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  1. Article ; Online: Assessing ecological health in a semi-arid basin: a case study of the Wei River Basin, China.

    Yang, Yonglin / Cao, Hongye / Xia, Yuyun / Liu, Dong / Liu, Yang / Qiao, Jianwei

    Environmental science and pollution research international

    2024  Volume 31, Issue 14, Page(s) 21687–21708

    Abstract: ... health has emerged as a primary focus in current research. In this study, we selected the Wei River Basin ... River Ecological Health Assessment Index (REHAI) system. The research findings indicate that the Wei ... as sub-healthy. Furthermore, we observed variations within the Wei River system itself; the upper reaches ...

    Abstract A healthy water ecosystem within a river basin is essential for maintaining ecological security, preserving species diversity, and ensuring sustainable socio-economic development. Unfortunately, human activities have significantly threatened the health of water ecosystems in various basins. Consequently, timely restoration and targeted protection of damaged river ecosystems have become crucial objectives in watershed management. As a prerequisite and cornerstone for river protection and management, assessing river ecological health has emerged as a primary focus in current research. In this study, we selected the Wei River Basin, a representative area of the Yellow River Basin, as our research subject. We identified multiple influencing factors, including society, biology, water quality, and habitat, which collectively impact this semi-arid region. To assess the overall impact of these factors on ecological health, we developed a comprehensive River Ecological Health Assessment Index (REHAI) system. The research findings indicate that the Wei River system, as a whole, is currently in a healthy state, while the Jing and Luo River systems are classified as sub-healthy. Furthermore, we observed variations within the Wei River system itself; the upper reaches of the Wei River exhibit higher levels of health compared to the middle reaches, whereas the water environment in the lower reaches is the most compromised. This degradation can be attributed to downstream subsidence, increased pollution, and rapid urbanization. By establishing a river ecosystem health assessment methodology and conducting a comprehensive evaluation of the health status of river ecosystems, this paper puts forward management recommendations for river basins. These findings provide a scientific basis for the sustainable utilization of water resources in river basins and promote the harmonious coexistence of humanity and nature.
    MeSH term(s) Humans ; Ecosystem ; Water Quality ; Water Resources ; Rivers ; China
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32377-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Gut Microbial Co-Abundance Gene Groups (CAGs) Differentially Respond to the Flavor (Yao-Wei) of Chinese Materia Medica.

    Yang, Ya-Nan / Deng, Yu-Ting / Zang, Chen-Chen / Zhang, Fang / Huang, Zi-Bao / Dong, Lin / Lu, Wei-Ying / Zhang, Xiao-Po / Wu, Chong-Ming

    The American journal of Chinese medicine

    2022  Volume 50, Issue 8, Page(s) 2223–2244

    Abstract: The property theory is a unique principle instructing traditional Chinese doctors to prescribe proper medicines against diseases. As an essential part of it, the five-flavor theory catalogs various Chinese materia medicas (CMMs) into five flavors (sweet, ...

    Abstract The property theory is a unique principle instructing traditional Chinese doctors to prescribe proper medicines against diseases. As an essential part of it, the five-flavor theory catalogs various Chinese materia medicas (CMMs) into five flavors (sweet, bitter, sour, salty, and pungent) based on their taste and medical functions. Although CMM has been successfully applied in China for thousands of years, it is still a big challenge to interpret CMM flavor via modern biomarkers, further deepening its elusiveness. Herein, to identify the correlation between gut microbiota and CMM flavor, we selected 14 CMMs with different flavors to prepare their aqueous extracts, quantified the contained major chemical components, and then performed full-length 16S rRNA sequencing to analyze the gut microbiota of C57BL/6 mice administrated with CMM extracts. We found that flavones, alkaloids, and saponins were the richest components for sweet-, bitter-, and pungent-flavored CMMs, respectively. Medicines with merged flavors (bitter-pungent and sweet-pungent) displayed mixed profiles of components. According to gut microbial analysis, modulation of CMMs belonging to the same flavor on the taxonomic classification was inconsistent to an extent, while the functional sets of gut microbiota, co-abundance gene groups (CAGs), strongly and differentially responded to distinct flavors. Moreover, these correlations were in line with their pharmacological actions. Therefore, the gut microbial functional sets (CAGs) could act as the possible indicator to reflect CMM flavor, rather than the composition of microbial community.
    MeSH term(s) Mice ; Animals ; Materia Medica ; Medicine, Chinese Traditional ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; Mice, Inbred C57BL
    Chemical Substances Materia Medica ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-10-20
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 193085-0
    ISSN 1793-6853 ; 0090-2942 ; 0192-415X
    ISSN (online) 1793-6853
    ISSN 0090-2942 ; 0192-415X
    DOI 10.1142/S0192415X22500963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

    Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1038273

    Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

    Abstract Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites.
    Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed
    Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera
    Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1038273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway.

    Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt B, Page(s) 117020

    Abstract: Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis ( ... ...

    Abstract Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys).
    Materials and methods: Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected.
    Results: WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65.
    Conclusion: WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
    MeSH term(s) Rats ; Animals ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Methylnitronitrosoguanidine ; Pepsin A/metabolism ; Inflammation/pathology ; Precancerous Conditions/drug therapy ; Hyperplasia/pathology ; Stomach Neoplasms/pathology ; Metaplasia/metabolism ; Metaplasia/pathology ; Gastric Mucosa/pathology
    Chemical Substances NF-kappa B ; Tumor Necrosis Factor-alpha ; Methylnitronitrosoguanidine (12H3O2UGSF) ; Pepsin A (EC 3.4.23.1)
    Language English
    Publishing date 2023-08-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lowering serum urate level to a guideline-based target is associated with a lower risk of incident fracture in people with gout: comment on the article by Wei et al.

    Wang, Gang / Zhuo, Ning / Yan, Dong / Liu, Zhichun

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 10, Page(s) 1869–1870

    MeSH term(s) Humans ; Fractures, Bone ; Gout/blood ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Risk ; Uric Acid/blood ; Treatment Outcome
    Chemical Substances Gout Suppressants ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Letter
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer.

    Wang, Huijun / Wu, Ruoming / Xie, Dong / Ding, Liqin / Lv, Xing / Bian, Yanqin / Chen, Xi / Nisma Lena, Bahaji Azami / Wang, Shunchun / Li, Kun / Chen, Wei / Ye, Guan / Sun, Mingyu

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 558471

    Abstract: Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China ...

    Abstract Wei-Fu-Chun (WFC) tablet is a commercial medicinal product approved by China Food and Drug Administration, which is made of
    Language English
    Publishing date 2020-11-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.558471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

    Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

    Journal of Ethnopharmacology. 2023 Aug. 09, p.117020-

    2023  , Page(s) 117020–

    Abstract: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous ... ...

    Abstract Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
    Keywords Food and Drug Administration ; body weight ; bone marrow ; ethanol ; fasting ; gastric acid ; gastric mucosa ; gastritis ; herbal medicines ; histopathology ; inflammation ; interleukin-6 ; intestines ; macrophages ; metaplasia ; pH ; pepsin ; rats ; traditional medicine ; transcription factor NF-kappa B ; China ; Wei-fu-chun tablet ; Gastric intestinal metaplasia ; Gastric dysplasia ; NF-κB pathway
    Language English
    Dates of publication 2023-0809
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117020
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model.

    Qin, Jingjing / Wuniqiemu, Tulake / Wei, Ying / Teng, Fangzhou / Cui, Jie / Sun, Jing / Yi, La / Tang, Weifeng / Zhu, Xueyi / Xu, Weifang / Dong, Jingcheng

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 95, Page(s) 153803

    Abstract: Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used ...

    Abstract Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription for treating asthma patients. However, the targeted proteins associated with JWBSYQF treatment remain unknown.
    Purpose: Present study aims to evaluate the therapeutic efficacy of JWBSYQF and identify the targeted proteins in addition to functional pathways.
    Study design: The ovalbumin (OVA)-induced murine asthma model was established to explore the therapeutic effect of JWBSYQF treatment. Proteomic profiling and quantifications were performed using data-independent acquisition (DIA) methods. Differentially expressed proteins (DEPs) were validated via western blot (WB) and immunohistochemistry (IHC).
    Methods: A murine asthma model was made by OVA sensitization and challenge, and JWBSYQF (2.25, 4.50, 9,00 g/kg body weight) or dexamethasone (1 mg/ kg body weight) were administered orally. Airway hyperresponsiveness (AHR) to methacholine (Mch), inflammatory cell counts and classification in bronchoalveolar lavage fluid (BALF), lung histopathology, and cytokine levels were measured. Furthermore, DIA proteomic analyses were performed to explore the DEPs targeted by JWBSYQF and were further validated by WB and IHC.
    Results: Our results exhibited that JWBSYQF attenuated AHR which was mirrored by decreased airway resistance and increased lung compliance. In addition, JWBSYQF-treated mice showed reduced inflammatory score, mucus hypersecretion, as well as reduced the number of BALF leukocytes along with decreased content of BALF Th2 inflammatory cytokines (IL-4, IL-5, IL-13) and serum IgE. Proteomics analysis identified 704 DEPs between the asthmatic mice and control group (MOD vs CON), and 120 DEPs between the JWBSYQF-treatment and the asthmatic mice (JWB-M vs MOD). A total of 33 overlapped DEPs were identified among the three groups. Pathway enrichment analysis showed that DEPs were significantly enriched in IL-17 signaling pathway, in which DEPs, Lcn2, TGF-β1, Gngt2, and Ppp2r5e were common DEPs between three experimental groups. WB and IHC results further validated expressional levels and tendency of these proteins. Our results also showed that JWBSYQF affects mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, that are activated by IL-17 signaling.
    Conclusion: The present study suggested that JWBSYQF could attenuate AHR and airway inflammation in OVA-induced asthmatic mice. In addition, proteomics analysis revealed that suppression of IL-17 signaling pathways contributes to the therapeutic effects of JWBSYQF.
    MeSH term(s) Animals ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid ; Cytokines ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Interleukin-17 ; Lung ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Proteomics ; Signal Transduction
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; Interleukin-17 ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2021-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD

    Qing Kong / Shuming Mo / Wenqian Wang / Zihui Tang / Ying Wei / Yijie Du / Baojun Liu / Lingwen Kong / Yubao Lv / Jingcheng Dong

    Trials, Vol 21, Iss 1, Pp 1-

    study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial

    2020  Volume 16

    Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

    Abstract Abstract Background Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime. Methods In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient’s next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well. Discussion By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies. Trial registration www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
    Keywords Randomized clinical trial ; Design and method ; Acute exacerbation of COPD ; Traditional Chinese medicine ; Systemic glucocorticoids duration ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Efficacy and safety of Jia Wei Bushen Yiqi formulas as an adjunct therapy to systemic glucocorticoids on acute exacerbation of COPD: study protocol for a randomized, double-blinded, multi-center, placebo-controlled clinical trial.

    Kong, Qing / Mo, Shuming / Wang, Wenqian / Tang, Zihui / Wei, Ying / Du, Yijie / Liu, Baojun / Kong, Lingwen / Lv, Yubao / Dong, Jingcheng

    Trials

    2020  Volume 21, Issue 1, Page(s) 760

    Abstract: ... the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations ...

    Abstract Background: Systemic glucocorticoids are effective for the management of chronic obstructive pulmonary disease (COPD) exacerbation but have serious adverse effects. Traditional Chinese medicine (TCM) can bring additional benefits to these patients but has few adverse effects. The present study aims to evaluate the efficacy and safety of Jia Wei Bushen Yiqi (JWBY) formulas in patients who suffer from COPD exacerbations and to investigate whether the short-term (5-days) systemic glucocorticoid therapy is non-inferior to the long-term (9-day) regime.
    Methods: In this multi-center, randomized, double-blinded trial, eligible inpatients with COPD exacerbation are randomly assigned to four groups (A, B, C, and D). Group A will receive placebo plus 5-day prednisone, group B will receive placebo plus 9-day prednisone, group C will receive JWBY formulas plus 5-day prednisone, and group D will receive JWBY formulas plus 9-day prednisone. The primary outcomes are the time interval to the patient's next exacerbation during a 180-day following up and the COPD assessment test (CAT) during treatment. Secondary outcomes include lung function, TCM syndrome assessment, laboratory tests, and safety. The changes of the hypothalamic pituitary adrenaline axis (HPA axis) and inflammatory cytokine will be measured as well.
    Discussion: By demonstrating the advantages of utilizing TCM and an appropriate duration of systemic glucocorticoids, this effectiveness comparison trial will provide new references to physicians on how to improve the management of COPD exacerbation. The results of HPA axis and inflammation cytokine measurements will shed light on the molecular mechanisms and entail further mechanism studies.
    Trial registration: www.chictr.org.cn ChiCTR1900023364. Registered on 24 May 2019.
    MeSH term(s) Double-Blind Method ; Glucocorticoids/adverse effects ; Humans ; Hypothalamo-Hypophyseal System ; Medicine, Chinese Traditional ; Multicenter Studies as Topic ; Pituitary-Adrenal System ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Glucocorticoids
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1468-6708
    ISSN (online) 1745-6215 ; 1468-6694
    ISSN 1468-6708
    DOI 10.1186/s13063-020-04669-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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