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  1. Article ; Online: Susceptibilities of Helicoverpa zea (Lepidoptera: Noctuidae) Populations From the Mississippi Delta to a Diamide Insecticide.

    Allen, K C / Little, N S / Perera, O P

    Journal of economic entomology

    2022  Volume 116, Issue 1, Page(s) 160–167

    Abstract: ... Through weights of 2nd and 3rd instar larvae, there appears to be a substantial fitness cost associated ... annually since 2016. Overall, 58 populations of H. zea were examined for their susceptibility ...

    Abstract The corn earworm, Helicoverpa zea (Boddie), is a major pest of row crops in the Southern United States. Control of this insect is dependent on preventative insecticidal transgenic crops and synthetic insecticide applications when damaging populations are encountered in the field. Recently, the use of chemicals from the diamide class of insecticides, particularly chlorantraniliprole, has been used to control unacceptable populations. Due to the increased importance of this active ingredient for control of corn earworms, populations of this insect from the Mississippi Delta have been monitored for susceptibilities annually since 2016. Overall, 58 populations of H. zea were examined for their susceptibility to chlorantraniliprole through diet-incorporated bioassays from 2016 to 2021. Based on probit analysis, there was only a 4-fold difference between the highest and lowest LC50 estimates for all populations tested. Through weights of 2nd and 3rd instar larvae, there appears to be a substantial fitness cost associated with surviving caterpillars that fed on various concentrations of chlorantraniliprole in bioassays, which is not captured through the yes or no response of typical survival analysis. Overall, there was not a detectable trend of reduced susceptibility to chlorantraniliprole over the course of the six-year study.
    MeSH term(s) United States ; Animals ; Insecticides/pharmacology ; Lepidoptera ; Diamide ; Zea mays ; Moths ; Larva ; Insecticide Resistance ; Pest Control, Biological
    Chemical Substances Insecticides ; chlorantranilipole (622AK9DH9G) ; Diamide (10465-78-8)
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 3031-4
    ISSN 1938-291X ; 0022-0493
    ISSN (online) 1938-291X
    ISSN 0022-0493
    DOI 10.1093/jee/toac180
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  2. Article: Sleep-wake patterns and disturbances in Portuguese primary school children: a comparison between 1995 and 2016.

    Clara, Maria Inês / Clemente, Vanda / Abrantes, Joana / Marques, Daniel R / Azevedo, Maria H P / Allen Gomes, Ana

    Sleep and biological rhythms

    2022  Volume 20, Issue 4, Page(s) 541–549

    Abstract: ... the 3rd and 4th grades of basic education were combined from two different cross-sectional school-based ...

    Abstract Purpose: It is often assumed sleep duration has decreased and sleep schedules have delayed over the last decades, as society modernized. We aimed to investigate changes in the sleep patterns of school-age children over time.
    Methods: We compared the sleep timings, durations, and disturbances of primary school-age children in 1995 and roughly two decades later, in 2016. Data from 666 children attending the 3rd and 4th grades of basic education were combined from two different cross-sectional school-based studies conducted within the same educational region of mainland Portugal using the same parent-report questionnaire (Children's Sleep-wake Patterns Questionnaire).
    Results: Mean sleep duration did not differ significantly between the two time points (schooldays:
    Conclusions: Sleep onset-related disturbances appear to have increased from 1995 to 2016. One possible explanation for this increase might be the change in parental practices preventing children from learning to fall asleep autonomously.
    Language English
    Publishing date 2022-07-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2185804-4
    ISSN 1479-8425 ; 1446-9235
    ISSN (online) 1479-8425
    ISSN 1446-9235
    DOI 10.1007/s41105-022-00400-w
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    Zs.A 6051: Show issues Location:
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  3. Article ; Online: Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.

    Peres, Bernardo U / Hirsch Allen, A J / Daniele, Patrick / Humphries, Karin H / Taylor, Carolyn / Laher, Ismail / Almeida, Fernanda / Jen, Rachel / Sandford, Andrew J / van Eeden, Stephan F / Ayas, Najib T

    PloS one

    2021  Volume 16, Issue 7, Page(s) e0255306

    Abstract: ... with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients ... in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile ... with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events ...

    Abstract Background: Obstructive sleep apnea (OSA) patients are at increased risk of cardiovascular disease (CVD). Cell adhesion molecules (CAM) are increased in OSA and CAM are also implicated in the development of CVD.
    Research question: Do CAM (ICAM-1, VCAM-1 and E-selectin) have prognostic value in identifying risk of cardiovascular events in OSA?
    Study design and methods: Patients with suspected OSA referred for a polysomnogram provided a fasting blood sample. Plasma levels of ICAM-1, VCAM-1 and E-selectin were determined by multiplex Luminex Assay (Milliporesigma ON, Canada). Cardiovascular events were determined by deterministic linkage to provincial health databases.
    Results: 418 patients were included in the analysis. Mostly male (68.2%), mean age of 50.7 yrs, median AHI 16.5 events/hour, and mean BMI of 31.7 kg/m2. 36 cardiovascular events occurred in 8-yrs of follow up. Higher levels of ICAM-1 were associated with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile) but not in patients without moderate to severe OSA (HR = 0.67 95% CI 0.19-2.38), p-value for interaction = 0.07.
    Interpretation: In a suspected OSA cohort, patients with higher levels of ICAM-1 (>816 ng/ml) were significantly more likely to experience a cardiovascular event within 8 years after PSG. In moderate to severe OSA patients, a higher E-selectin (>36.4 ng/ml) was significantly associated with cardiovascular events.
    MeSH term(s) Adult ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/etiology ; Cell Adhesion Molecules/blood ; Fasting/blood ; Follow-Up Studies ; Humans ; Middle Aged ; Sleep Apnea, Obstructive/blood ; Sleep Apnea, Obstructive/complications
    Chemical Substances Cell Adhesion Molecules
    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0255306
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  4. Article ; Online: The 6-Month Efficacy of an Intensive Lifestyle Modification Program on Type 2 Diabetes Risk Among Rural Women with Prior Gestational Diabetes Mellitus: a Cluster Randomized Controlled Trial.

    Chen, Yao / Zhong, Qinyi / Luo, Jiaxin / Tang, Yujia / Li, Mingshu / Lin, Qian / Willey, James Allen / Chen, Jyu-Lin / Whittemore, Robin / Guo, Jia

    Prevention science : the official journal of the Society for Prevention Research

    2022  Volume 23, Issue 7, Page(s) 1156–1168

    Abstract: ... in the Chinese Clinical Trial Registry (ChiCTR2000037956) on 3rd Jan 2018. ... significant reductions in fasting blood glucose, oral glucose tolerance test 2 h, waist circumference, and ... behavioral outcomes and type 2 diabetes risk score, which were collected at baseline, 3-month, and 6-month ...

    Abstract This study aimed to evaluate the efficacy of an intensive lifestyle modification program tailored to rural Chinese women with prior gestational diabetes mellitus compared with usual care. In a cluster randomized controlled trial, 16 towns (clusters) in two distinct rural areas in China were randomly selected (8 towns per district); and 320 women with prior gestational diabetes mellitus were recruited from these towns. With stratification for the two study districts, eight towns (160 women) were randomly assigned to the intervention group of a tailored intensive lifestyle modification program and 8 towns (160 women) to the control group. Process measures were collected on attendance, engagement, fidelity, and satisfaction. Primary efficacy outcomes included glycemic and weight-related outcomes, while secondary efficacy outcomes were behavioral outcomes and type 2 diabetes risk score, which were collected at baseline, 3-month, and 6-month follow-up. Generalized estimation equations were used to analyze the data. High attendance (72% of sessions), engagement (67% of interactive activities and group discussions), fidelity (98%), and satisfaction (92%) with the tailored intensive lifestyle modification program were achieved. There were significant reductions in fasting blood glucose, oral glucose tolerance test 2 h, waist circumference, and type 2 diabetes risk score of participants in the intervention group compared to the control group (p < .05). There was no significant intervention effect on body mass index or behavioral outcomes (p > .05). In this study, we demonstrate the successful efficacy of an Intensive Lifestyle Modification Program in reducing type 2 diabetes risk among younger women with prior gestational diabetes mellitus. This tailored program delivered by local healthcare providers is a promising approach for diabetes prevention in rural China, reducing health disparities in rural communities about diabetes prevention. Registered in the Chinese Clinical Trial Registry (ChiCTR2000037956) on 3rd Jan 2018.
    MeSH term(s) Blood Glucose ; Diabetes Mellitus, Type 2/prevention & control ; Diabetes, Gestational/prevention & control ; Female ; Humans ; Life Style ; Pregnancy ; Rural Population
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2251270-6
    ISSN 1573-6695 ; 1389-4986
    ISSN (online) 1573-6695
    ISSN 1389-4986
    DOI 10.1007/s11121-022-01392-2
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    Zs.A 6466: Show issues Location:
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  5. Article ; Online: Circulating levels of cell adhesion molecules and risk of cardiovascular events in obstructive sleep apnea.

    Bernardo U Peres / A J Hirsch Allen / Patrick Daniele / Karin H Humphries / Carolyn Taylor / Ismail Laher / Fernanda Almeida / Rachel Jen / Andrew J Sandford / Stephan F van Eeden / Najib T Ayas

    PLoS ONE, Vol 16, Iss 7, p e

    2021  Volume 0255306

    Abstract: ... with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients ... in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile ... with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events ...

    Abstract Background Obstructive sleep apnea (OSA) patients are at increased risk of cardiovascular disease (CVD). Cell adhesion molecules (CAM) are increased in OSA and CAM are also implicated in the development of CVD. Research question Do CAM (ICAM-1, VCAM-1 and E-selectin) have prognostic value in identifying risk of cardiovascular events in OSA? Study design and methods Patients with suspected OSA referred for a polysomnogram provided a fasting blood sample. Plasma levels of ICAM-1, VCAM-1 and E-selectin were determined by multiplex Luminex Assay (Milliporesigma ON, Canada). Cardiovascular events were determined by deterministic linkage to provincial health databases. Results 418 patients were included in the analysis. Mostly male (68.2%), mean age of 50.7 yrs, median AHI 16.5 events/hour, and mean BMI of 31.7 kg/m2. 36 cardiovascular events occurred in 8-yrs of follow up. Higher levels of ICAM-1 were associated with developing CVD (HR = 3.65 95% CI 1.40-9.53, 2nd and 3rd tertiles vs. 1st tertile), including in patients with OSA (HR = 3.1 95% CI 1.16-8.25). E-selectin was significantly associated with cardiovascular events in patients with moderate to severe OSA (HR = 3.31 95% CI 0.94-11.72, 2nd and 3rd tertiles vs. 1st tertile) but not in patients without moderate to severe OSA (HR = 0.67 95% CI 0.19-2.38), p-value for interaction = 0.07. Interpretation In a suspected OSA cohort, patients with higher levels of ICAM-1 (>816 ng/ml) were significantly more likely to experience a cardiovascular event within 8 years after PSG. In moderate to severe OSA patients, a higher E-selectin (>36.4 ng/ml) was significantly associated with cardiovascular events.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616 ; 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A study of genetic polymorphisms in mitochondrial DNA hypervariable regions I and II of the five major ethnic groups and Vedda population in Sri Lanka.

    Ranasinghe, Ruwandi / Tennekoon, Kamani H / Karunanayake, Eric H / Lembring, Maria / Allen, Marie

    Legal medicine (Tokyo, Japan)

    2015  Volume 17, Issue 6, Page(s) 539–546

    Abstract: ... About 2/3rd of the Vedda population comprised of macro-haplogroup N or its subclades R and U ...

    Abstract Diversity of the hypervariable regions (HV) I and II of the mitochondrial genome was studied in maternally unrelated Sri Lankans (N=202) from six ethnic groups (i.e.: Sinhalese, Sri Lankan Tamil, Muslim, Malay, Indian Tamil and Vedda). DNA was extracted from blood and buccal swabs and HVI and HVII regions were PCR amplified and sequenced. Resulting sequences were aligned and edited between 16024-16365 and 73-340 regions and compared with revised Cambridge reference sequences (rCRS). One hundred and thirty-five unique haplotypes and 22 shared haplotypes were observed. A total of 145 polymorphic sites and 158 polymorphisms were observed. Hypervariable region I showed a higher polymorphic variation than hypervariable region II. Nucleotide diversities were quite low and similar for all ethnicities apart from a slightly higher value for Indian Tamils and a much lower value for the Vedda population compared to the other groups. When the total population was considered South Asian (Indian) haplogroups were predominant, but there were differences in the distribution of phylo-geographical haplogroups between ethnic groups. Sinhalese, Sri Lankan Tamil and Vedda populations had a considerable presence of West Eurasian haplogroups. About 2/3rd of the Vedda population comprised of macro-haplogroup N or its subclades R and U, whereas macro-haplogroup M was predominant in all other populations. The Vedda population clustered separately from other groups and Sri Lankan Tamils showed a closer genetic affiliation to Sinhalese than to Indian Tamils. Thus this study provides useful information for forensic analysis and anthropological studies of Sri Lankans.
    MeSH term(s) DNA, Mitochondrial/genetics ; Ethnic Groups/genetics ; Female ; Genetics, Population ; Haplotypes ; Humans ; Male ; Polymorphism, Genetic ; Sequence Analysis, DNA ; Sri Lanka
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2015-11
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2019555-2
    ISSN 1873-4162 ; 1344-6223
    ISSN (online) 1873-4162
    ISSN 1344-6223
    DOI 10.1016/j.legalmed.2015.05.007
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    Zs.A 5250: Show issues Location:
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  7. Article ; Online: Serological responses of Australian horses using a commercial duplex indirect ELISA following vaccination against strangles.

    El-Hage, C M / Bannai, H / Wiethoelter, A K / Firestone, S M / Heislers, C M / Allen, J L / Waller, A S / Gilkerson, J R

    Australian veterinary journal

    2019  Volume 97, Issue 7, Page(s) 220–224

    Abstract: ... 56 days following the 3rd vaccination (V3).: Results: Significant increases in mean antibody ... V3, 14 days following V2 (ratio of geometric means = 3.7; 95% confidence interval (CI): 1.6, 8.4; P ... 3.2; P = 0.39). Four horses (22%) exceeded the test cut-off for AgC following vaccination ...

    Abstract Objective: To determine the nature of serological responses in Australian horses using a commercial duplex indirect ELISA (iELISA) following vaccination against strangles.
    Design: A group (n = 19) of client-owned horses from five properties were recruited to receive a primary course of a Streptococcus equi subsp. equi (S. equi) extract vaccine. Serological responses were determined by duplex iELISA incorporating S. equi-specific fragments of two cell wall proteins, SEQ2190 and SeM (antigens (Ag) A and C, respectively).
    Methods: The horses were administered a primary strangles vaccination course. Blood was collected immediately prior to each of the three vaccinations at 2-week intervals and additionally at 28 and 56 days following the 3rd vaccination (V3).
    Results: Significant increases in mean antibody levels of horses following vaccination were limited only to AgC, which was significantly increased at T2/V3, 14 days following V2 (ratio of geometric means = 3.7; 95% confidence interval (CI): 1.6, 8.4; P = 0.003). There was no increase in mean antibody to Ag A (ratio of geometric means = 1.4; 95% CI: 0.6, 3.2; P = 0.39). Four horses (22%) exceeded the test cut-off for AgC following vaccination.
    Conclusion: Vaccination of Australian horses is unlikely to interfere greatly with detection of strangles using the duplex iELISA. No responses would be anticipated to AgA following vaccination with Equivac© S/Equivac© 2in1 and only a minority are likely to respond to AgC. We conclude that the results of this study validate the usefulness of the duplex iELISA to assist control measures for strangles outbreaks in Australian horse populations.
    MeSH term(s) Animals ; Antibodies, Bacterial/blood ; Australia ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Female ; Horse Diseases/blood ; Horse Diseases/prevention & control ; Horses ; Male ; Streptococcal Infections/blood ; Streptococcal Infections/prevention & control ; Streptococcal Infections/veterinary ; Streptococcus equi ; Vaccination/veterinary
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 41542-x
    ISSN 1751-0813 ; 0005-0423
    ISSN (online) 1751-0813
    ISSN 0005-0423
    DOI 10.1111/avj.12825
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  8. Article ; Online: Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse.

    Klocke, Carolyn / Allen, Joshua L / Sobolewski, Marissa / Mayer-Pröschel, Margot / Blum, Jason L / Lauterstein, Dana / Zelikoff, Judith T / Cory-Slechta, Deborah A

    Toxicological sciences : an official journal of the Society of Toxicology

    2017  Volume 156, Issue 2, Page(s) 492–508

    Abstract: ... development, equivalent to human 3rd trimester, produced male-predominant neuropathological and behavioral ... 2nd trimesters. Pregnant mice were exposed 6 h/day from gestational days (GDs) 0.5-16.5 using ...

    Abstract Increasing evidence indicates that the central nervous system (CNS) is a target of air pollution. We previously reported that postnatal exposure of mice to concentrated ambient ultrafine particles (UFP; ≤100 nm) via the University of Rochester HUCAPS system during a critical developmental window of CNS development, equivalent to human 3rd trimester, produced male-predominant neuropathological and behavioral characteristics common to multiple neurodevelopmental disorders, including autism spectrum disorder (ASD), in humans. The current study sought to determine whether vulnerability to fine (≤2.5 μm) and UFP air pollution exposure extends to embryonic periods of brain development in mice, equivalent to human 1st and 2nd trimesters. Pregnant mice were exposed 6 h/day from gestational days (GDs) 0.5-16.5 using the New York University VACES system to concentrated ambient fine/ultrafine particles at an average concentration of 92.69 μg/m3 over the course of the exposure period. At postnatal days (PNDs) 11-15, neuropathological consequences were characterized. Gestational air pollution exposures produced ventriculomegaly, increased corpus callosum (CC) area and reduced hippocampal area in both sexes. Both sexes demonstrated CC hypermyelination and increased microglial activation and reduced total CC microglia number. Analyses of iron deposition as a critical component of myelination revealed increased iron deposition in the CC of exposed female offspring, but not in males. These findings demonstrate that vulnerability of the brain to air pollution extends to gestation and produces features of several neurodevelopmental disorders in both sexes. Further, they highlight the importance of the commonalities of components of particulate matter exposures as a source of neurotoxicity and common CNS alterations.
    MeSH term(s) Air Pollutants/toxicity ; Animals ; Brain/drug effects ; Brain/embryology ; Brain/pathology ; Female ; Gestational Age ; Male ; Mice ; Neurodevelopmental Disorders/chemically induced ; Neurodevelopmental Disorders/pathology ; Organ Size/drug effects ; Particulate Matter/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects/etiology ; Prenatal Exposure Delayed Effects/pathology
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2017-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420885-4
    ISSN 1096-0929 ; 1096-6080
    ISSN (online) 1096-0929
    ISSN 1096-6080
    DOI 10.1093/toxsci/kfx010
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  9. Article ; Online: Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster.

    Nolan, Terry M / Deliyannis, Georgia / Griffith, Maryanne / Braat, Sabine / Allen, Lilith F / Audsley, Jennifer / Chung, Amy W / Ciula, Marcin / Gherardin, Nicholas A / Giles, Michelle L / Gordon, Tom P / Grimley, Samantha L / Horng, Lana / Jackson, David C / Juno, Jennifer A / Kedzierska, Katherine / Kent, Stephen J / Lewin, Sharon R / Littlejohn, Mason /
    McQuilten, Hayley A / Mordant, Francesca L / Nguyen, Thi H O / Soo, Vanessa Pac / Price, Briony / Purcell, Damian F J / Ramanathan, Pradhipa / Redmond, Samuel J / Rockman, Steven / Ruan, Zheng / Sasadeusz, Joseph / Simpson, Julie A / Subbarao, Kanta / Fabb, Stewart A / Payne, Thomas J / Takanashi, Asuka / Tan, Chee Wah / Torresi, Joseph / Wang, Jing Jing / Wang, Lin-Fa / Al-Wassiti, Hareth / Wong, Chinn Yi / Zaloumis, Sophie / Pouton, Colin W / Godfrey, Dale I

    EBioMedicine

    2023  Volume 98, Page(s) 104878

    Abstract: ... vaccine (10, 20, or 50 μg, N = 32), or placebo (saline, N = 12) at least 90 days after a 3rd boost ...

    Abstract Background: SARS-CoV-2 booster vaccination should ideally enhance protection against variants and minimise immune imprinting. This Phase I trial evaluated two vaccines targeting SARS-CoV-2 beta-variant receptor-binding domain (RBD): a recombinant dimeric RBD-human IgG
    Methods: 76 healthy adults aged 18-64 y, previously triple vaccinated with licensed SARS-CoV-2 vaccines, were randomised to receive a 4th dose of either an adjuvanted (MF59®, CSL Seqirus) protein vaccine (5, 15 or 45 μg, N = 32), mRNA vaccine (10, 20, or 50 μg, N = 32), or placebo (saline, N = 12) at least 90 days after a 3rd boost vaccination or SARS-CoV-2 infection. Bleeds occurred on days 1 (prior to vaccination), 8, and 29.
    Clinicaltrials: govNCT05272605.
    Findings: No vaccine-related serious or medically-attended adverse events occurred. The protein vaccine reactogenicity was mild, whereas the mRNA vaccine was moderately reactogenic at higher dose levels. Best anti-RBD antibody responses resulted from the higher doses of each vaccine. A similar pattern was seen with live virus neutralisation and surrogate, and pseudovirus neutralisation assays. Breadth of immune response was demonstrated against BA.5 and more recent omicron subvariants (XBB, XBB.1.5 and BQ.1.1). Binding antibody titres for both vaccines were comparable to those of a licensed bivalent mRNA vaccine. Both vaccines enhanced CD4
    Interpretation: There were no safety concerns and the reactogenicity profile was mild and similar to licensed SARS-CoV-2 vaccines. Both vaccines showed strong immune boosting against beta, ancestral and omicron strains.
    Funding: Australian Government Medical Research Future Fund, and philanthropies Jack Ma Foundation and IFM investors.
    MeSH term(s) Adult ; Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; Australia ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; mRNA Vaccines ; SARS-CoV-2 ; Adolescent ; Young Adult ; Middle Aged
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; mRNA Vaccines
    Language English
    Publishing date 2023-11-27
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Clinical Trial, Phase I ; Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2023.104878
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  10. Article: Serological responses of Australian horses using a commercial duplex indirect ELISA following vaccination against strangles

    El‐Hage, CM / Bannai, H / Wiethoelter, AK / Firestone, SM / Heislers, CM / Allen, JL / Waller, AS / Gilkerson, JR

    Australian veterinary journal. 2019 July, v. 97, no. 7

    2019  

    Abstract: ... 56 days following the 3rd vaccination (V3). RESULTS: Significant increases in mean antibody levels ... days following V2 (ratio of geometric means = 3.7; 95% confidence interval (CI): 1.6, 8.4; P = 0.003 ... There was no increase in mean antibody to Ag A (ratio of geometric means = 1.4; 95% CI: 0.6, 3.2; P = 0 ...

    Abstract OBJECTIVE: To determine the nature of serological responses in Australian horses using a commercial duplex indirect ELISA (iELISA) following vaccination against strangles. DESIGN: A group (n = 19) of client‐owned horses from five properties were recruited to receive a primary course of a Streptococcus equi subsp. equi (S. equi) extract vaccine. Serological responses were determined by duplex iELISA incorporating S. equi‐specific fragments of two cell wall proteins, SEQ2190 and SeM (antigens (Ag) A and C, respectively). METHODS: The horses were administered a primary strangles vaccination course. Blood was collected immediately prior to each of the three vaccinations at 2‐week intervals and additionally at 28 and 56 days following the 3rd vaccination (V3). RESULTS: Significant increases in mean antibody levels of horses following vaccination were limited only to AgC, which was significantly increased at T2/V3, 14 days following V2 (ratio of geometric means = 3.7; 95% confidence interval (CI): 1.6, 8.4; P = 0.003). There was no increase in mean antibody to Ag A (ratio of geometric means = 1.4; 95% CI: 0.6, 3.2; P = 0.39). Four horses (22%) exceeded the test cut‐off for AgC following vaccination. CONCLUSION: Vaccination of Australian horses is unlikely to interfere greatly with detection of strangles using the duplex iELISA. No responses would be anticipated to AgA following vaccination with Equivac© S/Equivac© 2in1 and only a minority are likely to respond to AgC. We conclude that the results of this study validate the usefulness of the duplex iELISA to assist control measures for strangles outbreaks in Australian horse populations.
    Keywords Streptococcus equi subsp. equi ; antibodies ; antigens ; blood ; confidence interval ; enzyme-linked immunosorbent assay ; horses ; strangles ; structural proteins ; vaccination ; vaccines
    Language English
    Dates of publication 2019-07
    Size p. 220-224.
    Publishing place Wiley Publishing Asia Pty Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 41542-x
    ISSN 1751-0813 ; 0005-0423
    ISSN (online) 1751-0813
    ISSN 0005-0423
    DOI 10.1111/avj.12825
    Database NAL-Catalogue (AGRICOLA)

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