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  1. Article ; Online: The 5

    Basolo, Fulvio / Macerola, Elisabetta / Poma, Anello Marcello / Torregrossa, Liborio

    Endocrine

    2023  Volume 80, Issue 3, Page(s) 470–476

    Abstract: ... The ... ...

    Abstract The 5
    MeSH term(s) Humans ; Adenocarcinoma, Follicular/diagnosis ; Adenocarcinoma, Follicular/pathology ; Thyroid Neoplasms/pathology ; Endocrine Glands ; Prognosis ; World Health Organization
    Language English
    Publishing date 2023-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-023-03336-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Response to Letter to the Editor From Green and Gosmanov: "Tall Cell Percentage Alone in PTC Without Aggressive Features Should not Guide Patients' Clinical Management".

    Viola, David / Poma, Anello Marcello / Elisei, Rossella / Basolo, Fulvio

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 6, Page(s) e2653–e2654

    MeSH term(s) Carcinoma, Papillary ; Humans ; Thyroid Cancer, Papillary ; Thyroid Neoplasms
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Indeterminate Thyroid Nodules: From Cytology to Molecular Testing.

    Vignali, Paola / Macerola, Elisabetta / Poma, Anello Marcello / Sparavelli, Rebecca / Basolo, Fulvio

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 18

    Abstract: Thyroid cancer is the most common malignancy of the endocrine system. Fine-needle aspiration (FNA) biopsy of thyroid nodules has become the gold standard procedure, in terms of cost and efficacy, for guiding clinicians towards appropriate patients' ... ...

    Abstract Thyroid cancer is the most common malignancy of the endocrine system. Fine-needle aspiration (FNA) biopsy of thyroid nodules has become the gold standard procedure, in terms of cost and efficacy, for guiding clinicians towards appropriate patients' management. One challenge for cytopathologists is to accurately classify cytological specimens as benign or malignant based on cytomorphological features. In fact, with a frequency ranging from 10% to 30%, nodules are diagnosed as indeterminate. In recent years, the mutational landscape of thyroid tumors has been extensively described, and two molecular profiles have been identified:
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13183008
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  4. Article: Early-Stage Non-Small Cell Lung Cancer: Prevalence of Actionable Alterations in a Monocentric Consecutive Cohort.

    Bruno, Rossella / Poma, Anello Marcello / Panozzi, Martina / Lenzini, Alessandra / Elia, Gianmarco / Zirafa, Carmelina Cristina / Aprile, Vittorio / Ambrogi, Marcello Carlo / Baldini, Editta / Lucchi, Marco / Melfi, Franca / Chella, Antonio / Sbrana, Andrea / Alì, Greta

    Cancers

    2024  Volume 16, Issue 7

    Abstract: Early-stage (ES) non-small cell lung cancer (NSCLC) is diagnosed in about 30% of cases. The preferred treatment is surgery, but a significant proportion of patients experience recurrence. Neoadjuvant and adjuvant chemotherapy has a limited clinical ... ...

    Abstract Early-stage (ES) non-small cell lung cancer (NSCLC) is diagnosed in about 30% of cases. The preferred treatment is surgery, but a significant proportion of patients experience recurrence. Neoadjuvant and adjuvant chemotherapy has a limited clinical benefit. EGFR tyrosine kinase inhibitors and immunotherapy have recently opened new therapeutic scenarios. However, only a few data are available about the ES-NSCLC molecular landscape and the impact of oncogene addiction on therapy definition. Here, we determined the prevalence of the main lung cancer driver alterations in a monocentric consecutive cohort. Molecular analysis was performed on 1122 cases, including 368 ES and 754 advanced NSCLC. The prevalence of actionable alterations was similar between early and advanced stages. ES-NSCLC was significantly enriched for
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16071410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Validation of a Gene Expression Approach for the Cytological Diagnosis of Epithelioid and Biphasic Pleural Mesothelioma on a Consecutive Series.

    Bruno, Rossella / Poma, Anello Marcello / Alì, Greta / Proietti, Agnese / Ribechini, Alessandro / Chella, Antonio / Fontanini, Gabriella

    Cancers

    2023  Volume 15, Issue 23

    Abstract: Cytological diagnosis of pleural mesothelioma (PM) is controversial, even using ancillary markers (BAP1, MTAP and CDKN2A). Here, we aimed to prospectively validate a previously developed 117-gene expression panel for the differential cytological ... ...

    Abstract Cytological diagnosis of pleural mesothelioma (PM) is controversial, even using ancillary markers (BAP1, MTAP and CDKN2A). Here, we aimed to prospectively validate a previously developed 117-gene expression panel for the differential cytological diagnosis of epithelioid, biphasic PM and mesothelial hyperplasia. Seventy-seven pleural effusions were classified using the 117-gene expression levels (NanoString system). Sixty-eight cases were also screened for ancillary markers. The performance of both gene panel and ancillary markers was evaluated using ROC metrics. A score using the top consistently deregulated genes between epithelioid and biphasic PM was built to subtype malignant effusions. The panel alone reached a diagnostic accuracy (0.89) comparable to the best marker combination (BAP1 plus MTAP: 0.88). Ancillary tests missed 8 PMs, 7 of which were correctly classified by the panel. The score built by averaging the expression levels of
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15235534
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  6. Article ; Online: Salvage total thyroidectomy for amiodarone-induced thyrotoxicosis in a SARS-CoV-2 positive patient: results of the viral genome research on the pathology sample of this destructive thyroiditis.

    Cappellani, Daniele / Torregrossa, Liborio / Papini, Piermarco / Poma, Anello Marcello / Ambrosini, Enrico / De Napoli, Luigi / Materazzi, Gabriele / Basolo, Fulvio / Bogazzi, Fausto

    Endocrine

    2022  Volume 76, Issue 2, Page(s) 495–498

    MeSH term(s) Amiodarone/adverse effects ; COVID-19 ; Genome, Viral ; Humans ; Hyperthyroidism ; SARS-CoV-2 ; Thyroidectomy ; Thyroiditis ; Thyrotoxicosis
    Chemical Substances Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-022-03028-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: NanoString in the screening of genetic abnormalities associated with thyroid cancer.

    Macerola, Elisabetta / Poma, Anello Marcello / Basolo, Fulvio

    Seminars in cancer biology

    2020  Volume 79, Page(s) 132–140

    Abstract: In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the ... ...

    Abstract In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clinics, tumor pathology and molecular features. In the clinical management of patients with thyroid nodules and thyroid tumors, the aid of molecular testing is encouraged but still not strongly recommended by current guidelines. Also for this reason this field of study is attracting much interest. The nCounter system is a relatively new technology based on a direct hybridization of fluorescent probes to specific nucleic acid targets, followed by digital measurement of signals; the reaction is highly multiplexable and results are robust and reproducible. This review reports and discusses the available data related to the application of this specific technique to thyroid nodules and thyroid tumors samples. The available data indicate that nCounter system represents a solid approach for the research of relevant diagnostic and prognostic biomarkers in thyroid pathology.
    MeSH term(s) Biomarkers, Tumor/genetics ; DNA Barcoding, Taxonomic ; Early Detection of Cancer ; Fluorescent Dyes ; Gene Expression/genetics ; Gene Expression Profiling ; Genetic Markers/genetics ; Humans ; Molecular Diagnostic Techniques ; RNA, Messenger/genetics ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Thyroid Nodule/genetics ; Thyroid Nodule/pathology
    Chemical Substances Biomarkers, Tumor ; Fluorescent Dyes ; Genetic Markers ; RNA, Messenger
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2020.10.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Transcriptional changes in multiple endocrine organs from lethal cases of COVID-19.

    Poma, Anello Marcello / Bonuccelli, Diana / Macerola, Elisabetta / Niballi, Sara / Basolo, Alessio / Santini, Ferruccio / Basolo, Fulvio / Toniolo, Antonio

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 8, Page(s) 973–986

    Abstract: Altered circulating hormone and metabolite levels have been reported during and post-COVID-19. Yet, studies of gene expression at the tissue level capable of identifying the causes of endocrine dysfunctions are lacking. Transcript levels of endocrine- ... ...

    Abstract Altered circulating hormone and metabolite levels have been reported during and post-COVID-19. Yet, studies of gene expression at the tissue level capable of identifying the causes of endocrine dysfunctions are lacking. Transcript levels of endocrine-specific genes were analyzed in five endocrine organs of lethal COVID-19 cases. Overall, 116 autoptic specimens from 77 individuals (50 COVID-19 cases and 27 uninfected controls) were included. Samples were tested for the SARS-CoV-2 genome. The adrenals, pancreas, ovary, thyroid, and white adipose tissue (WAT) were investigated. Transcript levels of 42 endocrine-specific and 3 interferon-stimulated genes (ISGs) were measured and compared between COVID-19 cases (virus-positive and virus-negative in each tissue) and uninfected controls. ISG transcript levels were enhanced in SARS-CoV-2-positive tissues. Endocrine-specific genes (e.g., HSD3B2, INS, IAPP, TSHR, FOXE1, LEP, and CRYGD) were deregulated in COVID-19 cases in an organ-specific manner. Transcription of organ-specific genes was suppressed in virus-positive specimens of the ovary, pancreas, and thyroid but enhanced in the adrenals. In WAT of COVID-19 cases, transcription of ISGs and leptin was enhanced independently of virus detection in tissue. Though vaccination and prior infection have a protective role against acute and long-term effects of COVID-19, clinicians must be aware that endocrine manifestations can derive from virus-induced and/or stress-induced transcriptional changes of individual endocrine genes. KEY MESSAGES: • SARS-CoV-2 can infect adipose tissue, adrenals, ovary, pancreas and thyroid. • Infection of endocrine organs induces interferon response. • Interferon response is observed in adipose tissue independently of virus presence. • Endocrine-specific genes are deregulated in an organ-specific manner in COVID-19. • Transcription of crucial genes such as INS, TSHR and LEP is altered in COVID-19.
    MeSH term(s) Female ; Humans ; COVID-19/genetics ; SARS-CoV-2/genetics ; Interferons ; Pancreas
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2023-05-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02334-3
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    Ua VI Zs.36: Show issues Location:
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  9. Article: Immune Transcriptome of Cells Infected with Enterovirus Strains Obtained from Cases of Autoimmune Thyroid Disease.

    Poma, Anello Marcello / Hammerstad, Sarah Salehi / Genoni, Angelo / Basolo, Alessio / Dahl-Jorgensen, Knut / Toniolo, Antonio

    Microorganisms

    2021  Volume 9, Issue 4

    Abstract: Background: Hashimoto's thyroiditis and Graves' disease are autoimmune thyroid disorders (AITD) of unknown origin. Enterovirus (EV) infection of thyroid cells has been implicated as a possible initiator of cell damage and of organ-specific autoimmunity. ...

    Abstract Background: Hashimoto's thyroiditis and Graves' disease are autoimmune thyroid disorders (AITD) of unknown origin. Enterovirus (EV) infection of thyroid cells has been implicated as a possible initiator of cell damage and of organ-specific autoimmunity. We asked whether persistent infection of human epithelial cells with EV strains obtained from thyroid tissue of AITD patients could be associated with transcriptional changes capable of fostering immunopathology.
    Methods: EV isolates obtained from thyroid tissue of AITD cases were used to infect the AV3 epithelial cell line. AV3 cells incubated with a virus-free medium from thyroid tissue of subjects without evidence of thyroid autoimmunity were used as uninfected controls. Transcripts of immune-related genes were compared in infected vs. uninfected cells.
    Results: The EV genome and antigens were detected only in the cells exposed to AITD-derived virus isolates, not in control cells. Persistent EV infection, while suppressing transcription of several type I IFN and cytokine determinants, was associated with enhanced transcription of NFKB1/RELA, IFNAR1, JAK1/STAT1, i.e., the determinants that play key immunologic roles. Infection also led to upregulation of the CCL2 chemokine and the IL-18 pro-inflammatory interleukin.
    Conclusion: As in the case of EV strains obtained from autoimmune diabetes, results show that the EV strains that are present in the thyroid of AITD cases do repress IFN and cytokine pathways. JAK1/STAT1 upregulation supports activation of TLR pathways and aberrant T cell signaling. In the early phases of AITD, our results highlight the potential benefit of interventions aimed at blocking the viral infection and easing the inflammatory response.
    Language English
    Publishing date 2021-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9040876
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  10. Article: Inflammatory Profiles of Tracheal Biopsies From SARS-CoV-2 Patients.

    Fiacchini, Giacomo / Proietti, Agnese / Poma, Anello Marcello / Picariello, Miriana / Dallan, Iacopo / Guarracino, Fabio / Forfori, Francesco / Fontanini, Gabriella / Bruschini, Luca

    Frontiers in microbiology

    2022  Volume 13, Page(s) 851460

    Abstract: Purpose: An increasing number of laryngotracheal complications in mechanically ventilated COVID-19 patients has been reported in the last few months. Many etiopathogenetic hypotheses were proposed but no clear explanation of these complications was ... ...

    Abstract Purpose: An increasing number of laryngotracheal complications in mechanically ventilated COVID-19 patients has been reported in the last few months. Many etiopathogenetic hypotheses were proposed but no clear explanation of these complications was identified. In this paper we evaluated the possibility that the tracheal mucosa could be a high viral replication site that could weaken the epithelium itself.
    Methods: Subjects for the COVID-19 group and the control group were selected retrospectively according to specific criteria. Patients' basic and clinical data were recorded and analyzed. Tracheal samples of both groups were collected during surgical tracheostomies and then analyzed from a histological and genetic-transcriptional point of view.
    Results: Four COVID-19 patients were enrolled in this study and compared with four non-COVID-19 patients. No laryngotracheal complications were identified in both groups. The SARS-CoV-2 was detected in one out of four COVID-19 samples. A subepithelial inflammatory lymphomonocyte infiltrate was observed in all patients but two cases of the COVID-19 group showed vasculitis of small subepithelial vessels associated with foci of coagulative necrosis. Two gene sets (HALLMARK_INFLAMMATORY_RESPONSE and HALLMARK_ESTROGEN_RESPONSE_LATE) were significantly deregulated in COVID-19 patients compared to the control group.
    Conclusion: The altered inflammatory response of the COVID-19 patients could be another possible explanation of the increasing number of laryngotracheal complications.
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.851460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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