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Article ; Online: A MAN WHO KNEW MEN

S. Monick

Scientia Militaria, Vol 20, Iss

THE MEMOIRS OF MAJ M.G. IND

2012 Volume 1

Abstract: In January 1990 there occurred the death of Maj Montagu G. lnd, at the age of 89. He was, to the best of the author's knowledge, the last surviving member of those seconded Royal Navy personnel who sailed to South Africa in the three vessels, Crozier, ... ...

Abstract	In January 1990 there occurred the death of Maj Montagu G. lnd, at the age of 89. He was, to the best of the author's knowledge, the last surviving member of those seconded Royal Navy personnel who sailed to South Africa in the three vessels, Crozier, Eden and Foyle, and who formed the nucleus of the South African Naval Services (1921-1934). However, it is felt that his memoirs possess a deep and multi-faceted appeal, which transcend his long and extremely varied military career (spanning 40 years and encompassing service in the Royal Navy, South African Naval Services, South African Instructional Corps and South African Air Force). This interest may be defined in terms which the author categorizes as both intrinsic and extrinsic. The intrinsic facet relates to the subject of the memoirs, rooted in the personality and service of Maj Ind. It is beyond dispute that that career is truly extraordinary, in several important respects. First, with regard to the biographical dimension, Maj Ind was, in all probability, the youngest member to serve in the ill-starred and horrendous Gallipoli campaign, serving in the Royal Naval Division, renowned for the extremely heavy casualties that this unit incurred, and the savage fighting in which it was involved. Indeed, his extremely youthful experiences in combat have provided the source of the title of these memoirs. As Maj Ind states at one point, his service in the Dardanelles had formed a profound barrier between himself and those of his own age, as he had 'known men' in the extremities of combat, an awareness which, obviously, could not be shared with his peer group. Second, Maj Ind participated in little known, but nevertheless fascinating, episodes in British military history; exemplified in his service with the naval expeditionary force to Russia, immediately following the end of World War I. His ship's sinking of a Russian destroyer, and capture of a second, highlights the revelation of obscure passages in the Royal Navy's history, through the medium of Maj Ind's ...
Keywords	Maj Montagu G. lnd ; the youngest member to serve in the ill-starred and horrendous Gallipoli campaign ; Royal Naval Division ; Crozier ; Eden and Foyle ; South African Naval Services ; Military Science ; U
Subject code	940
Language	Afrikaans
Publishing date	2012-02-01T00:00:00Z
Publisher	Stellenbosch University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Prioritized Patient-Centered Research Agenda to Reduce Disparities in Telehealth Uptake: Results from a National Consensus Conference.

Rising, Kristin L / Kemp, Mackenzie / Leader, Amy E / Chang, Anna Marie / Monick, Andrew J / Guth, Amanda / Esteves Camacho, Tracy / Laynor, Gregory / Worster, Brooke

Telemedicine reports

2023 Volume 4, Issue 1, Page(s) 387–395

Abstract: Introduction: We hosted a national consensus conference with a diverse group of stakeholders to develop a patient-centered research agenda focused on reducing disparities in telehealth use.: Methods: Attendees were purposively invited to participate ... ...

Abstract	Introduction: We hosted a national consensus conference with a diverse group of stakeholders to develop a patient-centered research agenda focused on reducing disparities in telehealth use. Methods: Attendees were purposively invited to participate in a 2-day virtual conference. The group developed a prioritized research agenda focused on reducing disparities in telehealth uptake, with discussion informed by findings from a scoping review. All work was conducted in partnership with a Steering Committee of national experts in telehealth and patient-centered care ( Results: Sixty individuals participated in the conference and discussion resulted in a final list of 20 questions. Fifty-two attendees voted on the final prioritization of these questions. Results were aggregated for all voters ( Conclusions: This project involved extensive patient and stakeholder engagement. While voting varied between patients only and the entire group of conference attendees, top identified priorities included patient and family perspectives on important barriers to telehealth, trust and cultural barriers and facilitators to telehealth, and assessment of telehealth's impact on patient outcomes. This research agenda can inform design of future research focused on addressing disparities in telehealth use.
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ISSN	2692-4366
ISSN (online)	2692-4366
DOI	10.1089/tmr.2023.0051
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Article: Emergency Medicine Clinician Experiences Addressing Uncertainty in First-Trimester Bleeding.

Nord, Garrison A / Doty, Amanda Mb / Monick, Andrew J / McCarthy, Danielle M / Casten, Robin J / Aldeen, Amer Z / Nawrocki, Philip S / Rising, Kristin L

Journal of patient experience

2022 Volume 9, Page(s) 23743735221140698

Abstract: The purpose of this work is to understand Emergency Department (ED) clinicians' experiences in communicating uncertainty about first-trimester bleeding (FTB) and their need for training on this topic. This cross-sectional study surveyed a national sample ...

Abstract	The purpose of this work is to understand Emergency Department (ED) clinicians' experiences in communicating uncertainty about first-trimester bleeding (FTB) and their need for training on this topic. This cross-sectional study surveyed a national sample of attending physicians and advanced practice providers (APPs). The survey included quantitative and qualitative questions about communicating with patients presenting with FTB. These questions assessed clinicians' frequency encountering challenges, comfort, training, prior experience, and interest in training on the topic. Of 402 respondents, 54% reported that they encountered challenges at least sometimes when discussing FTB with patients where the pregnancy outcome is uncertain. While the majority (84%) were at least somewhat prepared for these conversations from their training, which commonly addressed the diagnostic approach to this scenario, 39% strongly or moderately agreed that they could benefit from training on the topic. Because the majority of ED clinicians identified at least sometimes encountering challenges communicating with pregnant patients about FTB, our study indicates a need exists for more training in this skill.
Language	English
Publishing date	2022-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2857285-3
ISSN	2374-3743 ; 2374-3735
ISSN (online)	2374-3743
ISSN	2374-3735
DOI	10.1177/23743735221140698
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Article ; Online: Tracing the relationship among HIV-1 sub-subtype F1 strains: a phylodynamic perspective.

Silva, Gabriela Porto Santos Almeida / Oliveira, Rodrigo Cunha / de Souza, Juliana Sacramento Mota / Giovanetti, Marta / Guimarães, Monick Lindenmeyer / Brites, Carlos / Monteiro-Cunha, Joana Paixão

Memorias do Instituto Oswaldo Cruz

2023 Volume 117, Page(s) e220109

Abstract: Background: The human immunodeficiency virus type 1, F1 sub-subtype (HIV-1 F1) circulates in three continents: Africa, Europe, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms, mainly BF1 ... ...

Abstract	Background: The human immunodeficiency virus type 1, F1 sub-subtype (HIV-1 F1) circulates in three continents: Africa, Europe, and South America. In Brazil, this sub-subtype co-circulates with subtypes B and C and several recombinant forms, mainly BF1 variants. Objectives: This study aimed to reconstruct the dynamic history of HIV-1 F1 in Brazil. Methods: HIV-1 near full-length genome and pol gene nucleotide sequences available in public databases were assembled in two datasets (POL671 and NFLG53) to cover the largest number of F1 sub-subtype sequences. Phylodynamic and temporal analyses were performed. Findings: Two main strains of the F1 sub-subtype are circulating worldwide. The first (F1.I) was found among Brazilian samples (75%) and the second (F1.II) among Romanian (62%) and other European and African isolates. The F1 subtype epidemic in Brazil originated from a single entry into the country around 1970. This ancestral sample is related to samples isolated in European countries (France, Finland, and Belgium), which are possibly of African origin. Moreover, further migration (1998 CI: 1994-2003) of strains from Brazil to Europe (Spain and the UK) was observed. Interestingly, all different recombinant BF patterns found, even those from outside Brazil, present the same F1 lineage (F1.I) as an ancestor, which could be related to the acquisition of adaptive advantages for the recombinant progenies. Main conclusions: These findings are important for the understanding of the origin and dynamics of the F1 sub-subtype and a consequent better and greater understanding of the HIV-1 F1 and BF epidemic that still spreads from Brazil to other countries.
MeSH term(s)	Humans ; Brazil ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; Phylogeny
Language	English
Publishing date	2023-01-20
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	953293-6
ISSN	1678-8060 ; 0074-0276
ISSN (online)	1678-8060
ISSN	0074-0276
DOI	10.1590/0074-02760220109
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Article: Vitamin D effects on lung immunity and respiratory diseases.

Hansdottir, Sif / Monick, Martha M

Vitamins and hormones

2011 Volume 86, Page(s) 217–237

Abstract: Our understanding of vitamin D metabolism and biological effects has grown exponentially in recent years and it has become clear that vitamin D has extensive immunomodulatory effects. The active vitamin D generating enzyme, 1α-hydroxylase, is expressed ... ...

Abstract	Our understanding of vitamin D metabolism and biological effects has grown exponentially in recent years and it has become clear that vitamin D has extensive immunomodulatory effects. The active vitamin D generating enzyme, 1α-hydroxylase, is expressed by the airway epithelium, alveolar macrophages, dendritic cells, and lymphocytes indicating that active vitamin D can be produced locally within the lungs. Vitamin D generated in tissues is responsible for many of the immunomodulatory actions of vitamin D. The effects of vitamin D within the lungs include increased secretion of the antimicrobial peptide cathelicidin, decreased chemokine production, inhibition of dendritic cell activation, and alteration of T-cell activation. These cellular effects are important for host responses against infection and the development of allergic lung diseases like asthma. Epidemiological studies do suggest that vitamin D deficiency predisposes to viral respiratory tract infections and mycobacterial infections and that vitamin D may play a role in the development and treatment of asthma. Randomized, placebo-controlled trials are lacking but ongoing.
MeSH term(s)	Animals ; Calcitriol/metabolism ; Humans ; Immunity ; Lung/immunology ; Lung/metabolism ; Respiratory Tract Diseases/etiology ; Respiratory Tract Diseases/immunology ; Respiratory Tract Diseases/metabolism ; Vitamin D/physiology ; Vitamin D Deficiency/physiopathology
Chemical Substances	Vitamin D (1406-16-2) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2011-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	201161-x
ISSN	2162-2620 ; 0083-6729
ISSN (online)	2162-2620
ISSN	0083-6729
DOI	10.1016/B978-0-12-386960-9.00009-5
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Article ; Online: Efficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults.

Patel, Anand Ashwin / Heng, Joseph / Dworkin, Emily / Monick, Sarah / Derman, Benjamin A / DuVall, Adam S / Gurbuxani, Sandeep / Kosuri, Satyajit / Liu, Hongtao / Thirman, Michael / Godley, Lucy A / Odenike, Olatoyosi / Larson, Richard A / Stock, Wendy

EJHaem

2021 Volume 2, Issue 3, Page(s) 413–420

Abstract: ... BMI) ≥ 30 kg/m which leads to poor tolerance of these regimens. We tested the safety and efficacy ...

Abstract	Although acute lymphoblastic leukemia (ALL) is most common in pediatric and adolescent and young adult (AYA) patients, 20% of cases are diagnosed in patients ≥ 55 years old. Use of intensive pediatric regimens in AYA populations has demonstrated excellent tolerability and significant improvements in event-free survival (EFS) and overall survival (OS). The backbone of pediatric regimens includes asparaginase and corticosteroids, both of which are associated with more toxicity in older patients and those with body mass index (BMI) ≥ 30 kg/m which leads to poor tolerance of these regimens. We tested the safety and efficacy of a dose-modified The Cancer and Leukemia Group B 10403 regimen using reduced doses of pegylated (PEG)-asparaginase (ASP) and corticosteroids (RD-10403) in 30 patients with Philadelphia-chromosome negative ALL who were ≥50-year-old and younger adults with significant metabolic or hepatic co-morbidities. The complete remission rate on day 28 was 77%, 3-year EFS was 54%, and estimated 3-year OS was 55%. Grade 3+ toxicity was noted in 40% of patients during induction, and induction-related mortality was 3%. Additional prospective evaluation of RD-10403 is merited to determine efficacy and safety of this regimen and to serve as a framework for chemoimmunotherapy combination therapy.
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.224
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Article ; Online: Prevalence of HIV-1 infection and associated characteristics in a Brazilian indigenous population: a cross-sectional study.

Schnaufer, Erica C S / Barbosa, Marcelo S / Marques, Michele F R / Brito, Gabriel T / Ferreira, Tiago S / Ribeiro, Anny D C / Valiente, Anna C / Machado, Indianara R / Gonçalves, Crhistinne C M / Tanaka, Tayana S O / Guimarães, Monick L / Ribeiro, Suzana M / Croda, Julio / Simionatto, Simone

Lancet regional health. Americas

2023 Volume 25, Page(s) 100562

Abstract: Background: Despite significant progress in the areas of prevention, diagnosis, and treatment, HIV continues to result in a substantial number of fatalities on a global scale each year. Gaining insights from epidemiological data can prove instrumental ... ...

Abstract	Background: Despite significant progress in the areas of prevention, diagnosis, and treatment, HIV continues to result in a substantial number of fatalities on a global scale each year. Gaining insights from epidemiological data can prove instrumental in the development of health promotion strategies, particularly within vulnerable populations, such as indigenous groups. Consequently, our study aimed to investigate the prevalence of HIV infection within the indigenous population residing in the second-largest region of Brazil. Additionally, we sought to explore the subtypes of HIV-1 and detect any drug-resistance mutations present within this population. Methods: In this cross-sectional study, we aimed to evaluate the prevalence of HIV-1 infection and explore its associated characteristics within the indigenous population residing in the villages of Jaguapiru and Bororó, located in the Dourados area of Mato Grosso do Sul (MS), Brazil. Blood samples were collected for rapid HIV screening, serological tests, nucleic acid amplification, and HIV subtyping. Additionally, the HIV-1 viral load and CD4+ T lymphocyte count of the people living with HIV (PLHIV) were assessed at the time of recruitment and 24 weeks later. Findings: Out of the 2190 invited individuals, 1927 (88%) were included in this study. The average age of the participants was 34.2 (±13.8) years, with a majority of 74% being female. Moreover, 68.44% of the participants identified themselves as belonging to the Guarani-Kaiowa ethnic group. HIV seroprevalence was 0.93% (18/1927), and 73.22% (1411/1927) were unaware of their serological status. The prevalence of HIV-1 was higher in single indigenous people [10/617 (1.62%)], who received government benefits [14/1021 (1.37%)], had less than five years of formal education [11/685 (1.61%)], had sexual intercourse with users of injectable drugs [2/21 (9.52%)], with history of sexually transmitted infections (STIs) [10/62 (16.2%)] and incarceration [3/62 (4.84%)]. Of 18 positive samples, 44.4% (8/18) were successfully amplified, and HIV-1 subtype C was prevalent. Furthermore, we identified HIV-1 drug resistance mutations in four patients, specifically from the classes of Protease Inhibitor, Nucleoside Reverse Transcriptase Inhibitor, and Non-Nucleoside Reverse Transcriptase Inhibitor. Notably, three of these patients exhibited a high viral load even after 24 weeks of undergoing antiretroviral therapy. Out of the 18 PLHIV, 66.66% (12/18) had a viral load below 1000 copies/mL, while 50% (9/18) had a CD4+ T lymphocytes count greater than 350 cells/mL after 24 weeks of treatment. Interpretation: Despite the concerted efforts to control HIV infection, the prevalence observed in the indigenous population under study surpassed that reported in other Brazilian indigenous groups. This disparity highlights the disproportionate impact of the disease on this particular group. The detection of drug-resistance mutations further emphasizes the critical need to expand diagnostic coverage, closely monitor treatment strategies, and maintain ongoing molecular surveillance. These measures are imperative for enhancing HIV management within this vulnerable population. Funding: This study was partially funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Secretaria do Estado de Saúde (SES) of Governo do Estado de Mato Grosso do Sul, and Universidade Federal da Grande Dourados (UFGD).
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2023.100562
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Article: Identification of New HIV-1 Circulating Recombinant Forms CRF81_cpx and CRF99_BF1 in Central Western Brazil and of Unique BF1 Recombinant Forms.

Reis, Mônica N G / Guimarães, Monick L / Bello, Gonzalo / Stefani, Mariane M A

Frontiers in microbiology

2019 Volume 10, Page(s) 97

Abstract: Intersubtype recombinants classified as circulating recombinant forms (CRFs) or unique recombinant forms (URFs) have been shown to play an important role in the complex and dynamic Brazilian HIV/AIDS epidemic. ... ...

Abstract	Intersubtype recombinants classified as circulating recombinant forms (CRFs) or unique recombinant forms (URFs) have been shown to play an important role in the complex and dynamic Brazilian HIV/AIDS epidemic. Previous
Language	English
Publishing date	2019-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.00097
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Article: Emotional Distress in Portuguese Cancer Patients: The Use of the Emotion Thermometers (ET) Screening Tool.

Silva, Sónia / Paredes, Tiago / Teixeira, Ricardo João / Brandão, Tânia / Dimitrovová, Klára / Marques, Diogo / Sousa, Joana / Leal, Monick / Dias, Albina / Neves, Carole / Marques, Graciete / Amaral, Natália

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 19

Abstract: Cancer patients may experience significant distress. The "Emotion Thermometers" (ETs) are a short visual analogue scale used to screen patients for psychosocial risk. This study aimed to assess emotional distress in a large sample of cancer patients ... ...

Abstract	Cancer patients may experience significant distress. The "Emotion Thermometers" (ETs) are a short visual analogue scale used to screen patients for psychosocial risk. This study aimed to assess emotional distress in a large sample of cancer patients attending psychological services at an non-governmental organization (NGO), and to explore factors that may contribute to it. The ETs were answered by 899 cancer patients. They were, on average, 59.9 years old, the majority were female, had breast cancer, were under treatment or were disease-free survivors, and reported high levels of emotional distress, above the cut-off (≥5). A Generalized Linear Model was used to measure the association between the level of distress, age, gender, disease phase and 33 items of the problem list. Four items-sadness, depression, sleep and breathing-were found to be significantly related to a higher level of distress. Additionally, women and patients who were in the palliative phase also had significantly higher levels of distress. The results confirm the need for early emotional screening in cancer patients, as well as attending to the characteristics of each patient. Additionally, they highlight the utility of the ETs for the clinical practice, allowing to optimize the referral to specialized psychosocial services.
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11192689
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Article ; Online: Genetic Characterization of a New HIV-1 Sub-Subtype A in Cabo Verde, Denominated A8.

Mendes Da Silva, Rayana Katylin / Monteiro de Pina Araujo, Isabel Inês / Venegas Maciera, Karine / Gonçalves Morgado, Mariza / Lindenmeyer Guimarães, Monick

Viruses

2021 Volume 13, Issue 6

Abstract: Previous molecular characterization of Human immunodeficiency virus (HIV-1) samples from Cabo Verde pointed out a vast HIV- ... ...

Abstract	Previous molecular characterization of Human immunodeficiency virus (HIV-1) samples from Cabo Verde pointed out a vast HIV-1
MeSH term(s)	Adult ; Cabo Verde ; Evolution, Molecular ; Female ; Genetic Variation ; Genome, Viral ; Genotype ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; Humans ; Male ; Middle Aged ; Phylogeny ; Public Health Surveillance ; Young Adult ; pol Gene Products, Human Immunodeficiency Virus/genetics
Chemical Substances	pol Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2021-06-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13061093
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