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Article ; Online: Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID-19.

Manickam, Manoj / Meenakshisundaram, Sangeetha / Pillaiyar, Thanigaimalai

2021 Volume 355, Issue 3, Page(s) e2100367

Abstract: Anti-inflammatory, specialized proresolving mediators such as resolvins, protectins, maresins, and lipoxins derived from polyunsaturated acids may play a potential role in lung diseases as they protect different organs in animal disease models. ... ...

Abstract	Anti-inflammatory, specialized proresolving mediators such as resolvins, protectins, maresins, and lipoxins derived from polyunsaturated acids may play a potential role in lung diseases as they protect different organs in animal disease models. Polyunsaturated fatty acids are an important resource for epoxy fatty acids (EET, EEQ, and EDP) that mediate a broad array of anti-inflammatory and proresolving mechanisms, such as mitigation of the cytokine storm. However, epoxy fatty acids are rapidly metabolized by soluble epoxide hydrolase (sEH). In animal studies, administration of sEH inhibitors (sEHIs) increases epoxy fatty acid levels, reduces lung inflammation, and improves lung function, making it a viable COVID-19 treatment approach. Thus, using sEHIs to activate endogenous resolution pathways might be a novel method to minimize organ damage in severe cases and improve outcomes in COVID-19 patients. This review focuses on the use of sEH inhibitors to activate endogenous resolution mechanisms for the treatment of COVID-19.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Antiviral Agents/pharmacology ; COVID-19/immunology ; Clinical Trials as Topic ; Docosahexaenoic Acids ; Epoxide Hydrolases/antagonists & inhibitors ; Epoxide Hydrolases/physiology ; Fatty Acids, Unsaturated/pharmacology ; Humans ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Fatty Acids, Unsaturated ; resolvin D1 ; Docosahexaenoic Acids (25167-62-8) ; Epoxide Hydrolases (EC 3.3.2.-)
Language	English
Publishing date	2021-11-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202100367
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Article: The burden of snakebite envenomation demands a hospital-based registry in India.

Rubeshkumar, Polani Chandrasekar / Ponnaiah, Manickam / Murhekar, Manoj Vasant

The National medical journal of India

2021 Volume 34, Issue 2, Page(s) 107

MeSH term(s)	Hospitals ; Humans ; India/epidemiology ; Registries ; Retrospective Studies ; Snake Bites/epidemiology ; Snake Bites/therapy
Language	English
Publishing date	2021-08-11
Publishing country	India
Document type	Journal Article
ZDB-ID	645116-0
ISSN	0970-258X
ISSN	0970-258X
DOI	10.4103/0970-258X.326767
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Article ; Online: A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery.

Pillaiyar, Thanigaimalai / Meenakshisundaram, Sangeetha / Manickam, Manoj / Sankaranarayanan, Murugesan

European journal of medicinal chemistry

2020 Volume 195, Page(s) 112275

Abstract: Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach ... ...

Abstract	Drug repurposing is a strategy consisting of finding new indications for already known marketed drugs used in various clinical settings or highly characterized compounds despite they can be failed drugs. Recently, it emerges as an alternative approach for the rapid identification and development of new pharmaceuticals for various rare and complex diseases for which lack the effective drug treatments. The success rate of drugs repurposing approach accounts for approximately 30% of new FDA approved drugs and vaccines in recent years. This review focuses on the status of drugs repurposing approach for various diseases including skin diseases, infective, inflammatory, cancer, and neurodegenerative diseases. Efforts have been made to provide structural features and mode of actions of drugs.
MeSH term(s)	Animals ; Chemistry, Pharmaceutical ; Drug Discovery/methods ; Drug Repositioning/methods ; Humans
Keywords	covid19
Language	English
Publishing date	2020-04-02
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2020.112275
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Article ; Online: Recent discovery and development of inhibitors targeting coronaviruses.

Pillaiyar, Thanigaimalai / Meenakshisundaram, Sangeetha / Manickam, Manoj

Drug discovery today

2020 Volume 25, Issue 4, Page(s) 668–688

Abstract: Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe ... ...

Abstract	Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle.
MeSH term(s)	Animals ; Antiviral Agents/adverse effects ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Coronaviridae Infections/diagnosis ; Coronaviridae Infections/drug therapy ; Coronaviridae Infections/virology ; Coronavirus/drug effects ; Coronavirus/growth & development ; Coronavirus/pathogenicity ; Drug Design ; Drug Development ; Humans ; Molecular Structure ; Molecular Targeted Therapy ; Structure-Activity Relationship
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-01-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2020.01.015
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Zs.A 4725: Show issues

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Article ; Online: Clinico-Histological Features of Thrombotic Microangiopathy in Renal Biopsies: A Retrospective Study.

Manickam, Niraimathi / Agrawal, Vinita / Prasad, Pallavi / Jain, Manoj / Prasad, Narayan

Turk patoloji dergisi

2021 Volume 38, Issue 1, Page(s) 1–8

Abstract: Objective: Thrombotic microangiopathy (TMA) is often first detected on a renal biopsy performed for renal manifestations. Apart from hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura, there are various secondary conditions ... ...

Title translation	Clinico-Histological Features of Thrombotic Microangiopathy in Renal Biopsies: A Retrospective Study.
Abstract	Objective: Thrombotic microangiopathy (TMA) is often first detected on a renal biopsy performed for renal manifestations. Apart from hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura, there are various secondary conditions associated with TMA. This study analyzes the clinico-pathological spectrum, etiological factors and renal outcome of TMA diagnosed on renal biopsy. Material and method: A retrospective evaluation of renal biopsies for TMA over 5.5 years was performed. Clinical and laboratory data was collected from patient records. Results: A total of 40 biopsies from 39 patients showed TMA comprising 33 native and 7 transplant biopsies. Malignant hypertension (n=13) was the most common etiology in native biopsies followed by postpartum TMA (n=7), atypical HUS (aHUS) (n=7), and lupus nephritis (n=6). TMA in transplant biopsies was due to acute rejection (n=4) and CNI toxicity (n=3). Serum creatinine was high in most patients (mean 5.6 + 2.5 mg/ dl). aHUS showed the highest mean LDH levels and the lowest average platelet counts. Renal biopsies in malignant hypertension and postpartum TMA showed isolated arterial changes while aHUS and lupus nephritis showed both glomerular and arterial involvement. Postpartum TMA and aHUS had poor renal outcome requiring renal replacement therapy. Conclusion: Most postpartum TMA and aHUS had systemic features of TMA while malignant hypertension and lupus nephritis showed 'isolated renal TMA'. This emphasizes the importance of careful evaluation of renal biopsies even in the absence of systemic features of TMA.
MeSH term(s)	Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Biopsy ; Female ; Humans ; Lupus Nephritis/complications ; Lupus Nephritis/diagnosis ; Retrospective Studies ; Thrombotic Microangiopathies/complications ; Thrombotic Microangiopathies/diagnosis
Language	English
Publishing date	2021-09-04
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2515899-5
ISSN	1309-5730 ; 1309-5730
ISSN (online)	1309-5730
ISSN	1309-5730
DOI	10.5146/tjpath.2021.01536
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Article ; Online: Informing primi and elderly pregnant women about iron sucrose administration for moderate anemia can improve treatment compliance in public health facilities, Kancheepuram health district, Tamil Nadu, India, 2017

Anandan Mohan / Sakthivel Manikandanesan / Ponnaiah Manickam / Karumanagounder Kolandaswamy / Manoj Murhekar

Clinical Epidemiology and Global Health, Vol 10, Iss , Pp 100681- (2021)

A cross-sectional study

2021

Abstract: Introduction: Tamil Nadu administers intravenous iron sucrose for correcting moderate anaemia among pregnant women (Haemoglobin level 7–8.9 g/dl) based on preliminary studies. We did a cross-sectional study to estimate compliance level and that of ... ...

Abstract	Introduction: Tamil Nadu administers intravenous iron sucrose for correcting moderate anaemia among pregnant women (Haemoglobin level 7–8.9 g/dl) based on preliminary studies. We did a cross-sectional study to estimate compliance level and that of factors associated with intravenous iron sucrose treatment for moderate anaemia among pregnant women attending health facilities of Kancheepuram health district, Tamil Nadu, India, 2017. Methods: We needed five pregnant women of 20–30 weeks from 70 clusters (health subcentres) for the assumptions of 64% compliance, 7% absolute precision, 95% Confidence Interval (CI) and a design effect of two. We collected data on knowledge and experience with iron sucrose treatment and reasons for non-compliance. We abstracted haemoglobin levels and administered doses from records. We computed compliance level (%) with 95% CI and estimated adjusted odds ratio (AOR) for non-compliance through logistic regression analysis. Results: The median age of 350 women was 24 years (Range = 22 to 26). Compliance level to intravenous iron sucrose was 79% (95% CI: 73 to 84). Non-compliance was more likely among women aged 25–35 years (AOR: 2.1, 95% CI: 1.2 to 3.7), primi (AOR: 2.2’ 95% CI: 1.2 to 3.8) and not received treatment information (AOR: 3.1, 95% CI: 1.1 to 8.8). Major reasons for non-compliance were lack of information about treatment, belief that food was better than injections and that injections could harm the baby. Conclusions: The compliance to intravenous iron sucrose was insufficient. Providing clear information about intravenous iron sucrose to moderately anaemic pregnant women could increase the compliance to intravenous iron sucrose.
Keywords	Compliance ; Iron sucrose ; Moderate anaemia ; Pregnancy ; Kancheepuram ; Public aspects of medicine ; RA1-1270
Subject code	320
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploration of imidazole and imidazopyridine dimers as anticancer agents: Design, synthesis, and structure-activity relationship study.

Meenakshisundaram, Sangeetha / Manickam, Manoj / Pillaiyar, Thanigaimalai

Archiv der Pharmazie

2019 Volume 352, Issue 12, Page(s) e1900011

Abstract: Dimerization of proteins/receptors plays a critical role in various cellular processes, including cell proliferation and differentiation. Therefore, targeting such dimeric proteins/receptors by dimeric small molecules could be a potential therapeutic ... ...

Abstract	Dimerization of proteins/receptors plays a critical role in various cellular processes, including cell proliferation and differentiation. Therefore, targeting such dimeric proteins/receptors by dimeric small molecules could be a potential therapeutic approach to treating various diseases, including inflammation-associated diseases like cancer. A novel series of bis-imidazoles (13-18) and bis-imidazo[1,2-a]pyridines (19-28) were designed and synthesized from Schiff base dimers (1-12) for their anticancer activities. All the synthesized compounds were screened for anticancer activities against three cancer cell lines, including cervical (HeLa), breast (MDA-MB-231), and renal cancer (ACHN). From structure-activity relationship studies, imidazo[1,2-a]pyridines (19-28) showed remarkable cytotoxic activities, with compounds 19 and 24 showing the best inhibitory activities against all three cell lines. Especially, both 19 and 24 were very effective against the breast cancer cell line (19, GI
MeSH term(s)	Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Design ; Humans ; Imidazoles/chemical synthesis ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Mammary Neoplasms, Experimental/drug therapy ; Molecular Structure ; Protein Multimerization/drug effects ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/pharmacology ; Rats ; Structure-Activity Relationship ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Imidazoles ; Pyridines ; imidazopyridine ; imidazole (7GBN705NH1)
Language	English
Publishing date	2019-10-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.201900011
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Article: Pioneering an online course on research methods for India's medical postgraduates & faculty members.

Ponnaiah, Manickam / Bhatnagar, Tarun / Parasuraman, Ganeshkumar / Murhekar, Manoj V / Sankar, M Jeeva / Awasthi, Shally / Ramji, Siddarth / Bhargava, Balram

The Indian journal of medical research

2022 Volume 156, Issue 3, Page(s) 384–387

MeSH term(s)	Humans ; Research Design ; Faculty ; India
Language	English
Publishing date	2022-12-13
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/ijmr.ijmr_1077_21
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Article ; Online: The recent outbreaks of human coronaviruses: A medicinal chemistry perspective.

Pillaiyar, Thanigaimalai / Wendt, Lukas L / Manickam, Manoj / Easwaran, Maheswaran

Medicinal research reviews

2020 Volume 41, Issue 1, Page(s) 72–135

Abstract: Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal. Since the start of the 21st century, three β-coronaviruses have crossed the ... ...

Abstract	Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal. Since the start of the 21st century, three β-coronaviruses have crossed the species barrier to infect humans: severe-acute respiratory syndrome (SARS)-CoV-1, Middle East respiratory syndrome (MERS)-CoV, and SARS-CoV-2 (2019-nCoV). These viruses are dangerous and can easily be transmitted from human to human. Therefore, the development of anticoronaviral therapies is urgently needed. However, to date, no approved vaccines or drugs against CoV infections are available. In this review, we focus on the medicinal chemistry efforts toward the development of antiviral agents against SARS-CoV-1, MERS-CoV, SARS-CoV-2, targeting biochemical events important for viral replication and its life cycle. These targets include the spike glycoprotein and its host-receptors for viral entry, proteases that are essential for cleaving polyproteins to produce functional proteins, and RNA-dependent RNA polymerase for viral RNA replication.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19/epidemiology ; Chemistry, Pharmaceutical ; Disease Outbreaks ; Drug Repositioning ; Humans ; Virus Internalization/drug effects
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603210-2
ISSN	1098-1128 ; 0198-6325
ISSN (online)	1098-1128
ISSN	0198-6325
DOI	10.1002/med.21724
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Zs.A 1764: Show issues

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Article: Synthesis of Nontoxic Pyrazolidine-Based Benzoxazine-Coated Cotton Fabric for Oil–Water Separation

Manickam, Manoj / Pichaimani, Prabunathan / Arumugam, Hariharan / Muthukaruppan, Alagar

Industrial & engineering chemistry process design and development. 2019 Nov. 04, v. 58, no. 47

2019

Abstract: In the present work, pyrazolidine bisphenol (PYBP)-based superhydrophobic/superoleophilic benzoxazine (PBz) matrices were synthesized and described in comparison with bisphenol F benzoxazines. The preliminary in vitro toxicity assay reveals the nontoxic ... ...

Abstract	In the present work, pyrazolidine bisphenol (PYBP)-based superhydrophobic/superoleophilic benzoxazine (PBz) matrices were synthesized and described in comparison with bisphenol F benzoxazines. The preliminary in vitro toxicity assay reveals the nontoxic nature of PYBP. Data obtained from thermal and surface studies indicate that the prepared PYBP-based PBzs have enhanced thermal stability than those of bisphenol F benzoxazines. Further, the prepared PYBP-based PBz-coated cotton fabric displayed superior water contact angle (WCA = 154.7°) and sliding contact angle (θ = 9°). Observations from SEM images suggest that the inherent superhydrophobic nature was due to the formation of rough surfaces. Furthermore, oil–water separation was successfully ascertained from the appropriate experimental conditions using the PYBP-coated fabric. The separation efficiency and flux are found to be greater than 90% after 10 cycles. Thus, the PYBP-based superhydrophobic/superoleophilic polybenzoxazines (PBzs) have been synthesized and characterized to assess their suitability for water-repellent and oil–water separation applications.
Keywords	bisphenol F ; contact angle ; cotton fabric ; hydrophobicity ; scanning electron microscopy ; thermal stability ; toxicity
Language	English
Dates of publication	2019-1104
Size	p. 21419-21430.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.9b03440
Database	NAL-Catalogue (AGRICOLA)

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