 Cells ; Humans ; Image Processing, Computer-Assisted ; RNA, Small Interfering/genetics ; Transfection
    Chemical Substances GAPVD1 protein, human ; Guanine Nucleotide Exchange Factors ; RNA, Small Interfering
    Language English
    Publishing date 2015-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-2569-8_24
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  10. Article ; Online: Reading Heidegger.

    Smythe, Elizabeth / Spence, Deb

    Nursing philosophy : an international journal for healthcare professionals

    2019  Volume 21, Issue 2, Page(s) e12271

    Abstract: Heidegger's philosophy is a significant contribution to understanding the meaning of lived experience. Recognizing this, nurses and other health professionals have taken on the research approach of Heideggerian hermeneutic phenomenology. This requires ... ...

    Abstract Heidegger's philosophy is a significant contribution to understanding the meaning of lived experience. Recognizing this, nurses and other health professionals have taken on the research approach of Heideggerian hermeneutic phenomenology. This requires reading the writing of Heidegger. Philosophers themselves acknowledge this writing is dense, difficult to grasp, uses language for which there is no easy translation, and leaves the reader with more questions than answers. Drawing on commentary from philosophers who seek to read Heidegger and from a research study which interviewed doctoral students who were "reading Heidegger," we seek to show the nature of the experience of pursuing such a challenging quest.
    MeSH term(s) Hermeneutics ; Humans ; Philosophy ; Reading
    Language English
    Publishing date 2019-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2029286-7
    ISSN 1466-769X ; 1466-7681
    ISSN (online) 1466-769X
    ISSN 1466-7681
    DOI 10.1111/nup.12271
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