LIVIVO - Search results -

Search results

Result 1 - 10 of total 2858

Search options

Article ; Online: Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms.

Lu, Huan-Jun / Gao, Yong-Jing

2022 Volume 39, Issue 3, Page(s) 425–439

Abstract: Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, ... ...

Abstract	Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, including chronic pain. Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exaggerate pain signals under chronic pain conditions. It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Therefore, this review presents our current understanding of the roles of astrocytes in chronic pain, how they regulate nociceptive responses, and their cellular and molecular mechanisms of action.
MeSH term(s)	Humans ; Astrocytes/pathology ; Chronic Pain/pathology ; Neuroglia/physiology ; Neurons/physiology ; Synaptic Transmission ; Chronic Disease
Language	English
Publishing date	2022-11-14
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2419741-5
ISSN	1995-8218 ; 1673-7067
ISSN (online)	1995-8218
ISSN	1673-7067
DOI	10.1007/s12264-022-00961-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6734: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Editorial: Pain, immunity, and neurological and autoimmune disorders.

Tan, Ping-Heng / Gao, Yong-Jing / Di, Yuanpu Peter / Cheng, Jen-Kun

Frontiers in immunology

2023 Volume 14, Page(s) 1195204

MeSH term(s)	Humans ; Pain ; Autoimmune Diseases
Language	English
Publishing date	2023-04-04
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1195204
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Targeting TRIP13 for overcoming anticancer drug resistance (Review).

Zhao, Liwen / Ye, Siyu / Jing, Shengnan / Gao, Yong-Jing / He, Tianzhen

Oncology reports

2023 Volume 50, Issue 5

Abstract: Cancer is one of the greatest dangers to human wellbeing and survival. A key barrier to effective cancer therapy is development of resistance to anti‑cancer medications. In cancer cells, the AAA+ ATPase family member thyroid hormone receptor interactor ... ...

Abstract	Cancer is one of the greatest dangers to human wellbeing and survival. A key barrier to effective cancer therapy is development of resistance to anti‑cancer medications. In cancer cells, the AAA+ ATPase family member thyroid hormone receptor interactor 13 (TRIP13) is key in promoting treatment resistance. Nonetheless, knowledge of the molecular processes underlying TRIP13‑based resistance to anticancer therapies is lacking. The present study evaluated the function of TRIP13 expression in anticancer drug resistance and potential methods to overcome this resistance. Additionally, the underlying mechanisms by which TRIP13 promotes resistance to anticancer drugs were explored, including induction of mitotic checkpoint complex surveillance system malfunction, promotion of DNA repair, the enhancement of autophagy and the prevention of immunological clearance. The effects of combination treatment, which include a TRIP13 inhibitor in addition to other inhibitors, were discussed. The present study evaluated the literature on TRIP13 as a possible target and its association with anticancer drug resistance, which may facilitate improvements in current anticancer therapeutic options.
MeSH term(s)	Humans ; Cell Cycle Proteins/genetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; ATPases Associated with Diverse Cellular Activities/metabolism
Chemical Substances	Cell Cycle Proteins ; Antineoplastic Agents ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; TRIP13 protein, human (EC 3.6.4.-)
Language	English
Publishing date	2023-10-06
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2023.8639
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4213: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: 2019 Academic Annual Meeting and the Frontier Seminar on "Glial Cell Function and Disease" (Nantong, China).

Wang, Yu-Feng / Gao, Yong-Jing

ASN neuro

2019 Volume 11, Page(s) 1759091419863576

MeSH term(s)	Central Nervous System Diseases ; China ; Humans ; Neuroglia
Language	English
Publishing date	2019-08-09
Publishing country	United States
Document type	Congress
ZDB-ID	2485467-0
ISSN	1759-0914 ; 1759-0914
ISSN (online)	1759-0914
ISSN	1759-0914
DOI	10.1177/1759091419863576
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Chemokine CCL7 mediates trigeminal neuropathic pain

Zhu, Lin-Peng / Xu, Meng-Lin / Yuan, Bao-Tong / Ma, Ling-Jie / Gao, Yong-Jing

Molecular pain

2023 Volume 19, Page(s) 17448069231169373

Abstract: Background: Chemokine-mediated neuroinflammation plays an important role in the pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor CCR2 have been reported to contribute to neuropathic pain via astrocyte-microglial ... ...

Abstract	Background: Chemokine-mediated neuroinflammation plays an important role in the pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor CCR2 have been reported to contribute to neuropathic pain via astrocyte-microglial interaction in the spinal cord. Whether CCL7 in the trigeminal ganglion (TG) involves in trigeminal neuropathic pain and the involved mechanism remain largely unknown. Methods: The partial infraorbital nerve transection (pIONT) was used to induce trigeminal neuropathic pain in mice. The expression of Results: Ccl7 Conclusion: CCL7 activates ERK in TG neurons via CCR2 and CCR3 to enhance neuronal excitability, which contributes to the maintenance of trigeminal neuropathic pain. CCL7-CCR2/CCR3-ERK pathway may be potential targets for treating trigeminal neuropathic pain.
MeSH term(s)	Animals ; Mice ; Chemokine CCL2/metabolism ; Chemokine CCL7/metabolism ; Chemokine CCL7/pharmacology ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Hyperalgesia/metabolism ; Ligands ; MAP Kinase Signaling System ; Neuralgia/metabolism ; Trigeminal Ganglion/metabolism ; Trigeminal Neuralgia/metabolism ; Receptors, CCR2/metabolism ; Receptors, CCR3/metabolism
Chemical Substances	Chemokine CCL2 ; Chemokine CCL7 ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Ligands ; Receptors, CCR2 ; Receptors, CCR3
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/17448069231169373
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cytochrome P450 26A1 Contributes to the Maintenance of Neuropathic Pain.

Cao, De-Li / Ma, Ling-Jie / Jiang, Bao-Chun / Gu, Qiang / Gao, Yong-Jing

Neuroscience bulletin

2023 Volume 40, Issue 3, Page(s) 293–309

Abstract: The cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases. CYP26A1, a member of the CYP450 family, carries out the oxidative metabolism of retinoic acid (RA), ...

Abstract	The cytochrome P450 proteins (CYP450s) have been implicated in catalyzing numerous important biological reactions and contribute to a variety of diseases. CYP26A1, a member of the CYP450 family, carries out the oxidative metabolism of retinoic acid (RA), the active metabolite of vitamin A. Here we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation (SNL). CYP26A1 was mainly expressed in spinal neurons and astrocytes. HPLC analysis displayed that the content of all-trans-RA (at-RA), the substrate of CYP26A1, was reduced in the spinal cord on day 7 after SNL. Inhibition of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic pain. Talarozole also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine (IL-10) production. The RA receptors RARα, RXRβ, and RXRγ were expressed in spinal neurons and glial cells. The promoter of Il-10 has several binding sites for RA receptors, and at-RA directly increased Il-10 mRNA expression in vitro. Finally, intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and microglia. Collectively, the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial activation. CYP26A1 may be a potential therapeutic target for the treatment of neuropathic pain.
MeSH term(s)	Humans ; Interleukin-10/metabolism ; Retinoic Acid 4-Hydroxylase/metabolism ; Spinal Cord/metabolism ; Neuralgia/metabolism ; Cytokines/metabolism ; Hyperalgesia/metabolism
Chemical Substances	Interleukin-10 (130068-27-8) ; Retinoic Acid 4-Hydroxylase (EC 1.14.14.1) ; Cytokines
Language	English
Publishing date	2023-08-28
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2419741-5
ISSN	1995-8218 ; 1673-7067
ISSN (online)	1995-8218
ISSN	1673-7067
DOI	10.1007/s12264-023-01101-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6734: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: CCL2/CCR2 Contributes to the Altered Excitatory-inhibitory Synaptic Balance in the Nucleus Accumbens Shell Following Peripheral Nerve Injury-induced Neuropathic Pain.

Wu, Xiao-Bo / Zhu, Qian / Gao, Yong-Jing

Neuroscience bulletin

2021 Volume 37, Issue 7, Page(s) 921–933

Abstract: The medium spiny neurons (MSNs) in the nucleus accumbens (NAc) integrate excitatory and inhibitory synaptic inputs and gate motivational and emotional behavior output. Here we report that the relative intensity of excitatory and inhibitory synaptic ... ...

Abstract	The medium spiny neurons (MSNs) in the nucleus accumbens (NAc) integrate excitatory and inhibitory synaptic inputs and gate motivational and emotional behavior output. Here we report that the relative intensity of excitatory and inhibitory synaptic inputs to MSNs of the NAc shell was decreased in mice with neuropathic pain induced by spinal nerve ligation (SNL). SNL increased the frequency, but not the amplitude of spontaneous inhibitory postsynaptic currents (sIPSCs), and decreased both the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) in the MSNs. SNL also decreased the paired-pulse ratio (PPR) of evoked IPSCs but increased the PPR of evoked EPSCs. Moreover, acute bath application of C-C motif chemokine ligand 2 (CCL2) increased the frequency and amplitude of sIPSCs and sEPSCs in the MSNs, and especially strengthened the amplitude of N-methyl-D-aspartate receptor (NMDAR)-mediated miniature EPSCs. Further Ccl2 overexpression in the NAc in vivo decreased the peak amplitude of the sEPSC/sIPSC ratio. Finally, Ccr2 knock-down improved the impaired induction of NMDAR-dependent long-term depression (LTD) in the NAc after SNL. These results suggest that CCL2/CCR2 signaling plays a role in the integration of excitatory/inhibitory synaptic transmission and leads to an increase of the LTD induction threshold at the synapses of MSNs during neuropathic pain.
MeSH term(s)	Animals ; Chemokine CCL2 ; Chemokines ; Ligands ; Mice ; Neuralgia ; Nucleus Accumbens ; Peripheral Nerve Injuries/complications ; Receptors, CCR2 ; Synaptic Transmission
Chemical Substances	Ccl2 protein, mouse ; Ccr2 protein, mouse ; Chemokine CCL2 ; Chemokines ; Ligands ; Receptors, CCR2
Language	English
Publishing date	2021-05-18
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2419741-5
ISSN	1995-8218 ; 1673-7067
ISSN (online)	1995-8218
ISSN	1673-7067
DOI	10.1007/s12264-021-00697-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6734: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

Jing, Peng-Bo / Chen, Xiao-Hong / Lu, Huan-Jun / Gao, Yong-Jing / Wu, Xiao-Bo

Molecular pain

2022 Volume 18, Page(s) 17448069211053255

Abstract: N-methyl-d-aspartate receptors (NMDARs) dysfunction in the nucleus accumbens (NAc) participates in regulating many neurological and psychiatric disorders such as drug addiction, chronic pain, and depression. NMDARs are heterotetrameric complexes ... ...

Abstract	N-methyl-d-aspartate receptors (NMDARs) dysfunction in the nucleus accumbens (NAc) participates in regulating many neurological and psychiatric disorders such as drug addiction, chronic pain, and depression. NMDARs are heterotetrameric complexes generally composed of two NR1 and two NR2 subunits (NR2A, NR2B, NR2C and NR2D). Much attention has been focused on the role of NR2A and NR2B-containing NMDARs in a variety of neurological disorders; however, the function of NR2C/2D subunits at NAc in chronic pain remains unknown. In this study, spinal nerve ligation (SNL) induced a persistent sensory abnormity and depressive-like behavior. The whole-cell patch clamp recording on medium spiny neurons (MSNs) in the NAc showed that the amplitude of NMDAR-mediated excitatory postsynaptic currents (EPSCs) was significantly increased when membrane potential held at -40 to 0 mV in mice after 14 days of SNL operation. In addition, selective inhibition of NR2C/2D-containing NMDARs with PPDA caused a larger decrease on peak amplitude of NMDAR-EPSCs in SNL than that in sham-operated mice. Appling of selective potentiator of NR2C/2D, CIQ, markedly enhanced the evoked NMDAR-EPSCs in SNL-operated mice, but no change in sham-operated mice. Finally, intra-NAc injection of PPDA significantly attenuated SNL-induced mechanical allodynia and depressive-like behavior. These results for the first time showed that the functional change of NR2C/2D subunits-containing NMDARs in the NAc might contribute to the sensory and affective components in neuropathic pain.
MeSH term(s)	Animals ; Depression/etiology ; Humans ; Mice ; Neuralgia ; Nucleus Accumbens ; Peripheral Nerve Injuries/complications ; Receptors, N-Methyl-D-Aspartate/metabolism
Chemical Substances	Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2174252-2
ISSN	1744-8069 ; 1744-8069
ISSN (online)	1744-8069
ISSN	1744-8069
DOI	10.1177/17448069211053255
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential.

Jiang, Bao-Chun / Liu, Tong / Gao, Yong-Jing

Pharmacology & therapeutics

2020 Volume 212, Page(s) 107581

Abstract: Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or treatment, is a major health problem impacting the quality of life and producing a significant economic and social burden. However, the current analgesic drugs including ...

Abstract	Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or treatment, is a major health problem impacting the quality of life and producing a significant economic and social burden. However, the current analgesic drugs including non-steroidal anti-inflammatory drugs and opioids are inadequate to relieve chronic pain due to the lack of efficacy or severe side-effects. Chemokines are a family of small secreted proteins that bind to G protein-coupled receptors to trigger intracellular signaling pathways and direct cell migration, proliferation, survival, and inflammation under homeostatic and pathological conditions. Accumulating evidence supports the important role of chemokines and chemokine receptors in the peripheral and central nervous system in mediating chronic pain via enhancing neuroinflammation. In this review, we focus on recent progress in understanding the comprehensive roles of chemokines and chemokine receptors in the generation and maintenance of different types of chronic pain, including neuropathic pain, inflammatory pain, cancer pain, and visceral pain. The current review also summarizes the upstream signaling of transcriptional and epigenetic regulation on the expression of chemokines and chemokine receptors as well as the downstream signaling of chemokine receptors underlying chronic pain. As chronic itch and chronic pain share some common mechanisms, we also discuss the emerging roles of chemokines and chemokine receptors in chronic itch. Targeting specific chemokines or chemokine receptors by siRNAs, blocking antibodies, or small-molecule antagonists may offer new therapeutic potential for the management of chronic pain.
MeSH term(s)	Animals ; Cell Communication ; Chemokines/antagonists & inhibitors ; Chemokines/physiology ; Chronic Pain/drug therapy ; Chronic Pain/etiology ; Humans ; Hyperalgesia/etiology ; Neuralgia/etiology ; Neuronal Plasticity ; Pruritus/etiology ; Receptors, Chemokine/antagonists & inhibitors ; Receptors, Chemokine/physiology ; Visceral Pain/etiology
Chemical Substances	Chemokines ; Receptors, Chemokine
Language	English
Publishing date	2020-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2020.107581
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1183: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Excitatory Projections from the Prefrontal Cortex to Nucleus Accumbens Core D1-MSNs and κ Opioid Receptor Modulate Itch-Related Scratching Behaviors.

Wu, Xiao-Bo / Zhu, Qian / Gao, Ming-Hui / Yan, Sheng-Xiang / Gu, Pan-Yang / Zhang, Peng-Fei / Xu, Meng-Lin / Gao, Yong-Jing

The Journal of neuroscience : the official journal of the Society for Neuroscience

2023 Volume 43, Issue 8, Page(s) 1334–1347

Abstract: Itch is an uncomfortable and complex sensation that elicits the desire to scratch. The nucleus accumbens (NAc) activity is important in driving sensation, motivation, and emotion. Excitatory afferents from the medial prefrontal cortex (mPFC), amygdala, ... ...

Abstract	Itch is an uncomfortable and complex sensation that elicits the desire to scratch. The nucleus accumbens (NAc) activity is important in driving sensation, motivation, and emotion. Excitatory afferents from the medial prefrontal cortex (mPFC), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor D1-expressing and D2-expressing medium spiny neurons (Drd1-MSN and Drd2-MSN) in the NAc. However, a cell-type and neural circuity-based mechanism of the NAc underlying acute itch remains unclear. We found that acute itch induced by compound 48/80 (C48/80) decreased the intrinsic membrane excitability in Drd1-MSNs, but not in Drd2-MSNs, in the NAc core of male mice. Chemogenetic activation of Drd1-MSNs alleviated C48/80-induced scratching behaviors but not itch-related anxiety-like behaviors. In addition, C48/80 enhanced the frequency of spontaneous EPSCs (sEPSCs) and reduced the paired-pulse ratio (PPR) of electrical stimulation-evoked EPSCs in Drd1-MSNs. Furthermore, C48/80 increased excitatory synaptic afferents to Drd1-MSNs from the mPFC, not from the basolateral amygdala (BLA) or ventral hippocampus (vHipp). Consistently, the intrinsic excitability of mPFC-NAc projecting pyramidal neurons was increased after C48/80 treatment. Chemogenetic inhibition of mPFC-NAc excitatory synaptic afferents relieved the scratching behaviors. Moreover, pharmacological activation of κ opioid receptor (KOR) in the NAc core suppressed C48/80-induced scratching behaviors, and the modulation of KOR activity in the NAc resulted in the changes of presynaptic excitatory inputs to Drd1-MSNs in C48/80-treated mice. Together, these results reveal the neural plasticity in synapses of NAc Drd1-MSNs from the mPFC underlying acute itch and indicate the modulatory role of the KOR in itch-related scratching behaviors.
MeSH term(s)	Mice ; Male ; Animals ; Nucleus Accumbens/physiology ; Receptors, Opioid, kappa ; Hippocampus/physiology ; Neurons/physiology ; Receptors, Dopamine D1/metabolism ; Prefrontal Cortex/metabolism
Chemical Substances	Receptors, Opioid, kappa ; Receptors, Dopamine D1
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604637-x
ISSN	1529-2401 ; 0270-6474
ISSN (online)	1529-2401
ISSN	0270-6474
DOI	10.1523/JNEUROSCI.1359-22.2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1668: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito