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  1. Article ; Online: Actinoplanes Swims into the Molecular Age.

    Buttner, Mark J

    Journal of bacteriology

    2017  Volume 199, Issue 12

    Abstract: The survival strategy ... ...

    Abstract The survival strategy of
    MeSH term(s) Cyclic GMP/genetics ; Gene Expression Regulation, Bacterial
    Chemical Substances Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2017-05-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00070-17
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  2. Article ; Online: Global Effects of the Developmental Regulator BldB in Streptomyces venezuelae.

    Avramova, Marieta M / Stevenson, Clare E M / Chandra, Govind / Holmes, Neil A / Bush, Matthew J / Findlay, Kim C / Buttner, Mark J

    Journal of bacteriology

    2023  Volume 205, Issue 6, Page(s) e0013523

    Abstract: ... ...

    Abstract In
    MeSH term(s) Streptomyces/genetics ; Streptomyces/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Phenotype ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial
    Chemical Substances Transcription Factors ; Bacterial Proteins
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00135-23
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  3. Article ; Online: Discovery of the extracytoplasmic function σ factors.

    Lonetto, Michael A / Donohue, Timothy J / Gross, Carol A / Buttner, Mark J

    Molecular microbiology

    2019  Volume 112, Issue 2, Page(s) 348–355

    Abstract: This special issue of Molecular Microbiology marks the 25 ...

    Abstract This special issue of Molecular Microbiology marks the 25
    MeSH term(s) Bacteria/genetics ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Extracellular Space/genetics ; Extracellular Space/metabolism ; Gene Expression Regulation, Bacterial ; Sigma Factor/genetics ; Sigma Factor/metabolism ; Signal Transduction
    Chemical Substances Bacterial Proteins ; Sigma Factor
    Language English
    Publishing date 2019-06-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14307
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  4. Article ; Online: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.

    Lilic, Mirjana / Holmes, Neil A / Bush, Matthew J / Marti, Alexandra K / Widdick, David A / Findlay, Kim C / Choi, Young Joo / Froom, Ruby / Koh, Steven / Buttner, Mark J / Campbell, Elizabeth A

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 11, Page(s) e2220785120

    Abstract: Studies of transcriptional initiation in different bacterial clades reveal diverse molecular mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both required to express cell division genes in Actinobacteria and are ... ...

    Abstract Studies of transcriptional initiation in different bacterial clades reveal diverse molecular mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both required to express cell division genes in Actinobacteria and are essential in notable pathogens such as
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Cryoelectron Microscopy ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Division/genetics ; Sigma Factor/genetics ; Sigma Factor/metabolism ; DNA-Directed RNA Polymerases/genetics ; DNA-Directed RNA Polymerases/metabolism ; Gene Expression Regulation, Bacterial
    Chemical Substances Transcription Factors ; Bacterial Proteins ; Sigma Factor ; DNA-Directed RNA Polymerases (EC 2.7.7.6)
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2220785120
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  5. Article ; Online: Interaction of the

    Stewart, Melissa Y Y / Bush, Matthew J / Crack, Jason C / Buttner, Mark J / Le Brun, Nick E

    The Journal of biological chemistry

    2020  Volume 295, Issue 28, Page(s) 9752–9765

    Abstract: The bacterial protein WhiD belongs to the Wbl family of iron-sulfur [Fe-S] proteins present only in the actinomycetes. ... ...

    Abstract The bacterial protein WhiD belongs to the Wbl family of iron-sulfur [Fe-S] proteins present only in the actinomycetes. In
    MeSH term(s) Bacterial Proteins/chemistry ; Bacterial Proteins/metabolism ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Mycobacterium tuberculosis/chemistry ; Mycobacterium tuberculosis/metabolism ; Sigma Factor/chemistry ; Sigma Factor/metabolism ; Streptomyces/chemistry ; Streptomyces/metabolism ; Transcription Factors/chemistry ; Transcription Factors/metabolism
    Chemical Substances Bacterial Proteins ; DNA-Binding Proteins ; Sigma Factor ; Transcription Factors ; HrdB protein, Streptomyces (146409-37-2)
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA120.012708
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  6. Article ; Online: When is a transcription factor a NAP?

    Dorman, Charles J / Schumacher, Maria A / Bush, Matthew J / Brennan, Richard G / Buttner, Mark J

    Current opinion in microbiology

    2020  Volume 55, Page(s) 26–33

    Abstract: ... mechanisms, target gene number, or the features of their DNA-binding sites are insufficient as marks ...

    Abstract Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins (NAPs). Anachronistic descriptions of NAPs as 'histone-like' implied an organizational function in a bacterial chromatin-like complex. Definitions based on protein abundance, regulatory mechanisms, target gene number, or the features of their DNA-binding sites are insufficient as marks of distinction, and trying to distinguish transcription factors and NAPs based on their ranking within regulatory hierarchies or positions in gene-control networks is also unsatisfactory. The terms 'transcription factor' and 'NAP' are ad hoc operational definitions with each protein lying along a spectrum of structural and functional features extending from highly specific actors with few gene targets to those with a pervasive influence on the transcriptome. The Streptomyces BldC protein is used to illustrate these issues.
    MeSH term(s) Bacterial Proteins/physiology ; Binding Sites ; Biological Evolution ; DNA-Binding Proteins/physiology ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Protein Conformation ; Streptomyces/physiology ; Transcription Factors/physiology
    Chemical Substances Bacterial Proteins ; DNA-Binding Proteins ; MerR protein, Bacteria ; Transcription Factors
    Language English
    Publishing date 2020-02-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2020.01.019
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  7. Article ; Online: Streptomyces venezuelae NRRL B-65442: genome sequence of a model strain used to study morphological differentiation in filamentous actinobacteria.

    Gomez-Escribano, Juan Pablo / Holmes, Neil A / Schlimpert, Susan / Bibb, Maureen J / Chandra, Govind / Wilkinson, Barrie / Buttner, Mark J / Bibb, Mervyn J

    Journal of industrial microbiology & biotechnology

    2021  Volume 48, Issue 9-10

    Abstract: For over a decade, Streptomyces venezuelae has been used to study the molecular mechanisms that control morphological development in streptomycetes and is now a well-established model strain. Its rapid growth and ability to sporulate in a near- ... ...

    Abstract For over a decade, Streptomyces venezuelae has been used to study the molecular mechanisms that control morphological development in streptomycetes and is now a well-established model strain. Its rapid growth and ability to sporulate in a near-synchronised manner in liquid culture, unusual among streptomycetes, greatly facilitates the application of modern molecular techniques such as ChIP-seq and RNA-seq, as well as time-lapse fluorescence imaging of the complete Streptomyces life cycle. Here we describe a high-quality genome sequence of our isolate of the strain (Northern Regional Research Laboratory [NRRL] B-65442) consisting of an 8.2 Mb chromosome and a 158 kb plasmid, pSVJI1, which had not been reported previously. Surprisingly, while NRRL B-65442 yields green spores on MYM agar, the American Type Culture Collection (ATCC) type strain 10712 (from which NRRL B-65442 was derived) produces grey spores. While comparison of the genome sequences of the two isolates revealed almost total identity, it did reveal a single nucleotide substitution in a gene, vnz_33525, involved in spore pigment biosynthesis. Replacement of the vnz_33525 allele of ATCC 10712 with that of NRRL B-65442 resulted in green spores, explaining the discrepancy in spore pigmentation. We also applied CRISPR-Cas9 to delete the essential parB of pSVJI1 to cure the plasmid from the strain without obvious phenotypic consequences.
    MeSH term(s) DNA, Bacterial/genetics ; Genome, Bacterial ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Streptomyces/cytology ; Streptomyces/genetics
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2021-06-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1093/jimb/kuab035
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  8. Article ; Online: Evolution of a σ-(c-di-GMP)-anti-σ switch.

    Schumacher, Maria A / Gallagher, Kelley A / Holmes, Neil A / Chandra, Govind / Henderson, Max / Kysela, David T / Brennan, Richard G / Buttner, Mark J

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 30

    Abstract: Filamentous actinobacteria of the ... ...

    Abstract Filamentous actinobacteria of the genus
    MeSH term(s) Actinobacteria/genetics ; Actinobacteria/metabolism ; Crystallography, X-Ray ; Cyclic GMP/analogs & derivatives ; Fimbriae, Bacterial ; Gene Expression Regulation, Bacterial ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Domains ; Sigma Factor/genetics ; Sigma Factor/metabolism ; Streptomyces/genetics ; Streptomyces/metabolism
    Chemical Substances Sigma Factor ; bis(3',5')-cyclic diguanylic acid (61093-23-0) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2105447118
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  9. Article: Komplexe Schmerztherapie unter Einbeziehung eines Ischiadikus- und Saphenuskatheters in palliativer Situation bei ausgeprägter Metastasierung eines Bronchialkarzinoms

    Kus, Jan Wilhelm / Schulte, Erika / Büttner, Benedikt / Erlenwein, Joachim / Petzke, Frank / Höhl, Carl Fabian / Weber-Krüger, Mark / Nauck, Friedemann

    Zeitschrift für Palliativmedizin

    2023  Volume 24, Issue 02, Page(s) 85–89

    Abstract: Hintergrund: Kontinuierliche periphere Nervenblockaden (Continuous peripheral nerve blocks, CPNB) werden am häufigsten zur perioperativen Analgesie bei chirurgischen Eingriffen eingesetzt. Alternative Indikationen wie die Behandlung tumorbedingter ... ...

    Abstract Hintergrund: Kontinuierliche periphere Nervenblockaden (Continuous peripheral nerve blocks, CPNB) werden am häufigsten zur perioperativen Analgesie bei chirurgischen Eingriffen eingesetzt. Alternative Indikationen wie die Behandlung tumorbedingter Schmerzen sind die Ausnahme, gleichwohl das Verfahren auch hier effektiv eingesetzt werden kann.
    Fallbericht: Bei einer 59-jährigen Patientin mit Bronchialkarzinom konnte der durch Metastasierung in der Tibia verursachte starke Schmerz mittels 28-tägiger CPNB des N. ischiadicus und des N. saphenus bis zu ihrem Versterben effektiv behandelt werden. Neben der Schmerzreduktion auf ein Minimum wurde die vorhergehende opioidassoziierte Vigilanzminderung verringert, wodurch sich die Lebensqualität in der letzten Lebensphase steigern ließ.
    Schlussfolgerungen: CPNB können auch in der Palliativmedizin regional begrenzte Schmerzen effektiv behandeln. Aufgrund der notwendigen Versorgungsstrukturen wird es aber ein Verfahren bleiben, das nur für einzelne Palliativpatient*innen sinnvoll und indiziert ist.
    Keywords periphere Ischiadikusblockade ; Saphenusblockade ; periphere Regionalanästhesie ; Tumorschmerztherapie ; Palliativmedizin ; ischiadicus nerve block ; saphenous nerve block ; regional anesthesia ; tumor pain therapy ; palliative care
    Language German
    Publishing date 2023-02-27
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072361-1
    ISSN 1615-293X ; 1615-2921
    ISSN (online) 1615-293X
    ISSN 1615-2921
    DOI 10.1055/a-2013-5778
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  10. Article ; Online: Evaluation of two surface sampling methods for the detection of Bacillus atrophaeus aerosolized in a test chamber.

    Buttner, Mark P / Cruz, Patricia / Detrick, Elizabeth / Gunter, Jessica / Medley, Steven

    Journal of microbiological methods

    2022  Volume 198, Page(s) 106507

    Abstract: In response to the airborne release of biothreat agents, surface sampling is often used to provide information on bioaerosol dispersal and deposition, to identify biocontaminant sources, and determine the effectiveness of decontamination. The objective ... ...

    Abstract In response to the airborne release of biothreat agents, surface sampling is often used to provide information on bioaerosol dispersal and deposition, to identify biocontaminant sources, and determine the effectiveness of decontamination. The objective of this project was to use aerosolization and deposition of dry spores to evaluate the efficiency of the cellulose sponge wipe and 37-mm cassette micro vacuum surface sampling methods for the collection of microorganisms from two contaminated surfaces, metal and concrete. Aerosolization trials were performed in a room-sized test chamber with known airborne concentrations of Bacillus atrophaeus spores serving as a surrogate for a bioterrorism agent. Following each aerosolization trial, the chamber heating, ventilation, air conditioning (HVAC) system was turned off to allow airborne spores to settle onto the test materials. Surface sampling was conducted and culture analysis was used to determine the concentration of B. atrophaeus on the surfaces. Results were compared with reference samples to determine the collection efficiency of the sampling methods. The sponge wipe sampling method was significantly more effective than the vacuum method for the collection of B. atrophaeus from both metal and concrete surfaces (P < 0.001). The collection efficiency of the sponge wipe method was 39.5% for metal and 26.5% for concrete, while the collection efficiency of the vacuum method was 7.6% for metal and 9.3% for concrete. The results of this study provided data on the collection efficiencies of two surface sampling methods for detection and enumeration of biocontaminants and can aid in selection of sampling methods.
    MeSH term(s) Bacillus ; Metals ; Specimen Handling/methods ; Spores, Bacterial
    Chemical Substances Metals
    Language English
    Publishing date 2022-05-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2022.106507
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