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Book ; Thesis: Genetic characterization of bone and soft tissue tumors

Dahlén, Anna

2005

Author's details	Anna Dahlén
Language	English
Size	Getr. Zählung : Ill., graph. Darst.
Publishing country	Sweden
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Lund, Univ., Diss., 2005
Note	Zsfassung in schwed. Sprache
HBZ-ID	HT014568460
ISBN	91-628-6378-9 ; 978-91-628-6378-4
Database	Catalogue ZB MED Medicine, Health

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2005 E 2223	order for loan	Magazin

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Article ; Online: Defined daily doses in pediatric dosing- a theoretical example.

Dahlén, Elin / Kindblom, Jenny Marianne / Kimland, Elin Eyfells

Pharmacology research & perspectives

2023 Volume 11, Issue 2, Page(s) e01061

Abstract: A defined daily dose for children (cDDD) taking body weight into account, was proposed as a better measure of drug utilization in children than the World Health Organization's DDD. There is no global definition of DDDs for children, and it is unclear ... ...

Abstract	A defined daily dose for children (cDDD) taking body weight into account, was proposed as a better measure of drug utilization in children than the World Health Organization's DDD. There is no global definition of DDDs for children, and it is unclear which standard doses should be used for children when conducting drug utilization studies. We used doses according to the authorized medical product information and body weight according to national pediatric growth curves to calculate theoretical cDDD for three common medicines in children in a Swedish setting. These examples demonstrate that the concept of cDDD may not be optimal for drug utilization studies in children, especially not for younger children and when dosing is done according to weight is crucial. Validation of cDDD in real-world data is warranted. When conducting pediatric drug utilization studies, accessibility to individual-level data on body weight and age combined with dosing information is needed.
MeSH term(s)	Child ; Humans ; Body Weight ; Drug Utilization
Language	English
Publishing date	2023-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.1061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply: U-BIOPRED/BIOAIR proteins: inflammation or infection?

Sparreman Mikus, Maria / Kolmert, Johan / Andersson, Lars I / Dahlén, Sven-Erik / James, Anna

The European respiratory journal

2022 Volume 60, Issue 6

MeSH term(s)	Humans ; Asthma/metabolism ; Inflammation ; Blood Proteins ; Steroids
Chemical Substances	Blood Proteins ; Steroids
Language	English
Publishing date	2022-12-01
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01795-2022
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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Article ; Online: A novel assay for improved detection of sputum periostin in patients with asthma.

Ono, Junya / Takai, Masayuki / Kamei, Ayami / Ohta, Shoichiro / Nair, Parameswaran / Izuhara, Kenji / Dahlén, Sven-Erik / James, Anna

PloS one

2023 Volume 18, Issue 2, Page(s) e0281356

Abstract: Background: Serum periostin associates with type-2 inflammation in asthmatic airways, but also reflects whole body periostin levels originating from multiple sources. Less is known about sputum periostin as a biomarker in asthma as detection levels are ... ...

Abstract	Background: Serum periostin associates with type-2 inflammation in asthmatic airways, but also reflects whole body periostin levels originating from multiple sources. Less is known about sputum periostin as a biomarker in asthma as detection levels are low using currently available periostin assays. We aimed to investigate detection of sputum periostin using ELISA assays targeting different periostin epitopes and relate levels to clinical characteristics. Methods: Two ELISA systems were developed using antibodies detecting whole periostin or cleavage products, the molecular weight and amino acid sequences of which were confirmed. The ELISA assays were applied to sputum from 80 patients with mild-to-moderate and severe asthma enrolled in the European, multi-center study BIOAIR. Results were related to clinical characteristics. Results: Sputum was found to contain smaller periostin fragments, possibly due to proteolytic cleavage at a C-terminal site. Comparing ELISA methodology using antibodies against cleaved versus whole periostin revealed detectable levels in 90% versus 44% of sputum samples respectively. Sputum periostin showed associations with blood and sputum eosinophils. Furthermore, sputum, but not serum, periostin correlated with reduced lung function and sputum IL-13 and was reduced by oral corticosteroid treatment. Conclusions: We present an ELISA method for improved analysis of sputum periostin by detecting cleavage products of the periostin protein. Using this assay, sputum periostin was detectable and associated with more disease-relevant parameters in asthma than serum periostin. Sputum periostin is worth considering as a phenotype-specific biomarker in asthma as its proximity to the airways may eliminate some of the confounding factors known to affect serum periostin.
MeSH term(s)	Humans ; Sputum/chemistry ; Asthma/drug therapy ; Eosinophils ; Biomarkers ; Phenotype
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281356
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Combined exposure to the alarmins TSLP, IL-33 and IL-25 enhances mast cell-dependent contractions of human bronchi.

Belikova, Maria / Säfholm, Jesper / Al-Ameri, Mamdoh / Orre, Ann-Charlotte / Dahlén, Sven-Erik / Adner, Mikael

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2023 Volume 53, Issue 10, Page(s) 1062–1066

MeSH term(s)	Humans ; Alarmins ; Mast Cells ; Interleukin-33 ; Bronchi ; Asthma ; Cytokines
Chemical Substances	Alarmins ; Interleukin-33 ; Cytokines
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14367
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Article ; Online: A comparative study on periodontitis and periodontitis-associated bacteria in Somali and non-Somali children and adolescents living in Trollhättan, Sweden.

Thorbert-Mros, Sara / Ali, Nawal / Ali, Meis / Ayas, Mert / Trullenque-Eriksson, Anna / Dahlén, Gunnar

European journal of oral sciences

2021 Volume 130, Issue 2, Page(s) e12843

Abstract: The reported prevalence of periodontitis in children and adolescents varies considerably between populations globally. This cross-sectional study compares clinical and microbiological findings on 83 Somali immigrants and 96 non-Somali children aged 10-17 ...

Abstract	The reported prevalence of periodontitis in children and adolescents varies considerably between populations globally. This cross-sectional study compares clinical and microbiological findings on 83 Somali immigrants and 96 non-Somali children aged 10-17 years old living in Trollhättan, Sweden. The clinical examination included registration of bleeding on probing, plaque, and calculus on incisors and first molars. The distance between cemento-enamel junction and bone level was measured on bitewing radiographs. Pooled microbiological samples (1 μL) were taken from the mesial surface of 16, 11, 31, 36, and analyzed by culture and real-time polymerase chain reaction for seven periodontal associated bacterial species. The Somali participants had poorer oral hygiene and more bleeding, plaque, and calculus. Ten of the Somali but none of the non-Somali participants showed periodontal breakdown (radiographical bone loss > 3 mm), corresponding to a prevalence of 12% (95% CI: 5.9, 21.0%). The presence of A. actinomycetemcomitans was almost exclusively associated with Somali participants. Further, the JP2 clone was found in five Somalis (including two periodontitis cases) confirming the association of this clone with African populations. The Somali group showed significantly higher frequencies and numbers of Porphyromonas gingivalis and Treponema denticola, implying a mature and adult type of subgingival microbiota.
MeSH term(s)	Adolescent ; Adult ; Aggregatibacter actinomycetemcomitans/genetics ; Calculi ; Child ; Cross-Sectional Studies ; Dental Plaque/microbiology ; Humans ; Periodontitis/microbiology ; Porphyromonas gingivalis ; Real-Time Polymerase Chain Reaction ; Somalia ; Sweden/epidemiology
Language	English
Publishing date	2021-12-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1224820-4
ISSN	1600-0722 ; 0909-8836
ISSN (online)	1600-0722
ISSN	0909-8836
DOI	10.1111/eos.12843
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Zs.MO 76: Show issues

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Article ; Online: Non-adherence and sub-optimal treatment with asthma medications in young adults: a population-based cohort study.

Dahlén, Elin / Bergström, Anna / Ödling, Maria / Ekström, Sandra / Melén, Erik / Kull, Inger

The Journal of asthma : official journal of the Association for the Care of Asthma

2021 Volume 59, Issue 8, Page(s) 1661–1669

Abstract: Objective: Pharmacological treatment plays a key role in the management of asthma, but medication adherence is generally low. Our aim was to assess factors associated with dispensing patterns of, and adherence to, asthma medication in young adults with ... ...

Abstract	Objective: Pharmacological treatment plays a key role in the management of asthma, but medication adherence is generally low. Our aim was to assess factors associated with dispensing patterns of, and adherence to, asthma medication in young adults with asthma. Methods: The study included young adults (age 22-24 years) from the Swedish population-based birth cohort BAMSE ( Results: In total, 234 individuals (7.6%) had asthma (doctor's diagnosis of asthma in combination with respiratory symptoms) and had been dispensed at least one prescription of asthma medication during the study period. Among them, 77% were dispensed a controller medication. The mean number of prescriptions dispensed per individual was higher in males than females (11.0 vs. 7.2; Conclusion: Young adults with asthma had few prescriptions of asthma medication dispensed, indicating sub-optimal treatment. A considerable proportion was dispensed only SABA. Furthermore, adherence to controller medication was relatively low.
MeSH term(s)	Adult ; Anti-Asthmatic Agents/therapeutic use ; Asthma/diagnosis ; Cohort Studies ; Female ; Humans ; Male ; Medication Adherence ; Social Class ; Young Adult
Chemical Substances	Anti-Asthmatic Agents
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2021.1941092
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Article ; Online: The sustainability of midwifery group practice: A cross-sectional study of midwives and managers.

Hewitt, Leonie / Dadich, Ann / Hartz, Donna L / Dahlen, Hannah G

Women and birth : journal of the Australian College of Midwives

2024 Volume 37, Issue 3, Page(s) 101602

Abstract: Problem: Although there is robust evidence for the benefits of midwifery group practice (MGP) caseload care, there are limited opportunities for women to access this model in Australia. There is also limited knowledge on how to sustain these services.!## ...

Abstract	Problem: Although there is robust evidence for the benefits of midwifery group practice (MGP) caseload care, there are limited opportunities for women to access this model in Australia. There is also limited knowledge on how to sustain these services. Background: MGP can benefit childbearing women and babies and improve satisfaction for women and midwives. However, sustainability of the model is challenging. While MGPs are often supported and celebrated, in Australia some services have closed, while others struggle to adequately staff MGPs. Aim: To investigate midwives and managers opinions on the management, culture, and sustainability of MGP. Methods: A national survey of MGP midwives and managers was distributed (2021 and 2022). Quantitative data were analysed using descriptive statistics, and qualitative data were analysed using content analysis. Results: A total of 579 midwives and 90 managers completed the survey. The findings suggest that many MGPs do not support new graduates and students to work in MGP. Over half (59.8%) the participants (midwives and managers) reported that the women and families were the best aspect about working in MGP, while 44.3% said the effects on midwives' lifestyle and families were the worst aspect. Discussion: The relationship with women remains the major motivator for providing MGP care. However, work-life imbalance is a deterrent, exacerbated by staffing shortages. Staffing might be improved by adequate renumeration, strengthening orientation, and attracting new graduates and students through experience in MGP. Conclusions: There is a need to attract midwives to MGP and improve work-life balance and sustainability.
MeSH term(s)	Pregnancy ; Female ; Humans ; Midwifery/methods ; Cross-Sectional Studies ; Australia ; Surveys and Questionnaires ; Group Practice ; Nurse Midwives ; Qualitative Research
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2235085-8
ISSN	1878-1799 ; 1871-5192
ISSN (online)	1878-1799
ISSN	1871-5192
DOI	10.1016/j.wombi.2024.101602
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Article ; Online: The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study.

Dahlén, Torsten / Flygt, Hjalmar / Lübking, Anna / Olsson-Strömberg, Ulla / Wennström, Lovisa / Dreimane, Arta / Själander, Anders / Leach, Susannah / Gisslén, Magnus / Li, Huiqi / Höglund, Martin / Stenke, Leif / Nyberg, Fredrik

Leukemia

2023 Volume 37, Issue 5, Page(s) 1156–1159

MeSH term(s)	Humans ; COVID-19/epidemiology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/epidemiology ; Leukemia, Myeloid ; Chronic Disease
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-01893-1
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Article ; Online: A novel assay for improved detection of sputum periostin in patients with asthma.

Junya Ono / Masayuki Takai / Ayami Kamei / Shoichiro Ohta / Parameswaran Nair / Kenji Izuhara / Sven-Erik Dahlén / Anna James / BIOAIR consortium

PLoS ONE, Vol 18, Iss 2, p e

2023 Volume 0281356

Abstract: Background Serum periostin associates with type-2 inflammation in asthmatic airways, but also reflects whole body periostin levels originating from multiple sources. Less is known about sputum periostin as a biomarker in asthma as detection levels are ... ...

Abstract	Background Serum periostin associates with type-2 inflammation in asthmatic airways, but also reflects whole body periostin levels originating from multiple sources. Less is known about sputum periostin as a biomarker in asthma as detection levels are low using currently available periostin assays. We aimed to investigate detection of sputum periostin using ELISA assays targeting different periostin epitopes and relate levels to clinical characteristics. Methods Two ELISA systems were developed using antibodies detecting whole periostin or cleavage products, the molecular weight and amino acid sequences of which were confirmed. The ELISA assays were applied to sputum from 80 patients with mild-to-moderate and severe asthma enrolled in the European, multi-center study BIOAIR. Results were related to clinical characteristics. Results Sputum was found to contain smaller periostin fragments, possibly due to proteolytic cleavage at a C-terminal site. Comparing ELISA methodology using antibodies against cleaved versus whole periostin revealed detectable levels in 90% versus 44% of sputum samples respectively. Sputum periostin showed associations with blood and sputum eosinophils. Furthermore, sputum, but not serum, periostin correlated with reduced lung function and sputum IL-13 and was reduced by oral corticosteroid treatment. Conclusions We present an ELISA method for improved analysis of sputum periostin by detecting cleavage products of the periostin protein. Using this assay, sputum periostin was detectable and associated with more disease-relevant parameters in asthma than serum periostin. Sputum periostin is worth considering as a phenotype-specific biomarker in asthma as its proximity to the airways may eliminate some of the confounding factors known to affect serum periostin.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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