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  1. Article ; Online: Clinical Images: Dacryoadenitis as the herald symptom for systemic lupus erythematosus.

    Sullivan, Megan M / Salem, Fadi / Albadri, Sam / Berianu, Florentina

    ACR open rheumatology

    2023  Volume 5, Issue 9, Page(s) 436

    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Rectal adenocarcinoma in the eye: An unexpected destination.

    Lahham, Elias Edward / Alsahouri, Mohammad I / Alsalah, Qusai A / Billan, Salem / Atrash, Fadi

    SAGE open medical case reports

    2024  Volume 12, Page(s) 2050313X241242608

    Abstract: Colorectal cancer ranks third in cancer incidence in the United States, commonly metastasizing to the liver and lungs. Despite its high prevalence, colorectal cancer with intraocular metastasis is exceedingly rare, with only a few cases reported in the ... ...

    Abstract Colorectal cancer ranks third in cancer incidence in the United States, commonly metastasizing to the liver and lungs. Despite its high prevalence, colorectal cancer with intraocular metastasis is exceedingly rare, with only a few cases reported in the literature. This study presents a 58-year-old male, previously treated for rectal adenocarcinoma with liver and lung metastases, who developed choroidal metastasis causing visual impairment. Despite radiotherapy, moderate improvement was observed, and subsequent disease progression led to systemic chemotherapy. Intraocular metastasis, primarily affecting the choroid, is infrequent, often originating from breast and lung cancers. The presented case, originating from primary KRAS wild-type rectal cancer, adds to the limited gastrointestinal-tract-related occurrences. This report underscores the importance of recognizing intraocular metastasis in colorectal cancer, contributing valuable insights for improved understanding and potential guidance for future clinical decisions. Choroidal metastasis carries a poor prognosis, emphasizing the need for tailored management strategies.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X241242608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A late presentation of inguinoscrotal cutaneous squamous cell carcinoma (cSCC) masquerading as hidradenitis suppurativa-a case report.

    Lahham, Elias Edward / Billan, Salem / Atrash, Fadi / Fararja, Walid

    Journal of surgical case reports

    2023  Volume 2023, Issue 8, Page(s) rjad459

    Abstract: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects apocrine gland-bearing skin in intertriginous areas; it is characterized by persistent or recurrent abscesses that culminate in a purulent discharge, sinuses and scarring. ...

    Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects apocrine gland-bearing skin in intertriginous areas; it is characterized by persistent or recurrent abscesses that culminate in a purulent discharge, sinuses and scarring. Although it is a common condition, it is rarely associated with cutaneous squamous cell carcinoma (cSCC). Whereas the female-to-male ratio of HS is 3:1, SCC in HS has a female-to-male ratio of 1:5. In this study, we present a 50-year-old male patient with a late presentation of inguinoscrotal cSCC with extensive ulceration and erythema that was hidden by neglected HS and the presence of underlying human papillomavirus in the affected area. The histomorphologic and immunohistochemical findings support the diagnosis of cSCC. Timely detection is the key to improve prognosis, regular clinical examination and biopsy of any suspicious lesions in high-risk patients is highly recommended.
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis.

    Khosla, Atulya Aman / Saunders, Hollie / Helgeson, Scott / Hikida, Hiroshi / Aslam, Nabeel / Salem, Fadi / Albadri, Sam / Baig, Hassan

    Case reports in pulmonology

    2023  Volume 2023, Page(s) 1461011

    Abstract: Hydralazine is a vasodilator used for the management of hypertension, heart failure, and hypertensive emergencies in pregnancy. It has been implicated in the causation of drug-induced lupus erythematosus (DLE) and rarely with ANCA-associated vasculitis ( ... ...

    Abstract Hydralazine is a vasodilator used for the management of hypertension, heart failure, and hypertensive emergencies in pregnancy. It has been implicated in the causation of drug-induced lupus erythematosus (DLE) and rarely with ANCA-associated vasculitis (AAV), which may present as a pulmonary-renal syndrome and be rapidly fatal. Herein, we describe a case of hydralazine-associated AAV presenting as acute kidney injury with the use of early bronchoalveolar lavage (BAL) with serial aliquots to aid with diagnosis. Our case highlights how, in the correct clinical setting, BAL can act as a rapid diagnostic test to help guide quicker treatment to allow for better patient outcomes.
    Language English
    Publishing date 2023-04-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2666707-1
    ISSN 2090-6854 ; 2090-6846
    ISSN (online) 2090-6854
    ISSN 2090-6846
    DOI 10.1155/2023/1461011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Report of Three Cases of Minimal Change Disease Following the Second Dose of mRNA SARS-CoV-2 COVID-19 Vaccine.

    Salem, Fadi / Rein, Joshua L / Yu, Samuel Mon-Wei / Abramson, Mathew / Cravedi, Paolo / Chung, Miriam

    Kidney international reports

    2021  Volume 6, Issue 9, Page(s) 2523–2524

    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease.

    Clair, Geremy / Soloyan, Hasmik / Cravedi, Paolo / Angeletti, Andrea / Salem, Fadi / Al-Rabadi, Laith / De Filippo, Roger E / Da Sacco, Stefano / Lemley, Kevin V / Sedrakyan, Sargis / Perin, Laura

    JCI insight

    2024  Volume 9, Issue 6

    Abstract: Here, we used digital spatial profiling (DSP) to describe the glomerular transcriptomic signatures that may characterize the complex molecular mechanisms underlying progressive kidney disease in Alport syndrome, focal segmental glomerulosclerosis, and ... ...

    Abstract Here, we used digital spatial profiling (DSP) to describe the glomerular transcriptomic signatures that may characterize the complex molecular mechanisms underlying progressive kidney disease in Alport syndrome, focal segmental glomerulosclerosis, and membranous nephropathy. Our results revealed significant transcriptional heterogeneity among diseased glomeruli, and this analysis showed that histologically similar glomeruli manifested different transcriptional profiles. Using glomerular pathology scores to establish an axis of progression, we identified molecular pathways with progressively decreased expression in response to increasing pathology scores, including signal recognition particle-dependent cotranslational protein targeting to membrane and selenocysteine synthesis pathways. We also identified a distinct signature of upregulated and downregulated genes common to all the diseases investigated when compared with nondiseased tissue from nephrectomies. These analyses using DSP at the single-glomerulus level could help to increase insight into the pathophysiology of kidney disease and possibly the identification of biomarkers of disease progression in glomerulopathies.
    MeSH term(s) Humans ; Transcriptome ; Kidney Glomerulus/pathology ; Glomerulosclerosis, Focal Segmental/pathology ; Nephritis, Hereditary/pathology ; Renal Insufficiency, Chronic/metabolism
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.165515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: COVAN Leading to ESKD Despite Minimal COVID Symptoms.

    Maldonado, Dawn / Ray, Justina / Lin, XiongBin / Salem, Fadi / Brown, Maritza / Bansal, Ishita

    Journal of investigative medicine high impact case reports

    2022  Volume 10, Page(s) 23247096221093888

    Abstract: We report a case of dialysis dependence in a patient with COVID-19-associated nephropathy (COVAN) who had minimal respiratory manifestations. A 25-year-old man with a history of multiple sclerosis in remission presented with mild dyspnea due to COVID-19 ... ...

    Abstract We report a case of dialysis dependence in a patient with COVID-19-associated nephropathy (COVAN) who had minimal respiratory manifestations. A 25-year-old man with a history of multiple sclerosis in remission presented with mild dyspnea due to COVID-19 pneumonia and was found to have rapidly worsening kidney function. He only required nasal cannula and was able to be weaned off within a few days. Despite having only mild respiratory disease, his kidney function worsened and urgent hemodialysis was started for hyperkalemia and uremic encephalopathy. Kidney biopsy demonstrated collapsing glomerulopathy due to COVID-19 with moderate interstitial fibrosis and tubular atrophy. His kidney function did not recover, and he unfortunately now has been dependent on hemodialysis for over 3 months. Multiple case reports have described COVAN causing dialysis dependence, but to our knowledge this is the first reported case of COVAN causing dialysis dependence in a patient with such mild respiratory disease. Currently the indications for intensive COVID-19 therapies are based on oxygen requirements. This case demonstrates that the oxygen requirement may not fully reflect the severity of COVID-19 and raises the question of whether these therapies should be considered in patients with COVAN.
    MeSH term(s) Adult ; COVID-19/complications ; Female ; Humans ; Kidney Diseases/pathology ; Male ; Oxygen ; Renal Dialysis
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-04-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096221093888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Artificial Intelligence Advances in Transplant Pathology.

    Rahman, Md Arafatur / Yilmaz, Ibrahim / Albadri, Sam T / Salem, Fadi E / Dangott, Bryan J / Taner, C Burcin / Nassar, Aziza / Akkus, Zeynettin

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 9

    Abstract: Transplant pathology plays a critical role in ensuring that transplanted organs function properly and the immune systems of the recipients do not reject them. To improve outcomes for transplant recipients, accurate diagnosis and timely treatment are ... ...

    Abstract Transplant pathology plays a critical role in ensuring that transplanted organs function properly and the immune systems of the recipients do not reject them. To improve outcomes for transplant recipients, accurate diagnosis and timely treatment are essential. Recent advances in artificial intelligence (AI)-empowered digital pathology could help monitor allograft rejection and weaning of immunosuppressive drugs. To explore the role of AI in transplant pathology, we conducted a systematic search of electronic databases from January 2010 to April 2023. The PRISMA checklist was used as a guide for screening article titles, abstracts, and full texts, and we selected articles that met our inclusion criteria. Through this search, we identified 68 articles from multiple databases. After careful screening, only 14 articles were included based on title and abstract. Our review focuses on the AI approaches applied to four transplant organs: heart, lungs, liver, and kidneys. Specifically, we found that several deep learning-based AI models have been developed to analyze digital pathology slides of biopsy specimens from transplant organs. The use of AI models could improve clinicians' decision-making capabilities and reduce diagnostic variability. In conclusion, our review highlights the advancements and limitations of AI in transplant pathology. We believe that these AI technologies have the potential to significantly improve transplant outcomes and pave the way for future advancements in this field.
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10091041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Robust Automated Analog Circuits Classification Involving a Graph Neural Network and a Novel Data Augmentation Strategy.

    Deeb, Ali / Ibrahim, Abdalrahman / Salem, Mohamed / Pichler, Joachim / Tkachov, Sergii / Karaj, Anjeza / Al Machot, Fadi / Kyandoghere, Kyamakya

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: Analog mixed-signal (AMS) verification is one of the essential tasks in the development process of modern systems-on-chip (SoC). Most parts of the AMS verification flow are already automated, except for stimuli generation, which has been performed ... ...

    Abstract Analog mixed-signal (AMS) verification is one of the essential tasks in the development process of modern systems-on-chip (SoC). Most parts of the AMS verification flow are already automated, except for stimuli generation, which has been performed manually. It is thus challenging and time-consuming. Hence, automation is a necessity. To generate stimuli, subcircuits or subblocks of a given analog circuit module should be identified/classified. However, there currently needs to be a reliable industrial tool that can automatically identify/classify analog sub-circuits (eventually in the frame of a circuit design process) or automatically classify a given analog circuit at hand. Besides verification, several other processes would profit enormously from the availability of a robust and reliable automated classification model for analog circuit modules (which may belong to different levels). This paper presents how to use a Graph Convolutional Network (GCN) model and proposes a novel data augmentation strategy to automatically classify analog circuits of a given level. Eventually, it can be upscaled or integrated within a more complex functional module (for a structure recognition of complex analog circuits), targeting the identification of subcircuits within a more complex analog circuit module. An integrated novel data augmentation technique is particularly crucial due to the harsh reality of the availability of generally only a relatively limited dataset of analog circuits' schematics (i.e., sample architectures) in practical settings. Through a comprehensive ontology, we first introduce a graph representation framework of the circuits' schematics, which consists of converting the circuit's related netlists into graphs. Then, we use a robust classifier consisting of a GCN processor to determine the label corresponding to the given input analog circuit's schematics. Furthermore, the classification performance is improved and robust by involving a novel data augmentation technique. The classification accuracy was enhanced from 48.2% to 76.6% using feature matrix augmentation, and from 72% to 92% using Dataset Augmentation by Flipping. A 100% accuracy was achieved after applying either multi-Stage augmentation or Hyperphysical Augmentation. Overall, extensive tests of the concept were developed to demonstrate high accuracy for the analog circuit's classification endeavor. This is solid support for a future up-scaling towards an automated analog circuits' structure detection, which is one of the prerequisites not only for the stimuli generation in the frame of analog mixed-signal verification but also for other critical endeavors related to the engineering of AMS circuits.
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23062989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Decay-Accelerating Factor Restrains Complement Activation and Delays Progression of Murine cBSA-Induced Membranous Nephropathy.

    Budge, Kelly L / Verlato, Alberto / Bin, Sofia / Salem, Fadi E / Perin, Laura / La Manna, Gaetano / Zaza, Gianluigi / Fiaccadori, Enrico / Cantarelli, Chiara / Cravedi, Paolo

    Kidney360

    2023  Volume 4, Issue 6, Page(s) e769–e776

    MeSH term(s) Mice ; Animals ; Glomerulonephritis, Membranous ; CD55 Antigens ; Glomerulonephritis ; Kidney Glomerulus ; Complement Activation
    Chemical Substances CD55 Antigens
    Language English
    Publishing date 2023-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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